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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-352</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8569</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ ПИЩЕВОДА И ЖЕЛУДКА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ESOPHAGEAL AND GASTRIC DISEASES</subject></subj-group></article-categories><title-group><article-title>Распространенность и особенности клинического  течения гастроэзофагеальной рефлюксной болезни  у жителей Махачкалинско-Каспийской агломерации</article-title><trans-title-group xml:lang="en"><trans-title>Prevalence and clinical features of gastroesophageal reflux disease in residents of the Makhachkala-Caspian agglomeration</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-3232-3617</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмедова</surname><given-names>П. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedova</surname><given-names>P. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахмедова Пахай Набиевна, ассистент кафедры факультетской терапии</p><p>367000, Махачкала, площадь Ленина, д. 1</p></bio><bio xml:lang="en"><p>Pakhay N. Akhmedova, Assistant of the Department of Faculty Therapy</p><p>1, Lenin Square, Makhachkala, 367000</p></bio><email xlink:type="simple">11.08.2010a@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3124-0272</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чамсутдинов</surname><given-names>Н. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Chamsutdinov</surname><given-names>N. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чамсутдинов Наби Умматович, д.м.н., профессор, заведующий кафедрой факультетской терапии</p><p>367000, Махачкала, площадь Ленина, д. 1</p></bio><bio xml:lang="en"><p>Nabi U. Chamsutdinov, Dr. Sci. (Med.), Professor, Head of the Department of Faculty Therapy</p><p>1, Lenin Square, Makhachkala, 367000</p></bio><email xlink:type="simple">nauchdoc60@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Дагестанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dagestan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>16</day><month>10</month><year>2024</year></pub-date><volume>0</volume><issue>15</issue><elocation-id>30–36</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Ахмедова П.Н., Чамсутдинов Н.У., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ахмедова П.Н., Чамсутдинов Н.У.</copyright-holder><copyright-holder xml:lang="en">Akhmedova P.N., Chamsutdinov N.U.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8569">https://www.med-sovet.pro/jour/article/view/8569</self-uri><abstract><sec><title>Введение</title><p>Введение. Гастроэзофагеальная рефлюксная болезнь является наиболее распространенным заболеванием желудочно-кишечного тракта. В последние десятилетия с целью изучения ее распространенности использовались различные опросники: GERD-Q, QUEST, FSSG, RDQ, GERD-HRQL, применение которых позволило установить отчетливую тенденцию к увеличению частоты заболевания во всем мире, в том числе в России.</p></sec><sec><title>Цель</title><p>Цель. Изучить распространенность и особенности клинического течения гастроэзофагеальной рефлюксной болезни у жителей Махачкалинско-Каспийской агломерации Республики Дагестан.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведено анкетирование 496 жителей Республики Дагестан (308 женщин и 188 мужчин, средний возраст – 40 ± 0,7 года) с использованием опросников GERD-Q и ЭФГАРД (Эпидемиология и Факторы риска развития Гастроэзофагеальной Рефлюксной болезни в Дагестане).</p></sec><sec><title>Результаты</title><p>Результаты. Распространенность гастроэзофагеальной рефлюксной болезни у жителей Махачкалинско-Каспийской агломерации Республики Дагестан по данным опросника GERD-Q составила 11,8%, по данным опросника ЭФГАРД ‒ 26,2%. Наиболее часто среди жителей Республики Дагестан страдают гастроэзофагеальной рефлюксной болезнью даргинцы (39,8%), аварцы (38,2%) и кумыки (37,0%), несколько реже – лезгины (30,7%) и метисы (31,6%), значительно реже – лакцы (12%) и табасаранцы (8,9%). Установлено, что, помимо пищеводных симптомов заболевания, у пациентов с гастроэзофагеальной рефлюксной болезнью часто встречаются симптомы заболеваний желудочно-кишечного тракта, а также отоларингологические, бронхолегочные, кардиальные и стоматологические.</p></sec><sec><title>Заключение</title><p>Заключение. Распространенность гастроэзофагеальной рефлюксной болезни у жителей Махачкалинско-Каспийской агломерации Республики Дагестан согласно опроснику ЭФГАРД составила 26,2%. При этом опросник показал свою высокую диагностическую ценность, что позволяет рекомендовать его для ранней диагностики гастроэзофагеальной рефлюксной болезни и ее внепищеводных проявлений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Gastroesophageal reflux disease is the most common gastrointestinal disease. In recent decades, various questionnaires have been used to study the prevalence of gastroesophageal reflux disease: GERD-Q, QUEST, FSSG, RDQ, GERD-HRQL, the use of which has allowed us to establish a clear trend towards an increase in the frequency of gastroesophageal reflux disease throughout the world, including in Russia.</p></sec><sec><title>Aim</title><p>Aim. To study the prevalence and features of the clinical course of gastroesophageal reflux disease in residents of the Makhachkala- Caspian agglomeration of the Republic of Dagestan.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A survey was conducted of 496 residents of the Republic of Dagestan (308 women and 188 men, average age ‒ 40 ± 0.7 years) using the GERD-Q and EFGERD (Epidemiology and Risk Factors for the Development of Gastroesophageal Reflux Disease in Dagestan) questionnaires.</p></sec><sec><title>Results</title><p>Results. The prevalence of gastroesophageal reflux disease in residents of the Makhachkala-C aspian agglomeration of the Republic of Dagestan according to the GERD-Q questionnaire was 11.8%, according to the EFGERD questionnaire – 26.2%. The most common residents of the Republic of Dagestan who suffer from gastroesophageal reflux disease are Dargins (39.8%), Avars (38.2%) and Kumyks (37.0%). Somewhat less common are Lezgins (30.7%) and mestizos (31.6%). Laks (12%) and Tabasarans (8.9%) suffer from gastroesophageal reflux disease much less frequently. It has been established that in addition to esophageal symptoms of the disease, patients with gastroesophageal reflux disease often have symptoms of gastrointestinal tract diseases, as well as otolaryngological, bronchopulmonary, cardiac and dental symptoms.</p></sec><sec><title>Conclusion</title><p>Conclusion. The prevalence of gastroesophageal reflux disease in residents of the Makhachkala-C aspian agglomeration of the Republic of Dagestan according to the EFGERD questionnaire was 26.2%. At the same time, the EFGERD questionnaire has shown its high diagnostic value, which makes it possible to recommend it for the purpose of early diagnosis of gastroesophageal reflux disease and its extraesophageal manifestations.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Республика Дагестан</kwd><kwd>распространенность</kwd><kwd>опросники</kwd><kwd>пищеводные симптомы</kwd><kwd>внепищеводные симптомы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Republic of Dagestan</kwd><kwd>prevalence</kwd><kwd>questionnaires</kwd><kwd>esophageal symptoms</kwd><kwd>extraesophageal symptoms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gyawali CP, Kahrilas PJ, Savarino E, Zerbib F, Mion F, Smout AJPM et al. Modern diagnosis of GERD: the Lyon Consensus. Gut. 2018;67(7):1351–1362. https://doi.org/10.1136/gutjnl-2017-314722.</mixed-citation><mixed-citation xml:lang="en">Gyawali CP, Kahrilas PJ, Savarino E, Zerbib F, Mion F, Smout AJPM et al. Modern diagnosis of GERD: the Lyon Consensus. Gut. 2018;67(7):1351–1362. https://doi.org/10.1136/gutjnl-2017-314722.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Shaqran TM, Ismaeel MM, Alnuaman AA, Al Ahmad FA, Albalawi GA, Almubarak JN et al. Epidemiology, Causes, and Management of Gastroesophageal Reflux Disease: A Systematic Review. Cureus. 2023;15(10):e47420. https://doi.org/10.7759/cureus.47420.</mixed-citation><mixed-citation xml:lang="en">Shaqran TM, Ismaeel MM, Alnuaman AA, Al Ahmad FA, Albalawi GA, Almubarak JN et al. Epidemiology, Causes, and Management of Gastroesophageal Reflux Disease: A Systematic Review. Cureus. 2023;15(10):e47420. https://doi.org/10.7759/cureus.47420.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Maev I, Bakulin I, Bordin D, Bakulina N, Oganezova I, Skazyvaeva E et al. Epidemiological and clinical risk factors for non-erosive reflux disease, erosive esophagitis and Barrett’s esophagus in Russia. Gastroenterol Hepatol Open Access. 2021;12(6):185–189. https://doi.org/10.15406/ghoa.2021.12.00482.</mixed-citation><mixed-citation xml:lang="en">Maev I, Bakulin I, Bordin D, Bakulina N, Oganezova I, Skazyvaeva E et al. Epidemiological and clinical risk factors for non-erosive reflux disease, erosive esophagitis and Barrett’s esophagus in Russia. Gastroenterol Hepatol Open Access. 2021;12(6):185–189. https://doi.org/10.15406/ghoa.2021.12.00482.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Contreras-Omaña R, Sánchez-Reyes O, Ángeles-Granados E. Comparison of the Carlsson-Dent and GERD-Q questionnaires for gastroesophageal reflux disease symptom detection in a general population. Rev Gastroenterol Mex. 2017;82(1):19–25. https://doi.org/10.1016/j.rgmx.2016.05.005.</mixed-citation><mixed-citation xml:lang="en">Contreras-Omaña R, Sánchez-Reyes O, Ángeles-Granados E. Comparison of the Carlsson-Dent and GERD-Q questionnaires for gastroesophageal reflux disease symptom detection in a general population. Rev Gastroenterol Mex. 2017;82(1):19–25. https://doi.org/10.1016/j.rgmx.2016.05.005.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Sugihartono T, Hidayat AA, Lusida MAP, Kuntaman, Aftab H, Miftahussurur M. Comparison of RDQ and GERDQ for Predicting Erosive Esophagitis in Patients with Typical GERD Symptoms. Korean J Gastroenterol. 2023;82(2):84–90. https://doi.org/10.4166/kjg.2023.027.</mixed-citation><mixed-citation xml:lang="en">Sugihartono T, Hidayat AA, Lusida MAP, Kuntaman, Aftab H, Miftahussurur M. Comparison of RDQ and GERDQ for Predicting Erosive Esophagitis in Patients with Typical GERD Symptoms. Korean J Gastroenterol. 2023;82(2):84–90. https://doi.org/10.4166/kjg.2023.027.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Simadibrata DM, Ngadiono E, Sinuraya FAG, Damara I, Fass R, Simadibrata M. Diagnostic accuracy of gastroesophageal reflux disease questionnaire for gastroesophageal reflux disease: A systematic review and meta-analysis. Neurogastroenterol Motil. 2023;35(12):e14619. https://doi.org/10.1111/nmo.14619.</mixed-citation><mixed-citation xml:lang="en">Simadibrata DM, Ngadiono E, Sinuraya FAG, Damara I, Fass R, Simadibrata M. Diagnostic accuracy of gastroesophageal reflux disease questionnaire for gastroesophageal reflux disease: A systematic review and meta-analysis. Neurogastroenterol Motil. 2023;35(12):e14619. https://doi.org/10.1111/nmo.14619.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Saragih RH, Rey I. FSSG Scale System in Comparison with GERD Questionnaires in Predicting Endoscopic Findings with Reflux Esophagitis. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy. 2012;13(3):136–140. Available at: https://www.ina-jghe.com/index.php/jghe/article/view/388.</mixed-citation><mixed-citation xml:lang="en">Saragih RH, Rey I. FSSG Scale System in Comparison with GERD Questionnaires in Predicting Endoscopic Findings with Reflux Esophagitis. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy. 2012;13(3):136–140. Available at: https://www.ina-jghe.com/index.php/jghe/article/view/388.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shimoyama Y, Kusano M, Sugimoto S, Kawamura O, Maeda M, Minashi K et al. Diagnosis of gastroesophageal reflux disease using a new questionnaire. J Gastroenterol Hepatol. 2005;20(4):643–647. https://doi.org/10.1111/j.1440-1746.2005.03776.x.</mixed-citation><mixed-citation xml:lang="en">Shimoyama Y, Kusano M, Sugimoto S, Kawamura O, Maeda M, Minashi K et al. Diagnosis of gastroesophageal reflux disease using a new questionnaire. J Gastroenterol Hepatol. 2005;20(4):643–647. https://doi.org/10.1111/j.1440-1746.2005.03776.x.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kurokawa R, Kanemitsu Y, Fukumitsu K, Takeda N, Yap JM, Suzuki M et al. The diagnostic utility of the frequency scale for the symptoms of gastroesophageal reflux disease questionnaire (FSSG) for patients with subacute/chronic cough. J Asthma. 2021;58(11):1502–1511. https://doi.org/10.1080/02770903.2020.1805750.</mixed-citation><mixed-citation xml:lang="en">Kurokawa R, Kanemitsu Y, Fukumitsu K, Takeda N, Yap JM, Suzuki M et al. The diagnostic utility of the frequency scale for the symptoms of gastroesophageal reflux disease questionnaire (FSSG) for patients with subacute/chronic cough. J Asthma. 2021;58(11):1502–1511. https://doi.org/10.1080/02770903.2020.1805750.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy AT, Posner S, Harbrecht M, Koutlas N, Reichstein J, Cantrell S, Leiman DA. Reflux Disease Questionnaire Scoring and Utilization: A Scoping Review. Foregut. 2024;4(2):130–137. https://doi.org/10.1177/26345161231198622.</mixed-citation><mixed-citation xml:lang="en">Reddy AT, Posner S, Harbrecht M, Koutlas N, Reichstein J, Cantrell S, Leiman DA. Reflux Disease Questionnaire Scoring and Utilization: A Scoping Review. Foregut. 2024;4(2):130–137. https://doi.org/10.1177/26345161231198622.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mouli VP, Ahuja V. Questionnaire based gastroesophageal reflux disease (GERD) assessment scales. Indian J Gastroenterol. 2011;30(3):108–117. https://doi.org/10.1007/s12664-011-0105-9.</mixed-citation><mixed-citation xml:lang="en">Mouli VP, Ahuja V. Questionnaire based gastroesophageal reflux disease (GERD) assessment scales. Indian J Gastroenterol. 2011;30(3):108–117. https://doi.org/10.1007/s12664-011-0105-9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Бордин ДС, Абдулхаков РА, Осипенко МФ, Соловьева АВ, Абдулхаков СР, Кириленко НП и др. Многоцентровое исследование распространенности симптомов гастроэзофагеальной рефлюксной болезни у пациентов поликлиник в России. Терапевтический архив. 2022;94(1):48–56. https://doi.org/10.26442/00403660.2022.01.201322.</mixed-citation><mixed-citation xml:lang="en">Bordin DS, Abdulkhakov RА, Osipenko MF, Solovyeva AV, Abdulkhakov SR, Kirilenko NP et al. Multicenter study of gastroesophageal reflux disease symptoms prevalence in outpatients in Russia. Terapevticheskii Arkhiv. 2022;94(1):48–56. (In Russ.) https://doi.org/10.26442/00403660.2022.01.201322.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ахмедова ПН, Чамсутдинов НУ. Диагностические подходы к гастроэзофагеальной рефлюксной болезни. В: Актуальные вопросы внутренней медицины: материалы II Всероссийской научно-­практической конференции с международным участием. Махачкала, 31 мая 2024 г. Махачкала; 2024. С. 38–53. Режим доступа: https://dgmu.ru/wp-content/uploads/2024/06/II-Vserossijskaya-nauchno-prakticheskaya-konferentsiya-Aktualnyevoprosy-vnutrennej-meditsiny-31.05.2024-g.-kopiya_compressed.pdf.</mixed-citation><mixed-citation xml:lang="en">Ахмедова ПН, Чамсутдинов НУ. Диагностические подходы к гастроэзофагеальной рефлюксной болезни. В: Актуальные вопросы внутренней медицины: материалы II Всероссийской научно-­практической конференции с международным участием. Махачкала, 31 мая 2024 г. Махачкала; 2024. С. 38–53. Режим доступа: https://dgmu.ru/wp-content/uploads/2024/06/II-Vserossijskaya-nauchno-prakticheskaya-konferentsiya-Aktualnyevoprosy-vnutrennej-meditsiny-31.05.2024-g.-kopiya_compressed.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tutuian R, Castell DO. Management of gastroesophageal reflux disease. Am J Med Sci. 2003;326(5):309–318. https://doi.org/10.1097/00000441-200311000-00007.</mixed-citation><mixed-citation xml:lang="en">Tutuian R, Castell DO. Management of gastroesophageal reflux disease. Am J Med Sci. 2003;326(5):309–318. https://doi.org/10.1097/00000441-200311000-00007.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer JL, Tolisano AM, Navarro AI, Trinh L, Abuzeid WM, Humphreys IM et al. Layperson Perception of Reflux-Related Symptoms. OTO Open. 2023;7(2):e51. https://doi.org/10.1002/oto2.51.</mixed-citation><mixed-citation xml:lang="en">Fischer JL, Tolisano AM, Navarro AI, Trinh L, Abuzeid WM, Humphreys IM et al. Layperson Perception of Reflux-Related Symptoms. OTO Open. 2023;7(2):e51. https://doi.org/10.1002/oto2.51.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Маев ИВ, Казюлин АН, Юренев ГЛ, Вьюхнова ЕС, Лебедева ЕГ, Дичева ДТ, Бусарова ГА. Маски гастроэзофагеальной рефлюксной болезни. Результаты 20-летнего наблюдения. Фарматека. 2018;(13):30–43. https://doi.org/10.18565/pharmateca.2018.13.30-43.</mixed-citation><mixed-citation xml:lang="en">Mayev IV, Kazyulin AN, Yurenev GL, Vyuchnova ES, Lebedeva EG, Dicheva DT, Busarova GA. Masks of gastroesophageal reflux disease. Results of 20-year observation. Farmateka. 2018;(13):30–43. (In Russ.) https://doi.org/10.18565/pharmateca.2018.13.30-43.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Antunes C, Aleem A, Curtis SA. Gastroesophageal Reflux Disease. Treasure Island (FL): StatPearls Publishing; 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK441938/.</mixed-citation><mixed-citation xml:lang="en">Antunes C, Aleem A, Curtis SA. Gastroesophageal Reflux Disease. Treasure Island (FL): StatPearls Publishing; 2024. Available at: https://www.ncbi.nlm.nih.gov/books/NBK441938/.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Yim M, Chiou EH, Ongkasuwan J. Otolaryngologic Manifestations of Gastroesophageal Reflux. Curr Treat Options Peds. 2016;2(3):236–245. https://doi.org/10.1007/s40746-016-0057-5.</mixed-citation><mixed-citation xml:lang="en">Yim M, Chiou EH, Ongkasuwan J. Otolaryngologic Manifestations of Gastroesophageal Reflux. Curr Treat Options Peds. 2016;2(3):236–245. https://doi.org/10.1007/s40746-016-0057-5.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dong R, Zhang Q, Peng H. Gastroesophageal reflux disease and the risk of respiratory diseases: a Mendelian randomization study. J Transl Med. 2024;22(1):60. https://doi.org/10.1186/s12967-023-04786-0.</mixed-citation><mixed-citation xml:lang="en">Dong R, Zhang Q, Peng H. Gastroesophageal reflux disease and the risk of respiratory diseases: a Mendelian randomization study. J Transl Med. 2024;22(1):60. https://doi.org/10.1186/s12967-023-04786-0.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Grandes XA, Talanki Manjunatha R, Habib S, Sangaraju SL, Yepez D. Gastroesophageal Reflux Disease and Asthma: A Narrative Review. Cureus. 2022;14(5):e24917. https://doi.org/10.7759/cureus.24917.</mixed-citation><mixed-citation xml:lang="en">Grandes XA, Talanki Manjunatha R, Habib S, Sangaraju SL, Yepez D. Gastroesophageal Reflux Disease and Asthma: A Narrative Review. Cureus. 2022;14(5):e24917. https://doi.org/10.7759/cureus.24917.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang L, Aierken A, Zhang M, Qiu Z. Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review. J Thorac Dis. 2023;15(4):2314–2323. https://doi.org/10.21037/jtd-22-1757.</mixed-citation><mixed-citation xml:lang="en">Zhang L, Aierken A, Zhang M, Qiu Z. Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review. J Thorac Dis. 2023;15(4):2314–2323. https://doi.org/10.21037/jtd-22-1757.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chen CH, Lin CL, Kao CH. Association between gastroesophageal reflux disease and coronary heart disease: A nationwide population-based analysis. Medicine (Baltimore). 2016;95(27):e4089. https://doi.org/10.1097/MD.0000000000004089.</mixed-citation><mixed-citation xml:lang="en">Chen CH, Lin CL, Kao CH. Association between gastroesophageal reflux disease and coronary heart disease: A nationwide population-based analysis. Medicine (Baltimore). 2016;95(27):e4089. https://doi.org/10.1097/MD.0000000000004089.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gries JJ, Chen B, Virani SS, Virk HUH, Jneid H, Krittanawong C. Heartburn’s Hidden Impact: A Narrative Review Exploring Gastroesophageal Reflux Disease (GERD) as a Cardiovascular Disease Risk Factor. J Clin Med. 2023;12(23):7400. https://doi.org/10.3390/jcm12237400.</mixed-citation><mixed-citation xml:lang="en">Gries JJ, Chen B, Virani SS, Virk HUH, Jneid H, Krittanawong C. Heartburn’s Hidden Impact: A Narrative Review Exploring Gastroesophageal Reflux Disease (GERD) as a Cardiovascular Disease Risk Factor. J Clin Med. 2023;12(23):7400. https://doi.org/10.3390/jcm12237400.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Song JH, Kim YS, Choi SY, Yang SY. Association between gastroesophageal reflux disease and coronary atherosclerosis. PLoS ONE. 2022;17(5):e0267053. https://doi.org/10.1371/journal.pone.0267053.</mixed-citation><mixed-citation xml:lang="en">Song JH, Kim YS, Choi SY, Yang SY. Association between gastroesophageal reflux disease and coronary atherosclerosis. PLoS ONE. 2022;17(5):e0267053. https://doi.org/10.1371/journal.pone.0267053.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Юренев ГЛ, Самсонов АА, Юренева-Тхоржевская ТВ. Современный взгляд на кардиальные проявления гастроэзофагеальной рефлюксной болезни. Consilium Medicum. 2015;17(12):44–49. Режим доступа: https://journals.eco-vector.com/2075-1753/article/view/94375.</mixed-citation><mixed-citation xml:lang="en">Yurenev GL, Samsonov AA, Yureneva-Tkhorzhevskaya TV. Modern look at cardiac manifestations of gastroesophageal reflux disease. Consilium Medicum. 2015;17(12):44–49. (In Russ.) Available at: https://journals.eco-vector.com/2075-1753/article/view/94375.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева ОП, Пикулев ДВ. Гастроэзофагеальная рефлюксная болезнь и ишемическая болезнь сердца – существует ли синдром взаимного отягощения? Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2019;29(4):66–73. https://doi.org/10.22416/1382-4376-2019-29-4-66-73.</mixed-citation><mixed-citation xml:lang="en">Alekseeva OP, Pikulev DV. Gastroesophageal reflux disease and coronary heart disease: is there a “mutual burden” syndrome? Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2019;29(4):66–73. (In Russ.) https://doi.org/10.22416/1382-4376-2019-29-4-66-73.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nordin PA, Charitakis E, Carnlöf C, Åkerström F, Drca N. Symptoms of gastroesophageal reflux disease predicts low voltage zones in the posteroinferior left atrium in patients with persistent atrial fibrillation. Heart Rhythm O2. 2024;5(6):351–356. https://doi.org/10.1016/j.hroo.2024.05.001.</mixed-citation><mixed-citation xml:lang="en">Nordin PA, Charitakis E, Carnlöf C, Åkerström F, Drca N. Symptoms of gastroesophageal reflux disease predicts low voltage zones in the posteroinferior left atrium in patients with persistent atrial fibrillation. Heart Rhythm O2. 2024;5(6):351–356. https://doi.org/10.1016/j.hroo.2024.05.001.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Chatzidimitriou K, Papaioannou W, Seremidi K, Bougioukas K, Haidich AB. Prevalence and association of gastroesophageal reflux disease and dental erosion: An overview of reviews. J Dent. 2023;133:104520. https://doi.org/10.1016/j.jdent.2023.104520.</mixed-citation><mixed-citation xml:lang="en">Chatzidimitriou K, Papaioannou W, Seremidi K, Bougioukas K, Haidich AB. Prevalence and association of gastroesophageal reflux disease and dental erosion: An overview of reviews. J Dent. 2023;133:104520. https://doi.org/10.1016/j.jdent.2023.104520.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Preetha A, Sujatha D, Patil BA, Hegde S. Oral manifestations in gastroesophageal reflux disease. Gen Dent. 2015;63(3):e27–31. Available at: https://pubmed.ncbi.nlm.nih.gov/25945775/.</mixed-citation><mixed-citation xml:lang="en">Preetha A, Sujatha D, Patil BA, Hegde S. Oral manifestations in gastroesophageal reflux disease. Gen Dent. 2015;63(3):e27–31. Available at: https://pubmed.ncbi.nlm.nih.gov/25945775/.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
