medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-436medsovet-8607Research ArticleАРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯARTERIAL HYPERTENSIONЗначительная регрессия гипертрофии левого желудочка у пациентки с артериальной гипертензией на фоне лечения периндоприлом и аторвастатиномSignificant regression of left ventricular hypertrophy in patient with arterial hypertension during antihypertensive treatment with perindopril and atorvastatinhttps://orcid.org/0000-0003-3984-8482ТарадинГ. Г.TaradinG. G.

Тарадин Геннадий Геннадьевич, к.м.н., доцент, заведующий кафедрой терапии имени профессора А.И. Дядыка факультета непрерывного медицинского и фармацевтического образования

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Gennady G. Taradin, Cand. Sci. (Med.), Associate Professor, Head of Therapy Department named after Prof. A.I. Dyadyk, Faculty of Continuing Medical and Pharmaceutical Education

16, Ilyicha Ave., Donetsk, 283003

taradin@inbox.ruhttps://orcid.org/0000-0003-2694-6614РакитскаяИ. В.RakitskayaI. V.

Ракитская Ирина Валериевна, к.м.н., доцент, доцент кафедры терапии имени профессора А.И. Дядыка факультета непрерывного медицинского и фармацевтического образования

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Irina V. Rakitskaya, Cand. Sci. (Med.), Associate Professor, Associate Professor of Therapy Department named after Prof. A.I. Dyadyk, Faculty of Continuing Medical and Pharmaceutical Education

16, Ilyicha Ave., Donetsk, 283003

rakytskaya@yandex.ruhttps://orcid.org/0000-0002-9128-2511ПриколотаА. В.PrikolotaA. V.

Приколота Алина Вадимовна, к.м.н., доцент кафедры терапии имени профессора А.И. Дядыка факультета непрерывного медицинского и фармацевтического образования

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Alina V. Prikolota, Cand. Sci. (Med.), Associate Professor of Therapy Department named after Prof. A.I. Dyadyk, Faculty of Continuing Medical and Pharmaceutical Education

16, Ilyicha Ave., Donetsk, 283003

prikav@yandex.ruМоногароваН. Е.MonogarovaN. E.

Моногарова Надежда Егоровна, д.м.н., профессор, заведующая кафедрой факультетской терапии имени профессора А.Я. Губергрица

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Nadezhda E. Monogarova, Dr. Sci. (Med.), Professor, Head of Intermediate Level Therapy Department named after Prof. A.Ya. Gubergrits

16, Ilyicha Ave., Donetsk, 283003

kaf_vnutr_med@mail.ruhttps://orcid.org/0000-0001-9720-0276БагрийВ. А.BagriyV. A.

Багрий Василий Андреевич, к.м.н., заведующий кардиологическим отделением, Центральная городская клиническая больница №1;

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Vasiliy A. Bagriy, Cand. Sci. (Med.), Head of Cardiology Department

57, Artema St., Donetsk, 283003

dr.bagriy@gmail.comhttps://orcid.org/0009-0008-4795-6903МартыненкоА. Ю.MartynenkoA. Yu.

Мартыненко Анастасия Юрьевна, ординатор кафедры терапии имени профессора А.И. Дядыка факультета непрерывного медицинского и фармацевтического образования

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Anastasiya Y. Martynenko, Clinical Resident of Therapy Department named after Prof. A.I. Dyadyk, Faculty of Continuing Medical and Pharmaceutical Education

16, Ilyicha Ave., Donetsk, 283003

anastasya080@gmail.comДонецкий государственный медицинский университет имени М. ГорькогоРоссияDonetsk State Medical University named after M. GorkyRussian FederationЦентральная городская клиническая больница №1РоссияCentral City Clinical Hospital No. 1Russian Federation2024291020240162026Copyright © Тарадин Г.Г., Ракитская И.В., Приколота А.В., Моногарова Н.Е., Багрий В.А., Мартыненко А.Ю., 20242024Тарадин Г.Г., Ракитская И.В., Приколота А.В., Моногарова Н.Е., Багрий В.А., Мартыненко А.Ю.Taradin G.G., Rakitskaya I.V., Prikolota A.V., Monogarova N.E., Bagriy V.A., Martynenko A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8607

Гипертрофия левого желудочка (ГЛЖ) при артериальной гипертензии (АГ) относится к числу модифицируемых факторов риска сердечно-сосудистых событий и служит оправданной целью для антигипертензивной терапии. В статье представлено наблюдение за пациенткой 60 лет с гипертонической болезнью и гиперлипидемией, у которой диагностирована ГЛЖ на основании данных электрокардиографии и эхокардиографии. Кроме вольтажных критериев Соколова – Лайона и Корнелла, при исходном эхокардиографическом исследовании регистрировались утолщение межжелудочковой перегородки, задней стенки левого желудочка (ЛЖ), увеличение массы миокарда ЛЖ и индекса массы миокарда ЛЖ. Больной был рекомендован прием представителя класса ингибиторов ангиотензин-превращающего фермента периндоприла и аторвастатина. Пациентка регулярно принимала терапию и периодически проходила повторное эхокардиографическое обследование. Спустя 40 мес. наблюдения отмечено существенное уменьшение гипертрофии межжелудочковой перегородки (с 1,22 до 0,76 см, -37,7%), задней стенки ЛЖ (с 1,05 до 0,49, -53,3%), а также массы миокарда ЛЖ (с 197,9 до 96 г, -51,5%) и индекса массы миокарда ЛЖ (с 111,18 до 59,11 г/м2, -51,5%). Таким образом, за весь период наблюдения масса ЛЖ уменьшилась практически в два раза. Отмечено уменьшение размеров левого предсердия, относительной толщины стенки при тех же параметрах объема ЛЖ, показателях систолической и диастолической функции. Среди благоприятных факторов, способствовавших существенной регрессии ГЛЖ, выделяется высокая приверженность лечению, эффективность ингибиторов ангиотензин-превращающего фермента и возможное антигипертрофическое влияние аторвастатина.

Left ventricular hypertrophy (LVH) in arterial hypertension (AH) is one of the modifiable risk factors for cardiovascular events and serves as a justified goal for antihypertensive therapy. The article presents follow-up of a 60-year-old female with AH, hyperlipidemia, and discovered of LVH on the data of electrocardiography and echocardiography. In addition to the SokolowLyon and Cornell voltage criteria, the baseline echocardiographic examination revealed and increase in thickness of the ventricular septum and the left ventricular (LV) posterior wall, an increase in LV myocardial mass and LV myocardial mass index. The patient was recommended to take a drug of the class of angiotensin converting enzyme inhibitors perindopril and atorvastatin. The patient regularly received therapy and periodically underwent repeated echocardiographic examinations. After 40 months follow-up there are a significant decrease in septal hypertrophy (from 1.22 to 0.76 cm, -37.7%), LV posterior wall (from 1.05 to 0.49, -53.3%), as well as LV myocardial mass (from 197.9 to 96 g, -51.5%) and LV myocardial mass index (from 111.18 to 59.11 g/ m2, -51.5%). Thus, during the entire period of follow-up, the LV mass decreased almost twice. There was a decrease in the size of the left atrium, the relative wall thickness, with the same parameters of LV volumes, characteristics of systolic and diastolic function. Among the favorable factors contributing to significant LVH regression, high adherence to treatment, the efficacy of angiotensin converting enzyme inhibitors and the possible antihypertrophic influence of atorvastatin are discussed.

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The authors declare that there are no conflicts of interest present.