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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-354</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8546</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КОСМЕТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>COSMETOLOGY</subject></subj-group></article-categories><title-group><article-title>Сочетанное применение трегалозы и ботулинического токсина типа A в программах оздоровления кожи REVITOX</article-title><trans-title-group xml:lang="en"><trans-title>Combination of trehalose and botulinum toxin type A in REVITOX skin treatment protocols</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7879-6625</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Разумовская</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Razumovskaya</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Разумовская Елена Александровна, врач-косметолог, пластический хирург, главный врач</p><p>443001, Самара, ул. Садовая, д. 199</p></bio><bio xml:lang="en"><p>Elena A. Razumovskaya, Aesthetic Physician, Plastic Surgeon, Medical Director</p><p>199, Sadovaya St., Samara, 443001</p></bio><email xlink:type="simple">ra3umovskaya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ренессанс-Косметология</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Renessans Kosmetologiya</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2024</year></pub-date><volume>0</volume><issue>14</issue><fpage>177</fpage><lpage>185</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Разумовская Е.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Разумовская Е.А.</copyright-holder><copyright-holder xml:lang="en">Razumovskaya E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8546">https://www.med-sovet.pro/jour/article/view/8546</self-uri><abstract><p>В статье представлен разработанный автором протокол REVITOX, предусматривающий сочетанное применение препаратов REVI (нативная гиалуроновая кислота и трегалоза) и ботулинического токсина типа А (БТА) для лечения розацеа и коррекции возрастных изменений лица. Многочисленные исследования подтверждают, что трегалоза обладает выраженным стабилизирующим эффектом в отношении белков, способствует сохранению целостности клеток, проявляет антиоксидантное и ангиопротекторное действие, а также характеризуется способностью к активации аутофагии. В сочетании с доказанными эффектами гиалуроновой кислоты и БТА данные свойства обеспечивают оптимальные условия функционирования клеточных структур, воздействуя на основные механизмы патогенеза розацеа и способствуя уменьшению выраженности возрастных изменений лица за счет устранения динамических и статических морщин, стимуляции неоколлагеногенеза и улучшения механических свойств дермы. Воздействие на многофакторный процесс формирования морщин, повышение увлажненности и эластичности кожи с помощью протокола REVITOX Beauty способствовало получению гармоничных результатов коррекции возрастных изменений периоральной и периорбитальной области со значительным улучшением качества кожи, подтвержденным результатами 3D-диагностики. У пациентов с розацеа после лечения по программе REVITOX Derma отмечено улучшение состояния кожи лица, заметное уменьшение выраженности эритемы и телеангиэктазий, регресс папулопустулезных элементов, повышение увлажненности и эластичности кожи с отсутствием рецидивов заболевания по результатам последующего наблюдения. Дальнейшие исследования сочетанного применения БТА и REVI позволят изучить возможности использования протоколов при других дерматозах, а также в комбинациях с аппаратными и инъекционными методами эстетической коррекции.</p></abstract><trans-abstract xml:lang="en"><p>This article presents the REVITOX protocol, developed by the author, which includes the combination of REVI products (native hyaluronic acid + trehalose) and botulinum toxin type A (BTA) for the treatment of rosacea and correction of age-related changes. A plethora of studies has demonstrated that trehalose, an exceptional stabilizer of proteins, contributes to maintaining cellular integrity, exhibits antioxidant and angioprotective effects, and has been shown to induce autophagy. In combination with the proven effects of hyaluronic acid and BTA, these properties facilitate the optimal environment for cellular structure functioning, influencing the basic mechanisms of rosacea pathogenesis and mitigating the severity of age-related changes through the balanced elimination of dynamic and static rhytides, stimulation of neocollagenesis and improvement of the mechanical properties of the dermis. By targeting the multifactorial processes of facial aging, improving skin hydration and elasticity, the REVITOX Beauty protocol has ensured the balanced rejuvenation of the perioral and periorbital skin, resulting in a significant improvement in skin quality, as confirmed by the results of 3D diagnostics. After 3 treatment sessions of the REVITOX Derma program, the patients showed a general improvement of facial skin, a visible reduction in erythema and telangiectasia severity, regression of papulopustular elements, enhanced skin hydration and elasticity, and no recurrences at the follow-up. Further studies on the combined use of BTA and REVI will investigate the potential for using these protocols in the treatment of other dermatological conditions, including in combination with energy-based devices and beauty injections.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>трегалоза</kwd><kwd>гиалуроновая кислота</kwd><kwd>ботулинический токсин типа А</kwd><kwd>оздоровление кожи</kwd><kwd>омоложение кожи</kwd><kwd>розацеа</kwd><kwd>сочетанное применение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>trehalose</kwd><kwd>hyaluronic acid</kwd><kwd>botulinum toxin type A</kwd><kwd>skin revitalization</kwd><kwd>skin rejuvenation</kwd><kwd>rosacea</kwd><kwd>combined treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Juncan AM, Moisă DG, Santini A, Morgovan C, Rus LL, Vonica-Țincu AL, Loghin F. 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