medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-497medsovet-8662Research ArticleПРЕГРАВИДАРНАЯ ПОДГОТОВКА И БЕРЕМЕННОСТЬPREGRAVID PREPARATION AND PREGNANCYГенетические основы коморбидности эндометриозаGenetic basis of endometriosis comorbidityhttps://orcid.org/0009-0007-8533-9319ПономареваТ. А.PonomarevaT. A.

Пономарева Татьяна Андреевна, аспирант кафедры медико-биологических дисциплин, Белгородский государственный национальный исследовательский университет; врач – акушер-гинеколог, Белгородская областная клиническая больница Святителя Иоасафа

308015, Белгород, ул. Победы, д. 85,

308007, Белгород, ул. Некрасова, д. 8\9

Tatyana A. Ponomareva, Postgraduate Student of the Department of Medical and Biological Disciplines, Belgorod State University; Obstetrician-Gynecologist, Belgorod Regional Clinical Hospital of St Joasaph

85, Pobedy St., Belgorod, 308007,

8/9, Nekrasov St., Belgorod, 308015

rybaarbusova@icloud.comАлтуховаО. Б.AltukhovaO. B.

Алтухова Оксана Борисовна, д.м.н., доцент, заведующая кафедрой акушерства и гинекологии, Белгородский государственный национальный исследовательский университет; заведующая отделением гинекологии, Белгородская областная клиническая больница Святителя Иоасафа

308015, Россия, Белгород, ул. Победы, д. 85,

308007, Белгород, ул. Некрасова, д. 8\9

Oksana B. Altukhova, Dr. Sci. (Med.), Associate Professor, Head of the Department of Obstetrics and Gynecology, Belgorod State University; Head of the Department of Gynecology, Belgorod Regional Clinical Hospital of St Joasaph

85, Pobedy St., Belgorod, 308007,

8/9, Nekrasov St., Belgorod, 308015

https://orcid.org/0000-0002-5652-0166ПономаренкоИ. В.PonomarenkoI. V.

Пономаренко Ирина Васильевна, д.м.н., доцент кафедры медико-биологических дисциплин

308007, Белгород, ул. Некрасова, д. 8\9

Irina V. Ponomarenko, Dr. Sci. (Med.), Associate Professor of the Department of Medical and Biological Disciplines

8/9, Nekrasov St., Belgorod, 308015

ponomarenko_i@bsu.edu.ruhttps://orcid.org/0000-0003-1254-6134ЧурносовМ. И.ChurnosovM. I.

Чурносов Михаил Иванович, д.м.н., профессор, заведующий кафедрой медико-биологических дисциплин

308007, Белгород, ул. Некрасова, д. 8\9

Mikhail I. Churnosov, Dr. Sci. (Med.), Professor, Head of the Department of Medical and Biological Disciplines

8/9, Nekrasov St., Belgorod, 308015

churnosov@bsu.edu.ruБелгородская областная клиническая больница Святителя Иоасафа; Белгородский государственный национальный исследовательский университетРоссияBelgorod Regional Clinical Hospital of St Joasaph; Belgorod State UniversityRussian FederationБелгородская областная клиническая больница Святителя Иоасафа; Белгородский государственный национальный исследовательский университетРоссияBelgorod Regional Clinical Hospital of St Joasaph Belgorod State UniversityRussian FederationБелгородский государственный национальный исследовательский университетРоссияBelgorod State UniversityRussian Federation20240711202401792102Copyright © Пономарева Т.А., Алтухова О.Б., Пономаренко И.В., Чурносов М.И., 20242024Пономарева Т.А., Алтухова О.Б., Пономаренко И.В., Чурносов М.И.Ponomareva T.A., Altukhova O.B., Ponomarenko I.V., Churnosov M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8662Введение

Введение. Результаты ряда исследований свидетельствуют о коморбидности эндометриоза с различными заболеваниями, такими как миома матки, рак эндометрия, мигрень, депрессия, бесплодие, бронхиальная астма, а также заболевания желудка.

Цель

Цель. Представить данные литературы о коморбидности эндометриоза и различных заболеваний.

Материалы и методы

Материалы и методы. Проведен обзор литературы за 2010–2023 гг. в базах PubMed (National Library of Medicine), Cochrane Library, CyberLeninka, Medline, а также в базах данных научного цитирования (Scopus, Web of Science).

Результаты и обсуждение

Результаты и обсуждение. Установлено, что в основе коморбидности эндометриоза и описанных болезней лежат общность факторов риска (ранний возраст наступления менархе, поздняя менопауза, отсутствие родов в анамнезе, хронические воспалительные заболевания органов малого таза, курение, хронический стресс, воздействие фталатных эфиров), молекулярно-патогенетических механизмов (изменения экспрессии генов, уровня половых гормонов, аберрантный иммунный ответ, субклиническая воспалительная реакция, гиперэстрогения, характерные как для эндометриоза, так и для коморбидных болезней), а также генов, которые участвуют в развитии данных заболеваний. По результатам проведенных полногеномных исследований установлено более 170 полиморфных локусов, ассоциированных с развитием эндометриоза и различных коморбидных заболеваний, выявлена положительная корреляция между эндометриозом и данными болезнями.

Заключение

Заключение. Проведенные исследования диктуют необходимость учитывать в клинической практике синтропию эндометриоза с другими заболеваниями, что, в свою очередь, требует мультидисциплинарного подхода к ведению пациенток с эндометриозом.

Introduction

Introduction. The results of a number of studies indicate the comorbidity of endometriosis with various diseases, such as uterine fibroids, endometrial cancer, migraine, depression, infertility, bronchial asthma, and stomach diseases.

Aim

Aim. Present literature data on the comorbidity of endometriosis and various diseases.

Materials and methods

Materials and methods. A review of the literature for 2021–2023 in the databases PubMed (National Library of Medicine), Cochrane Library, CyberLeninka, Medline, as well as in scientific citation databases (Scopus, Web of Science).

Results and discussion

Results and discussion. This paper analyzes data on the comorbidity of endometriosis and various diseases such as uterine myoma, endometrial cancer, migraine, depression, infertility, bronchial asthma, and gastric diseases. It was found that the comorbidity of endometriosis and the described diseases is based on common risk factors (early age of menarche, late menopause, absence of childbirth in the anamnesis, chronic inflammatory diseases of the pelvic organs, smoking, chronic stress, exposure to phthalate esters), molecular pathogenetic mechanisms (changes in gene expression, sex hormone levels, aberrant immune response, subclinical inflammatory response, hyperestrogenism, characteristic of both endometriosis and comorbid diseases), as well as genes involved in the development of these diseases. According to the results of full genomic studies, more than 170 polymorphic loci associated with the development of endometriosis and various comorbid diseases have been identified, and a positive correlation between endometriosis and these diseases has been revealed.

Conclusion

Conclusion. These studies dictate the need to take into account in clinical practice the syntropy of endometriosis with other diseases, which, in turn, requires a multidisciplinary approach to the management of patients with endometriosis. 

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The authors declare that there are no conflicts of interest present.