medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-132medsovet-9019Research ArticleРЕПРОДУКТИВНОЕ ЗДОРОВЬЕ И ВРТREPRODUCTIVE HEALTH AND ARTИммунологические аспекты артериальной гипертензии во время гестацииImmunological aspects of arterial hypertension during gestationhttps://orcid.org/0000-0002-7561-0706ШамаиловаД. И.ShamailovaD. I.

Шамаилова Диана Ифраимовна, к.м.н., ассистент кафедры акушерства, гинекологии и репродуктивной медицины

127006, Москва, ул. Долгоруковская, д. 4

Diana I. Shamailova, Cand. Sci. (Med.), Assistant Professor, Department of Obstetrics, Gynecology and Reproductive Medicine

4, Dolgorukovskaya St., Moscow, 127006

diana_28_03_94@mail.ruhttps://orcid.org/0009-0009-4199-1844КудрявцеваД. А.KudryavtsevaD. A.

Кудрявцева Диана Андреевна, студент, Российский университет медицины (РосУниМед)

127006, Москва, ул. Долгоруковская, д. 4

Diana A. Kudryavtseva, Student

4, Dolgorukovskaya St., Moscow, 127006

invulnerableshadow@mail.ruhttps://orcid.org/0009-0005-9596-9782НарскийА. А.NarskiyA. A.

Нарский Артем Александрович, студент

119435, Москва, ул. Большая Пироговская, д. 2, стр. 4

Artеm A. Narskiy, Student

2, Bldg. 4, Bolshaya Pirogovskaya St., Moscow, 119435

artem_narskiy@mail.ruhttps://orcid.org/0009-0005-6154-4460АббасоваЗ. Ч.AbbasovaZ. Ch.

Аббасова Зарифа Чингиз кызы, студент

119435, Москва, ул. Большая Пироговская, д. 2, стр. 4

Zarifa Ch. Abbasova, Student

2, Bldg. 4, Bolshaya Pirogovskaya St., Moscow, 119435

zarifa.abbasova2001@inbox.ruhttps://orcid.org/0009-0002-1562-2227МироноваВ. В.MironovaV. V.

Миронова Виктория Витальевна, студент

119435, Москва, ул. Большая Пироговская, д. 2, стр. 4

Victoria V. Mironova, Student

2, Bldg. 4, Bolshaya Pirogovskaya St., Moscow, 119435

vikager32@mail.ruhttps://orcid.org/0009-0006-2206-5253ЮсуппаеваП. П.YusuppaevaP. P.

Юсуппаева Патимат Пайзутдиновна, студент

119435, Москва, ул. Большая Пироговская, д. 2, стр. 4

Patimat P. Yusuppaeva, Student

2, Bldg. 4, Bolshaya Pirogovskaya St., Moscow, 119435

pyusuppaeva@mail.ruhttps://orcid.org/0009-0003-4446-7163ГасановаР. М.GasanovaR. M.

Гасанова Райганат Магомедшафиевна, студент

367000, Республика Дагестан, Махачкала, площадь Ленина, д. 1

Rayganat М. Gasanova, Student

1, Lenin Square, Makhachkala, Republic of Dagestan, 367000

gasanova1@mail.ruhttps://orcid.org/0009-0001-4630-5657АлхазоваИ. О.AlkhazovaI. O.

Алхазова Изумруд Омаровна, студент

367000, Республика Дагестан, Махачкала, площадь Ленина, д. 1

Izumrud О. Alkhazova, Student

1, Lenin Square, Makhachkala, Republic of Dagestan, 367000

michjack7@mail.ruhttps://orcid.org/0009-0005-2255-9838МусаеваМ. А.MusaevaM. A.

Мусаева Марьян Ахмедхановна, студент

367000, Республика Дагестан, Махачкала, площадь Ленина, д. 1

Maryan A. Musaeva, Student

1, Lenin Square, Makhachkala, Republic of Dagestan, 367000

musaeva@gmail.comРоссийский университет медицины (РосУниМед)РоссияRussian University of Medicine (ROSUNIMEDRussian FederationПервый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)РоссияSechenov First Moscow State Medical University (Sechenov University)Russian FederationДагестанский государственный медицинский университетРоссияDagestan State Medical UniversityRussian Federation202526042025041420Copyright © Шамаилова Д.И., Кудрявцева Д.А., Нарский А.А., Аббасова З.Ч., Миронова В.В., Юсуппаева П.П., Гасанова Р.М., Алхазова И.О., Мусаева М.А., 20252025Шамаилова Д.И., Кудрявцева Д.А., Нарский А.А., Аббасова З.Ч., Миронова В.В., Юсуппаева П.П., Гасанова Р.М., Алхазова И.О., Мусаева М.А.Shamailova D.I., Kudryavtseva D.A., Narskiy A.A., Abbasova Z.C., Mironova V.V., Yusuppaeva P.P., Gasanova R.M., Alkhazova I.O., Musaeva M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9019Введение

Введение. Во всем мире более четверти населения страдают гипертонической болезнью, что составляет в общей сложности более 1 млрд человек. Иммунные механизмы в настоящее время признаны неотъемлемой частью многофакторной этиологии гипертонии и связанных с ней повреждений органов.

Цель

Цель. Изучить аутоиммунные антитела у беременных женщин с хронической артериальной гипертензией для прогнозирования и профилактики плацента-ассоциированных осложнений беременности, что, в свою очередь, позволит снизить частоту неблагоприятных перинатальных исходов.

Материалы и методы

Материалы и методы. В исследование включено 115 пациенток, 85 беременных женщин с хронической артериальной гипертензией (основная группа), 30 пациенток (группа контроля) с физиологическим течением беременности. Всем пациенткам групп исследования проводилось определение аутоиммунных антител с помощью методов ЭЛИ-П-комплекс.

Результаты

Результаты. Статистическое отклонение профиля аутоиммунных антител наблюдалось у женщин с артериальной гипертензией, а именно отклонение профиля к β2-гликопротеину, аутоантител к коллагену, аутоантител к белку S100, аутоантител к цитоплазматическому антигену клеток эндотелия сосудов (ANCA), аутоантител к белку мембраны тромбоцитов (TrM), аутоантител к мембранному антигену клеток клубочков почек (KiMS).

Выводы

Выводы. Результаты исследования демонстрируют изменение профиля аутоантител, участвующих в развитии плацента-ассоциированных осложнений беременности у пациенток с хронической артериальной гипертензией. Определение аутоиммунных антител позволит снизить частоту неблагоприятных перинатальных исходов.

Introduction

Introduction. Immune mechanisms are currently recognized as an integral part of the multifactorial etiology of hypertension and related organ damage.

Aim

Aim. To study autoimmune antibodies in pregnant women with chronic arterial hypertension for the prediction and prevention placenta-associated pregnancy complications, which in turn will reduce the incidence of adverse perinatal pregnancy outcomes.

Materials and methods

Materials and methods. The study included 115 patients, 85 patients (the main group) with hypertension, 30 patients (the control group) with the physiological course of pregnancy, without hypertension. All patients in the study groups underwent the determination of autoimmune antibodies using ELIPP complex methods.

Results

Results. A statistical deviation of the spectrum of autoimmune antibodies was observed in women with arterial hypertension, namely, a deviation of the spectrum to β2 – glycoprotein, autoantibodies to collagen, autoantibodies to protein S100, autoantibodies to cytoplasmic antigen of vascular endothelial cells (ANCA), autoantibodies to platelet membrane protein (TrM), autoantibodies to membrane antigen of glomerular kidney cells (KiMS).

Conclusions

Conclusions. The results of the study demonstrate the role of autoantibodies in the development of placenta-associated pregnancy complications in patients with chronic arterial hypertension. The determination of autoimmune antibodies will reduce the frequency of adverse perinatal outcomes.

 

 

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The authors declare that there are no conflicts of interest present.