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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2016-4-110-115</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-87</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Эффективность препарата Спарекс в коррекции моторных нарушений кишечника</article-title><trans-title-group xml:lang="en"><trans-title>Efficacy of Sparex in the management of intestinal motility disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковенко</surname><given-names>Э. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovenko</surname><given-names>E. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агафонова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Agafonova</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковенко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovenko</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Research University named after N.I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>4</issue><fpage>110</fpage><lpage>115</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Яковенко Э.П., Агафонова Н.А., Иванов А.Н., Яковенко А.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Яковенко Э.П., Агафонова Н.А., Иванов А.Н., Яковенко А.В.</copyright-holder><copyright-holder xml:lang="en">Yakovenko E.P., Agafonova N.A., Ivanov A.N., Yakovenko A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/87">https://www.med-sovet.pro/jour/article/view/87</self-uri><abstract><p>Синдром раздраженного кишечника (СРК) является одним из наиболее распространенных функциональных заболеваний кишечника. Кроме того, при многих заболеваниях органов пищеварения отмечаются симптомы, сходные с СРК. Принципы лечения СРК и СРК-подобных расстройств однотипны. В основе формирования основного симптома СРК - абдоминальной боли лежит спастическая или гипермоторная дискинезия, поэтому основной группой препаратов для ее купирования являются спазмолитики. Предпочтение отдается селективным спазмолитикам. Спарекс является отечественным дженериком известного с 1965 г. селективного кишечного спазмолитика мебеверина гидрохлорида, отличается наиболее доступной ценой среди аналогов. Проведенное исследование, включающее 48 пациентов, показало высокую эффективность четырехнедельного приема Спарекса в дозе 200 мг 2 раза в сутки по купированию болевого синдрома, метеоризма и нормализации стула как при СРК, так и СРК-подобных нарушениях. Хороший и удовлетворительный результат, оцениваемый по 3-балльной шкале, получен у 87,5% больных. Полученные результаты позволили также сделать заключение о наличии у данного препарата не только выраженного спазмолитического эффекта, но и эукинетического действия - нормализации транзита химуса по кишке как при запорах, так и при диарее. Нормализация стула отмечена у 77,2% больных как при запорах, так и при диарее, у остальных больных выраженность нарушения стула снизилась более чем на 1 балл. В процессе исследования при использовании Спарекса побочных эффектов не отмечено.</p></abstract><trans-abstract xml:lang="en"><p>Irritable bowel syndrome (IBS) is one of the most common functional bowel diseases. What is more, a number of digestive diseases are characterized by symptoms similar to those observed in IBS. The principles of treatment of IBS and IBS-related disorders are same. The key symptom of IBS - abdominal pain - is developed as a result of spasmodic or hyperkinetic dyskinesia, so the main group of drugs to be used in the treatment are antispasmodics. Preference is given to selective antispasmodics. Sparex is a national generic of the selective intestinal antispasmodic mebeverine hydrochloride which has been known since 1965, and is characterized by the most affordable price among analogues. The study which included 48 patients demonstrated high efficacy of Sparex administered for 4 weeks in a dosage of 200 mg twice daily for relief of pain, flatulence and stool normalization both in IBS and IBS-related disorders. Good and satisfactory results evaluated by a 3-point scale were achieved in 87.5% of patients. The results allowed to conclude that the medicine, apart from its strong antispasmodic effect, also provided a eukinetic action - normalization of the transit of chyme in the intestine both in constipation and diarrhea. Normalization of stool was observed in 77.2% of patients with both constipation and diarrhea, and in the rest of patients the severity of stool disorders decreased by more than 1 point. In the course of the study, no side effects were observed while taking Sparex.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром раздраженного кишечника</kwd><kwd>(СРК)</kwd><kwd>СРК-подобные нарушения</kwd><kwd>абдоминальная боль</kwd><kwd>мебеверина гидрохлорид</kwd><kwd>Спарекс</kwd><kwd>irritable bowel syndrome (IBS)</kwd><kwd>IBS-related disorders</kwd><kwd>abdominal pain</kwd><kwd>mebeverine hydrochloride</kwd><kwd>Sparex</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Drossman DA, CamiLLeri M, Mayer EA, Whitehead WE. AGA technical review on irritable boweL syndrome. Gastroenterology, 2002, 123: 2108-31.</mixed-citation><mixed-citation xml:lang="en">Drossman DA, CamiLLeri M, Mayer EA, Whitehead WE. AGA technical review on irritable boweL syndrome. 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