medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-369medsovet-8641Research ArticleПРИКЛАДНЫЕ АСПЕКТЫ ЭНДОКРИНОЛОГИИ И КАРДИОЛОГИИAPPLIED ASPECTS OF ENDOCRINOLOGY AND CARDIOLOGYПрепараты сердечно-сосудистого профиля и состояние тканей пародонтаCardiovascular profile drugs and the state of periodontal tissueshttps://orcid.org/0000-0001-8055-6233СабироваА. И.SabirovaA. I.

Сабирова Азиза Ибрагимовна, к.м.н., доцент, кафедра хирургической стоматологии

720000, Кыргызстан, Бишкек, ул. Киевская, д. 44

Aziza I. Sabirova, Cand. Sci. (Med.), Associate Professor, Department of Operative Dentistry

44, Kievskaya St., Bishkek, 720000

azizasabirova@bk.ruhttps://orcid.org/0009-0008-9077-7679КаршинаО. О.KarshinaO. O.

Каршина Олеся Олеговна, старший преподаватель, кафедра терапии №2, специальность «Лечебное дело»

720000, Кыргызстан, Бишкек, ул. Киевская, д. 44

Olesya O. Karshina, Senior Lecturer, Department of Therapy No. 2, Specialty “General Medicine”

44, Kievskaya St., Bishkek, 720000

karshinapoliklinika@mail.ruСабировИ. С.SabirovI. S.

Сабиров Ибрагим Самижонович, д.м.н., профессор, заведующий кафедрой терапии №2, специальность «Лечебное дело»

720000, Кыргызстан, Бишкек, ул. Киевская, д. 44

Ibragim S. Sabirov, Dr. Sci. (Med.), Professor, Head Department of Therapy No. 2, Specialty “General Medicine”

44, Kievskaya St., Bishkek, 720000

 

sabirov_is@mail.ruКыргызско-Российский Славянский университет имени первого президента РФ Б.Н. ЕльцинаРоссияKyrgyz Russian Slavic University named after the First President of Russia B.N. EltsinRussian Federation202401112024016317324Copyright © Сабирова А.И., Каршина О.О., Сабиров И.С., 20242024Сабирова А.И., Каршина О.О., Сабиров И.С.Sabirova A.I., Karshina O.O., Sabirov I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8641

Лица с сердечно-сосудистыми заболеваниями (ССЗ), в основном старше 50 лет, регулярно принимают такие лекарства, как бета-блокаторы (ББ), ингибиторы ангиотензинпревращающего фермента (иАПФ), блокаторы кальциевых каналов (БКК), блокаторы рецепторов ангиотензина II (БРА), статины и ацетилсалициловую кислоту (АСК). Болезни тканей пародонта (БТП) встречаются в возрастной группе 35–44 лет в 60% случаев, в группе людей 65–74 лет – около 70%, т. е. в том периоде жизни, когда начинают развиваться и прогрессировать ССЗ. Некоторые кардиопротекторные препараты, такие как антигипертензивные средства, вызывают ксеростомию. Медикаментозная ксеростомия является одной из распространенных причин проблем, связанных со здоровьем полости рта у пожилых людей, которые находятся на длительной лекарственной терапии. Ксеростомия является распространенным изнурительным состоянием, которое вызывает такие проблемы, как дисфагия, потеря вкуса и боль в полости рта, а также увеличивает риск кариеса зубов и инфекции полости рта. Лекарственно-индуцированное разрастание десен (ЛИРД) представляет собой патологическую гипертрофию десны, которая может быть вызвана рядом лекарственных препаратов, в т. ч. и БКК. ЛИРД характеризуется накоплением соединительной ткани, которое в первую очередь поражает передние отделы верхней и нижней челюсти, а также вызывает проблемы с поддержанием гигиены полости рта, что приводит к восприимчивости к инфекциям и заболеваниям пародонта и может привести к потере зубов. Антикоагулянты, используемые при ССЗ ввиду риска развития кровоточивости, требуют особых подходов при профилактике и терапии БТП. Рассматриваются возможности использования статинов при БТП за счет плейотропных свойств, не зависящих от гиполипидемического действия. Обзорная статья посвящена влиянию препаратов сердечно-сосудистого профиля на состояние тканей пародонта и механизмов развития побочных эффектов, а также возможностям использования статинов с учетом их плейотропных эффектов. 

People with CVD, mostly over 50 years of age, regularly take medications such as beta-blockers (BBs), angiotensin-converting enzyme inhibitors (ACEIs), calcium channel blockers (CCBs), angiotensin II receptor blockers (ARBs), statins and acetylsalicylic acid (ASA). Periodontal tissue disease (PTD) occurs in the age group 35–44 years in 60% of cases, in the group of people 65–74 years – about 70%, that is, in that period of life when cardiovascular disease (CVD) begins to develop and progress. Some cardioprotective drugs, such as antihypertensives, cause xerostomia. Medication-induced xerostomia is one of the common causes of oral health problems in older adults who are on long-term drug therapy. Xerostomia is a common debilitating condition that causes problems such as dysphagia, loss of taste, and oral pain, as well as increasing the risk of tooth decay and oral infections. Drug-induced gingival overgrowth is an abnormal hypertrophy of the gingiva that can be caused by a number of medications, including calcium channel blockers. Drug-induced gingival overgrowth is characterized by the accumulation of connective tissue that primarily affects the anterior regions of the upper and lower jaw, and also causes problems with oral hygiene, which leads to susceptibility to infections and periodontal disease and can lead to tooth loss. Anticoagulants used in CVD due to the risk of bleeding require special approaches in the prevention and therapy of periodontal tissue disease. The possibilities of using statins in PTD due to their pleiotropic properties, independent of hypolipidemic action. The review article is devoted to the influence of drugs of cardiovascular profile on the state of periodontal tissues and mechanisms of development of side effects, as well as the possibilities of using statins taking into account their pleiotropic effects.

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The authors declare that there are no conflicts of interest present.