medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-358medsovet-9402Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESАзелаиновая кислота как препарат выбора при акне легкой степени тяжестиAzelaic acid as the treatment of choice for mild acnehttps://orcid.org/0000-0001-5723-6573ЖуковаО. В.ZhukovaO. V.

Жукова Ольга Валентиновна - д.м.н., профессор, заведующая кафедрой дерматовенерологии, аллергологии и косметологии Медицинского института, РУДН имени Патриса Лумумбы; главный врач, Московский НПЦ дерматовенерологии и косметологии;

117198, Москва, ул. Миклухо-Маклая, д. 6; 119071, Москва, Ленинский проспект, д. 17

Olga V. Zhukova - Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology, Allergology and Cosmetology, Medical Institute, PFUR named after Patrice Lumumba; Chief Medical Officer, MSPC of Dermatovenereology and Cosmetology;

6, Miklukho-Maklai St., Moscow, 117198; 17, Leninsky Ave., Moscow, 119071

klinderma@inbox.ruhttps://orcid.org/0000-0002-2793-8862АртемьеваС. И.ArtemyevaS. I.

Артемьева Софья Иосифовна - ассистент кафедры дерматовенерологии, аллергологии и косметологии Медицинского института; РУДН имени Патриса Лумумбы; научный сотрудник отдела клинической дерматовенерологии и косметологии, врач-дерматовенеролог, Московский НПЦ дерматовенерологии и косметологии

117198, Москва, ул. Миклухо-Маклая, д. 6; 119071, Москва, Ленинский проспект, д. 17

Sofya I. Artemyeva - Assistant of the Department of Dermatovenereology, Allergology and Cosmetology, Medical Institute, PFUR named after Patrice Lumumba; Researcher of the Department of Clinical Dermatovenereology and Cosmetology, Dermatovenerologist, MSPC of Dermatovenereology and Cosmetology

6, Miklukho-Maklai St., Moscow, 117198; 17, Leninsky Ave., Moscow, 119071

sofya.chern@gmail.comРоссийский университет дружбы народов имени Патриса Лумумбы; Московский научно-практический центр дерматовенерологии и косметологииРоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; Moscow Scientific and Practical Center of Dermatovenereology and CosmetologyRussian Federation2025300920250142328Copyright © Жукова О.В., Артемьева С.И., 20252025Жукова О.В., Артемьева С.И.Zhukova O.V., Artemyeva S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9402

Акне легкой степени тяжести является одним из наиболее распространенных дерматологических состояний, особенно в подростковом и молодом взрослом возрасте. Несмотря на благоприятное течение, даже легкие формы акне могут существенно снижать качество жизни пациентов и требуют своевременной эффективной терапии. Азелаиновая кислота, входящая в состав современных топических средств, обладает доказанным комедонолитическим, противовоспалительным и бактериостатическим действием, не вызывая при этом устойчивости микрофлоры. Это делает ее важным компонентом терапии, особенно в условиях амбулаторной практики. В настоящей работе представлен обзор современных подходов к лечению акне легкой степени тяжести с акцентом на клинический потенциал азелаиновой кислоты. Дополнительно описан опыт применения лекарственного средства Скиноклир, выпускаемого в форме крема с концентрацией 20% и геля с концентрацией 15%. Препарат применялся в рамках амбулаторной практики с документированной фотофиксацией кожного процесса до и после терапии. У всех пациентов было отмечено снижение количества воспалительных и невоспалительных элементов в течение 4–8 нед. Лечение переносилось хорошо, случаев выраженных побочных реакций или отмены терапии не зарегистрировано. Таким образом, азелаиновая кислота в составе препарата Скиноклир демонстрирует хорошую клиническую эффективность и переносимость, подтверждая свою значимость как компонента выбора в терапии акне легкой степени тяжести.

Mild acne is one of the most common dermatological conditions, particularly among adolescents and young adults. Despite its generally favorable course, even mild forms of acne can significantly reduce patients’ quality of life and require timely and effective treatment. Azelaic acid, included in modern topical formulations, has well-documented comedolytic, anti-inflammatory, and bacteriostatic properties, without contributing to microbial resistance. This makes it an important component of acne therapy, especially in outpatient clinical settings. This paper presents a review of current approaches to the treatment of mild acne, with a focus on the clinical potential of azelaic acid. In addition, the authors describe clinical experience with the topical medication Skinoclear, available in cream form with a 20% concentration and gel form with a 15% concentration. The product was used in outpatient practice, with photographic documentation of the skin condition before and after treatment. All patients showed a reduction in both inflammatory and non-inflammatory lesions within 4 to 8 weeks. The treatment was well tolerated, with no reported significant adverse reactions or treatment discontinuations. Thus, azelaic acid as part of the Skinoclear formulation demonstrates good clinical efficacy and tolerability, supporting its role as a treatment of choice in the management of mild acne.

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The authors declare that there are no conflicts of interest present.