<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-425</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8632</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДРУГИЕ ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OTHER PROBLEMS OF ENDOCRINOLOGY</subject></subj-group></article-categories><title-group><article-title>Региональные и этнические факторы ожирения и сахарного диабета у женщин репродуктивного возраста в Прибайкалье</article-title><trans-title-group xml:lang="en"><trans-title>Regional and ethnic factors of obesity and diabetes mellitus in women of re-productive age in the Pribaikal region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-2788-3148</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Татьяна Владимировна, к.м.н., заместитель главного врача по клинико-экспертной работе</p><p>664033, Иркутск, ул. Лермонтова, д. 283 В</p></bio><bio xml:lang="en"><p>Tatyana V. Egorova, Cand. Sci. (Med.), Deputy Chief Physician for Clinical and Expert Work</p><p>283 B, Lermontov St., Irkutsk, 664033</p></bio><email xlink:type="simple">dr.egorova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3696-9799</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киреева</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kireeva</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Киреева Виктория Владимировна, к.м.н., заместитель главного врача по поликлиническому разделу работы, Клиническая больницаИркутского научного центра Сибирского отделения Российской академии наук; старший научный сотрудник, Иркутский институт химии им. А.Е. Фаворского Сибирского отделения Российской академии наук</p><p>664033, Иркутск, ул. Лермонтова, д. 283 В,</p><p>664033, Иркутск, ул. Фаворского, д. 1</p></bio><bio xml:lang="en"><p>Victoria V. Kireeva, Cand. Sci. (Med.), Deputy Chief Physician for the Polyclinic Section of Work, Clinical Hospital of the Irkutsk Scientific Centre of the Siberian Branch of the Russian Academy of Sciences</p><p>283 B, Lermontov St., Irkutsk, 664033,</p><p>1, Favorsky St., Irkutsk, 664033</p></bio><email xlink:type="simple">ms.kireevav@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6296-898X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамнуева</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamnueva</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хамнуева Лариса Юрьевна, д.м.н., профессор, проректор по учебной работе, заведующий кафедрой эндокринологии и фармакологии</p><p>664003, Иркутск, ул. Красного Восстания, д. 1</p></bio><bio xml:lang="en"><p>Larisa Yu. Khamnueva, Dr. Sci. (Med.), Professor, Vice-Rector for Academic Affairs, Head of the Department of Endocrinology and Pharmacology</p><p>1, Krasnogo Vosstaniya St., Irkutsk, 664003</p></bio><email xlink:type="simple">hamnueval@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Клиническая больница Иркутского научного центра Сибирского отделения Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Hospital of the Irkutsk Scientific Centre of the Siberian Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Клиническая больница Иркутского научного центра Сибирского отделения Российской академии наук;&#13;
Иркутский институт химии им. А.Е. Фаворского Сибирского отделения Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Hospital of the Irkutsk Scientific Centre of the Siberian Branch of the Russian Academy of Sciences;&#13;
Irkutsk Institute of Chemistry named after A.E. Favorsky, Siberian Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Иркутский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>16</issue><fpage>238</fpage><lpage>245</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Егорова Т.В., Киреева В.В., Хамнуева Л.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Егорова Т.В., Киреева В.В., Хамнуева Л.Ю.</copyright-holder><copyright-holder xml:lang="en">Egorova T.V., Kireeva V.V., Khamnueva L.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8632">https://www.med-sovet.pro/jour/article/view/8632</self-uri><abstract><sec><title>Введение</title><p>Введение. В настоящее время избыточный вес является одной из ведущих глобальных медицинских проблем. Лишний вес и ожирение вносят весомый вклад в развитие таких заболеваний, как сердечно-сосудистая патология, сахарный диабет, а также могут привести к преждевременной смерти. Ожирение негативно сказывается на репродуктивной функции; почти четвертая часть женщин детородного возраста имеют избыток массы тела и приблизительно треть из них страдает ожирением.</p></sec><sec><title>Цель</title><p>Цель. Изучить особенности углеводного обмена, гормональных показателей и клинико-метаболических характеристик, а также оценку потенциального риска возникновения сахарного диабета у женщин фертильного возраста с избыточным весом и ожирением, проживающих в Прибайкалье.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследовании приняли участие 60 женщин Прибайкалья в репродуктивном возрасте с лишним весом и ожирением, из них 33 женщины русской национальности (1-я группа), 27 женщин бурятской национальности (2-я группа). Проведен анализ антропометрических, социально-демографических и поведенческих критериев, анкетирование с использованием Шкалы FINDRISC. Исследования включали выполнение общеклинических анализов крови и мочи, а также были изучены параметры липидного профиля, уровни глюкозы, инсулина, креатинина, трансаминаз, эстрадиола, тиреотропного гормона, лептина. Помимо этого выполнен пероральный глюкозо-толерантный тест и рассчитан индекс резистентности к инсулину (HOMA-IR).</p></sec><sec><title>Результаты</title><p>Результаты. В группе женщин бурятской национальности при меньшей массе тела, по сравнению с русскими, наблюдаются более высокие уровни лептина, индекса HOMA-IR, а также больший объем талии. У женщин бурятской этнической принадлежности существенный вклад в развитие избыточного веса и ожирения вносит низкая физическая активность, а для русских женщин большее значение имеет избыточная калорийность питания. По результатам опроса, проведенного с помощью шкалы FINDRISC, наиболее значимый вклад в потенциальное развитие сахарного диабета в русской группе вносит индекс массы тела (вес), а в бурятской группе, помимо этих показателей, еще и обхват талии, и сниженная физическая активность.</p></sec><sec><title>Выводы</title><p>Выводы. Результаты исследования окажут значительную помощь в разработке программ для профилактики ожирения и сахарного диабета с учетом региональных и этнических различий среди населения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Overweight is currently one of the leading global medical problems. Overweight and obesity contribute significantly to the development of diseases such as diabetes, cardiovascular disorder and can also cause premature death. Obesity has a negative impact on reproductive function; almost a quarter of women of childbearing age are overweight and about a third of them are obese.</p></sec><sec><title>Aim</title><p>Aim. To study the characteristics of carbohydrate metabolism, hormonal indicators, and clinical-metabolic profiles, as well as to assess the potential risk of developing diabetes mellitus in women of fertile age with overweight and obesity residing in the Baikal region.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study involved 60 overweight and obese women of reproductive age in the Pribaikalye region, including 33 women of Russian nationality (group 1) and 27 women of Buryat nationality (group 2). Anthropo-metric, sociodemographic and behavioural criteria were analysed, as well as questionnaires using the FINDRISC Scale. General clinical analyses of blood and urine were performed, lipid profile parameters, glucose, insulin, creatinine, transaminases, estradiol, thyroid hormone, leptin levels in blood plasma were studied. In addition, an oral glucose tolerance test was performed and the insulin resistance index (HOMA-IR) was calculated.</p></sec><sec><title>Results</title><p>Results. In the group of Buryat women with lower body weight as compared to Russians, higher levels of leptin, HOMA- IR index, and larger waist circumference are observed. In Buryat women, low physical activity makes a significant contribution to the development of overweight and obesity, while for Russian women, excessive caloric intake is more important. In accordance with the results of the FINDRISC scale survey, the greatest contribution to the potential development of diabetes mellitus in the Russian group is body mass index (weight), and in the Buryat group, in addition to these indicators, waist circumference and reduced physical activity.</p></sec><sec><title>Conclusions</title><p>Conclusions. The results of the study will be of great help in the development of pro-grammes for the prevention of diabetes and obesity, taking into account regional and ethnic differences among the population.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>избыточный вес</kwd><kwd>национальность</kwd><kwd>физическая активность</kwd><kwd>лептин</kwd><kwd>обхват талии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>overweight</kwd><kwd>ethnicity</kwd><kwd>physical activity</kwd><kwd>leptin</kwd><kwd>waist circumference</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кологривова ИВ, Винницкая ИВ, Кошельская ОА, Суслова ТЕ. Висцеральное ожирение и кардиометаболический риск: особенности гормональной и иммунной регуляции. Ожирение и метаболизм. 2017;14(3):3–10. https://doi.org/10.14341/omet201733-10.</mixed-citation><mixed-citation xml:lang="en">Kologrivova IV, Vinnitskaya IV, Koshelskaya OA, Suslova TE. Visceral obesity and cardiometabolic risk: features of hormonal and immune regulation. Obesity and Metabolism. 2017;14(3):3–10. (In Russ.) https://doi.org/10.14341/omet201733-10.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Шестакова ЕА, Лунина ЕЮ, Галстян ГР, Шестакова МВ, Дедов ИИ. Распространенность нарушений углеводного обмена у лиц с различными сочетаниями факторов риска сахарного диабета 2 типа в когорте пациентов исследования NATION. Сахарный диабет. 2020;23(1):4–11. https://doi.org/10.14341/DM12286.</mixed-citation><mixed-citation xml:lang="en">Shestakova EA, Lunina EY, Galstyan GR, Shestakova MV, Dedov II. Type 2 diabetes and prediabetes prevalence in patients with different risk factor combinations in the NATION study. Diabetes Mellitus. 2020;23(1):4–11. (In Russ.) https://doi.org/10.14341/DM12286.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Андреева ЕН, Шереметьева ЕВ, Фурсенко ВА. Ожирение – угроза репродуктивного потенциала России. Ожирение и метаболизм. 2019;16(3):20–28. https://doi.org/10.14341/omet10340.</mixed-citation><mixed-citation xml:lang="en">Andreeva EN, Sheremetyeva EV, Fursenko VA. Obesity – threat to the reproductive potential of Russia. Obesity and Metabolism. 2019;16(3):20–28. (In Russ.) https://doi.org/10.14341/omet10340.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Алфёрова ВИ, Мустафина СВ. Распространенность ожирения во взрослой популяции Российской Федерации (обзор литературы). Ожирение и метаболизм. 2022;19(1):96–105. https://doi.org/10.14341/omet12809.</mixed-citation><mixed-citation xml:lang="en">Alferova VI, Mustafina SV. The prevalence of obesity in the adult population of the Russian Federation (literature review). Obesity and Metabolism. 2022;19(1):96–105. (In Russ.) https://doi.org/10.14341/omet12809.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Мартинчик АН, Лайкам КЭ, Козырева НА, Кешабянц ЭЭ, Михайлов НА, Батурин АК, Смирнова ЕА. Распространение ожирения в различных социально-демографических группах населения России. Вопросы питания. 2021;90(3):67–76. https://doi.org/10.33029/0042-8833-2021-90-3-67-76.</mixed-citation><mixed-citation xml:lang="en">Martinchik AN, Laikam KE, Kozyreva NA, Keshabyants EE, Mikhailov NA, Baturin AK, Smirnova EA. The prevalence of obesity in various socio-demographic groups of the population of Russia. Voprosy Pitaniia. 2021;90(3):67–76. (In Russ.) https://doi.org/10.33029/0042-8833-2021-90-3-67-76.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина ОМ, Елиашевич СО, Шепель РН. Ожирение как фактор риска хронических неинфекционных заболеваний. Российский кардиологический журнал. 2016;(6):73–79. https://doi.org/10.15829/1560-4071-2016-6-73-79.</mixed-citation><mixed-citation xml:lang="en">Drapkina OM, Eliashevich SO, Shepel RN. Obesity as a risk factor for chronic non-communicable diseases. Russian Journal of Cardiology. 2016;(6):73–79. (In Russ.) https://doi.org/10.15829/1560-4071-2016-6-73-79.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Scully T, Ettela A, LeRoith D, Gallagher EJ. Obesity, Type 2 Diabetes, and Cancer Risk. Front Oncol. 2021;10:615375. https://doi.org/10.3389/fonc.2020.615375.</mixed-citation><mixed-citation xml:lang="en">Scully T, Ettela A, LeRoith D, Gallagher EJ. Obesity, Type 2 Diabetes, and Cancer Risk. Front Oncol. 2021;10:615375. https://doi.org/10.3389/fonc.2020.615375.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Степанова ЕВ, Лоранская ИД, Ракитская ЛГ, Мамедова ЛД. Ожирение как универсальный фактор риска серьезных заболеваний. Эффективная фармакотерапия. 2019;15(18):68–77. https://doi.org/10.33978/2307-3586-2019-15-18-68-77.</mixed-citation><mixed-citation xml:lang="en">Stepanova YeV, Loranskaya ID, Rakitskaya LG, Mamedova LD. Obesity as the Omni-Factor for Serious Diseases. Effective Pharmacotherapy. 2019;15(18):68–77. https://doi.org/10.33978/2307-3586-2019-15-18-68-77.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Yong W, Wang J, Leng Y, Li L, Wang H. Role of Obesity in Female Reproduction. Int J Med Sci. 2023;20(3):366–375. https://doi.org/10.7150/ijms.80189.</mixed-citation><mixed-citation xml:lang="en">Yong W, Wang J, Leng Y, Li L, Wang H. Role of Obesity in Female Reproduction. Int J Med Sci. 2023;20(3):366–375. https://doi.org/10.7150/ijms.80189.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lainez NM, Coss D. Obesity, Neuroinflammation, and Reproductive Function. Endocrinology. 2019;160(11):2719–2736. https://doi.org/10.1210/en.2019-00487.</mixed-citation><mixed-citation xml:lang="en">Lainez NM, Coss D. Obesity, Neuroinflammation, and Reproductive Function. Endocrinology. 2019;160(11):2719–2736. https://doi.org/10.1210/en.2019-00487.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity’s impact. Fertil Steril. 2017;107(4):840–847. https://doi.org/10.1016/j.fertnstert.2017.01.017.</mixed-citation><mixed-citation xml:lang="en">Broughton DE, Moley KH. Obesity and female infertility: potential mediators of obesity’s impact. Fertil Steril. 2017;107(4):840–847. https://doi.org/10.1016/j.fertnstert.2017.01.017.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Roman Lay AA, Pereira A, Garmendia Miguel ML. Association between obesity with pattern and length of menstrual cycle: The role of metabolic and hormonal markers. Eur J Obstet Gynecol Reprod Biol. 2021;260:225–231. https://doi.org/10.1016/j.ejogrb.2021.02.021.</mixed-citation><mixed-citation xml:lang="en">Roman Lay AA, Pereira A, Garmendia Miguel ML. Association between obesity with pattern and length of menstrual cycle: The role of metabolic and hormonal markers. Eur J Obstet Gynecol Reprod Biol. 2021;260:225–231. https://doi.org/10.1016/j.ejogrb.2021.02.021.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kuchenbecker WKH, Groen H, Zijlstra TM, Bolster JHT, Slart RHJ, van der Jagt EJ et al. The Subcutaneous abdominal fat and not the intraabdominal fat compartment is associated with anovulation in women with obesity and infertility. J Clin Endocrinol Metab. 2010;95(5):2107–2112. https://doi.org/10.1210/jc.2009-1915.</mixed-citation><mixed-citation xml:lang="en">Kuchenbecker WKH, Groen H, Zijlstra TM, Bolster JHT, Slart RHJ, van der Jagt EJ et al. The Subcutaneous abdominal fat and not the intraabdominal fat compartment is associated with anovulation in women with obesity and infertility. J Clin Endocrinol Metab. 2010;95(5):2107–2112. https://doi.org/10.1210/jc.2009-1915.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Giviziez CR, Sanchez EG, Approbato MS, Maia MC, Fleury EA, Sasaki RS. Obesity and anovulatory infertility: A review. JBRA Assist Reprod. 2016;20(4):240–245. https://doi.org/10.5935/1518-0557.20160046.</mixed-citation><mixed-citation xml:lang="en">Giviziez CR, Sanchez EG, Approbato MS, Maia MC, Fleury EA, Sasaki RS. Obesity and anovulatory infertility: A review. JBRA Assist Reprod. 2016;20(4):240–245. https://doi.org/10.5935/1518-0557.20160046.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chandrasekaran S, Neal-Perry G. Long-term consequences of obesity on female fertility and the health of the offspring. Curr Opin Obstet Gynecol. 2017;29(3):180–187. https://doi.org/10.1097/GCO.0000000000000364.</mixed-citation><mixed-citation xml:lang="en">Chandrasekaran S, Neal-Perry G. Long-term consequences of obesity on female fertility and the health of the offspring. Curr Opin Obstet Gynecol. 2017;29(3):180–187. https://doi.org/10.1097/GCO.0000000000000364.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Pigeyre M, Yazdi FT, Kaur Y, Meyre D. Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. Clin Sci (Lond). 2016;130(12):943–986. https://doi.org/10.1042/CS20160136.</mixed-citation><mixed-citation xml:lang="en">Pigeyre M, Yazdi FT, Kaur Y, Meyre D. Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. Clin Sci (Lond). 2016;130(12):943–986. https://doi.org/10.1042/CS20160136.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017;356:j1. https://doi.org/10.1136/bmj.j1.</mixed-citation><mixed-citation xml:lang="en">Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ. 2017;356:j1. https://doi.org/10.1136/bmj.j1.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Маркова ТН, Мищенко НК, Петина ДВ. Адипоцитокины: современный взгляд на дефиницию, классификацию и роль в организме. Проблемы эндокринологии. 2022;68(1):73–80. https://doi.org/10.14341/probl12805.</mixed-citation><mixed-citation xml:lang="en">Markova TN, Mishchenko NK, Petina DV. Adipocytokines: modern definition, classification and physiological role. Problemy Endokrinologii. 2022;68(1):73–80. (In Russ.) https://doi.org/10.14341/probl12805.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Izquierdo AG, Crujeiras AB, Casanueva FF, Carreira MC. Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? Nutrients. 2019;11(11):2704. https://doi.org/10.3390/nu11112704.</mixed-citation><mixed-citation xml:lang="en">Izquierdo AG, Crujeiras AB, Casanueva FF, Carreira MC. Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? Nutrients. 2019;11(11):2704. https://doi.org/10.3390/nu11112704.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Yadav A, Kataria MA, Saini V, Yadav A. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta. 2013;417:80–84. https://doi.org/10.1016/j.cca.2012.12.007.</mixed-citation><mixed-citation xml:lang="en">Yadav A, Kataria MA, Saini V, Yadav A. Role of leptin and adiponectin in insulin resistance. Clin Chim Acta. 2013;417:80–84. https://doi.org/10.1016/j.cca.2012.12.007.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">López-Jaramillo P, Gómez-Arbeláez D, López-López J, López-López C, Martínez-Ortega J, Gómez-Rodríguez A, Triana-Cubillos S. The role of leptin/ adiponectin ratio in metabolic syndrome and diabetes. Horm Mol Biol Clin Investig. 2014;18(1):37–45. https://doi.org/10.1515/hmbci-2013-0053.</mixed-citation><mixed-citation xml:lang="en">López-Jaramillo P, Gómez-Arbeláez D, López-López J, López-López C, Martínez-Ortega J, Gómez-Rodríguez A, Triana-Cubillos S. The role of leptin/ adiponectin ratio in metabolic syndrome and diabetes. Horm Mol Biol Clin Investig. 2014;18(1):37–45. https://doi.org/10.1515/hmbci-2013-0053.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Marinelli S, Napoletano G, Straccamore M, Basile G. Female obesity and infertility: outcomes and regulatory guidance. Acta Biomed. 2022;93(4):e2022278. https://doi.org/10.23750/abm.v93i4.13466.</mixed-citation><mixed-citation xml:lang="en">Marinelli S, Napoletano G, Straccamore M, Basile G. Female obesity and infertility: outcomes and regulatory guidance. Acta Biomed. 2022;93(4):e2022278. https://doi.org/10.23750/abm.v93i4.13466.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Передереева ЕВ, Лушникова АА, Фрыкин АД, Пароконная АА. Гормон лептин и проблемы репродукции. Злокачественные опухоли. 2012;2(1):35–39. Режим доступа: https://www.malignanttumors.org/jour/article/view/64.</mixed-citation><mixed-citation xml:lang="en">Peredereeva EV, Lushnikova AA, Frykin AD, Parokonnaya AA. The hormone leptin and reproductive problems. Malignant Tumors. 2012;2(1):35–39. (In Russ.) Available at: https://www.malignanttumors.org/jour/article/view/64.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: emerging biological mechanisms and perspectives. Metabolism. 2019;92:121–135. https://doi.org/10.1016/j.metabol.2018.11.001.</mixed-citation><mixed-citation xml:lang="en">Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: emerging biological mechanisms and perspectives. Metabolism. 2019;92:121–135. https://doi.org/10.1016/j.metabol.2018.11.001.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N. Endometrial cancer. Lancet. 2022;399(10333):1412–1428. https://doi.org/10.1016/S0140-6736(22)00323-3.</mixed-citation><mixed-citation xml:lang="en">Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N. Endometrial cancer. Lancet. 2022;399(10333):1412–1428. https://doi.org/10.1016/S0140-6736(22)00323-3.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Wang J, Yang DL, Chen ZZ, Gou BF. Associations of body mass index with cancer incidence among populations, genders, and menopausal status: A systematic review and meta-analysis. Cancer Epidemiol. 2016;42:1–8. https://doi.org/10.1016/j.canep.2016.02.010.</mixed-citation><mixed-citation xml:lang="en">Wang J, Yang DL, Chen ZZ, Gou BF. Associations of body mass index with cancer incidence among populations, genders, and menopausal status: A systematic review and meta-analysis. Cancer Epidemiol. 2016;42:1–8. https://doi.org/10.1016/j.canep.2016.02.010.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J et al. Risk factors for endometrial cancer: An umbrella review of the literature. Int J Cancer. 2019;145(7):1719–1730. https://doi.org/10.1002/ijc.31961.</mixed-citation><mixed-citation xml:lang="en">Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J et al. Risk factors for endometrial cancer: An umbrella review of the literature. Int J Cancer. 2019;145(7):1719–1730. https://doi.org/10.1002/ijc.31961.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Misra A, Jayawardena R, Anoop S. Obesity in South Asia: Phenotype, Morbidities, and Mitigation. Curr Obes Rep. 2019;8(1):43–52. https://doi.org/10.1007/s13679-019-0328-0.</mixed-citation><mixed-citation xml:lang="en">Misra A, Jayawardena R, Anoop S. Obesity in South Asia: Phenotype, Morbidities, and Mitigation. Curr Obes Rep. 2019;8(1):43–52. https://doi.org/10.1007/s13679-019-0328-0.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Nam GE, Park HS. Perspective on Diagnostic Criteria for Obesity and Abdominal Obesity in Korean Adults. J Obes Metab Syndr. 2018;27(3):134–142. https://doi.org/10.7570/jomes.2018.27.3.134.</mixed-citation><mixed-citation xml:lang="en">Nam GE, Park HS. Perspective on Diagnostic Criteria for Obesity and Abdominal Obesity in Korean Adults. J Obes Metab Syndr. 2018;27(3):134–142. https://doi.org/10.7570/jomes.2018.27.3.134.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов ИИ, Шестакова МВ, Мельниченко ГА, Мазурина НВ, Андреева ЕН, Бондаренко ИЗ, Гусова ЗР и др. Междисциплинарные клинические рекомендации «Лечение ожирения и коморбидных заболеваний». Ожирение и метаболизм. 2021;18(1):5–99. https://doi.org/10.14341/omet12714.</mixed-citation><mixed-citation xml:lang="en">Dedov II, Shestakova MV, Melnichenko GA, Mazurina NV, Andreeva EN, Bondarenko IZ, Gusova ZR et al. Interdisciplinary clinical practice guidelines “management of obesity and its comorbidities”. Obesity and Metabolism. 2021;18(1):5–99. (In Russ.) https://doi.org/10.14341/omet12714.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов ИИ, Колесникова ЛИ, Бардымова ТП, Прокофьев СА, Иванова ОН, Гнусина СВ. Этнические особенности сахарного диабета у народов Прибайкалья. Бюллетень Сибирского отделения Российской академии медицинских наук. 2008;28(1):16–20. https://www.elibrary.ru/juhnmn.</mixed-citation><mixed-citation xml:lang="en">Dedov II, Kolesnikova LI, Bardimova TP, Prokofiev SA, Ivanova ON, Gnusina SV. Ethnic specific features of diabetes mellitus in nations of Pribaikalje. Byulleten Sibirskogo Otdeleniya Rossiyskoy Akademii Meditsinskikh Nauk. 2008;28(1):16–20. (In Russ.) https://www.elibrary.ru/juhnmn.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Qi Q, Wang X, Strizich G, Wang T. Genetic Determinants of Type 2 Diabetes in Asians. Int J Diabetol Vasc Dis Res. 2015;34(6):1–9. https://doi.org/10.19070/2328-353X-SI01001.</mixed-citation><mixed-citation xml:lang="en">Qi Q, Wang X, Strizich G, Wang T. Genetic Determinants of Type 2 Diabetes in Asians. Int J Diabetol Vasc Dis Res. 2015;34(6):1–9. https://doi.org/10.19070/2328-353X-SI01001.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов ИИ, Шестакова МВ, Галстян ГР. Распространенность сахарного диабета 2 типа у взрослого населения России (исследование NATION). Сахарный диабет. 2016;19(2):104–112. https://doi.org/10.14341/DM2004116-17.</mixed-citation><mixed-citation xml:lang="en">Dedov II, Shestakova MV, Galstyan GR. The prevalence of type 2 diabetes mellitus in the adult population of Russia (NATION study). Diabetes Mellitus. 2016;19(2):104–112. (In Russ.) https://doi.org/10.14341/DM2004116-17.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Макарова ЕЛ, Олина АА, Падруль ММ. Оценка факторов риска развития избыточной массы тела и ожирения у женщин репродуктивного возраста. Анализ риска здоровью. 2020;(2):38–46. https://doi.org/10.21668/health.risk/2020.2.04.</mixed-citation><mixed-citation xml:lang="en">Makarova EL, Olina AA, Padrulʹ MM. Assessing risk factors that can cause overweight and obesity in women of reproductive age. Health Risk Analysis. 2020;(2):38–46. https://doi.org/10.21668/health.risk/2020.2.04.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
