medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-170medsovet-9052Research ArticleГАСТРОЭНТЕРОЛОГИЯGASTROENTEROLOGYКоморбидность воспалительных заболеваний кишечника и болезни ПаркинсонаComorbidity of inflammatory bowel diseases and Parkinson’s diseasehttps://orcid.org/0000-0002-1597-1876ТруханД. И.TrukhanD. I.

Трухан Дмитрий Иванович, д.м.н., доцент, профессор кафедры поликлинической терапии и внутренних болезней

644043, Омск, ул. Ленина, д. 12

Dmitry I. Trukhan, Dr. Sci. (Med.), Associate Professor, Professor of the Chair of Polyclinic Therapy and Internal Diseases

12, Lenin St., Omsk, 644043

dmitry_trukhan@mail.ruhttps://orcid.org/0000-0002-5207-5261КоншуН. В.KonshuN. V.

Коншу Надежда Вячеславовна, к.м.н., врач-ревматолог, Клиника «К+31»; врач-ревматолог, АО «Медицина» (клиника академика Ройтберга)

119415, Москва, ул. Лобачевского, д. 42,

125047, Москва, 2-й Тверской-Ямской переулок, д. 10

Nadezhda V. Konshu, Cand. Sci. (Med.), Rheumatologist, K+31 Clinic; Rheumatologist, JSC Medicina (Academican Roytberg’s Clinic)

42, Lobachevsky St., Moscow, 119415, 

10, 2nd Tverskaya-Yamskoy Lane, Moscow, 125047

nadias@mail.ruhttps://orcid.org/0009-0001-1127-0917МогилинаП. О.MogilinaP. O.

Могилина Полина Олеговна, студент

117997, Москва, ул. Островитянова, д. 1

Polina О. Mogilina, Student

1, Ostrovityanov St., Moscow, 117997

mogilina.poly@mail.ruОмский государственный медицинский университетРоссияOmsk State Medical UniversityRussian FederationКлиника «К+31»; АО «Медицина» (клиника академика Ройтберга)РоссияK+31 Clinic; JSC Medicina (Academican Roytberg’s Clinic)Russian FederationРоссийский национальный исследовательский медицинский университет имени Н.И. ПироговРоссияPirogov Russian National Research Medical UniversityRussian Federation202504052025058995Copyright © Трухан Д.И., Коншу Н.В., Могилина П.О., 20252025Трухан Д.И., Коншу Н.В., Могилина П.О.Trukhan D.I., Konshu N.V., Mogilina P.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9052

Исследования и публикации последнего десятилетия кардинально меняют традиционные медицинские представления и наше понимание о возможной взаимосвязи/коморбидности органов и систем организма. Множество исследований посвящено изучению связи микробиома кишечника и различных заболеваний. Воспалительные заболевания кишечника (ВЗК) и болезнь Паркинсона (БП) – хронические воспалительные заболевания, которые все чаще поражают миллионы людей во всем мире, представляя собой серьезную проблему для общественного здравоохранения. Мы провели поиск в информационных базах Pubmed и Scopus статей, опубликованных до 01.04.2025, в которых рассматривалась взаимосвязь ВЗК и БП. Эпидемиологические исследования и метаанализы демонстрируют наличие взаимосвязи между воспалительными заболеваниями кишечника и болезнью Паркинсона. К возможным механизмам этой связи относятся изменения кишечной микробиоты, взаимодействие по оси «кишечник – мозг», общие молекулярно-генетические механизмы. Наиболее интересным примером является LRRK2 (лейцин-богатая повторная киназа 2), первоначально идентифицированная как причинный ген при болезни Паркинсона, затем было установлено ее участие в патогенезе воспалительных заболеваний кишечника. Представленный обзор предполагает необходимость проведения дальнейших проспективных исследований для уточнения взаимосвязи между воспалительными заболеваниями кишечника и болезнью Паркинсона. Обзор подчеркивает важность междисциплинарных подходов в понимании системных последствий изменения кишечной микробиоты при воспалительных заболеваниях кишечника и их потенциального влияния на здоровье мозга. Модуляция микробиома кишечника с учетом их возможного влияния на болезнь Паркинсона имеет перспективный потенциал для улучшения профилактики и лечения с помощью инновационных терапевтических стратегий, особенно у коморбидных пациентов.

The research and publications of the last decade have radically changed traditional medical concepts and our understanding of the possible interrelationship/comorbidity of organs and body systems. A lot of research is devoted to studying the relationship between the gut microbiome and various diseases. Inflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic inflammatory diseases that are increasingly affecting millions of people worldwide, posing a major public health challenge. We searched the Pubmed and Scopus information databases for articles published before 04/01/2025 that examined the relationship between IBD and PD. Epidemiological studies and meta-analyses demonstrate the relationship between inflammatory bowel disease and Parkinson’s disease. Possible mechanisms of this relationship include changes in the intestinal microbiota, interaction along the gut-brain axis, and common molecular genetic mechanisms, the most interesting example being LRRK2 (leucine-rich repeat kinase 2), which was initially identified as a causative gene in Parkinson’s disease, and then its involvement in the pathogenesis of inflammatory bowel diseases was established. The presented review suggests the need for further prospective studies to clarify the relationship between inflammatory bowel diseases and Parkinson’s disease. The review highlights the importance of interdisciplinary approaches in understanding the systemic consequences of changes in the gut microbiota in inflammatory bowel diseases and their potential impact on brain health. The modulation of the gut microbiome, taking into account their possible impact on Parkinson’s disease, has a promising potential for improving prevention and treatment through innovative therapeutic strategies, especially in comorbid patients.

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The authors declare that there are no conflicts of interest present.