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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-054</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8951</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ КОЖИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Клинико-анамнестические особенности дисгидротической экземы: одномоментное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and anamnestic features of dyshidrotic eczema: A cross-sectional study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1655-8992</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шачнев</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shachnev</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шачнев Александр Сергеевич, аспирант кафедры дерматовенерологии, аллергологии и косметологии Медицинского института</p><p>17198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Aleksandr S. Shachnev, Postgraduate Student of the Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine</p><p>6, Miklukho-Maklaya St., Moscow, 117198</p></bio><email xlink:type="simple">dr.shachnev@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5723-6573</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жукова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhukova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жукова Ольга Валентиновна, д.м.н., профессор, заведующая кафедрой дерматовенерологии, аллергологии и косметологии Медицинского института, Российский университет дружбы народов имени Патриса Лумумбы; главный врач, Московский научно-практический центр дерматовенерологии и косметологии</p><p>17198, Москва, ул. Миклухо-Маклая, д. 6,</p><p>119071, Москва, Ленинский проспект, д. 17</p></bio><bio xml:lang="en"><p>Olga V. Zhukova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia named after Patrice Lumumba; Chief Medical Officer, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology</p><p>6, Miklukho-Maklaya St., Moscow, 117198,</p><p>17, Lenin Ave., Moscow, 119071</p></bio><email xlink:type="simple">klinderma@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0767-8821</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Касихина</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kasikhina</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Касихина Елена Игоревна, к.м.н., доцент, доцент кафедры дерматовенерологии, аллергологии и косметологии Медицинского института, Российский университет дружбы народов имени Патриса Лумумбы»; 117198, Россия, Москва, ул. Миклухо-Маклая, д. 6; врач-дерматовенеролог, Московский научно-практический центр дерматовенерологии и косметологии</p><p>17198, Москва, ул. Миклухо-Маклая, д. 6,</p><p>119071, Москва, Ленинский проспект, д. 17</p></bio><bio xml:lang="en"><p>Elena I. Kasikhina, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology, Allergology and Cosmetology, Institute of Medicine, Peoples’ Friendship University of Russia named after Patrice Lumumba; Dermatologist, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology</p><p>6, Miklukho-Maklaya St., Moscow, 117198,</p><p>17, Lenin Ave., Moscow, 119071</p></bio><email xlink:type="simple">kasprof@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia named after Patrice Lumumba</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы; &#13;
Московский центр дерматовенерологии и косметологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia named after Patrice Lumumba; &#13;
Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>31</day><month>03</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>73</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шачнев А.С., Жукова О.В., Касихина Е.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шачнев А.С., Жукова О.В., Касихина Е.И.</copyright-holder><copyright-holder xml:lang="en">Shachnev A.S., Zhukova O.V., Kasikhina E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8951">https://www.med-sovet.pro/jour/article/view/8951</self-uri><abstract><sec><title>Введение</title><p>Введение. Дисгидротическая экзема (ДЭ) – распространенная разновидность экземы, характеризующаяся везикулярными или буллезными высыпаниями на коже кистей и (или) стоп, склонная к хроническому и рецидивирующему течению, рефрактерности к проводимой терапии и развитию осложнений.</p></sec><sec><title>Цель</title><p>Цель. Провести анализ клинико-анамнестических особенностей дисгидротической экземы. Дать описание клинических случаев ДЭ и опыта наружной терапии.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование было включено 132 пациента (55 мужчин и 77 женщин) с ДЭ в возрасте от 19 до 78 лет. Средний возраст составил 33,7 ± 10,3 года. Для оценки тяжести течения ДЭ использовался Индекс площади поражения и степени тяжести ДЭ (Dyshidrotic Eczema Area and Severity Index, DASI), для оценки зуда использовалась визуальноаналоговая шкала, ВАШ (Visual Analogue Scale, VAS).</p></sec><sec><title>Результаты</title><p>Результаты. Отягощенный аллергоанамнез выявлен у 40,1% пациентов, атопический анамнез – у 18,2% пациентов. Гипергидроз кистей и стоп диагностирован у 3,8% пациентов. Средний балл индекса DASI составил 12,6 вне зависимости от пола (p = 0,096). Особенности клинического течения ДЭ характеризовались преобладанием легкой (68,2%) и средней степени тяжести (31,0%) с локализацией патологического процесса преимущественно на коже кистей в 73,5% случаев. Кожный зуд сопровождал высыпания в 54,5% случаев. Наружная терапия кремом, содержащим бетаметазона дипропионат 0,05%, гентамицина сульфат 0,1% и клотримазол 1%, показала высокую эффективность в терапии острого и подострого течения ДЭ кистей и стоп, осложненных вторичной инфекцией. Препарат продемонстрировал достижение клинического эффекта «чистой кожи» у 82,1% пациентов с ДЭ.</p></sec><sec><title>Выводы</title><p>Выводы. Изучение анамнестических и клинических особенностей ДЭ важно для оптимизации системной и наружной терапии заболевания, анализа факторов риска, позволяющих контролировать течение заболевания и разрабатывать индивидуальные схемы профилактики обострений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Dyshidrotic eczema (DE) is a common type of eczema characterized by vesicular or bullous rashes on the skin of hands and (or) feet, prone to chronic and recurrent course, refractoriness to therapy and development of complications.</p></sec><sec><title>Aim</title><p>Aim. To analyze the clinical and anamnestic features of dyshidrotic eczema. Describe clinical cases of DE and experience with external therapy.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 132 patients (55 men and 77 women) with DE aged 19 to 78 years, the average age was 33.7 ± 10.3 years. To assess the severity of the course of DE, The Dyshidrotic Eczema Area and Severity Index (DASI) was used, and a visual analog scale, The Visual Analogue Scale (VAS), was used to assess itching.</p></sec><sec><title>Results</title><p>Results. Aggravated allergic anamnesis was revealed in 40.1% of patients, atopic anamnesis – in 18.2% of patients. Hyperhidrosis of hands and feet was diagnosed in 3.8% of patients. The mean DASI index score was 12.6 regardless of gender (p = 0.096). The clinical course of DE was characterized by predominance of mild (68.2%) and moderate severity (31.0%) with localization of the pathological process mainly on the skin of hands in 73.5% of cases. Cutaneous itching accompanied the rashes in 54.5% of cases. External therapy with cream containing betamethasone dipropionate 0.05%, gentamicin sulfate 0.1% and clotrimazole 1% showed high efficacy in the treatment of acute and subacute course of DE of hands and feet complicated by secondary infection. The drug demonstrated achievement of the clinical effect of “clear skin” in 82.1% of patients with DE.</p></sec><sec><title>Conclusions</title><p>Conclusions. The study of anamnestic and clinical features of DE is important for optimization of systemic and external therapy of the disease, analysis of risk factors that allow to control the course of the disease and develop individual schemes for prevention of exacerbations.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дисгидротическая экзема</kwd><kwd>клинические особенности</kwd><kwd>наружная терапия</kwd><kwd>бетаметазона дипропионат</kwd><kwd>гентамицин</kwd><kwd>клотримазол</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dyshidrotic eczema</kwd><kwd>clinical features</kwd><kwd>topical therapy</kwd><kwd>betamethasone dipropionate</kwd><kwd>gentamicin</kwd><kwd>clotrimazole</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Veien NK. Acute and recurrent vesicular hand dermatitis. 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