medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-372medsovet-9412Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESТерапевтический потенциал плазмафереза при красной волчанке: биомаркеры и динамикаTherapeutic potential of plasmapheresis in lupus erythematosus: Biomarkers and follow-up controlhttps://orcid.org/0000-0001-8934-3197МихееваЭ. С.MikheevaE. S.

Михеева Элеонора Станиславовна - аспирант кафедры дерматовенерологии, аллергологии и косметологии Медицинского института.

117198, Москва, ул. Миклухо-Маклая, д. 8

Eleonora S. Mikheeva - Postgraduate Student of the Department of Dermatovenerology, Allergology and Cosmetology at the Medical Institute.

6, Miklukho-Maklai St., Moscow, 117198

eleonora3001@mail.ruhttps://orcid.org/0009-0009-8985-3387ЧехА. С.ChehA. S.

Чех Александр Сергеевич - врач-трансфузиолог.

119071, Москва, Ленинский проспект, д. 17

Alexander S. Cheh – Transfusiologist.

17, Leninsky Ave., Moscow, 119071

cheh.a@bk.ruhttps://orcid.org/0000-0001-5723-6573ЖуковаО. В.ZhukovaO. V.

Жукова Ольга Валентиновна - д.м.н., профессор, заведующая кафедрой дерматовенерологии, аллергологии и косметологии Медицинского института, РУДН имени Патриса Лумумбы; главный врач, Московский научно-практический центр дерматовенерологии и косметологии;

117198, Москва, ул. Миклухо-Маклая, д. 8; 119071, Москва, Ленинский проспект, д. 17

Olga V. Zhukova - Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenerology, Allergology and Cosmetology at the Medical Institute, PFUR named after Patrice Lumumba; Chief Medical Officer, Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology;

6, Miklukho-Maklai St., Moscow, 117198; 17, Leninsky Ave., Moscow, 119071

klinderma@inbox.ruhttps://orcid.org/0000-0002-6583-0318КорсунскаяИ. М.KorsunskayaI. M.

Корсунская Ирина Марковна, д.м.н., профессор, заведующая лабораторией.

109029, Москва, Средняя Калитниковская ул., д. 30

Irina M. Korsunskaya - Dr. Sci. (Med.), Professor, Head of the Laboratory.

30, Srednyaya Kalitnikovskaya St., Moscow, 109029

marykor@bk.ruРоссийский университет дружбы народов имени Патриса ЛумумбыРоссияPeoples’ Friendship University of Russia named after Patrice LumumbaRussian FederationМосковский научно-практический центр дерматовенерологии и косметологииРоссияMoscow Scientific and Practical Center of Dermatovenereology and CosmetologyRussian FederationРоссийский университет дружбы народов имени Патриса Лумумбы; Московский научно-практический центр дерматовенерологии и косметологииРоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; Moscow Scientific and Practical Center of Dermatovenereology and CosmetologyRussian FederationЦентр теоретических проблем физико-химической фармакологии Российской академии наукРоссияCenter for Theoretical Problems of Physical and Chemical Pharmacology of Russian Academy of SciencesRussian Federation202530092025014108115Copyright © Михеева Э.С., Чех А.С., Жукова О.В., Корсунская И.М., 20252025Михеева Э.С., Чех А.С., Жукова О.В., Корсунская И.М.Mikheeva E.S., Cheh A.S., Zhukova O.V., Korsunskaya I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9412Введение

Введение. Красная волчанка (КВ) представляет собой гетерогенное аутоиммунное заболевание, в патогенезе которого важную роль играют провоспалительные цитокины. Несмотря на значительное количество исследований, особенности цитокинового профиля при кожной форме КВ (ККВ), а также его изменения в ответ на плазмаферез остаются недостаточно изученными. Цель. Оценить уровни IL-17A, IL-31, IL-13 и IL-10 у пациентов с дискоидной (ДКВ) и системной (СКВ) формами КВ, а также их динамику после мембранного плазмафереза.

Материалы и методы

Материалы и методы. В исследование включены 30 пациентов (21 – с ДКВ, 9 – с СКВ), проходивших лечение в МНПЦДК ДЗМ. Уровни цитокинов определялись до начала лечения, после первой процедуры плазмафереза и через 14 дней. Результаты сопоставлялись с референсными значениями.

Результаты

Результаты. У пациентов с ДКВ исходно выявлено повышение IL-17A и IL-31. После первой процедуры отмечено снижение уровня IL-17A и IL-13 при резком увеличении IL-31. Через 14 дней сохранялось снижение IL-17A и IL-10, IL-13 восстановился до исходного уровня, IL-31 оставался повышенным. При СКВ отмечалось умеренное снижение IL-17A и повышение IL-13 и IL-10. Через 14 дней IL-17A и IL-10 снижались, IL-13 демонстрировал выраженные колебания, а IL-31 оставался стабильным в обоих случаях.

Выводы

Выводы. Плазмаферез оказывает модулирующее влияние на уровни цитокинов у пациентов с КВ. IL-31 и IL-10 могут рассматриваться как потенциальные биомаркеры активности и системного прогрессирования. Полученные данные подтверждают целесообразность включения плазмафереза в терапию резистентных форм КВ.

Introduction

Introduction. Lupus erythematosus (LE) is a heterogeneous autoimmune disease, and pro-inflammatory cytokines play important roles in its pathogenesis. Despite numerous studies, the features of the cytokine profile in cutaneous LE (CLE), as well as its changes in response to plasmapheresis, remain unclear.

Aim

Aim. To assess the levels of IL-17A, IL-31, IL-13 and IL-10 in patients with discoid (DLE) and systemic (SLE) LE, as well as changes in their levels at different time points after membrane plasmapheresis.

Materials and methods

Materials and methods. The study included 30 patients (21 with DLE, 9 with SLE), who were treated at the Moscow Scientific and Practical Center for Dermatovenereology and Cardiology of the Moscow Health Department. Cytokine levels were assessed before treatment, after the first plasmapheresis procedure, and at 14 days. The results were compared with reference values.

Results

Results. Patients with DLE showed elevated levels of IL-17A and IL-31 at baseline. After the first procedure, a decrease in IL-17A and IL-13 with a sharp increase in IL-31 were observed. At 14 days, IL-17A and IL-10 levels continued to decrease, IL-13 levels recovered to baseline, and IL-31 levels remained elevated. In patients with SLE, a moderate decrease in IL-17A and an increase in IL-13 and IL-10 were observed. At 14 days, IL-17A and IL-10 levels decreased, IL-13 levels demonstrated significant fluctuations, and IL-31 levels remained stable in both cases.

Conclusions

Conclusions. Plasmapheresis has been shown to have a modulating effect on cytokine levels in patients with LE. IL-31 and IL-10 can be considered potential biomarkers of disease activity and systemic progression. The data obtained support the feasibility of plasmapheresis in the therapy of resistant forms of LE.

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The authors declare that there are no conflicts of interest present.