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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-195</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9352</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПУЛЬМОНОЛОГИЯ, ОТОЛАРИНГОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PULMONOLOGY, OTORHINOLARYNGOLOGY</subject></subj-group></article-categories><title-group><article-title>Клинический опыт контроля болевого синдрома при инфекционно-воспалительной патологии глотки</article-title><trans-title-group xml:lang="en"><trans-title>Clinical experience of pain management in infectious and inflammatory diseases of pharynx</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6316-6046</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Ольга Анатольевна, к.м.н., доцент кафедры оториноларингологии, Смоленский государственный медицинский университет;  заведующая детским оториноларингологическим отделением, Смоленская областная клиническая больница</p><p>214018, Смоленск, проспект Гагарина, д. 28; 214018,  Смоленск, проспект Гагарина, д. 27</p></bio><bio xml:lang="en"><p>Olga A. Egorova, Cand. Sci. (Med.), Associate Professor of Department of Otorhinolaryngology; Smolensk State Medical University; Head of Department of Pediatric Otorhinolaryngology, Smolensk Regional Clinical Hospital</p><p>28, Gagarin Ave., Smolensk, 214018; 27, Gagarin Ave., Smolensk, 214018</p></bio><email xlink:type="simple">ola-egorova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3236-2642</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарасов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarasov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тарасов Александр Анатольевич, к.м.н., доцент кафедры оториноларингологии</p><p>214018, Смоленск, проспект Гагарина, д. 28</p></bio><bio xml:lang="en"><p>Aleksandr A. Tarasov, Cand. Sci. (Med.), Associate Professor of Department of Otorhinolaryngology</p><p>28, Gagarin Ave., Smolensk, 214018</p></bio><email xlink:type="simple">alat71@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Смоленский государственный медицинский университет; &#13;
Смоленская областная клиническая больница</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Smolensk State Medical University; &#13;
Smolensk Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Смоленский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Smolensk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>10</day><month>09</month><year>2025</year></pub-date><volume>19</volume><issue>13</issue><fpage>108</fpage><lpage>114</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Егорова О.А., Тарасов А.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Егорова О.А., Тарасов А.А.</copyright-holder><copyright-holder xml:lang="en">Egorova O.A., Tarasov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9352">https://www.med-sovet.pro/jour/article/view/9352</self-uri><abstract><p>В статье описаны клинические случаи использования кетопрофена в виде раствора для полоскания горла и флурбипрофена в виде таблеток для рассасывания у ребенка с острым вирусным тонзиллофарингитом и 2 взрослых пациентов с перитонзиллярными абсцессами. Показано, что препараты оказывают быстрый и выраженный обезболивающий эффект. Пациенты отмечали значительное уменьшение боли уже через 10–20 мин от момента применения препаратов. Отмечено, что комбинированное применение раствора для полоскания и таблеток для рассасывания дает более быстрый эффект по сравнению с использованием 1 препарата. У пациента с перитонзиллярным абсцессом, получавшего комбинацию препаратов, полное купирование боли в горле наступило на одни сут. раньше, чем у пациента, получавшего в качестве обезболивающей терапии только таблетки для рассасывания. У пациентов не было отмечено нежелательных реакций на прием препаратов. Описанные случаи сопровождаются обзором литературы, в котором представлены сведения об эпидемиологии, причинах и механизмах, методах терапии боли в горле. Чаще всего в практике оториноларинголога встречается ноцицептивная боль, вызываемая инфекционно-воспалительным фактором. Для купирования боли применяется широкий спектр препаратов, относящихся к различным группам (антисептики, антибиотики, местные анестетики и др.), но патогенетическим действием обладает только группа нестероидных противовоспалительных препаратов.</p></abstract><trans-abstract xml:lang="en"><p>The article presents clinical cases that focus on administration of ketoprofen as a throat wash and flurbiprofen as lozenges in a child with acute viral tonsillopharyngitis and two adult patients with peritonsillar abscesses. The drugs have been shown to provide a rapid and strong analgesic effect. Patients reported a significant reduction in pain within 10–20 minutes after administration of the drugs. It was emphasized that the combined use of a throat wash and lozenges produced a faster effect as compared to the single-drug therapy. The patient with a peritonsillar abscess who received a combination of two drugs demonstrated a complete relief of sore throat a day earlier than a patient who only received lozenges as pain relief therapy. No adverse reactions to the drugs were observed in patients. The presented cases are accompanied by a literature review, which provides information on the epidemiology, causes and mechanisms, as well as methods for treating a sore throat. Otolaryngologists most often see patients with nociceptive pain caused by an infectious and inflammatory factor in their practice. A wide range of drugs from various groups (antiseptics, antibiotics, local anesthetics, etc.) are used to relieve pain, but only a group of non-steroidal anti-inflammatory drugs has a pathogenetic effect.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый тонзиллофарингит</kwd><kwd>перитонзиллярный абсцесс</kwd><kwd>НПВС</kwd><kwd>боль в горле</kwd><kwd>комбинированная терапия</kwd><kwd>раствор для полоскания</kwd><kwd>таблетки для рассасывания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute tonsillopharyngitis</kwd><kwd>peritonsillar abscess</kwd><kwd>NSAIDs</kwd><kwd>sore throat</kwd><kwd>combination therapy</kwd><kwd>throat wash</kwd><kwd>lozenges</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Finley CR, Chan DS, Garrison S, Korownyk C, Kolber MR, Campbell S et al. What are the most common conditions in primary care? Systematic review. Can Fam Physician. 2018;64(11):832–840. Available at: https://pubmed.ncbi.nlm.nih.gov/30429181/.</mixed-citation><mixed-citation xml:lang="en">Finley CR, Chan DS, Garrison S, Korownyk C, Kolber MR, Campbell S et al. What are the most common conditions in primary care? Systematic review. Can Fam Physician. 2018;64(11):832–840. Available at: https://pubmed.ncbi.nlm.nih.gov/30429181/.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Krüger K, Töpfner N, Berner R, Windfuhr J, Oltrogge JH; Guideline group. Clinical Practice Guideline: Sore Throat. Dtsch Arztebl Int. 2021;118(11): 188–194. https://doi.org/10.3238/arztebl.m2021.0121.</mixed-citation><mixed-citation xml:lang="en">Krüger K, Töpfner N, Berner R, Windfuhr J, Oltrogge JH; Guideline group. Clinical Practice Guideline: Sore Throat. Dtsch Arztebl Int. 2021;118(11): 188–194.  https://doi.org/10.3238/arztebl.m2021.0121.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Renner B, Mueller CA, Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res. 2012;61(10):1041–1052. https://doi.org/10.1007/s00011-012-0540-9.</mixed-citation><mixed-citation xml:lang="en">Renner B, Mueller CA, Shephard A. Environmental and non-infectious factors in the aetiology of pharyngitis (sore throat). Inflamm Res. 2012;61(10):1041–1052.   https://doi.org/10.1007/s00011-012-0540-9.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hannaford PC, Simpson JA, Bisset AF, Davis A, McKerrow W, Mills R. The prevalence of ear, nose and throat problems in the community: results from a national cross-sectional postal survey in Scotland. Fam Pract. 2005;22(3):227–233. https://doi.org/10.1093/fampra/cmi004.</mixed-citation><mixed-citation xml:lang="en">Hannaford PC, Simpson JA, Bisset AF, Davis A, McKerrow W, Mills R. The prevalence of ear, nose and throat problems in the community: results from a national cross-sectional postal survey in Scotland. Fam Pract. 2005;22(3):227–233.  https://doi.org/10.1093/fampra/cmi004.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Little PS, Williamson I. Are antibiotics appropriate for sore throats? Costs outweigh the benefits. BMJ. 1994;309(6960):1010–1011. https://doi.org/10.1136/bmj.309.6960.1010.</mixed-citation><mixed-citation xml:lang="en">Little PS, Williamson I. Are antibiotics appropriate for sore throats? Costs outweigh the benefits. BMJ. 1994;309(6960):1010–1011. https://doi.org/10.1136/bmj.309.6960.1010.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Oliver J, Malliya Wadu E, Pierse N, Moreland NJ, Williamson DA, Baker MG. Group A Streptococcus pharyngitis and pharyngeal carriage: A metaanalysis. PLoS Negl Trop Dis. 2018;12(3):e0006335. https://doi.org/10.1371/journal.pntd.0006335.</mixed-citation><mixed-citation xml:lang="en">Oliver J, Malliya Wadu E, Pierse N, Moreland NJ, Williamson DA, Baker MG. Group A Streptococcus pharyngitis and pharyngeal carriage: A metaanalysis. PLoS Negl Trop Dis. 2018;12(3):e0006335. https://doi.org/10.1371/journal.pntd.0006335.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Крюков АИ, Кунельская НЛ, Туровский АБ, Изотова ГН. Тонзиллофарингиты: диагностика и лечение. Справочник поликлинического врача. 2007;(1):38–42. Режим доступа: https://elibrary.ru/ttmnpv.</mixed-citation><mixed-citation xml:lang="en">Kryukov AI, Kunelʹskaya NL, Turovskiy AB, Izotova GN. Tonsillopharyngitis: diagnosis and treatment. Spravochnik Poliklinicheskogo Vracha. 2007;(1):38–42. (In Russ.) Available at: https://elibrary.ru/ttmnpv.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Карнеева ОВ, Дайхес НА, Поляков ДП. Протоколы диагностики и лечения острых тонзиллофарингитов. РМЖ. 2015;23(6):307–310. Режим доступа: https://www.rmj.ru/articles/otorinolaringologiya/Protokoly_diagnostiki_i_lecheniya_ostryh_tonzillofaringitov/.</mixed-citation><mixed-citation xml:lang="en">Karneeva OV, Daykhes NA, Polyakov DP. Protocols for diagnosis and treatment of acute tonsillopharyngitis. RMJ. 2015;23(6):307–310. (In Russ.) Available at: https://www.rmj.ru/articles/otorinolaringologiya/Protokoly_diagnostiki_i_lecheniya_ostryh_tonzillofaringitov/.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fletcher AE, Palmer AJ, Bulpitt CJ. Cough with angiotensin converting enzyme inhibitors: how much of a problem? J Hypertens Suppl. 1994;12(2):S43–47. Available at: https://pubmed.ncbi.nlm.nih.gov/7965265/.</mixed-citation><mixed-citation xml:lang="en">Fletcher AE, Palmer AJ, Bulpitt CJ. Cough with angiotensin converting enzyme inhibitors: how much of a problem? J Hypertens Suppl. 1994;12(2):S43–47. Available at: https://pubmed.ncbi.nlm.nih.gov/7965265/.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bhalla RK, Taylor W, Jones AS, Roland NJ. The inflammation produced by corticosteroid inhalers in the pharynx in asthmatics. Clin Otolaryngol. 2008;33(6):581–586. https://doi.org/10.1111/j.1749-4486.2008.01837.x.</mixed-citation><mixed-citation xml:lang="en">Bhalla RK, Taylor W, Jones AS, Roland NJ. The inflammation produced by corticosteroid inhalers in the pharynx in asthmatics. Clin Otolaryngol. 2008;33(6):581–586.  https://doi.org/10.1111/j.1749-4486.2008.01837.x.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wolff AE, Hansen KE, Zakowski L. Acute Kawasaki disease: not just for kids. J Gen Intern Med. 2007;22(5):681–684. https://doi.org/10.1007/s11606-006-0100-5.</mixed-citation><mixed-citation xml:lang="en">Wolff AE, Hansen KE, Zakowski L. Acute Kawasaki disease: not just for kids. J Gen Intern Med. 2007;22(5):681–684. https://doi.org/10.1007/s11606-006-0100-5.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Poelmans J, Tack J. Extraoesophageal manifestations of gastro-oesophageal reflux. Gut. 2005;54(10):1492–1499. https://doi.org/10.1136/gut.2004.053025.</mixed-citation><mixed-citation xml:lang="en">Poelmans J, Tack J. Extraoesophageal manifestations of gastro-oesophageal reflux. Gut. 2005;54(10):1492–1499. https://doi.org/10.1136/gut.2004.053025.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Vedal S, Petkau J, White R, Blair J. Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children. Am J Respir Crit Care Med. 1998;157(4Pt1):1034–1043. https://doi.org/10.1164/ajrccm.157.4.9609008.</mixed-citation><mixed-citation xml:lang="en">Vedal S, Petkau J, White R, Blair J. Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children. Am J Respir Crit Care Med. 1998;157(4Pt1):1034–1043.  https://doi.org/10.1164/ajrccm.157.4.9609008.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Veneri L, Caso MA, Ravaioli M, Albonetti A, Ghini P, Mazzavillani M, Valentini MG. Study on prevalence of upper and lower airways disorders in woodworkers, using data from medical surveillance reports and exposure registers. G Ital Med Lav Ergon. 2007;29(3 Suppl):833–835. Available at: https://pubmed.ncbi.nlm.nih.gov/18409987/.</mixed-citation><mixed-citation xml:lang="en">Veneri L, Caso MA, Ravaioli M, Albonetti A, Ghini P, Mazzavillani M, Valentini MG. Study on prevalence of upper and lower airways disorders in woodworkers, using data from medical surveillance reports and exposure registers. G Ital Med Lav Ergon. 2007;29(3 Suppl):833–835. Available at: https://pubmed.ncbi.nlm.nih.gov/18409987/.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ginns SE, Gatrell AC. Respiratory health effects of industrial air pollution: a study in east Lancashire, UK. J Epidemiol Community Health. 1996;50(6):631–635. https://doi.org/10.1136/jech.50.6.631.</mixed-citation><mixed-citation xml:lang="en">Ginns SE, Gatrell AC. Respiratory health effects of industrial air pollution: a study in east Lancashire, UK. J Epidemiol Community Health. 1996;50(6):631–635. https://doi.org/10.1136/jech.50.6.631.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Triche EW, Belanger K, Bracken MB, Beckett WS, Holford TR, Gent JF et al. Indoor heating sources and respiratory symptoms in nonsmoking women. Epidemiology. 2005;16(3):377–384. https://doi.org/10.1097/01.ede.0000158225.44414.85.</mixed-citation><mixed-citation xml:lang="en">Triche EW, Belanger K, Bracken MB, Beckett WS, Holford TR, Gent JF et al. Indoor heating sources and respiratory symptoms in nonsmoking women. Epidemiology. 2005;16(3):377–384. https://doi.org/10.1097/01.ede.0000158225.44414.85.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lötsch J, Ahne G, Kunder J, Kobal G, Hummel T. Factors affecting pain intensity in a pain model based upon tonic intranasal stimulation in humans. Inflamm Res. 1998;47(11):446–450. https://doi.org/10.1007/s000110050359.</mixed-citation><mixed-citation xml:lang="en">Lötsch J, Ahne G, Kunder J, Kobal G, Hummel T. Factors affecting pain intensity in a pain model based upon tonic intranasal stimulation in humans. Inflamm Res. 1998;47(11):446–450. https://doi.org/10.1007/s000110050359.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Jammes Y, Delvolgo-Gori MJ, Badier M, Guillot C, Gazazian G, Parlenti L. One-year occupational exposure to a cold environment alters lung function. Arch Environ Health. 2002;57(4):360–365. https://doi.org/10.1080/00039890209601422.</mixed-citation><mixed-citation xml:lang="en">Jammes Y, Delvolgo-Gori MJ, Badier M, Guillot C, Gazazian G, Parlenti L. One-year occupational exposure to a cold environment alters lung function. Arch Environ Health. 2002;57(4):360–365. https://doi.org/10.1080/00039890209601422.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mäkinen TM, Juvonen R, Jokelainen J, Harju TH, Peitso A, Bloigu A et al. Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections. Respir Med. 2009;103(3):456–462. https://doi.org/10.1016/j.rmed.2008.09.011.</mixed-citation><mixed-citation xml:lang="en">Mäkinen TM, Juvonen R, Jokelainen J, Harju TH, Peitso A, Bloigu A et al. Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections. Respir Med. 2009;103(3):456–462. https://doi.org/10.1016/j.rmed.2008.09.011.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Корешкина МИ. Невропатическая боль. Проблемы и решения. Нервные болезни. 2016;(4):34–37. Режим доступа: https://www.atmosphere-ph.ru/modules/Magazines/articles/nervo/NB_4_2016_34.pdf.</mixed-citation><mixed-citation xml:lang="en">Koreshkina MI. Neuropathic pain: challenges and solutions. Nervous Diseases. 2016;(4):34–37. (In Russ.) Available at: https://www.atmosphereph.ru/modules/Magazines/articles/nervo/NB_4_2016_34.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Шостак НА, Правдюк НГ. Болевой синдром: некоторые диагностические аспекты. Клиницист. 2016;10(1):10–11. Режим доступа: https://klinitsist.abvpress.ru/Klin/article/view/239.</mixed-citation><mixed-citation xml:lang="en">Shostak NA, Pravdyuk NG. Pain syndrome: some diagnostic aspects. The Clinician. 2016;10(1):10–11. (In Russ.) Available at: https://klinitsist.abvpress.ru/Klin/article/view/239.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Парфенов ВА, Головачева ВА. Хроническая боль и ее лечение в неврологии. М.: ГЭОТАР-Медиа; 2018. 288 с.</mixed-citation><mixed-citation xml:lang="en">Парфенов ВА, Головачева ВА. Хроническая боль и ее лечение в неврологии. М.: ГЭОТАР-Медиа; 2018. 288 с.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Radkova E, Burova N, Bychkova V, DeVito R. Efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection: a randomized, non-inferiority trial in the Russian Federation. J Pain Res. 2017;10:1591–1600. https://doi.org/10.2147/JPR.S135602.</mixed-citation><mixed-citation xml:lang="en">Radkova E, Burova N, Bychkova V, DeVito R. Efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection: a randomized, non-inferiority trial in the Russian Federation. J Pain Res. 2017;10:1591–1600. https://doi.org/10.2147/JPR.S135602.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">de Looze F, Shephard A, Smith AB. Locally Delivered Flurbiprofen 8.75 mg for Treatment and Prevention of Sore Throat: A Narrative Review of Clinical Studies. J Pain Res. 2019;12:3477–3509. https://doi.org/10.2147/JPR.S221706.</mixed-citation><mixed-citation xml:lang="en">de Looze F, Shephard A, Smith AB. Locally Delivered Flurbiprofen 8.75 mg for Treatment and Prevention of Sore Throat: A Narrative Review of Clinical Studies. J Pain Res. 2019;12:3477–3509. https://doi.org/10.2147/JPR.S221706.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Карпова ЕП, Тулупов ДА, Федотов ФА. Использование нестероидных противовоспалительных средств для купирования болевого синдрома после тонзиллотомии у детей. Вестник оториноларингологии. 2017;82(5):48–51. https://doi.org/10.17116/otorino201782548-51.</mixed-citation><mixed-citation xml:lang="en">Karpova EP, Tulupov DA, Fedotov FA. The application of different nonsteroidal anti-inflammatory drugs for the elimination of pain syndrome during the early postoperative period in the children following the surgical interventions on palatine tonsils. Vestnik Oto-Rino-Laringologii. 2017;82(5):48–51. (In Russ.) https://doi.org/10.17116/otorino201782548-51.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Овчинников АЮ, Мирошниченко НА, Николаева ЮО, Васильев ММ, Швыдун АА. К вопросу о купировании боли у пациентов, перенесших тонзиллэктомию. Анализ эффективности двух популярных форм кетопрофена лизиновой соли. Эффективная фармакотерапия. 2024;20(41):28–35. Режим доступа: https://umedp.ru/articles/k_voprosu_o_kupirovanii_boli_u_patsientov_perenesshikh_tonzillektomiyu_analiz_effektivnosti_dvukh_po.html.</mixed-citation><mixed-citation xml:lang="en">Ovchinnikov AYu, Miroshnichenko NA, Nikolaeva YuO, Vasilyev MM, Shvydun AA. On the Issue of Pain Relief in Patients Who Have Undergone Tonsillectomy. Analysis of the Effectiveness of Two Popular Forms of Ketoprofen Lysine Salt. Effective Pharmacotherapy. 2024;20(41):28–35. Available at: https://umedp.ru/articles/k_voprosu_o_kupirovanii_boli_u_patsientov_perenesshikh_tonzillektomiyu_analiz_effektivnosti_dvukh_po.html.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Passàli D, Volonté M, Passàli GC, Damiani V, Bellussi L. Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study. Clin Ther. 2001;23(9):1508–1518. https://doi.org/10.1016/s0149-2918(01)80123-5</mixed-citation><mixed-citation xml:lang="en">Passàli D, Volonté M, Passàli GC, Damiani V, Bellussi L. Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study. Clin Ther. 2001;23(9):1508–1518. https://doi.org/10.1016/s0149-2918(01)80123-5</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">. Blagden M, Christian J, Miller K, Charlesworth A. Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, doubleblind, placebo-controlled study in UK general practice centres. Int J Clin Pract. 2002;56(2):95–100. Available at: https://pubmed.ncbi.nlm.nih.gov/11926713/.</mixed-citation><mixed-citation xml:lang="en">Blagden M, Christian J, Miller K, Charlesworth A. Multidose flurbiprofen 8.75 mg lozenges in the treatment of sore throat: a randomised, doubleblind, placebo-controlled study in UK general practice centres. Int J Clin Pract. 2002;56(2):95–100. Available at: https://pubmed.ncbi.nlm.nih.gov/11926713/.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Watson N, Nimmo WS, Christian J, Charlesworth A, Speight J, Miller K. Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomised, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract. 2000;54(8):490–496. Available at: https://pubmed.ncbi.nlm.nih.gov/11198725/.</mixed-citation><mixed-citation xml:lang="en">Watson N, Nimmo WS, Christian J, Charlesworth A, Speight J, Miller K. Relief of sore throat with the anti-inflammatory throat lozenge flurbiprofen 8.75 mg: a randomised, double-blind, placebo-controlled study of efficacy and safety. Int J Clin Pract. 2000;54(8):490–496. Available at: https://pubmed.ncbi.nlm.nih.gov/11198725/.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
