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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-374</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8539</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ КОЖИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Возможности повышения эффективности терапии акне</article-title><trans-title-group xml:lang="en"><trans-title>The possibilities of improving the effectiveness of acne therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0565-9149</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загртдинова</surname><given-names>Р. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagrtdinova</surname><given-names>R. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загртдинова Ризида Миннесагитовна, д.м.н., профессор, заведующая кафедрой дерматовенерологии</p><p>426034, Россия, Ижевск, ул. Коммунаров, д. 281</p></bio><bio xml:lang="en"><p>Rizida M. Zagrtdinova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenerology</p><p>281, Kommunarov St., Izhevsk, 426056</p></bio><email xlink:type="simple">kafedra.derma@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1509-093X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Загртдинова</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zagrtdinova</surname><given-names>R. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Загртдинова Ризиля Нуровна, ассистент кафедры дерматовенерологии</p><p>426034, Россия, Ижевск, ул. Коммунаров, д. 281</p></bio><bio xml:lang="en"><p>Rizilya N. Zagrtdinova, Assistant of the Department of Dermatoneverology</p><p>281, Kommunarov St., Izhevsk, 426056</p></bio><email xlink:type="simple">rizilya2012@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мустафаева</surname><given-names>Э. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Mustafayeva</surname><given-names>E. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мустафаева Эльнара Шахбазовна, клинический ординатор кафедры дерматовенерологии</p><p>426034, Россия, Ижевск, ул. Коммунаров, д. 281</p></bio><bio xml:lang="en"><p>Elnara Sh. Mustafayeva, Clinical Resident of the Department of Dermatovenerology</p><p>281, Kommunarov St., Izhevsk, 426056</p></bio><email xlink:type="simple">Ehl1308@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ижевская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Izhevsk State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>14</day><month>09</month><year>2024</year></pub-date><volume>0</volume><issue>14</issue><fpage>102</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Загртдинова Р.М., Загртдинова Р.Н., Мустафаева Э.Ш., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Загртдинова Р.М., Загртдинова Р.Н., Мустафаева Э.Ш.</copyright-holder><copyright-holder xml:lang="en">Zagrtdinova R.M., Zagrtdinova R.N., Mustafayeva E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8539">https://www.med-sovet.pro/jour/article/view/8539</self-uri><abstract><p>Акне – одна из актуальнейших проблем дерматологии, т. к. данный дерматоз является широко распространенным, часто встречается в пубертатном периоде, сопровождается косметическими дефектами, вызывает повышенную тревожность, дисморфофобию и депрессивные состояния. Как результат, у пациентов снижается качество жизни и возможность социальной адаптации, в связи с чем необходима оптимизация лечения данного заболевания с включением современных высокоэффективных препаратов. При назначении лечения необходимо учитывать все звенья патогенеза акне, а также помнить, что в развитии дерматоза, особенно тяжелого течения, важную роль играет воспаление. При легкой степени акне рекомендовано назначение только наружной терапии, при средней – наружная терапия и при необходимости системная, при тяжелой системная терапия применяется в качестве основной. Назначение антибиотиков при данном дерматозе продиктовано наличием бактериальной флоры. Клиндамицин является одним из антибиотиков, эффективно снижающих колонизацию С. acnes. Для обеспечения высокой эффективности и безопасности топической терапии, а также профилактики развития резистентности микроорганизмов существует необходимость применения комбинации как минимум двух препаратов. Так, сочетание клиндамицина с бензоила пероксидом дает возможность повысить эффективность терапии благодаря бактерицидному, бактериостатическому, противовоспалительному и кератолитическому действию. Удобный режим применения и быстрый терапевтический эффект позволяют включить данную комбинацию в группу приоритетных препаратов для лечения акне. Комедонолитический, противовоспалительный и бактерицидный эффект также наблюдается у азелаиновой кислоты, в связи чем препараты, содержащие данный компонент, показывают высокий патогенетический эффект при акне.</p></abstract><trans-abstract xml:lang="en"><p>Acne is one of the most urgent problems of dermatology, since this dermatosis is widespread, often occurs during puberty, is accompanied by cosmetic defects, causes increased anxiety, dysmorphic phobia and depressive states. As a result, the quality of life and the possibility of social adaptation decrease in patients. Therefore, it is necessary to optimize the treatment of this disease with the inclusion of modern highly effective drugs. When prescribing treatment, it is necessary to take into account all links in the pathogenesis of acne, and also remember that inflammation plays an important role in the development of dermatosis (especially severe course). With mild acne, it is recommended to prescribe only external therapy, with medium – external therapy and, if necessary, systemic, with severe systemic therapy is used as the main one. The appointment of antibiotics for this dermatosis is dictated by the presence of bacterial flora. Clindamycin is one of the antibiotics that effectively reduce colonization of C. аcnes. To ensure the high efficiency and safety of topical therapy, as well as the prevention of the development of resistance of microorganisms, there is a need to use a combination of at least two drugs. Thus, the combination of clindamycin with benzoyl peroxide makes it possible to increase the effectiveness of therapy due to bactericidal, bacteriostatic, anti-inflammatory and keratolytic actions. The convenient mode of use and the rapid therapeutic effect make it possible to include this combination in the group of priority drugs for the treatment of acne. Comedonolytic, anti-inflammatory and bactericidal effects are also observed in azelaic acid, and therefore drugs containing this component show a high pathogenetic effect in acne.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>акне</kwd><kwd>бензоил пероксид</kwd><kwd>клиндамицин</kwd><kwd>азелаиновая кислота</kwd><kwd>C. acnes</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acne</kwd><kwd>benzoyl peroxide</kwd><kwd>clindamycin</kwd><kwd>azelaic acid</kwd><kwd>C. acnes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Каминская ТВ, Маруев МБ, Раковецкая ОГ, Корнюшина НИ, Зотова ЕБ, Шкурина ОА и др. Современные аспекты комбинированной наружной терапии акне. 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