medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-013medsovet-8946Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESВлияние медикаментов на кожу: ксероз как побочный эффектDrug effects on skin: Xerosis as a side effecthttps://orcid.org/0000-0003-2027-5987СаканияЛ. Р.SakaniyaL. R.

Сакания Луиза Руслановна, врач-дерматовенеролог, косметолог, трихолог, Московский научно-практический центр дерматовенерологии и косметологии; ладший научный сотрудник, врач-дерматовенеролог, Центр теоретических проблем физико-химической фармакологии Российской академии наук

127473, Москва, ул. Селезневская, д. 20,

109029, Москва, ул. Средняя Калитниковская, д. 30

Luizа R. Sakaniya, Dermatovenerologist, Cosmetologist, Trichologist, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology; Junior Researcher, Dermatovenerologist, Center for Theoretical Problems of Physical and Chemical Pharmacology of Russian Academy of Sciences

20, Seleznevskaya St., Moscow, 127473,

30, Srednyaya Kalitnikovskaya St., Moscow, 109029

sakania.luiz@yandex.ruhttps://orcid.org/0000-0001-5753-2567ОленичИ. В.OlenichI. V.

Оленич Ирина Владимировна, врач-дерматолог, заведующая отделением дневного стационара

127473, Москва, ул. Селезневская, д. 20

Irina V. Olenich, Dermatologist, Head of the Day Hospital Department

20, Seleznevskaya St., Moscow, 127473

9332307@gmail.comhttps://orcid.org/0000-0002-6583-0318КорсунскаяИ. М.KorsunskayaI. M.

Корсунская Ирина Марковна, д.м.н., профессор, заведующая лабораторией физико-химических и генетических проблем дерматологии

109029, Москва, ул. Средняя Калитниковская, д. 30

Irina М. Korsunskaya, Dr. Sci. (Med.), Professor, Head of the Laboratory of Physicochemical and Genetic Problems in Dermatology

30, Srednyaya Kalitnikovskaya St., Moscow, 109029

marykor@bk.ruЦентр теоретических проблем физико-химической фармакологии Российской академии наук; Московский научно-практический центр дерматовенерологии и косметологииРоссияCenter for Theoretical Problems of Physical and Chemical Pharmacology of Russian Academy of Sciences; Moscow Scientific and Practical Center of Dermatovenereology and CosmetologyRussian FederationМосковский научно-практический центр дерматовенерологии и косметологииРоссияMoscow Scientific and Practical Center of Dermatovenereology and CosmetologyRussian FederationЦентр теоретических проблем физико-химической фармакологии Российской академии наукРоссияCenter for Theoretical Problems of Physical and Chemical Pharmacology of Russian Academy of SciencesRussian Federation202530032025023740Copyright © Сакания Л.Р., Оленич И.В., Корсунская И.М., 20252025Сакания Л.Р., Оленич И.В., Корсунская И.М.Sakaniya L.R., Olenich I.V., Korsunskaya I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/8946

Сухость кожных покровов – довольно распространенный симптом, особенно в группе пациентов старшего возраста. Причиной ксероза могут быть как возрастные особенности кожи и хронические заболевания, так и прием некоторых лекарственных препаратов. При лечении молодых пациентов такими лекарственными средствами являются ретиноиды, которые назначают по поводу акне и розацеа. Системные и топические ретиноиды провоцируют истончение рогового слоя, изменение состава кожного сала, что и становится причиной повышенной трансэпидермальной потери влаги. Противоопухолевые препараты также могут вызывать сухость кожи. В частности, ксероз является частым побочным эффектом при приеме ингибиторов рецепторов эпидермального фактора роста. Антигистаминные препараты, лекарственные средства против повышенного артериального давления, к примеру, диуретики, статины, используемые для снижения уровня холестерина, могут стать причиной ксероза. В связи с этим в протоколы лечения препаратами, вызывающими сухость кожных покровов, необходимо включать средства ухода с выраженным увлажняющим эффектом. Предпочтение стоит отдавать многокомпонентным средствам, чьи составляющие не только восстановят нормальный уровень увлажненности кожи, но и будут обладать противозудным действием, поскольку зуд часто наблюдается при ксерозе, а также устранят повреждения кожного барьера, которые неизбежно возникают при сухости кожи. Средства ухода должны обладать пролонгированным действием, позволяющим применять их 1–2 раза в сутки, приятной текстурой, быстро впитываться и не оставлять ощущения жирности. Это позволит не только устранить неприятный побочный эффект основной терапии, но и улучшить качество жизни пациентов.

Skin dryness is a moderately common symptom, especially in a group of elderly patients. Xerosis can be caused both by age‐associated skin features and chronic diseases, and the use of certain drugs. Retinoids are the drugs used to treat young patients, which are prescribed due to acne and rosacea. Systemic and topical retinoids induce thinning of the stratum corneum, changes in the sebum composition, which becomes the cause of increased transepidermal moisture loss. Antineoplastic drugs can also induce skin dryness. In particular, xerosis is a common side effect that occurs when epidermal growth factor receptor (EGFR) inhibitors are administered. Antihistamines, high blood pressure drugs, for instance diuretics, statins that are used to lower cholesterol levels, can induce xerosis. Therefore, care products with pronounced moisturizing effects should be included in the guidelines on the treatment with drugs inducing skin dryness. Preference should be given to combination drugs, which ingredients will not only restore the normal moisture level of the skin, but also have an antipruritic action, as itching is often observed in xerosis, and repair a damaged skin barrier that inevitably occurs in skin dryness. Care products should have a prolonged action, allowing them to be used 1–2 times a day, a pleasant texture, and be quickly absorbed without leaving a greasy feeling. This will not only eliminate the unpleasant side effect of the backbone therapy, but also improve the patients’ quality of life.

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The authors declare that there are no conflicts of interest present.