medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2024-532medsovet-8839Research ArticleЭНДОКРИНОЛОГИЯENDOCRINOLOGYТиоредоксинвзаимодействующий белок TXNIP как перспективный диагностический маркер метаболически ассоциированной жировой болезни печени у пациентов с сахарным диабетом 2-го типаThioredoxin-interacting protein TXNIP as a promising diagnostic marker for metabolic-associated fatty liver disease in patients with type 2 diabeteshttps://orcid.org/0000-0002-5149-4667МелтонянА. Р.MeltonianA. R.

Мелтонян Ася Робертовна - аспирант кафедры эндокринологии, врач-эндокринолог.

197341, Санкт-Петербург, ул. Аккуратова, д. 2

Asia R. Meltonian - Postgraduate Student, Endocrinologist, Department of Endocrinology, Institute of Medical Education.

2, Akkuratov St., St Petersburg, 197341

a.r.meltonyan@yandex.ruhttps://orcid.org/0000-0003-0837-8385ЛаевскаяМ. Ю.LaevskayaM. Yu.

Лаевская Мария Юрьевна - к.м.н., доцент кафедры эндокринологии Института медицинского образования, старший научный сотрудник научно-исследовательской лаборатории диабетологии Института эндокринологии.

197341, Санкт-Петербург, ул. Аккуратова, д. 2

Maria Yu. Laevskaya - Cand. Sci. (Med.), Associate Professor, Department of Endocrinology, Institute of Medical Education, Senior Research Scientist, Research Laboratory of Diabetology, Institute of Endocrinology.

2, Akkuratov St., St Petersburg, 197341

maria_laye@inbox.ruhttps://orcid.org/0000-0002-8258-522XСавченковЮ. Н.SavchenkovYu. N.

Савченков Юрий Николаевич - к.м.н., врач-рентгенолог, ассистент кафедры лучевой диагностики с курсом радиологии, Медикобиологический университет инноваций и непрерывного образования.

123098, Москва, ул. Маршала Новикова, д. 23

Yury N. Savchenkov - Cand. Sci. (Med.), Radiologist, Assistant of the Department of Radiology.

23, Marshal Novikov St., Moscow, 123098

yura_savchenkov@mail.ruhttps://orcid.org/0000-0002-0559-697XБабенкоА. Ю.BabenkoA. Yu.

Бабенко Алина Юрьевна - д.м.н., профессор кафедры эндокринологии Института медицинского образования, врач-эндокринолог высшей категории, заведующая научно-исследовательским отделом генетических рисков и персонифицированной профилактики Центра персонализированной медицины, главный научный сотрудник научно-исследовательской лаборатории диабетологии Института эндокринологии.

197341, Санкт-Петербург, ул. Аккуратова, д. 2

Alina Yu. Babenko - Dr. Sci. (Med.), Professor of the Department of Endocrinology, Institute of Medical Education, Endocrinologist of the Highest Category, Head of Research Institute of Genetic Risks and Personalized Prevention, World-Class Research Center for Personalised Medicine, Head of Leading Research Scientist, Diabetology Research Laboratory.

2, Akkuratov St., St Petersburg, 197341

alina_babenko@mail.ruНациональный медицинский исследовательский центр имени В.А. АлмазоваРоссияAlmazov National Medical Research CentreRussian FederationФедеральный медицинский биофизический центр имени А.И. Бурназяна Федерального медико-биологического агентстваРоссияBurnasyan Federal Medical Research Biophysical Center of Federal Medical Biological AgencyRussian Federation202422012025023137143Copyright © Мелтонян А.Р., Лаевская М.Ю., Савченков Ю.Н., Бабенко А.Ю., 20242024Мелтонян А.Р., Лаевская М.Ю., Савченков Ю.Н., Бабенко А.Ю.Meltonian A.R., Laevskaya M.Y., Savchenkov Y.N., Babenko A.Y.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8839Введение

Введение. Метаболически ассоциированная жировая болезнь печени (МАЖБП) – широко распространенное заболевание, имеющее патогенетическую взаимосвязь с сахарным диабетом 2-го типа (СД2).

Цель

Цель. Определить значения белка TXNIP у пациентов с МАЖБП и СД2, находящихся на монотерапии метформином, сопоставить полученные значения с результатами МРТ печени у данной группы пациентов, а также определить изменения уровней тиоредоксинвзаимодействующего белка (TXNIP) через 6 мес. от начала терапии агонистами рецептора глюкагоноподобного пептида 1 (арГПП-1) и ингибиторами натрий-глюкозного котранспортера 2-го типа (иНГЛТ-2).

Материалы и методы

Материалы и методы. В исследование были включены 49 пациентов с СД2 и МАЖБП в возрасте 55 ± 8 лет (34 женщины и 15 мужчин), наблюдавшихся в амбулаторно-поликлиническом отделении НМИЦ им. В.А. Алмазова (Санкт-Петербург) с января 2023 г. по март 2024 г., которые имели ИМТ 25–40 кг/м2, а также уровень гликированного гемоглобина не более 9,5%.

Результаты

Результаты. Исследование показало, что уровень белка TXNIP в сыворотке коррелировал с результатами оценки выраженности МАЖБП по данным МРТ печени, а также значимо снижался на фоне применения сахароснижающей терапии арГПП-1 и иНГЛТ-2. Выводы. Полученные нами данные корреляции свидетельствуют о возможном применении белка TXNIP в качестве перспективного диагностического маркера у пациентов с МАЖБП и СД2 как на этапе диагностики, так и при анализе результатов проводимой терапии.

Introduction

Introduction. Metabolic-associated fatty liver disease (MAFLD) is a common disease that has a pathogenesis-based relationship with type 2 diabetes (T2D).

Aim

Aim. To determine the levels of TXNIP protein in patients with MAFLD and T2D who were on metformin monotherapy, to compare these levels with the findings of MRI of the liver, and to assess changes in TXNIP protein levels six months after starting treatment with glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 (SGLT-2) inhibitors.

Materials and methods

Materials and methods. The study included 49 patients (34 female and 15 male) with T2D and MAFLD, aged 55 ± 8 years, who were followed up at the outpatient clinic of Almazov National Medical Research Centre (St. Petersburg) from January 2023 to March 2024. The eligibility criteria included BMI values of 25–40 kg/m² and a glycated hemoglobin level not exceeding 9.5%. Results. The study showed that serum TXNIP protein levels were positively correlated with the severity of MAFLD assessed based on MRI findings. Furthermore, TXNIP levels significantly decreased as a result of therapy with GLP-1RAs and SGLT-2 inhibitors.

Conclusion

Conclusion. These correlation data suggest that the TXNIP level could be used as a promising diagnostic marker in patients with MAFLD and T2D, both at the stage of diagnostic evaluation and when considering the outcomes of ongoing therapy.

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The authors declare that there are no conflicts of interest present.