medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2025-382medsovet-9445Research ArticleЗАБОЛЕВАНИЯ БИЛИАРНОЙ СИСТЕМЫ И ПЕЧЕНИDISEASES OF THE BILIARY SYSTEM AND LIVERФитотерапия при хронических заболеваниях печениPhytotherapy in chronic liver diseaseshttps://orcid.org/0000-0003-2182-8379ПолунинаТ. Е.PoluninaT. E.

Полунина Татьяна Евгеньевна - д.м.н., профессор кафедры пропедевтики внутренних болезней и гастроэнтерологии.

127006, Россия, Москва, ул. Долгоруковская, д. 4

Tatiana E. Polunina - Dr. Sci. (Med.), Professor of the Department of Propaedeutics of Internal Diseases and Gastroenterology, Russian University of Medicine (ROSUNIMED).

4, Dolgorukovskaya St., Moscow, 127006

poluntan@mail.ruРоссийский университет медицины (РосУниМед)РоссияRussian University of Medicine (ROSUNIMED)Russian Federation202517102025015139147Copyright © Полунина Т.Е., 20252025Полунина Т.Е.Polunina T.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9445

Печень участвует в метаболизме и детоксикации ксенобиотиков, а также в поддержании гомеостаза. Нарушения функции печени связаны с такими заболеваниями, как алкогольная болезнь печени, метаболически ассоциированная жировая болезнь печени, гепатиты, цирроз и рак печени. Лекарственное повреждение печени продолжает оставаться серьезной проблемой. Представленные заболевания печени в совокупности являются основной причиной смертности во всем мире. Хотя традиционные методы лечения помогают контролировать симптомы и замедлять прогрессирование заболеваний печени, им часто мешают такие проблемы, как резистентность к лекарственным препаратам и побочные эффекты. Терапия заболеваний печени с использованием фитопрепаратов предлагает путь для устранения этих ограничений, поскольку многочисленные растительные препараты демонстрируют гепатопротекторные свойства благодаря содержащимся в них биоактивным соединениям, таким как алкалоиды, гликозиды и флавоноиды. Эти природные агенты не только корректируют повреждение печени, но и стимулируют иммунные процессы, которые лежат в основе терапии хронических заболеваний. В статье рассматриваются механизмы повреждения гепатобилиарной зоны и подчеркивается терапевтический потенциал традиционно используемых лекарственных растений в лечении и профилактике заболеваний печени. Опубликованные данные о лечебных свойствах растительных препаратов подтверждают необходимость интеграции традиционных медицинских знаний с современными подходами, особенно в области гепатопротекции, иммуномодуляции и лечения хронических заболеваний печени. Целью данной статьи является оценка потенциала растительных препаратов в комплексной терапии основных заболеваний печени. В статье рассматривается биологическая активность отдельных фитопрепаратов, определяются их биологически активные соединения и выясняются пути, с помощью которых они корректируют повреждения печени.

The liver is involved in the metabolism and detoxification of xenobiotics, as well as in maintaining homeostasis. Impaired liver function has been linked with diseases such as alcoholic liver disease, metabolically associated fatty liver disease, hepatitis, cirrhosis, and liver cancer. Drug-induced liver injury remains a significant challenge. These liver diseases are collectively responsible for the significant mortality worldwide. Although traditional treatments help control symptoms and slow down the progression of liver diseases, they are frequently hindered by issues such as drug resistance and side effects. The treatment of liver diseases with herbal medicinal products offers a way for addressing these limitations, as numerous plant-based medicines exhibit hepatoprotective properties due to their bioactive compounds, such as alkaloids, glycosides, and flavonoids. These natural agents not only mitigate liver injury, but also stimulate immune processes that underlie the treatment of chronic diseases. This article examines the hepatobiliary injury mechanisms and highlights the therapeutic potential of traditionally used medicinal plants in treating and preventing the liver diseases. Published evidence on the therapeutic properties of herbal medicinal products show the importance of the integration of traditional medical knowledge with modern advancements, particularly in the areas of hepatoprotection, immunomodulation, and the treatment of chronic liver diseases. This article was aimed to evaluate the therapeutic potential of herbal medicinal products as part of the complex treatment of major liver diseases. The article explores the biological activity of individual herbal medicinal products, identifies their biologically active compounds, and determines the pathways by which they mitigate liver injury.

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The authors declare that there are no conflicts of interest present.