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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-429</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8639</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРИКЛАДНЫЕ АСПЕКТЫ ЭНДОКРИНОЛОГИИ И КАРДИОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>APPLIED ASPECTS OF ENDOCRINOLOGY AND CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Снижение уровня витамина D как фактор ухудшения остеоинтеграции при дентальной имплантации</article-title><trans-title-group xml:lang="en"><trans-title>Decreased vitamin D levels as a factor of deterioration of osseointegration during dental implantation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3261-7366</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иловайская</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilovayskaya</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иловайская Ирэна Адольфовна, д.м.н., профессор курса частной эндокринологии факультета усовершенствования врачей, заведующаяотделением нейроэндокринных заболеваний отдела общей эндокринологии</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Irena A. Ilovayskaya, Dr. Sci. (Med.), Professor of the Private Endocrinology Course, Faculty of Advanced Medical Trainnig, Head of the Neuroendocrine Diseases Department, Unit of General Endocrinology</p><p>61/2, Schepkin St., Moscow, 129110</p></bio><email xlink:type="simple">irena.ilov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9105-0796</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амхадова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Amkhadova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Амхадова Малкан Абдурашидовна, д.м.н., профессор, заведующая кафедрой хирургической стоматологии и имплантологии факультетаусовершенствования врачей</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Malkan A. Amkhadova, Dr. Sci. (Med.), Professor, Head of the Department of Surgical Dentistry and Implantology, Faculty of Advanced Medical Trainnig</p><p>61/2, Schepkin St., Moscow, 129110</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-4594-8990</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кадиев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kadiev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кадиев Арсен Асланович, аспирант кафедры хирургической стоматологии и имплантологии факультета усовершенствования врачей</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Arsen A. Kadiev, Postgraduate Student of the Department of Surgical Dentistry and Implantology, Faculty of Advanced Medical Trainnig</p><p>61/2, Schepkin St., Moscow, 129110</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2973-8351</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амхадов</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Amkhadov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Амхадов Ислам Султанович, к.м.н., доцент кафедры хирургической стоматологии и имплантологии факультета усовершенствования врачей</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Islam S. Amkhadov, Cand. Sci. (Med.), Associate Professor of the Department of Surgical Dentistry and Implantology, Faculty of Advanced Medical Trainnig</p><p>61/2, Schepkin St., Moscow, 129110</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-3886-2605</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джабраилова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhabrailova</surname><given-names>М. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джабраилова Марьям Абуевна, ассистент кафедры хирургической стоматологии и имплантологии факультета усовершенствования врачей</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Mariam A. Dzhabrailova, Assistant of the Department of Surgical Dentistry and Implantology, Faculty of Advanced Medical Trainnig</p><p>61/2, Schepkin St., Moscow, 129110</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research Clinical Institute named after M.F. Vladimirsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>16</issue><fpage>302</fpage><lpage>309</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иловайская И.А., Амхадова М.А., Кадиев А.А., Амхадов И.С., Джабраилова М.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Иловайская И.А., Амхадова М.А., Кадиев А.А., Амхадов И.С., Джабраилова М.А.</copyright-holder><copyright-holder xml:lang="en">Ilovayskaya I.A., Amkhadova M.A., Kadiev A.A., Amkhadov I.S., Dzhabrailova М.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8639">https://www.med-sovet.pro/jour/article/view/8639</self-uri><abstract><sec><title>Введение</title><p>Введение. Снижение уровня витамина D рассматривается как возможный фактор неуспешной дентальной имплантации. Однако исследований хорошего качества на этот предмет достаточно мало, часть исследований была проведена на животных моделях.</p></sec><sec><title>Цель</title><p>Цель. Выявить возможное влияние уровня витамина D на параметры остеоинтеграции при дентальной имплантации.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Было проведено ретроспективное одновыборочное когортное наблюдательное неинтервенционное исследование. Обследовано 78 пациенток, прошедших дентальную имплантацию, которых распределили на 3 группы: до 44 лет включительно – группа 1 (n = 20), 45–60 лет – группа 2 (n = 34), 60 лет и старше – группа 3 (n = 24). Всем пациенткам перед проведением имплантации выполняли: витамин D, ФСГ, эстрадиол, ТТГ, своб. Т4, компьютерную томографию костей челюсти, определение индексов состояния десен и пародонта. В момент установки имплантата и в момент протезирования определялся коэффициент стабильности имплантата (КСИ).</p></sec><sec><title>Результаты</title><p>Результаты. Показатели концентрации витамина D, эстрадиола, плотности челюстной кости, КСИ на момент установки и на момент протезирования были статистически значимо ниже в группе 3. Дефицит/недостаточность витамина D встречались у 38%, 58%, 88% пациенток в группах 1, 2, 3 соответственно (p &lt; 0,001). Отношение шансов выявить снижение витамина D в группе 3 по сравнению с группой 2 было 13,1 (ДИ 95% 2,9–60,2), по сравнению с группой 1 – 5,7 (ДИ 95% 1,4–22,6). Отношение шансов увеличения сроков остеоинтеграции при дефиците витамина D по сравнению с оптимальными значениями составило 11,6 (ДИ 95% 2,3–59,1), по сравнению с недостаточностью – 5,7 (ДИ 95% 1,4–24,1). Показатели витамина D статистически значимо обратно коррелировали с гигиеническими индексами состояния пародонта.</p></sec><sec><title>Выводы</title><p>Выводы. Снижение уровня витамина D можно рассматривать как фактор ухудшения остеоинтеграции при дентальной имплантации, так как это ассоциировано с удлинением сроков остеоинтеграции за счет снижения плотности костной ткани челюсти и ухудшения состояния пародонта.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Decreased vitamin D levels are considered as a possible factor in dental implantation failure. However, there arelack of good quality studies on this topic, some of which were conducted on animal models.</p></sec><sec><title>Aim</title><p>Aim. To identify the possible role of vitamin D levels on osseointegration parameters during dental implantation.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A retrospective single-sample cohort observational non-interventional study was conducted. 78 female patients who underwent dental implantation were examined, who were divided into 3 groups: up to 44 years old, group 1 (n = 20), 45-60 years old, group 2 (n = 34), 60 years and older, group 3 (n = 24). All patients were examined before implantation: vitamin D, FSH, estradiol, TSH, free T4, computed tomography of the jaw bones, indices of the gums and periodontium condition, also the implant stability quotient (ISQ) was determined at the time of implant placement and at the time of prosthetics.</p></sec><sec><title>Results</title><p>Results. The concentrations of vitamin D, estradiol, jaw bone density, and ISQ at the time of implantation and at the time of prosthetics were significantly lower in group 3. Vitamin D deficit/insufficiency occurred in 38%, 58%, 88% of patients in groups 1, 2, 3, respectively (p &lt; 0.001). The ratio of chances to detect a decrease in vitamin D was 13.1 (CI 95% 2.9–60.2) in group 3 compared to group 2, and 5.7 (CI 95% 1.4–22.6) compared to group 1. The ratio of the chances for an increase of osseointegration time was 11.6 (CI 95% 2.3–59.1) in case of vitamin D deficiency compared to optimal values, and 5.7 (CI 95% 1.4–24.1) compared to a insufficiency condition. Vitamin D levels significantly inversely correlated with hygienic indices of periodontal condition.</p></sec><sec><title>Conclusion</title><p>Conclusion. A decrease vitamin D levels can be strongly considered as a factor in the deterioration of osseointegration during dental implantation, since this is associated with an extended period of osseointegration due to a decrease in the bone density of the jaw and a worse periodontal condition.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>витамин D</kwd><kwd>дентальная имплантация</kwd><kwd>коэффициент стабильности имплантата</kwd><kwd>остеоинтеграция</kwd><kwd>пародонт</kwd></kwd-group><kwd-group xml:lang="en"><kwd>vitamin D</kwd><kwd>dental implantation</kwd><kwd>implant stability quotient (ISQ)</kwd><kwd>osseointegration</kwd><kwd>periodontal disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Махмудов ТГ. Коэффициент стабильности дентальных имплантатов и его связь с биомаркерами костного метаболизма. 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