References

medsovet

Медицинский Совет

Meditsinskiy sovet = Medical Council

2079-701X2658-5790

REMEDIUM GROUP Ltd.

10.21518/ms2024-376

medsovet-8622

Research Article

САХАРНЫЙ ДИАБЕТ

DIABETES MELLITUS

Изменения скелетных мышц при сахарном диабете

Changes in skeletal muscle in diabetes mellitus

https://orcid.org/0000-0003-1831-8052

Шацкая

О. А.

Shatskaya

O. A.

Шацкая Ольга Александровна, к.м.н., ведущий научный сотрудник отдела кардиологии и сосудистой хирургии

117036, Москва, ул. Дмитрия Ульянова, д. 11

Olga А. Shatskaya, Cand. Sci. (Med.), Senior Researcher at the Department of Cardiology and Vascular Surgery

1, Dmitry Ulyanov St., Moscow, 1170

shatskaya@bk.ru

https://orcid.org/0000-0002-5178-6029

Бондаренко

И. З.

Bondarenko

I. Z.

Бондаренко Ирина Зиятовна, д.м.н., главный научный сотрудник отдела кардиологии и сосудистой хирургии

117036, Москва, ул. Дмитрия Ульянова, д. 11

Irina Z. Bondarenko, Dr. Sci. (Med.), Chief Researcher of the Department of Cardiology and Vascular Surge

1, Dmitry Ulyanov St., Moscow, 1170

iz_bondarenko@mail.ru

https://orcid.org/0000-0003-1926-0091

Кухаренко

С. С.

Kushnarenko

S. S.

Кухаренко Светлана Семеновна, к.м.н., ведущий научный сотрудник отдела кардиологии и сосудистой хирургии

117036, Москва, ул. Дмитрия Ульянова, д. 11

Svetlana S. Kushnarenko, Cand. Sci. (Med.), Senior Researcher at the Department of Cardiology and Vascular Surgery

1, Dmitry Ulyanov St., Moscow, 1170

sveta_kukharenko@mail.ru

Национальный медицинский исследовательский центр эндокринологииРоссияNational Medical Research Center for EndocrinologyRussian Federation

2024

31102024

016148153

2024

Шацкая О.А., Бондаренко И.З., Кухаренко С.С.

Shatskaya O.A., Bondarenko I.Z., Kushnarenko S.S.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.med-sovet.pro/jour/article/view/8622

Сахарный диабет – это группа метаболических (обменных) заболеваний, характеризующихся хронической гипергликемией, количество больных сахарным диабетом ежегодно растет во всем мире. Частота микрои макрососудистых диабетических осложнений постепенно увеличивается по мере прогрессирования заболевания. В последние годы большое внимание уделяется влиянию сахарного диабета на состояние скелетных мышц. Структурно-функциональные и метаболические нарушения в скелетных мышцах, возникающие при старении организма, характерны и для больных сахарным диабетом, но проявляются в более раннем возрасте. Хроническая гипергликемия может ускорять процессы старения и играть решающую роль в возникновении диабетической миопатии, характерными признаками которой являются уменьшение мышечной массы, слабость и атрофия скелетных мышц, боль, нарушения чувствительности и даже квадриплегия в тяжелых случаях. Патофизиологическим признаком диабетической атрофии мышц является снижение синтеза мышечных белков и усиление их деградации. Изучение молекулярных механизмов диабетической миопатии позволит разработать эффективные методы профилактики и лечения, однако достижение и поддержание целевых значений гликемии играет решающую роль в обеспечении здоровья скелетных мышц, что позволит достичь снижения уровня инвалидизации и улучшить качество жизни пациентов. Усовершенствованные модели глюкометров, оснащенные рядом дополнительных функций, позволяют проводить структурированный самоконтроль гликемии, анализировать полученные данные и обеспечивать своевременную коррекцию терапии, активно вовлекать пациентов в процесс управления сахарным диабетом, что значительно повысит эффективность управления заболевания, позволит снизить риск возникновения и прогрессирования осложнений у пациентов с сахарным диабетом.

Diabetes mellitus is a group of metabolic (chemical processes) diseases characterized by chronic hyperglycemia. Globally, the number of patients with diabetes mellitus follows an upward trend with an annual increase. As the disease progresses, the frequency of the micro and macrovascular complications of diabetes gradually increases. In recent years, much attention has been paid to the effect of diabetes mellitus on the skeletal muscle status. Structural and functional abnormalities, and metabolic disorders in skeletal muscles that develop with ageing are also specifically attributed to patients with diabetes, but they manifest themselves at an earlier age. Chronic hyperglycemia can accelerate the ageing process and play a crucial role in the development of diabetic myopathy, which is characterized by decreased muscle mass, skeletal muscle weakness and atrophy, pain, impaired sensation and even quadriplegia in severe cases. A reduction in the rate of muscle protein synthesis and a rise in the rate of its degradation is a pathophysiological sign of diabetic muscle atrophy. Research into the molecular mechanisms of diabetic myopathy will aid the development of effective methods of prevention and treatment, however, the achievement and maintenance of glycaemic targets plays a critical role in ensuring health of skeletal muscles, which will make it possible to achieve the reduction in disability and improve the patients’ quality of life. Advanced glucometer models fitted with a range of additional functions allow for structured self-monitoring of blood glucose (SMBG), analysis of the obtained data and timely correction of therapy, active involvement of patients in the process of diabetes management, which will significantly increase the effectiveness of disease management and reduce the risk of complications in patients with diabetes.

скелетная мышцагипергликемиядиабетическая миопатияокислительный стресссамоконтрольглюкометр

skeletal musclehyperglycemiadiabetic myopathyoxidative stressself-controlglucose meter

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The authors declare that there are no conflicts of interest present.