medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-347medsovet-9421Research ArticleКОСМЕТОЛОГИЯCOSMETOLOGYЭкзосомы в эстетической медицине и дерматологии: обзор и опыт клинического примененияExosomes in aesthetic medicine and dermatology: A review and clinical experiencehttps://orcid.org/0000-0001-7879-6625РазумовскаяЕ. А.RazumovskayaE. A.

Разумовская Елена Александровна - врач-косметолог, пластический хирург, главный врач.

443068, Самара, ул. Ново-Садовая, д. 106н

Elena A. Razumovskaya - Cosmetologist, Plastic Surgeon, Medical Director.

106n, Novo-Sadovaya St., Samara, 443068

ra3umovskaya@mail.ruhttps://orcid.org/0000-0003-4330-2570МураковС. В.MurakovS. V.

Stanislav V. Murakov - Dr. Sci. (Med.), Professor of the Department of Dermatovenereology and Cosmetology, Academy of Postgraduate Education of the FCRC for Specialized Medical Care and Medical Technologies; Medical Director, Head of the Cosmetology Center, Cosmetologist, Lotos 288 LLC.

9, Volokolamskoye Shosse, Moscow, 125371; 111, Bldg. 1, Room 3p, Leninsky Ave., Moscow, 119421

stanislav@doctor.comhttps://orcid.org/0000-0001-5714-5495КапулерО. М.KapulerO. M.

Капулер Ольга Марселевна - д.м.н., профессор, врач высшей категории, главный внештатный специалист Управления здравоохранения г. Уфы по косметологии, внештатный врач-эксперт по косметологии Росздравнадзора по Республике Башкортостан, заслуженный врач РФ; врач-дерматовенеролог, врач-косметолог, Центр косметологии, пластической и реконструктивной хирургии.

450037, Республика Башкортостан, Уфа, ул. Комсомольская, д. 37

Olga M. Kapuler - Dr. Sci. (Med.), Professor, Board Certified Doctor, Chief Consultant for Esthetic Medicine in the Ufa Health Department, External Medical Officer for Esthetic Medicine in the Bashkortostan Department of the Federal Service for Surveillance in Healthcare, Distinguished Physician of the Russian Federation; Dermatovenerologist, Cosmetologist, Center for Esthetic Medicine, Plastic and Reconstructive Surgery.

37, Komsomolskaya St., Ufa, Republic of Bashkortostan, 450037

olga_kapuler@icloud.comhttps://orcid.org/0000-0001-5250-9288КалашниковаН. Г.KalashnikovaN. G.

Калашникова Наталья Геннадиевна - врач-хирург, косметолог, директор по научной работе сети клиник «Линлайн».

119333, Москва, Москва, Университетский проспект, д. 4

Natalia G. Kalashnikova - Surgeon, Сosmetologist, Director of Scientific Research.

4, Universitetsky Ave., Moscow, 119333

kalashnikovaline@mail.ruhttps://orcid.org/0009-0008-6734-1674ГлавноваА. М.GlavnovaA. M.

Главнова Анастасия Михайловна - врач-дерматовенеролог, врач-косметолог, медицинский советник, ООО «Лотос 288».

119421, Москва, Ленинский проспект, д. 111, корп. 1, помещ. 3П

Anastasia M. Glavnova - Dermatologist, Venereologist, Cosmetologist, Medical Advisor.

111, Bldg. 1, Room 3p, Leninsky Ave., Moscow, 119421

stepanicheva.anastasia@yandex.ruhttps://orcid.org/0009-0006-7124-2420КнязьковаЕ. Н.KnyzkovaE. N.

Князькова Елена Николаевна - врач-косметолог, ООО «Лотос 288».

119421, Москва, Ленинский проспект, д. 111, корп. 1, помещ. 3П

Elena N. Knyzkova – Cosmetologist.

111, Bldg. 1, Room 3p, Leninsky Ave., Moscow, 119421

lenaknyzkova@yandex.ruhttps://orcid.org/0009-0009-1098-3171ТимофеевА. В.TimofeevA. V.

Тимофеев Алексей Владимирович - врач-косметолог, пластический хирург, ООО «Лотос 288».

119421, Москва, Ленинский проспект, д. 111, корп. 1, помещ. 3П

Aleksey V. Timofeev - Cosmetologist, Plastic Surgeon.

111, Bldg. 1, Room 3p, Leninsky Ave., Moscow, 119421

dr.alextimofeev@mail.ruКлиника «Ренессанс-Косметология»РоссияRenaissance Cosmetology ClinicRussian FederationАкадемия постдипломного образования Федерального научно-клинического центра специализированных видов медицинской помощи и медицинских технологий; ООО «Лотос 288»РоссияAcademy of Postgraduate Education of the Federal Clinical Research Centre for Specialized Medical Care and Medical Technologies; Lotos 288 LLCRussian FederationЦентр косметологии, пластической и реконструктивной хирургииРоссияCenter for Esthetic Medicine, Plastic and Reconstructive SurgeryRussian FederationСеть клиник «Линлайн»РоссияLinline Clinic ChainRussian FederationООО «Лотос 288»РоссияLotos 288 LLCRussian Federation202530092025014168182Copyright © Разумовская Е.А., Мураков С.В., Капулер О.М., Калашникова Н.Г., Главнова А.М., Князькова Е.Н., Тимофеев А.В., 20252025Разумовская Е.А., Мураков С.В., Капулер О.М., Калашникова Н.Г., Главнова А.М., Князькова Е.Н., Тимофеев А.В.Razumovskaya E.A., Murakov S.V., Kapuler O.M., Kalashnikova N.G., Glavnova A.M., Knyzkova E.N., Timofeev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9421

Экзосомы представляют собой микроскопические частицы, секретируемые различными клетками растений и животных, в том числе человека. В их составе имеются ценные биологически активные вещества, такие как белки, липиды, нуклеиновые кислоты и метаболиты, благодаря которым они могут оказывать положительное воздействие на различные структуры и ткани. В области эстетической медицины и дерматологии экзосомы привлекли к себе внимание благодаря своей способности усиливать синтез коллагена, устранять воспаление и улучшать защиту кожи от внешних неблагоприятных факторов. К настоящему времени накоплен достаточно большой опыт применения продуктов с экзосомами в лечении кожных заболеваний, таких как розацеа, акне, нарушения пигментации, алопеция, а также для устранения косметических дефектов и омоложения кожи. При практическом применении экзосом важно понимание происхождения конкретного продукта, включая производителя и используемые им стандарты производства и анализа, что связано с отсутствием международной стандартизации в этой области. Для достижения максимальной эффективности применения экзосом необходимо следовать официальным инструкциям. В условиях отсутствия унифицированных протоколов применения особую значимость приобретает изучение и анализ практического опыта специалистов в данной сфере. В статье представлены фундаментальные характеристики экзосом, рассмотрены методы их получения и анализа в промышленном масштабе, а также описано текущее состояние их применения в клинической практике. Помимо этого, представлен опыт применения экзосомальной терапии в дерматологии и эстетической медицине.

Exosomes are microscopic particles secreted by various plant and animal cells, including human cells. They carry valuable biologically active substances such as proteins, lipids, nucleic acids, and metabolites that exert beneficial effects on various structures and tissues. In aesthetic medicine and dermatology, exosomes have attracted attention due to their ability to enhance collagen synthesis, eliminate inflammation, and improve the skin’s protection against harmful external factors. To date, considerable clinical experience has been gained in the use of exosome products for the treatment of skin diseases such as rosacea, acne, pigmentation disorders, and alopecia, as well as for aesthetic correction and skin rejuvenation. When using exosomes, it is important to have an understanding of the origin of a particular product, including the manufacturer, the production and analysis standards used, due to the lack of international standardization in this area. For the most effective implementation of exosome-based treatments, adherence to official directions for use is critical. With no unified application protocols available, the evaluation of specialists’ practical experience in this area is particularly valuable. This article presents a general overview of exosomes, discusses their production and analysis on an industrial scale, and describes the current state of their application in clinical practice. In addition, the experience of exosomal therapy in dermatology and aesthetic medicine is presented.

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The authors declare that there are no conflicts of interest present.