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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2024-443</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8704</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БРОНХОПУЛЬМОНОЛОГИЯ И ОТОЛАРИНГОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRONCHOPULMONOLOGY, OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Острый риносинусит у детей в амбулаторной практике: возможности рациональной терапии и профилактики осложнений</article-title><trans-title-group xml:lang="en"><trans-title>Acute rhinosinusitis in children in outpatient practice: The possibilities of rational therapy and prevention of complications</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6966-8656</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кириченко</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirichenko</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кириченко Ирина Михайловна - д.м.н., профессор кафедры оториноларингологии Медицинского института, РУДН имени Патриса Лумумбы; главный оториноларинголог, ММЦ «Он клиник».</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6; 121069, Москва, ул. Большая Молчановка, д. 32 стр. 1</p></bio><bio xml:lang="en"><p>Irina M. Kirichenko - Dr. Sci. (Med.), Department of Otorhinolaryngology of the Medical Institute, PFUR named after Patrice Lumumba; Head of the Department of Otorhinolaryngology, International Medical Center On Clinics.</p><p>6, Miklukho-Maklai St., Moscow, 117198; 32, Bldg. 1, Bolshaya Molchanovka St., Moscow, 121069</p></bio><email xlink:type="simple">loririna@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3309-4683</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попадюк</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Popadyuk</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попадюк Валентин Иванович - д.м.н., профессор¸ декан факультета непрерывного медицинского образования и заведующий кафедрой оториноларингологии Медицинского института.</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Valentin I. Popadyuk - Dr. Sci. (Med.), Dean of the Faculty of Postgraduate Education and Head of the Department of Otorhinolaryngology of the Medical Institute, PFUR named after Patrice Lumumba.</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">lorval04@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4437-9740</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козлова Наталья Сергеевна - ассистент кафедры оториноларингологии, РУДН; врач-оториноларинголог, Международный медицинский центр «Он клиник»;</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6; 121069, Москва, ул. Большая Молчановка, д. 32 стр. 1</p></bio><bio xml:lang="en"><p>Natalia S. Kozlova - Assistant of the Department of Otorhinolaryngology, PFUR named after Patrice Lumumba; Otorhinolaryngologist, International Medical Center On Clinics.</p><p>6, Miklukho-Maklai St., Moscow, 117198; 32, Bldg. 1, Bolshaya Molchanovka St., Moscow, 121069</p></bio><email xlink:type="simple">matyushkina.natalia@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3082-3182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернолев</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernolev</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чернолев Анна Ильинична, к.м.н., доцент кафедры оториноларингологии, РУДН имени Патриса Лумумбы.</p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Anna I. Chernolev - Cand. Sci. (Med.), Associate Professor of the Department of Otorhinolaryngology, PFUR named after Patrice Lumumba.</p><p>6, Miklukho-Maklai St., Moscow, 117198</p></bio><email xlink:type="simple">chernolev_ai@pfur.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы; Международный медицинский центр «Он Клиник»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia named after Patrice Lumumba; International Medical Center On Clinics</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia named after Patrice Lumumba</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>25</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>19</issue><fpage>69</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кириченко И.М., Попадюк В.И., Козлова Н.С., Чернолев А.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кириченко И.М., Попадюк В.И., Козлова Н.С., Чернолев А.И.</copyright-holder><copyright-holder xml:lang="en">Kirichenko I.M., Popadyuk V.I., Kozlova N.S., Chernolev A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8704">https://www.med-sovet.pro/jour/article/view/8704</self-uri><abstract><p>В амбулаторной практике как педиатра, так и оториноларинголога острый риносинусит является наиболее часто встречающимся инфекционным заболеванием верхних дыхательный путей. Формированию синусита на фоне острой респираторной вирусной инфекции у детей способствует неоправданное назначение антибиотиков, снижение иммунитета, аллергизация организма, наличие структурных изменений строения носа и околоносовых пазух, нарушение обменных процессов, авитаминозы, наличие сопутствующих хронических заболеваний, неблагоприятные факторы окружающей среды. Назначение системных антибиотиков при вирусных инфекциях верхних дыхательных путей приводит к нарушению иммунного ответа слизистых и не предотвращает развитие бактериальных осложнений. Мукоцилиарный транспорт является главным механизмом очистки полости носа и околоносовых пазух от слизи и патогенов, предотвращающим развитие воспаления. Нарушение мукоцилиарного транспорта на фоне вирусных инфекций приводит к развитию острого синусита, который может осложниться острым отитом, евстахиитом, аденоидитом. Иногда развиваются внутричерепные и орбитальные осложнения. В статье приведен клинический случай пациента 12 лет с жалобами на затруднение носового дыхания, слизисто-гнойные выделения из носа, стекание отделяемого по задней стенке глотки, малопродуктивный кашель, особенно беспокоящий в ночное время, периодическую лицевую боль справа, боль и заложенность в правом ухе. Было проведено эндоскопическое обследование носа, носоглотки и уха, также компьютерная томография. При назначении комплексного лечения, включающего комбинированный муколитический препарат, на 7-й день лечения было достигнуто полное выздоровление. Применение топического муколитического препарата, содержащего N-ацетилцистеин и туаминогептан, у детей позволяет улучшить реологию отделяемого из носа и околоносовых пазух и предотвращает развитие осложнений острого риносинусита.</p></abstract><trans-abstract xml:lang="en"><p>In outpatient practice, both pediatrician and otorhinolaryngologist, acute rhinosinusitis is the most common infectious disease of the upper respiratory tract. The formation of sinusitis against the background of acute respiratory viral infection (colds) in children is facilitated by the unjustified administration of antibiotics, decreased immunity, allergies, changes in the structure of the nose and paranasal sinuses, metabolic disorders, beriberi, chronic diseases, adverse environmental factors. The administration of systemic antibiotics for viral infections of the upper respiratory tract leads to a violation of the immune response of the mucous membranes and does not prevent the development of bacterial complications. Mucociliary transport is the main mechanism for cleaning the nasal cavity and paranasal sinuses from mucus and pathogens, preventing the development of inflammation. Violation of mucociliary transport against the background of viral infections leads to the development of acute sinusitis, which can be complicated by acute otitis media, eustachiitis, adenoiditis. Sometimes intracranial and orbital complications develop. The article presents a clinical case of a 12-year-old patient with complaints of difficulty in nasal breathing, mucopurulent nasal discharge, discharge from the back of the throat, unproductive cough, especially disturbing at night, periodic facial pain on the right, pain and congestion in the right ear. An endoscopic examination of the nose, nasopharynx and ear, as well as a computed tomography scan were performed. When prescribing complex treatment, including a combined mucolytic drug, a complete recovery was achieved on the 7th day of treatment. The use of the topical mucolytic drug (acetylcysteine, tuaminoheptane) in children improves the rheology of discharge from the nose and paranasal sinuses and prevents the development of complications of acute rhinosinusitis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мукоцилиарный транспорт</kwd><kwd>антибиотикорезистентность</kwd><kwd>муколитический препарат</kwd><kwd>N-ацетилцистеин</kwd><kwd>туаминогептан</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mucociliary transport</kwd><kwd>antibiotic resistance</kwd><kwd>mucolytic drug</kwd><kwd>acetylcysteine</kwd><kwd>tuaminoheptane</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Demuri GP, Wald ER. Clinical practice. Acute Bacterial Sinusitis in Children. N Engl J Med. 2012;367(12):1128–1134. https://doi.org/10.1056/NEJMcp1106638.</mixed-citation><mixed-citation xml:lang="en">Demuri GP, Wald ER. Clinical practice. 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