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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-146</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕПРОДУКТИВНОЕ ЗДОРОВЬЕ И ВРТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REPRODUCTIVE HEALTH AND ART</subject></subj-group></article-categories><title-group><article-title>Базисная терапия при хронических неинфекционных дерматозах аногенитальной области</article-title><trans-title-group xml:lang="en"><trans-title>Basic therapy for chronic non-infectious dermatoses of the anogenital region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8584-615X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>И. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>I. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смирнова Ирина Олеговна, д.м.н., профессор, заведующая кафедрой дерматовенерологии и косметологии, Санкт-Петербургский государственный университет; врач-дерматовенеролог, Городской кожно-венерологический диспансер</p><p>199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а,</p><p>192102, Санкт-Петербург, набережная реки Волковки, д. 3</p></bio><bio xml:lang="en"><p>Irina O. Smirnova, Dr. Sci. (Med.), Professor, Head of Department of Dermatovenerology and Cosmetology, St Petersburg State University; Dermatovenerologist, City Dermatovenerological Dispensary</p><p>8a, 21th Liniya Vasilevskogo Ostrova St., St Petersburg, 199106,</p><p>3, Emb. of the Volkovka River, St Petersburg, 192102</p></bio><email xlink:type="simple">driosmirnova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1045-9689</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смирнова Ольга Николаевна, к.м.н., доцент кафедры дерматовенерологии</p><p>195067, Санкт-Петербург, Пискаревский проспект, д. 47</p></bio><bio xml:lang="en"><p>Olga N. Smirnova, Cand. Sci. (Med.), Associate Professor of Department of Dermatovenerology</p><p>47, Piskarevskiy Ave., St Petersburg, 195067</p></bio><email xlink:type="simple">dronsmirnova@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-1170-0069</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федорова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Федорова Ирина Андреевна, клинический врач-ординатор кафедры дерматовенерологии и косметологии</p><p>199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а</p></bio><bio xml:lang="en"><p>Irina A. Fedorova, Clinical Resident Physician, Department of Dermatovenerology and Cosmetology</p><p>8a, 21th Liniya Vasilevskogo Ostrova St., St Petersburg, 199106</p></bio><email xlink:type="simple">vaniakina.irina@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4699-1746</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пташникова</surname><given-names>П. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Ptashnikova</surname><given-names>P. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пташникова Полина Дмитриевна, старший лаборант кафедры дерматовенерологии и косметологии</p><p>199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а</p></bio><bio xml:lang="en"><p>Polina D. Ptashnikova, Senior Lab Analyst, Department of Dermatovenerology and Cosmetology</p><p>8a, 21th Liniya Vasilevskogo Ostrova St., St Petersburg, 199106</p></bio><email xlink:type="simple">enternita7@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Санкт-Петербургский государственный университет; &#13;
Городской кожно-венерологический диспансер<country>Россия</country></aff><aff xml:lang="en">St Petersburg State University;&#13;
City Dermatovenerological Dispensary<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Северо-Западный государственный медицинский университет имени И.И. Мечникова<country>Россия</country></aff><aff xml:lang="en">North-Western State Medical University named after I.I. Mechnikov<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Санкт-Петербургский государственный университет<country>Россия</country></aff><aff xml:lang="en">St Petersburg State University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>26</day><month>04</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>53</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смирнова И.О., Смирнова О.Н., Федорова И.А., Пташникова П.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Смирнова И.О., Смирнова О.Н., Федорова И.А., Пташникова П.Д.</copyright-holder><copyright-holder xml:lang="en">Smirnova I.O., Smirnova O.N., Fedorova I.A., Ptashnikova P.D.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9024">https://www.med-sovet.pro/jour/article/view/9024</self-uri><abstract><p>Хронические неинфекционные дерматозы аногенитальной области (АГО) представляют собой гетерогенную по этиопатогенезу, клиническим проявлениям, характеру течения и прогнозу группу заболеваний. Лечение дерматологических заболеваний АГО нередко представляет сложную задачу и требует междисциплинарного подхода. Традиционно используют комплексную терапию с применением средств, направленных на восстановление кожного барьера, топических противовоспалительных препаратов, в частности глюкокортикостероидов (ГКС) и/или топических ингибиторов кальциневрина, реже – системных глюкокортикоидов, ретиноидов, гидроксихлорохина или дапсона, а также средств, направленных на ослабление субъективной симптоматики, профилактику и лечение вторичной инфекции. Целью публикации было обсуждение базисной терапии хронических неинфекционных дерматозов АГО. Под термином «базисная терапия» понимают комплекс мероприятий, которые пациент с дерматозом получает длительно или постоянно, даже в период ремиссии заболевания. Подходы к базисной терапии при дерматозах АГО разработаны мало и нуждаются в уточнении. Тем не менее регламентация спектра и количества средств, которые больной использует на область гениталий и перианальную зону, исключение ирритантов, нормализация ежедневной гигиены, использование средств, восстанавливающих кожный барьер, являются ключевым компонентом комплексной терапии заболеваний кожи этой локализации. Одним из ключевых аспектов успешного лечения АГО является восстановление кожного барьера, который может быть нарушен как в результате заболеваний, так и из-за воздействия внешних факторов. В статье подробно описаны эффекты препаратов на основе 5%-ного декспантенола, который рассматривается как увлажняющее и заживляющее средство. Декспантенол демонстрирует высокую противовоспалительную активность, сопоставимую с ГКС. Его использование в терапии не только улучшает состояние кожи, но и позволяет повысить эффективность ГКС, что является особенно важным для пациентов, нуждающихся в длительном контроле дерматозов.</p></abstract><trans-abstract xml:lang="en"><p>Chronic non-infectious dermatoses of the anogenital area comprise a heterogeneous group of diseases characterized by varied etiopathogenesis, clinical manifestations, disease course, and prognosis. Treatment of dermatological conditions in the anogenital area often presents a complex challenge and necessitates an interdisciplinary approach. Traditionally, comprehensive therapy is employed, including agents aimed at restoring the cutaneous barrier, topical anti-inflammatory medications, particularly glucocorticosteroids and/or topical calcineurin inhibitors, and less frequently, systemic glucocorticosteroids, retinoids, hydroxychloroquine, or dapsone, as well as interventions targeting the alleviation of subjective symptoms and the prevention and treatment of secondary infections. The purpose of this publication is to discuss the fundamental aspects of baseline therapy for chronic non-infectious dermatoses of anogenital area. Baseline therapy is defined as a set of interventions that a patient with a dermatosis receives over a prolonged or continuous period, even during disease remission. Approaches to baseline therapy for dermatoses of anogenital area are poorly developed and require further clarification. Nevertheless, the regulation of the spectrum and quantity of agents used by the patient on the genital and perianal areas, the elimination of irritants, normalization of daily hygiene practices, and the use of agents that restore the cutaneous barrier are crucial components of comprehensive therapy for skin diseases in this anatomical location. One of the key aspects of successful treatment of dermatoses of anogenital area is the restoration of the cutaneous barrier, which can be disrupted by both the underlying disease processes and exposure to external factors. This article details the effects of preparations based on 5% dexpanthenol, which is regarded as a moisturizing and wound-healing agent. Dexpanthenol demonstrates significant anti-inflammatory activity, comparable to that of corticosteroids. Its use in therapy not only improves skin condition but also enhances the efficacy of cjrticosteroids, which is particularly important for patients requiring long-term management of dermatoses.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронические дерматозы</kwd><kwd>аногенитальная область</kwd><kwd>базисная терапия</kwd><kwd>кожный барьер</kwd><kwd>декспантенол</kwd><kwd>глюкокортикостероиды</kwd><kwd>лечение</kwd><kwd>зуд</kwd><kwd>противовоспалительное действие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic dermatoses</kwd><kwd>anogenital region</kwd><kwd>baseline therapy</kwd><kwd>skin barrier</kwd><kwd>dexpanthenol</kwd><kwd>glucocorticosteroids</kwd><kwd>treatment</kwd><kwd>pruritus</kwd><kwd>clinical manifestations</kwd><kwd>anti-inflammatory effect</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lewin MR, Hick RW, Selim MA. 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