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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-012</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-8982</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ШКОЛА ПЕДИАТРА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PEDIATRICIAN SCHOOL</subject></subj-group></article-categories><title-group><article-title>Многогранность констипации у детей: клинический случай инфекции мочевой системы у ребенка, страдающего запором</article-title><trans-title-group xml:lang="en"><trans-title>The versatility of constipation in children: A clinical case of urinary system infection in a child suffering from constipation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8377-6212</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сагитова</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sagitova</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сагитова Гульнара Рафиковна - д.м.н., профессор, профессор кафедры госпитальной педиатрии и неонатологии.</p><p>414000, Астрахань, ул. Бакинская, д. 121</p></bio><bio xml:lang="en"><p>Gulnara R. Sagitova - Dr. Sci. (Med.), Professor, Professor of the Department of Hospital Pediatrics and Neonatology.</p><p>121, Bakinskaya St., Astrakhan, 414000</p></bio><email xlink:type="simple">sagitova-gulnara04@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Астраханский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Astrakhan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>05</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>197</fpage><lpage>203</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сагитова Г.Р., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сагитова Г.Р.</copyright-holder><copyright-holder xml:lang="en">Sagitova G.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/8982">https://www.med-sovet.pro/jour/article/view/8982</self-uri><abstract><p>В структуре общей заболеваемости запоры занимают одно из первых мест. Четкая статистика показателя, к сожалению, отсутствует. Причины разные: многоликость запора, отсутствие графы в официальных таблицах отчетности заболеваемости по учреждениям здравоохранения, недостаточная настороженность у педиатров / узких специалистов, умалчивание родителей, пациентов о столь деликатной теме. В целом частота встречаемости запоров в мире практически одинакова – от 16 до 37% среди детей школьного возраста (данные University of Michigan Health System, National Institute for Health and Clinical Excellence, Российского эпидемиологического исследования по округам). Это заболевание известно еще со времен древности. Так, Гиппократ, Авиценна и Парацельс указывали в своих трудах запор как одну из причин внутренних заболеваний. В 1929 г. Эванс сформулировал определение запора, которое близко к понятию в соответствии с Римскими критериями. Дети XXI в. имеют достаточно много рисков для развития запоров, и определено это прежде всего происходящими изменениями в макрои микросоциуме, образе жизни, гиподинамии, стрессовыми ситуациями, последствиями перенесенных вирусных инфекций, в т.ч. SARS-CoV-2, нарушениями правил и порядка применения принципов диетологии в педиатрии, соматическими заболеваниями и т.д. Качество жизни таких пациентов сравнимо с качеством жизни пациентов с сахарным диабетом, артериальной гипертензией и депрессией. Сегодня в помощь специалистам есть ряд документов, которые определяют понятие, критерии верификации диагноза, тактики ведения и профилактики запоров. Результаты исследований зарубежных и отечественных ученых указывают на то, что стимуляторы являются эффективными и безопасными для лечения функциональных запоров у детей. Одним из препаратов этой группы является пикосульфат натрия. Приводится случай из практики, когда нелеченый запор явился причиной развития у ребенка инфекции мочевыводящих путей с выраженной активностью.</p></abstract><trans-abstract xml:lang="en"><p>Constipation occupies one of the first places in the structure of the general morbidity. Unfortunately, there are no clear statistics on the indicator. The reasons are different: the multiplicity of constipation, the absence of columns in the official tables of morbidity reporting by healthcare institutions, insufficient vigilance among pediatricians / narrow specialists, the silence of parents and patients about such a delicate topic. In general, the incidence of constipation in the world is almost the same-from 16 to 37% among school-age children. This disease has been known since ancient times. Thus, Hippocrates, Avicenna, and Paracelsus pointed out in their writings constipation as one of the causes of internal diseases. In 1929, Evans formulated the definition of constipation, which is close to the concept according to the Roman criteria. Children of the 21st century have quite a lot of risks for the development of constipation, and this is determined primarily by changes in the macro and microsociety, lifestyle, physical inactivity, stressful situations, the consequences of viral infections, including SARS-CoV-2, violations of the rules and procedures for applying the principles of dietetics in pediatrics, somatic diseases, etc. The quality of life of such patients is comparable to that of patients with diabetes, hypertension, and depression. Today, specialists are assisted by a number of documents that define the concept, criteria for verifying the diagnosis, tactics for managing and preventing constipation. The research results of foreign and domestic scientists indicate that stimulants are effective and safe for the treatment of functional constipation, including in children’s practice. One of the drugs in this group is sodium picosulfate. A case from practice is given when untreated constipation caused a child to develop a urinary tract infection with pronounced activity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>запор</kwd><kwd>дети</kwd><kwd>причины</kwd><kwd>Римские критерии IV пересмотра</kwd><kwd>клиника</kwd><kwd>диагностика</kwd><kwd>лечение</kwd><kwd>инфекция мочевыводящих путей</kwd></kwd-group><kwd-group xml:lang="en"><kwd>constipation</kwd><kwd>children</kwd><kwd>causes</kwd><kwd>Roman criteria IV revision</kwd><kwd>clinic</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>urinary tract infection</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алхасов АБ, Батаев СМ, Бельмер СВ и др. Детская гастроэнтерология. Национальное руководство. М.: ГЭОТАР-Медиа; 2022. 856 с.</mixed-citation><mixed-citation xml:lang="en">Алхасов АБ, Батаев СМ, Бельмер СВ и др. Детская гастроэнтерология. Национальное руководство. М.: ГЭОТАР-Медиа; 2022. 856 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Симонян РЗ. История медицины: с древнейших времен до современности: учебное пособие для студентов лечебных факультетов образовательных организаций высшего образования. Чебоксары: Издательский дом «Среда»; 2020. 224 c. Режим доступа: https://phsreda.com/e-publications/e-publication-143.pdf.</mixed-citation><mixed-citation xml:lang="en">Симонян РЗ. История медицины: с древнейших времен до современности: учебное пособие для студентов лечебных факультетов образовательных организаций высшего образования. Чебоксары: Издательский дом «Среда»; 2020. 224 c. Режим доступа: https://phsreda.com/e-publications/e-publication-143.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ибн-Сина. Канон врачебной науки. М.: Изд-во МИКО «Коммерческий вестник»; Ташкент: Фан; 1994. 398 с. Режим доступа: https://rusneb.ru/catalog/000200_000018_rc_54590/.</mixed-citation><mixed-citation xml:lang="en">Ибн-Сина. Канон врачебной науки. М.: Изд-во МИКО «Коммерческий вестник»; Ташкент: Фан; 1994. 398 с. Режим доступа: https://rusneb.ru/catalog/000200_000018_rc_54590/.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Frexinos J. The history of constipation and the constipated. Bull Soc Liban Hist Med. 1993:(3):62–69. Available at: https://pubmed.ncbi.nlm.nih.gov/11619225/.</mixed-citation><mixed-citation xml:lang="en">Frexinos J. The history of constipation and the constipated. Bull Soc Liban Hist Med. 1993:(3):62–69. Available at: https://pubmed.ncbi.nlm.nih.gov/11619225/.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Цветкова ЛН. Профилактика и лечение запоров у детей. Вопросы современной педиатрии. 2004;3(5):74–81. Режим доступа: https://cyberleninka.ru/article/n/profilaktika-i-lechenie-zaporov-u-detey.</mixed-citation><mixed-citation xml:lang="en">Tsvetkova LN. Prevention and treatment of constipation in children. Current Pediatrics. 2004;3(5):74–81. Available at: https://cyberleninka.ru/article/n/profilaktika-i-lechenie-zaporov-u-detey.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon J, Blakeley K, Blannin J, Cave J, Hooban S, Jenkins H et al. Constipation in children and young people: Diagnosis and management of idiopathic childhood constipation in primary and secondary care. NICE clinical guideline. London; 2010. 249 p. Available at: https://www.nice.org.uk/guidance/cg99/evidence/full-guidance-245466253.</mixed-citation><mixed-citation xml:lang="en">Gordon J, Blakeley K, Blannin J, Cave J, Hooban S, Jenkins H et al. Constipation in children and young people: Diagnosis and management of idiopathic childhood constipation in primary and secondary care. NICE clinical guideline. London; 2010. 249 p. Available at: https://www.nice.org.uk/guidance/cg99/evidence/full-guidance-245466253.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Evaluation and Treatment of Constipation in Infants and Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2006;43(3):1–13. https://doi.org/10.1097/01.mpg.0000233159.97667.c3.</mixed-citation><mixed-citation xml:lang="en">Evaluation and Treatment of Constipation in Infants and Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2006;43(3):1–13. https://doi.org/10.1097/01.mpg.0000233159.97667.c3.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Poenaru D, Roblin M, Bird M, Duce S, Groll A, Pietak D et al. The pediatric bowel management clinic: Initial results of a multidisciplinary approach of functional constipation in children. J Pediatr Surg. 1997;32(6):843–848. https://doi.org/10.1016/S0022-3468(97)90633-3.</mixed-citation><mixed-citation xml:lang="en">Poenaru D, Roblin M, Bird M, Duce S, Groll A, Pietak D et al. The pediatric bowel management clinic: Initial results of a multidisciplinary approach of functional constipation in children. J Pediatr Surg. 1997;32(6):843–848. https://doi.org/10.1016/S0022-3468(97)90633-3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Кильдиярова РР. Диспансеризация здоровых детей. Вопросы современной педиатрии. 2018;17(3):246–250. https://doi.org/10.15690/vsp.v17i3.1896.</mixed-citation><mixed-citation xml:lang="en">Kil’diyarova RR. Preventive medical examination of healthy children. Current Pediatrics. 2018;17(3):246–250. https://doi.org/10.15690/vsp.v17i3.1896.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Эрдес СИ, Мацукатова БО, Ревякина СА. Запоры у детей (результаты нового российского популяционного исследования). РМЖ. 2011;(3):159–164. Режим доступа: https://www.rmj.ru/articles/pediatriya/Zapory_u_detey_rezulytaty_novogo_rossiyskogo_populyacionnogo_issledovaniya/.</mixed-citation><mixed-citation xml:lang="en">Erdes SI, Matsukatova BO, Revyakina SA. Constipation in children (results of a new Russian population study). RMJ. 2011;(3):159–164. (In Russ.) Available at: https://www.rmj.ru/articles/pediatriya/Zapory_u_detey_rezulytaty_novogo_rossiyskogo_populyacionnogo_issledovaniya/.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Бельмер СВ, Волынец ГВ, Горелов АВ, Гурова ММ, Звягин АА, Корниенко ЕА и др. Функциональные расстройства органов пищеварения у детей. Рекомендации Общества детских гастроэнтерологов, гепатологов и нутрициологов. Часть 3. Российский вестник перинатологии и педиатрии. 2020;65(6):133–144. https://doi.org/10.21508/1027-4065-2020-65-6-133-144.</mixed-citation><mixed-citation xml:lang="en">Belmer SV, Volynets GV, Gorelov AV, Gurova MM, Zvyagin AA, Kornienko EA et al. Functional Disorders of Digestive System in Children. Guidelines of Society of Pediatric Gastroenterology, Hepatology and Nutrition. Part 3. Russian Bulletin of Perinatology and Pediatrics. 2020;65(6):133–144. (In Russ.) https://doi.org/10.21508/1027-4065-2020-65-6-133-144.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Думова НБ, Кручина МК. Функциональный запор у детей разных возрастных групп. РМЖ. 2012;15:792–799. Режим доступа: https://www.rmj.ru/articles/gastroenterologiya/Funkcionalynyy_zapor_u_detey_raznyh_vozrastnyh_grupp/.</mixed-citation><mixed-citation xml:lang="en">Dumova NB, Kruchina MK. Functional constipation in children of different age groups. RMJ. 2012;15:792–799. (In Russ.) Available at: https://www.rmj.ru/articles/gastroenterologiya/Funkcionalynyy_zapor_u_detey_raznyh_vozrastnyh_grupp/.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Yost KJ, Haan MN, Levine RA, Gold EB. Comparing SF-36 scores across three groups of women with different health profiles. Qual Life Res. 2005;14(5):1251–1261. https://doi.org/10.1007/s11136-004-6673-8.</mixed-citation><mixed-citation xml:lang="en">Yost KJ, Haan MN, Levine RA, Gold EB. Comparing SF-36 scores across three groups of women with different health profiles. Qual Life Res. 2005;14(5):1251–1261. https://doi.org/10.1007/s11136-004-6673-8.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Файзуллина РА, Бельмер СВ. Хронические запоры в практике педиатра: что знаем? Что нового? Экспериментальная и клиническая гастроэнтерология. 2019;11(171):16–26. https://doi.org/10.31146/1682-8658-ecg-171-11-16-26.</mixed-citation><mixed-citation xml:lang="en">Fayzullina RA, Belmer SV. Chronic constipation in pediatric practice: what do we know? Anything new? Experimental and Clinical Gastroenterology. 2019;171(11):16–26 (In Russ.) https://doi.org/10.31146/1682-8658ecg-171-11-16-26.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko S. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016;150(6):1443–1455.e2. https://doi.org/10.1053/j.gastro.2016.02.016.</mixed-citation><mixed-citation xml:lang="en">Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko S. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016;150(6):1443–1455.e2. https://doi.org/10.1053/j.gastro.2016.02.016.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Сафина АИ. Запоры у детей в практике врача-педиатра. Медицинский совет. 2022;16(12):50–57. https://doi.org/10.21518/2079-701X-2022-16-12-50-57.</mixed-citation><mixed-citation xml:lang="en">Safina AI. Constipation in children in the practice of a pediatrician. Meditsinskiy Sovet. 2022;16(12):50–57. https://doi.org/10.21518/2079-701X-2022-16-12-50-57.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова ИН, Пупыкина ВВ. Воспитание туалетных навыков у детей раннего возраста: информация для врачей и родителей. Педиатрия. Consilium Medicum. 2024;(3):237–243. https://doi.org/10.26442/26586630.2024.3.202943.</mixed-citation><mixed-citation xml:lang="en">Zakharova IN, Pupykina VV. Features of developing toilet skills in young children: Information for clinicians and parents. A review. Pediatrics. Consilium Medicum. 2024;(3):237–243. (In Russ.) https://doi.org/10.26442/26586630.2024.3.202943.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cağan Appak Y, Yalın Sapmaz Ş, Doğan G, Herdem A, Ozyurt BC, Kasırga E. Clinical findings, child and mother psychosocial status in functional constipation. Turk J Gastroenterol. 2017;28(6):465–470. https://doi.org/10.5152/tjg.2017.17216.</mixed-citation><mixed-citation xml:lang="en">Cağan Appak Y, Yalın Sapmaz Ş, Doğan G, Herdem A, Ozyurt BC, Kasırga E. Clinical findings, child and mother psychosocial status in functional constipation. Turk J Gastroenterol. 2017;28(6):465–470. https://doi.org/10.5152/tjg.2017.17216.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Udoh EE, Rajindrajith S, Devanarayana NM, Benninga MA. Prevalence and risk factors for functional constipation in adolescent Nigerians. Arch Dis Child. 2017;102(9):841–844. https://doi.org/10.1136/archdischild-2016-311908.</mixed-citation><mixed-citation xml:lang="en">Udoh EE, Rajindrajith S, Devanarayana NM, Benninga MA. Prevalence and risk factors for functional constipation in adolescent Nigerians. Arch Dis Child. 2017;102(9):841–844. https://doi.org/10.1136/archdischild-2016-311908.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Inan M, Aydiner CY, Tokuc B, Aksu B, Ayvaz S, Ayhan S et al. Factors associated with childhood constipation. J Paediatr Child Health. 2007;43(10):700–706. https://doi.org/10.1111/j.1440-1754.2007.01165.x.</mixed-citation><mixed-citation xml:lang="en">Inan M, Aydiner CY, Tokuc B, Aksu B, Ayvaz S, Ayhan S et al. Factors associated with childhood constipation. J Paediatr Child Health. 2007;43(10):700–706. https://doi.org/10.1111/j.1440-1754.2007.01165.x.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Laffolie J, Ibrahimi G, Zimmer KP. Poor Perception of School Toilets and Increase of Functional Constipation. Klin Padiatr. 2021;233(1):5–9. https://doi.org/10.1055/a-1263-0747.</mixed-citation><mixed-citation xml:lang="en">Laffolie J, Ibrahimi G, Zimmer KP. Poor Perception of School Toilets and Increase of Functional Constipation. Klin Padiatr. 2021;233(1):5–9. https://doi.org/10.1055/a-1263-0747.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Poddar U. Approach to Constipation in Children. Indian Pediatr. 2016;53(4):319–327. https://doi.org/10.1007/s13312-016-0845-9.</mixed-citation><mixed-citation xml:lang="en">Poddar U. Approach to Constipation in Children. Indian Pediatr. 2016;53(4):319–327. https://doi.org/10.1007/s13312-016-0845-9.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Нижевич АА, Валеева ДС, Логиновская ВВ. Запор и мультиморбидная патология: взгляд педиатра. РМЖ. Мать и дитя. 2024;7(1):71–78. https://doi.org/10.32364/2618-8430-2024-7-1-11.</mixed-citation><mixed-citation xml:lang="en">Nizhevich AA, Valeeva DS, Loginovskaya VV. Constipation and multimorbidity: a pediatrician’s view. Russian Journal of Women’s and Children’s Health. 2024;7(1):71–78. (In Russ.) https://doi.org/10.32364/2618-8430-2024-7-1-11.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Москалец ОВ, Щербина ВИ. Особенности иммунного ответа при хронических запорах у детей. Кубанский научный медицинский вестник. 2016;(2):119–121. Режим доступа: https://ksma.elpub.ru/jour/article/view/498.</mixed-citation><mixed-citation xml:lang="en">Moskalets OV, Shcherbina VI. Immune response features in children with chronic constipation. Kuban Scientific Medical Bulletin. 2016;(2):119–121. (In Russ.) Available at: https://ksma.elpub.ru/jour/article/view/498.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Pinto-Sanchez MI, Bercik P, Verdu EF. Motility alterations in celiac disease and non-celiac gluten sensitivity. Dig Dis. 2015;33(2):200–207. https://doi.org/10.1159/000371400.</mixed-citation><mixed-citation xml:lang="en">Pinto-Sanchez MI, Bercik P, Verdu EF. Motility alterations in celiac disease and non-celiac gluten sensitivity. Dig Dis. 2015;33(2):200–207. https://doi.org/10.1159/000371400.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Husby S, Koletzko S, Korponay-Szabо, Kurppa K, Mearin ML, Ribes-Koninckx CR et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020;70(1):141–156. https://doi.org/10.1097/MPG.0000000000002497.</mixed-citation><mixed-citation xml:lang="en">Husby S, Koletzko S, Korponay-Szabо, Kurppa K, Mearin ML, Ribes-Koninckx CR et al. European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020. J Pediatr Gastroenterol Nutr. 2020;70(1):141–156. https://doi.org/10.1097/MPG.0000000000002497.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Huang YC, Wu MC, Wang YH, Wei JC. The influence of constipation on asthma: A real-world, population-based cohort study. Int J Clin Pract. 2021;75(10):e14540. https://doi.org/10.1111/ijcp.14540.</mixed-citation><mixed-citation xml:lang="en">Huang YC, Wu MC, Wang YH, Wei JC. The influence of constipation on asthma: A real-world, population-based cohort study. Int J Clin Pract. 2021;75(10):e14540. https://doi.org/10.1111/ijcp.14540.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Huang YC, Wu MC, Wang YH, Wei JC. Influence of constipation on atopic dermatitis: A nationwide population-based cohort study in Taiwan. Int J Clin Pract. 2021;75(3):e13691. https://doi.org/10.1111/ijcp.13691.</mixed-citation><mixed-citation xml:lang="en">Huang YC, Wu MC, Wang YH, Wei JC. Influence of constipation on atopic dermatitis: A nationwide population-based cohort study in Taiwan. Int J Clin Pract. 2021;75(3):e13691. https://doi.org/10.1111/ijcp.13691.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Gao M, Wang J, Liu P, Tu H, Zhang R, Sun N, Zhang K. Gut microbiota composition in depressive disorder: a systematic review, meta-analysis, and meta-regression. Transl Psychiatry. 2023;13(1):379. https://doi.org/10.1038/s41398023-02670-5.</mixed-citation><mixed-citation xml:lang="en">Gao M, Wang J, Liu P, Tu H, Zhang R, Sun N, Zhang K. Gut microbiota composition in depressive disorder: a systematic review, meta-analysis, and meta-regression. Transl Psychiatry. 2023;13(1):379. https://doi.org/10.1038/s41398023-02670-5.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Slyepchenko A, Maes M, Jacka FN, Kohler CA, Barichello T, McIntyre RS et al. Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and NonCommunicable Medical Comorbidities. Psychother Psychosom. 2017;86(1):31–46. https://doi.org/10.1159/000448957.</mixed-citation><mixed-citation xml:lang="en">Slyepchenko A, Maes M, Jacka FN, Kohler CA, Barichello T, McIntyre RS et al. Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and NonCommunicable Medical Comorbidities. Psychother Psychosom. 2017;86(1):31–46. https://doi.org/10.1159/000448957.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Сагитова ГР, Эрман МВ, Сердюков АГ. Болезни мочевой системы у детей. Организация диагностики и реабилитации. Астрахань: Изд-во Астраханской государственной медицинской академии; 2006. 145 с. Режим доступа: https://rusneb.ru/catalog/000199_000009_003023929/.</mixed-citation><mixed-citation xml:lang="en">Сагитова ГР, Эрман МВ, Сердюков АГ. Болезни мочевой системы у детей. Организация диагностики и реабилитации. Астрахань: Изд-во Астраханской государственной медицинской академии; 2006. 145 с. Режим доступа: https://rusneb.ru/catalog/000199_000009_003023929/.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Talley NJ, Lasch KL, Baum CL. A gap in our understanding: chronic constipation and its comorbid conditions. Clin Gastroenterol Hepatol. 2009;7(1):9–19. https://doi.org/10.1016/j.cgh.2008.07.005.</mixed-citation><mixed-citation xml:lang="en">Talley NJ, Lasch KL, Baum CL. A gap in our understanding: chronic constipation and its comorbid conditions. Clin Gastroenterol Hepatol. 2009;7(1):9–19. https://doi.org/10.1016/j.cgh.2008.07.005.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Dehghani SM, Basiratnia M, Matin M, Hamidpour L, Haghighat M, Imanieh MH. Urinary tract infection and enuresis in children with chronic functional constipation. Iran J Kidney Dis. 2013;7(5):363–366. Available at: https://pubmed.ncbi.nlm.nih.gov/24072148/.</mixed-citation><mixed-citation xml:lang="en">Dehghani SM, Basiratnia M, Matin M, Hamidpour L, Haghighat M, Imanieh MH. Urinary tract infection and enuresis in children with chronic functional constipation. Iran J Kidney Dis. 2013;7(5):363–366. Available at: https://pubmed.ncbi.nlm.nih.gov/24072148/.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Stepanova N. How Advanced Is Our Understanding of the Role of Intestinal Barrier Dysfunction in the Pathogenesis of Recurrent Urinary Tract Infections. Front Pharmacol. 2022;13:780122. https://doi.org/10.3389/fphar.2022.780122.</mixed-citation><mixed-citation xml:lang="en">Stepanova N. How Advanced Is Our Understanding of the Role of Intestinal Barrier Dysfunction in the Pathogenesis of Recurrent Urinary Tract Infections. Front Pharmacol. 2022;13:780122. https://doi.org/10.3389/fphar.2022.780122.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Tabbers MM, DiLorenzo C, Berger MY, Faure C, Langendam MW, Nurko S et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58(2):258–274. https://doi.org/10.1097/MPG.0000000000000266.</mixed-citation><mixed-citation xml:lang="en">Tabbers MM, DiLorenzo C, Berger MY, Faure C, Langendam MW, Nurko S et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014;58(2):258–274. https://doi.org/10.1097/MPG.0000000000000266.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Захарова ИН, Сугян НГ, Москвич ИК. Российские и международные рекомендации по ведению детей с запорами. Вопросы современной педиатрии. 2014;13(1):74–83. https://doi.org/10.15690/vsp.v13i1.914.</mixed-citation><mixed-citation xml:lang="en">Zakharova IN, Sugyan NG, Moskvich IK. Russian and international recommendations on management of constipations in children. Current Pediatrics. 2014;13(1):74–83. (In Russ.) https://doi.org/10.15690/vsp.v13i1.914.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Bekkali NL, van den Berg MM, Dijkgraaf MG, van Wijk MP, Bongers ME, Liem O, Benninga MA. Rectal fecal impaction treatment in childhood constipation: enemas versus high doses oral PEG. Pediatrics. 2009;124(6):e1108–1115. https://doi.org/10.1542/peds.2009-0022.</mixed-citation><mixed-citation xml:lang="en">Bekkali NL, van den Berg MM, Dijkgraaf MG, van Wijk MP, Bongers ME, Liem O, Benninga MA. Rectal fecal impaction treatment in childhood constipation: enemas versus high doses oral PEG. Pediatrics. 2009;124(6):e1108–1115. https://doi.org/10.1542/peds.2009-0022.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Tolia V, Lin CH, Elitsur Y. A prospective randomized study with mineral oil and oral lavage solution for treatment of faecal impaction in children. Aliment Pharmacol Ther. 1993;7(5):523–529. https://doi.org/10.1111/j.1365-2036.1993.tb00128.x.</mixed-citation><mixed-citation xml:lang="en">Tolia V, Lin CH, Elitsur Y. A prospective randomized study with mineral oil and oral lavage solution for treatment of faecal impaction in children. Aliment Pharmacol Ther. 1993;7(5):523–529. https://doi.org/10.1111/j.1365-2036.1993.tb00128.x.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ho JMD, How CH. Chronic constipation in infants and children. Singapore Med J. 2020;61(2):63–68. https://doi.org/10.11622/smedj.2020014.</mixed-citation><mixed-citation xml:lang="en">Ho JMD, How CH. Chronic constipation in infants and children. Singapore Med J. 2020;61(2):63–68. https://doi.org/10.11622/smedj.2020014.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Панова ЛД. Функциональные запоры у детей дошкольного и школьного возраста: пути решения проблемы. Медицинский совет. 2023;17(12):83–97. https://doi.org/10.21518/ms2023-169.</mixed-citation><mixed-citation xml:lang="en">Panova LD. Functional constipation in preschool and school age children: ways to solve the problem. Meditsinskiy Sovet. 2023;17(12):83–97. (In Russ.) https://doi.org/10.21518/ms2023-169.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Маланичева ТГ, Зиатдинова НВ, Ашрафуллина ЧИ. Эффективные методы терапии функциональных запоров у детей. Медицинский совет. 2022;16(19):105–109. https://doi.org/10.21518/2079-701X-2022-16-19-105-109.</mixed-citation><mixed-citation xml:lang="en">Malanicheva TG, Ziatdinova NV, Ashrafullina CI. Efficient methods of therapy of pediatric functional constipation. Meditsinskiy Sovet. 2022;16(19):105–109. (In Russ.) https://doi.org/10.21518/2079-701X-2022-16-19-105-109.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kienzle-Horn S, Vix JM, Schuijt C, Peil H, Jordan CC, Kamm MA. Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation. Curr Med Res Opin. 2007;23(4):691–699. https://doi.org/10.1185/030079907x178865.</mixed-citation><mixed-citation xml:lang="en">Kienzle-Horn S, Vix JM, Schuijt C, Peil H, Jordan CC, Kamm MA. Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation. Curr Med Res Opin. 2007;23(4):691–699. https://doi.org/10.1185/030079907x178865.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Mueller-Lissner S, Kamm MA, Wald A, Hinkel U, Koehler U, Richter E, Bubeck J. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol. 2010;105(4):897–903. https//doi.org/10.1038/ajg.2010.41.</mixed-citation><mixed-citation xml:lang="en">Mueller-Lissner S, Kamm MA, Wald A, Hinkel U, Koehler U, Richter E, Bubeck J. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. Am J Gastroenterol. 2010;105(4):897–903. https//doi.org/10.1038/ajg.2010.41.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
