medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-176medsovet-9048Research ArticleНЕВРОЛОГИЯ, ПСИХИАТРИЯNEUROLOGY AND PSYCHIATRYМетод глобальных триггеров в психиатрии: национальная панель триггеровThe Global Trigger Tool in Psychiatry: A National Trigger Panelhttps://orcid.org/0009-0008-5475-2757ГоловинаД. А.GolovinaD. A.

Головина Дарья Артемовна, студент, факультет фундаментальной медицины

119192, Москва, Ломоносовский проспект, д. 27, корп. 1

Daria A. Golovina, Student, Faculty of Medicine

27/1, Lomonosovsky Ave., Moscow, 119192

golov.in@inbox.ruhttps://orcid.org/0009-0005-1767-0101МозольЭ. А.MozolE. A.

Мозоль Эдвард Александрович, врач-психиатр

107076, Москва, ул. Потешная, д. 3

Edward A. Mozol, Psychiatrist

3, Poteshnaya St., Moscow, 107076

mozol.edward@gmail.comhttps://orcid.org/0000-0003-4263-6640КироваА. Г.KirovaA. G.

Кирова Анастасия Григорьевна,  лаборант кафедры психиатрии

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1

Anastasia G. Kirova, Laboratory Assistant of the Department of Psychiatry

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

nast.kirova@yandex.ruhttps://orcid.org/0009-0008-1618-4832СоловкинаЭ. Н.SolovkinaE. N.

Соловкина Элеонора Николаевна, клинический ординатор кафедры психиатрии

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1

Eleonora N. Solovkina, Resident of the Department of Psychiatry

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

eleonorasolovkina@gmail.comhttps://orcid.org/0000-0002-2314-7174СосинД. Н.SosinD. N.

Сосин Дмитрий Николаевич, к.м.н., доцент кафедры психиатрии, Российская медицинская академия непрерывного профессионального образования; врач-психиатр, Психиатрическая клиническая больница №4

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1,

107076, Москва, ул. Потешная, д. 3

 

Dmitriy N. Sosin, Cand. Sci. (Med.), Associate Professor of the Department of Psychiatry, Russian Medical Academy of Continuous Professional Education; Psychiatrist, Psychiatric Clinical Hospital No. 4

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993,

3, Poteshnaya St., Moscow, 107076

 

sosin.dmitriy@gmail.comhttps://orcid.org/0000-0002-5749-3964МосоловС. Н.MosolovS. N.

Мосолов Сергей Николаевич, д.м.н., профессор, заслуженный деятель науки РФ, заведующий кафедрой психиатрии, Российская медицинская академия непрерывного профессионального образования; заведующий отделом терапии психических заболеваний, Московский научно-исследовательский институт психиатрии – филиал Национального медицинского исследовательского центра психиатрии и наркологии имени В.П. Сербского

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1,

107076, Москва, ул. Потешная, д. 3

Sergey N. Mosolov, Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Head of the Department of Psychiatry, Russian Medical Academy of Continuous Professional Education; Head of the Therapy Department for Mental Disorders, Moscow Research Institute of Psychiatry – branch of the Serbsky National Medical Research Centre for Psychiatry and Narcology

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993,

3, Poteshnaya St., Moscow, 107076

profmosolov@mail.ruhttps://orcid.org/0000-0002-4496-3680СычевД. А.SychevD. A.

Сычев Дмитрий Алексеевич, академик РАН, профессор РАН, д.м.н., профессор, заведующий кафедрой клинической фармакологии и терапии имени Б.Е. Вотчала, ректор

125993, Москва, ул. Баррикадная, д. 2/1, стр. 1

Dmitriy A. Sychev, Academic RAS, Professor RAS, Dr. Sci. (Med.), Professor, Head of the Department of Clinical Pharmacology and Therapy named after B.E. Votchal, Rector

2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993

dmitry.alex.sychev@gmail.comМосковский государственный университет имени М.В. ЛомоносоваРоссияLomonosov Moscow State UniversityRussian FederationПсихиатрическая клиническая больница №4РоссияPsychiatric Clinical Hospital No. 4Russian FederationРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuous Professional EducationRussian FederationПсихиатрическая клиническая больница №4; Российская медицинская академия непрерывного профессионального образованияРоссияPsychiatric Clinical Hospital No. 4; Russian Medical Academy of Continuous Professional EducationRussian FederationРоссийская медицинская академия непрерывного профессионального образования; Московский научно-исследовательский институт психиатрии – филиал Национального медицинского исследовательского центра психиатрии и наркологии имени В.П. СербскогоРоссияRussian Medical Academy of Continuous Professional Education; Moscow Research Institute of Psychiatry – branch of the Serbsky National Medical Research Centre for Psychiatry and NarcologyRussian Federation202504052025054859Copyright © Головина Д.А., Мозоль Э.А., Кирова А.Г., Соловкина Э.Н., Сосин Д.Н., Мосолов С.Н., Сычев Д.А., 20252025Головина Д.А., Мозоль Э.А., Кирова А.Г., Соловкина Э.Н., Сосин Д.Н., Мосолов С.Н., Сычев Д.А.Golovina D.A., Mozol E.A., Kirova A.G., Solovkina E.N., Sosin D.N., Mosolov S.N., Sychev D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9048

Современные исследования все чаще обращаются к вопросам безопасности психофармакотерапии, в т. ч. в связи с необходимостью длительного применения лекарственных средств при лечении психических расстройств. В этом контексте метод глобальных триггеров (МГТ) является эффективным инструментом мониторинга нежелательных событий, однако его применение в психиатрии требует адаптации с учетом специфики данной медицинской области и особенностей организации психиатрической помощи в России. Настоящий систематический обзор включает в себя анализ 7 ключевых исследований, проведенных в Швеции, Норвегии, Сингапуре, США и России, найденных в базах PubMed, Google Scholar и Elibrary (до марта 2025 г.). Во включенных статьях описывается как применение оригинальной методики в области психиатрии, так и попытки ее модификации под данную сферу медицины. Особого внимания заслуживают работы, в которых предпринимались попытки адаптации МГТ под особенности как правового, так и культурного характера национальных систем здравоохранения. Все включенные исследования продемонстрировали ценность методики для контроля безопасности фармакотерапии в психиатрической практике. В связи с полученными результатами и с учетом международного опыта, беря во внимание особенности российской психиатрической практики, в ходе диалоговой конференции авторы разработали специализированную панель триггеров. Она позволяет создать единую систему мониторинга безопасности психофармакотерапии, что особенно актуально для российских медицинских учреждений. Внедрение данной методики способно не только стандартизировать процесс мониторинга безопасности, но и существенно повысить уровень безопасности фармакотерапии при лечении психических расстройств в Российской Федерации.

Recent research increasingly addresses the safety issues of psychopharmacotherapy, particularly in connection with the need for long-term medication use in the treatment of mental disorders. In this context, the Global Trigger Tool (GTT) method serves as an effective instrument for monitoring adverse events, however, its application in psychiatry requires adaptation considering the specifics of this medical field and the organizational features of psychiatric care in Russia. This systematic review includes an analysis of 7 key studies conducted in Sweden, Norway, Singapore, the USA, and Russia, identified in PubMed, Google Scholar, and Elibrary databases (up to March 2025). The included articles describe both the application of the original methodology in psychiatry and attempts to modify it for this medical domain. Of particular interest are studies that attempted to adapt the GTT to the legal and cultural characteristics of national healthcare systems. All included studies demonstrated the value of this methodology for monitoring the safety of pharmacotherapy in psychiatric practice. Based on the obtained results and considering international experience, while taking into account the specifics of Russian psychiatric practice, the authors developed a specialized trigger panel during a dialogue conference. This panel enables the creation of a unified system for monitoring psychopharmacotherapy safety, which is especially relevant for Russian medical institutions. The implementation of this methodology can not only standardize the safety monitoring process but also significantly enhance the safety level of pharmacotherapy in the treatment of mental disorders in the Russian Federation.

метод глобальных триггеровантипсихотикинеблагоприятные лекарственные реакциибезопасность психофармакотерапиипсихиатрияGlobal Trigger Toolantipsychoticsadverse drugs effectssafety of psychopharmacotherapypsychiatryДанная работа выполнена при финансовой поддержке Министерства здравоохранения Российской Федерации, тематика государственного задания «Разработка фармакогенетической тест-системы для повышения эффективности и безопасности фармакотерапии пациентов кардиологического и психиатрического профилей» (ЕГИСУ НИОКТР №124021200054-3)This work was financially supported by the Ministry of Health of the Russian Federation; the subject of the state assignment “Development of pharma-cogenetic test-system to improve the efficacy and safety of pharmacotherapy for cardiologic and psychiatric patients” (EGISU NIOCTR No. 124021200054-3)ReferencesSlawomirski L, Auraaen A, Klazinga N. The economics of patient safety: strengthening a value-based approach to reducing patient harm at national level. 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The authors declare that there are no conflicts of interest present.