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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-060</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9089</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФЕКЦИИ В ОТОРИНОЛАРИНГОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFECTIONS IN OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Принципы антибактериальной терапии при инфекциях, поражающих верхние отделы дыхательных путей: клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Principles of antibacterial therapy for infections affecting the upper respiratory tract: A clinical case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7071-2415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Еремеева</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Eremeeva</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Еремеева Ксения Владимировна - к.м.н., доцент кафедры болезней уха, горла и носа Института клинической медицины имени Н.В. Склифосовского.</p><p>119048, Москва, ул. Трубецкая д. стр. 2</p></bio><bio xml:lang="en"><p>Ksenia V. Eremeeva - Cand. Sci. (Med.), Associate Professor of the Department of Ear, Throat and Nose Diseases at the N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">eremeeva_ks@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-4445-3329</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лисенкова</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Lisenkova</surname><given-names>D. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лисенкова Дарья Дмитриевна - ординатор кафедры болезней уха, горла и носа Института клинической медицины имени Н.В. Склифосовского.</p><p>119048, Москва, ул. Трубецкая д. 8 стр. 2</p></bio><bio xml:lang="en"><p>Daria D. Lisenkova - Resident of the Department of Ear, Throat and Nose Diseases, N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">chartrandwza@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7372-3299</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соболев</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Sobolev</surname><given-names>V. Р.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соболев Василий Петрович - к.м.н., доцент кафедры болезней уха, горла и носа Института клинической медицины имени Н.В. Склифосовского.</p><p>119048, Москва, ул. Трубецкая д. 8 стр. 2</p></bio><bio xml:lang="en"><p>Vasiliy Р. Sobolev - Cand. Sci. (Med.), Associate Professor of the Department of Ear, Throat and Nose Diseases at the N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">sobolev1972@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4870-5977</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синьков</surname><given-names>Э. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinkov</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Синьков Эдуард Викторович - к.м.н., доцент кафедры болезней уха, горла и носа Института клинической медицины имени Н.В. Склифосовского.</p><p>119048, Москва, ул. Трубецкая д. 8 стр. 2</p></bio><bio xml:lang="en"><p>Eduard V. Sinkov - Cand. Sci. (Med.), Associate Professor of the Department of Ear, Throat and Nose Diseases at the N.V. Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">1178461@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>24</day><month>05</month><year>2025</year></pub-date><volume>0</volume><issue>7</issue><fpage>17</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Еремеева К.В., Лисенкова Д.Д., Соболев В.П., Синьков Э.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Еремеева К.В., Лисенкова Д.Д., Соболев В.П., Синьков Э.В.</copyright-holder><copyright-holder xml:lang="en">Eremeeva K.V., Lisenkova D.D., Sobolev V.Р., Sinkov E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9089">https://www.med-sovet.pro/jour/article/view/9089</self-uri><abstract><p>Острый бактериальный риносинусит составляет порядка 0,5–2% от общего числа острых риносинуситов. Чаще всего этиологическим агентом являются Streptococcus pneumoniae, Moraxella catarrhalis и Haemophilus influenzae. В качестве антибактериальной терапии первой линии достаточно часто применяют амоксициллин, однако, учитывая постоянно растущую резистентность S. pneumoniae к пенициллинам, становится актуальным поиск альтернативы, не уступающей по эффективности. Так, в качестве стартовой терапии следует рассмотреть цефалоспорины III поколения, в частности цефиксим. Представлен клинический случай лечения пациента с жалобами на гнойные выделения из обеих половин полости носа, стекание слизи по задней стенке глотки, снижение обоняния, неприятный запах из носа, температуру 37,6 °С, дискомфорт в проекции обеих верхнечелюстных пазух, отечность в области верхнего века правого глаза. В результате клинико-рентгенологического дообследования был установлен диагноз «Острый двусторонний гнойный гаймороэтмоидит». Пациент находился на амбулаторном лечении. В качестве стартовой антибактериальной терапии был назначен цефиксим в виде диспергируемых таблеток по 400 мг 1 раз в день на 7 дней. Положительная динамика была отмечена уже на 3-и сут. лечения, полное купирование клинической симптоматики было достигнуто к 10-м сут. По шкале NOSE пациент в день обращения набрал 80 баллов, на 3-и сут. – 40 баллов, на 7-е сут. – 20 баллов. Результаты микробиологического исследования были получены через семь дней после начала лечения, выявлен рост S. pneumoniae 10^6, чувствительный ко всем антибактериальным препаратам. Представленный клинический случай продемонстрировал высокую эффективность препарата в условиях амбулаторного приема. Цефиксим можно рекомендовать как препарат выбора в этиотропной терапии острого бактериального риносинусита, особенно в случае резистентности или аллергии к группе пенициллинов.</p></abstract><trans-abstract xml:lang="en"><p>Acute bacterial rhinosinusitis is about 0.5–2% of the total number of acute rhinosinusitis. Most often the etiological agents are Streptococcus pneumoniae, Moraxella Catarrhalis and Haemophilus Influenzae. Amoxicillin is most often used as antibacterial therapy of the first line. The growth of S. pneumoniae resistance to penicillins is increasing. Penicillin’s not working. It is necessary to find a viable alternative antibacterial treatment. It should be considered as an initial treatment of the third-generation cephalosporins, in particular Cefixime. A clinical case of patient treatment is presented sought medical care at the clinic of the ear, throat and nose diseases. The patient complained of а purulent nasal discharge, postnasal drip, hyposmia, unpleasant odor from the nose, temperature of 37.6 °C, discomfort in the projection of both maxillary sinuses, swelling in the area of the upper eyelid of the right eye. Аn additional examination was carried out and the diagnosis of “Acute bacterial rhinosinusitis” was established. The patient was on outpatient treatment. The initial antibacterial therapy was the Cefixime in the form of dispersed tablets 400 mg once a day for 7 days. Positive dynamics was already noted on the 3rd day of treatment, the complete relief of clinical symptoms was achieved by the tenth day. On the NOSE scale, the patient scored 80 points on the day of circulation, on 3 days – 40 points, on the 7th day – 20 points. The results of a microbiological examination were obtained seven days after the start of treatment. It detected the growth of S. Pneumoniae 10^6 sensitive to all antibacterial drugs. The presented clinical case demonstrates the high response of the outpatient medicine. The Cefixime can be recommended as the drug of choice in causal treatment of the acute bacterial rhinosinusitis, especially in the case of resistance or allergy to penicillin.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый бактериальный риносинусит</kwd><kwd>цефиксим</kwd><kwd>цефалоспорины</kwd><kwd>резистентность к антибиотикам</kwd><kwd>аллергия на пенициллин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute bacterial rhinosinusitis</kwd><kwd>cefixime</kwd><kwd>cephalosporins</kwd><kwd>resistance to antibiotics</kwd><kwd>penicillin allergy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Revai K, Dobbs LA, Nair S, Patel JA, Grady JJ, Chonmaitree T. Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: the effect of age. 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