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<article article-type="conference-paper" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medsovet-9244</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НОВОСТИ. ОТКРЫТИЯ И СОБЫТИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEWS, DISCOVERIES AND EVENTS</subject></subj-group></article-categories><title-group><article-title>Колоректальный рак с мутацией BRAF – новый подход к терапии</article-title><trans-title-group xml:lang="en"><trans-title>BRAFV600E-mutant colorectal cancer: A new approach to therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>редакционная</surname><given-names>статья</given-names></name><name name-style="western" xml:lang="en"><surname>Editorial</surname><given-names>Article</given-names></name></name-alternatives></contrib></contrib-group><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>07</month><year>2025</year></pub-date><volume>0</volume><issue>10</issue><fpage>10</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; редакционная с., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">редакционная с.</copyright-holder><copyright-holder xml:lang="en">editorial a.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9244">https://www.med-sovet.pro/jour/article/view/9244</self-uri><abstract><p>В России, как и во всем мире, постоянно растет заболеваемость рака толстой и прямой кишки (колоректального рака) – одного из наиболее часто диагностируемых злокачественных новообразований с высоким риском метастазирования и летального исхода. В стране, несмотря на успехи в диагностике этого заболевания на более ранних стадиях, за последние 10 лет отмечается постоянный рост числа пациентов с раком кишечника на 2% и каждый год регистрируется около 75 000 новых случаев. Более 90% пациентов – люди старше 50 лет, но в последние годы отмечается неуклонный рост заболеваемости у более молодых пациентов. Особенно агрессивно колоректальный рак (КРР) протекает при наличии мутаций в гене BRAF.</p></abstract><trans-abstract xml:lang="en"><p>The prevalence of colon and rectal cancer (colorectal cancer), one of the most commonly diagnosed malignant neoplasms with a high risk of metastasis and death, has been increasing steadily in Russia and throughout the world. Despite advances in the early diagnosis of the disease, there has been a constant increase in the number of patients with bowel cancer by 2% and about 75,000 new cases reported annually in this country over the past ten years. More than 90% of patients are people aged over 50 years, but recent years have witnessed a steady increase in the incidence of the disease among young patients. BRAF-mutated CRC follows an especially aggressive clinical course.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Федянин МЮ, Эльснукаева ХМ, Демидова ИА, Строяковский ДЛ, Шелыгин ЮА, Цуканов АС и др. Колоректальный рак с мутацией в гене BRAF в Российской Федерации: эпидемиология и клинические особенности. Результаты многоцентрового исследования. Медицинский совет. 2021;(4S):52–63. https://doi.org/10.21518/2079-701X-2021-4S-52-63.</mixed-citation><mixed-citation xml:lang="en">Fedyanin MY, Ehlsnukaeva КM, Demidova IA, Stroyakovskiy DL, Shelygin YA, Tsukanov АS et al. Incidence and prognostic factors in patents (pts) with mutant BRAF (mBRAF) metastatic colorectal cancer (mCRC) in Russia. 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