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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-336</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9420</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАБОЛЕВАНИЯ КОЖИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DERMAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Особенности себорейной экземы на фоне герпес-вирусных инфекций</article-title><trans-title-group xml:lang="en"><trans-title>Features of seborrheic eczema with underlying herpes-viral infections</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2694-8900</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евдокимов</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Evdokimov</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евдокимов Евгений Юрьевич - д.м.н., ведущий научный сотрудник клинического отдела.</p><p>111123, Москва, ул. Новогиреевская, д. 3а</p></bio><bio xml:lang="en"><p>Evgenii Yu. Evdokimov - Dr. Sci. (Med.), Leading Researcher.</p><p>3a, Novogireevskaya St., Moscow, 111123</p></bio><email xlink:type="simple">evdokimovevg@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5885-4872</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свечникова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Svechnikova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Свечникова Елена Владимировна - д.м.н., профессор кафедры «Кожные и венерические болезни с курсом косметологии».</p><p>125080, Москва, Волоколамское шоссе, д. 11</p></bio><bio xml:lang="en"><p>Elena V. Svechnikova - Dr. Sci. (Med.), Professor, Department of Skin and Venereal Diseases with a Cosmetology Course.</p><p>11, Volokolamskoe Shosse, Moscow, 125080</p></bio><email xlink:type="simple">elene-elene@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6539-4878</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Понежева</surname><given-names>Ж. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponezheva</surname><given-names>Zh. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Понежева Жанна Бетовна - д.м.н., доцент, заведующая клиническим отделом.</p><p>111123, Москва, ул. Новогиреевская, д. 3а</p></bio><bio xml:lang="en"><p>Zhanna B. Ponezheva - Dr. Sci. (Med.), Associate Professor, Head of the Clinical Department.</p><p>3a, Novogireevskaya St., Moscow, 111123</p></bio><email xlink:type="simple">doktorim@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тагирова</surname><given-names>З. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Tagirova</surname><given-names>Z. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тагирова Зарема Гаддимирзоевна - д.м.н., доцент, ведущий научный сотрудник клинического отдела.</p><p>111123, Москва, ул. Новогиреевская, д. 3а</p></bio><bio xml:lang="en"><p>Zarema G. Tagirova - Dr. Sci. (Med.), Associate Professor.</p><p>3a, Novogireevskaya St., Moscow, 111123</p></bio><email xlink:type="simple">tagirovaz05@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8578-2838</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антипят</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Antipyat</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Антипят Наталья Александровна, заместитель главного врача по медицинской части.</p><p>125367, Москва, Волоколамское шоссе, д. 63</p></bio><bio xml:lang="en"><p>Natalya A. Antipyat - Deputy Chief Physician for the Medical Department.</p><p>63, Volokolamskoe Shosse, Moscow, 125367</p></bio><email xlink:type="simple">natadoc70@bk.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-6168-9369</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ханова</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Khanova</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ханова Диана Сайпусадаровна - врач-инфекционист, заведующая инфекционно-боксированным отделением.</p><p>125367, Москва, Волоколамское шоссе, д. 63</p></bio><bio xml:lang="en"><p>Diana S. Khanova - Infectious Disease Specialist, Head of Infectious-Boxed Department.</p><p>63, Volokolamskoe Shosse, Moscow, 125367</p></bio><email xlink:type="simple">dia0207@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Центральный научно-исследовательский институт эпидемиологии Роспотребнадзора<country>Россия</country></aff><aff xml:lang="en">Central Research Institute of Epidemiology<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Российский биотехнологический университет (РОСБИОТЕХ)<country>Россия</country></aff><aff xml:lang="en">Russian Biotechnological University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Инфекционная клиническая больница №1<country>Россия</country></aff><aff xml:lang="en">Infectious Clinical Hospital No. 1<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2025</year></pub-date><volume>0</volume><issue>14</issue><fpage>160</fpage><lpage>166</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Евдокимов Е.Ю., Свечникова Е.В., Понежева Ж.Б., Тагирова З.Г., Антипят Н.А., Ханова Д.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Евдокимов Е.Ю., Свечникова Е.В., Понежева Ж.Б., Тагирова З.Г., Антипят Н.А., Ханова Д.С.</copyright-holder><copyright-holder xml:lang="en">Evdokimov E.Y., Svechnikova E.V., Ponezheva Z.B., Tagirova Z.G., Antipyat N.A., Khanova D.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9420">https://www.med-sovet.pro/jour/article/view/9420</self-uri><abstract><p>Себорейная экзема – хроническое рецидивирующее иммуноопосредованное кожное заболевание, влияющее на качество жизни пациентов. Патогенез развития и течения СЭ окончательно не ясен. Доказанным фактом, связанным с заболеванием, служит повышение на коже у больных в «себорейных зонах» количества дрожжеподобных грибов Malassezia spp. Рост грибов Malassezia spp. связывают с уровнем секреции и изменением состава кожного сала, а также с повышением потливости у пациентов. Но эти изменения не являются достаточными для формирования симптоматики себорейной экземы. Установлено, что помимо основных звеньев патогенеза СЭ существенное влияние на него могут оказывать сопутствующие заболевания и приводить к тому, что клиническая симптоматика СЭ становится более манифестной. По этой причине утяжеление симптоматики СД должно наводить специалиста на мысль о сочетании дерматоза с другими заболеваниями. Наиболее частыми сопутствующими заболеваниями выступают инфекционные процессы, в частности герпес-вирусные инфекции, которые не всегда имеют специфическую клиническую симптоматику. При этом роль герпес-вирусных инфекций в клинических проявлениях дерматоза не изучена. Герпес-вирусные заболевания относят к одним из самых распространенных. Так, в 2020 г. во всем мире среди пациентов возрастной категории от 15 до 50 лет насчитывалось около 570,1 млн (13,5%) человек, зараженных вирусом простого герпеса 2-го типа. Вирус герпеса 1-го типа в этой же возрастной категории и на этот же период выявлен у 395 млн (10,5%) человек. Из всего этого количества пациентов у 50% наблюдались обострения сопутствующих заболеваний, обусловленных наличием вирусной инфекции. При этом доказанным фактом является внесение герпес-вирусными инфекциями существенных нарушений в работу иммунной системы, в частности изменений, выступающих триггерами аутоиммунных процессов. Таким образом, тяжесть себорейной экземы, частота ее обострений могут указывать на наличие скрытых инфекций у пациента.</p></abstract><trans-abstract xml:lang="en"><p>Seborrheic eczema is a chronic recurrent immune – mediated skin disease that significantly impairs the quality of life of patients. The pathogenesis of the development and course of SE is not completely clear. A proven fact related to the disease is an increase in the number of yeast-like fungi Malassezia spp. on the skin of patients in “seborrheic zones”. The growth of fungi Malassezia spp. It is associated with the level of secretion and changes in the composition of sebum, as well as with increased sweating in patients. But these changes are not sufficient for the formation of symptoms of seborrheic eczema. It has been established that in addition to the main links in the pathogenesis of SE, concomitant diseases can have a significant impact on it and lead to the fact that the clinical symptoms of SE become more manifest. For this reason, the aggravation of the symptoms of diabetes should lead a specialist to think about the combination of dermatosis with other diseases. The most common concomitant diseases are infectious processes, in particular herpetisvirus infections, which do not always have specific clinical symptoms. At the same time, the role of herpesvirus infections in the clinical manifestations of dermatosis has not been studied. Herpesvirus diseases are among the most common. So in 2020, there were about 570.1 million (13.5%) people infected with the herpes simplex virus type 2 worldwide, among patients aged 15 to 50 years. Herpes type 1 virus in the same age group and for the same period was detected in 395 million (10.5%) people. Of the total number of patients, 50% had exacerbations of concomitant diseases due to the presence of a viral infection. At the same time, it is a proven fact that herpesvirus infections significantly disrupt the functioning of the immune system, in particular, changes that trigger autoimmune processes. Thus, the severity of seborrheic eczema and the frequency of its exacerbations may indicate the presence of latent infections in the patient.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>себорейная экзема</kwd><kwd>герпес-вирусные инфекции</kwd><kwd>воспалительные дерматозы</kwd><kwd>оксидативный стресс</kwd><kwd>воспаление</kwd></kwd-group><kwd-group xml:lang="en"><kwd>seborrheic eczema</kwd><kwd>herpesvirus infections</kwd><kwd>inflammatory dermatoses</kwd><kwd>oxidative stress</kwd><kwd>inflammation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кубанова АА, Артамонова ОГ, Воронцова АА, Заславский ДВ, Знаменская ЛФ, Зубарева ЕЮ. Экзема: клинические рекомендации. 2024. 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