medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-328medsovet-9417Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESЭозинофилы в крови и коже – сложная роль в патогенезе псориазаEosinophils in blood and skin – a complex role in the pathogenesis of psoriasishttps://orcid.org/0000-0002-7933-3515АрсеньеваА. А.ArsenyevaA. A.

Арсеньева Антонина Александровна - к.м.н., доцент, заведующая кафедрой дерматовенерологии и косметологии Института профессионального образования.

443099, Самара, ул. Чапаевская, д. 89

Antonina A. Arsenyeva - Cand. Sci. (Med.), Associate Professor, Head of the Department of Dermatovenereology and Cosmetology of the Institute of Professional Education.

89, Chapaevskaya St., Samara, 443099

a.a.arseneva@samsmu.ruhttps://orcid.org/0000-0003-0941-9871МигачеваН. Б.MigachevaN. B.

Мигачева Наталья Бегиевна - д.м.н., доцент, заведующая кафедрой педиатрии Института профессионального образования.

443099, Самара, ул. Чапаевская, д. 89

Natalia B. Migacheva - Dr. Sci. (Med.), Associate Professor, Head of the Department of Pediatrics Institute of Professional Education.

89, Chapaevskaya St., Samara, 443099

n.b.migacheva@samsmu.ruhttps://orcid.org/0000-0002-5905-1895ЛяминА. В.LyaminA. V.

Лямин Артем Викторович - д.м.н., доцент, директор Научно-образовательного профессионального центра генетических и лабораторных технологий.

443099, Самара, ул. Чапаевская, д. 89

Artem V. Lyamin - Dr. Sci. (Med.), Associate Professor, Director of the Scientific and Educational Professional Center of Genetic and Laboratory Technologies.

89, Chapaevskaya St., Samara, 443099

a.v.lyamin@samsmu.ruhttps://orcid.org/0000-0003-4114-5233КурмаевД. П.KurmayevD. P.

Курмаев Дмитрий Петрович - к.м.н., ассистент кафедры эндокринологии и гериатрии.

443099, Самара, ул. Чапаевская, д. 89

Dmitriy P. Kurmayev - Cand. Sci. (Med.), Assistant of the Department of Endocrinology and Geriatrics.

89, Chapaevskaya St., Samara, 443099

geriatry@mail.ruhttps://orcid.org/0000-0003-4689-8904ХалиулинА. В.KhaliulinA. V.

Халиулин Алмаз Вадимович - к.м.н., заведующий лабораторией морфологических и общеклинических исследований Научно-образовательного профессионального центра генетических и лабораторных технологий.

443099, Самара, ул. Чапаевская, д. 89

Almaz V. Khaliulin - Cand. Sci. (Med.), Head of Laboratory of Clinical Research of Research and Educational Professional Center for Genetic and Laboratory Technologies.

89, Chapaevskaya St., Samara, 443099

a.v.haliulin@samsmu.ruСамарский государственный медицинский университетРоссияSamara State Medical UniversityRussian Federation202530092025014136145Copyright © Арсеньева А.А., Мигачева Н.Б., Лямин А.В., Курмаев Д.П., Халиулин А.В., 20252025Арсеньева А.А., Мигачева Н.Б., Лямин А.В., Курмаев Д.П., Халиулин А.В.Arsenyeva A.A., Migacheva N.B., Lyamin A.V., Kurmayev D.P., Khaliulin A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9417

Псориаз – хроническое воспалительное папулосквамозное заболевание кожи, однако патологический спектр псориатических поражений далеко не исчерпывается кожными элементами. Псориаз является сложным заболеванием, вызванным взаимодействием между генетической предрасположенностью, экологическими триггерами и дисрегуляцией иммунной системы. В хроническом псориатическом воспалении принимают участие кератиноциты, а также разнообразные клеточные и гуморальные факторы, проникающие из крови. В настоящее время большой научный интерес вызывают эозинофилы, которые принимают активное участие в патогенезе псориаза. Данная научная работа является описательным обзором литературы и охватывает клинические и эпидемиологические исследования, а также описательные и систематические обзоры литературы. Информация, представленная в нашей научной статье, получена из ранее проведенных исследований. Согласно проанализированным данным, эозинофилы – плейотропные многофункциональные лейкоциты, участвующие в иммунной защите. Эозинофилы играют важную роль в реакциях гиперчувствительности и в ряде аутоиммунных заболеваний, могут мигрировать из кровяного русла в кожу в ответ на различные аттракторы и вырабатывать различные цитокины. Показано, что эозинофилы способны к секреции эозинофильного катионного белка в коже пациентов с псориазом. Степень эозинофилии может быть маркером тяжести и прогноза псориаза. Некоторые исследователи считают, что эозинофилия периферической крови связана с тяжелыми формами псориаза (генерализованная пустулезная и эритродермическая). Ряд ученых выявил важную негативную роль цитокина IL-31, который секретируют эозинофилы как основного фактора кожного зуда. Многочисленные научные работы свидетельствуют о важной роли эозинофилов в развитии псориатического воспаления. Необходимы дальнейшие исследования для изучения эозинофилов и их потенциального влияния на прогрессирование псориаза с целью совершенствования лечения и улучшения качества жизни пациентов.

Psoriasis is a chronic inflammatory papulosquamous skin disease, but the pathological spectrum of psoriatic lesions is far from limited to skin elements. Psoriasis is a complex disease caused by the interaction between genetic predisposition, environmental triggers and immune system dysregulation. Chronic psoriatic inflammation involves keratinocytes, as well as various cellular and humoral factors penetrating from the blood. Currently, eosinophils, which take an active part in the pathogenesis of psoriasis, are of great scientific interest. This scientific work is a narrative review of the literature and covers clinical and epidemiological studies, as well as descriptive and systematic reviews of the literature. The information presented in our scientific article is obtained from previously conducted studies. Eosinophils are pleiotropic multifunctional leukocytes involved in immune defense. Eosinophils play an important role in hypersensitivity reactions and in a number of autoimmune diseases, can migrate from the bloodstream to the skin in response to various attractors and produce various cytokines. It has been shown that eosinophils are capable of secreting eosinophilic cationic protein in the skin of patients with psoriasis. The degree of eosinophilia can be a marker of the severity and prognosis of psoriasis. Some researchers believe that peripheral blood eosinophilia is associated with severe forms of psoriasis (generalized pustular and erythrodermic). A number of scientists have identified an important negative role of the cytokine IL-31, which is secreted by eosinophils, as the main factor in skin itching. Numerous scientific papers indicate the important role of eosinophils in the development of psoriatic inflammation. Further research is needed to study eosinophils and their potential impact on the progression of psoriasis, with the aim of improving treatment and improving the quality of life of patients.

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The authors declare that there are no conflicts of interest present.