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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-433</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9565</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>САХАРНЫЙ ДИАБЕТ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DIABETES MELLITUS</subject></subj-group></article-categories><title-group><article-title>Возможности и ограничения применения методов физической терапии в комплексном лечении диабетической ангиопатии</article-title><trans-title-group xml:lang="en"><trans-title>Opportunities and limitations of physical therapy methods in the comprehensive management of diabetic angiopathy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-0658-0666</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симонян</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonyan</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симонян Мариам Андраниковна, младший научный сотрудник отдела нейрореабилитации и клинической психологии</p><p>121099, Россия, Москва, ул. Новый Арбат, д. 32</p></bio><bio xml:lang="en"><p>Mariam A. Simonyan, Junior Research Fellow, Department of Neurorehabilitation and Clinical Psychology</p><p>32, Novyy Arbat St., Moscow, 121099, Russia </p></bio><email xlink:type="simple">hsuum@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6526-4512</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasileva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильева Валерия Александровна, к.м.н., старший научный сотрудник отдела соматической реабилитации, репродуктивного здоровья и активного долголетия</p><p>121099, Россия, Москва, ул. Новый Арбат, д. 32</p></bio><bio xml:lang="en"><p>Valeriia A. Vasileva, Cand. Sci. (Med.), Senior Researcher, Somatic Rehabilitation, Active Longevity and Reproductive Health Department</p><p>32, Novyy Arbat St., Moscow, 121099, Russia </p></bio><email xlink:type="simple">valeri08.00@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1886-124X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марченкова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Marchenkova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марченкова Лариса Александровна, д.м.н., руководитель научно-исследовательского управления, заведующая отделом соматической реабилитации, репродуктивного здоровья и активного долголетия, главный научный сотрудник </p><p>121099, Россия, Москва, ул. Новый Арбат, д. 32</p></bio><bio xml:lang="en"><p>Larisa A. Marchenkova, Dr. Sci. (Med.), Head of Research Department, Head of Somatic Leading Researcher Rehabilitation, Active Longevity and Reproductive Health Department </p><p>32, Novyy Arbat St., Moscow, 121099, Russia </p></bio><email xlink:type="simple">marchenkovala@nmicrk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9275-6491</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузюкова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzyukova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузюкова Анна Александровна, к.м.н., ведущий научный сотрудник, заведующая отделом нейрореабилитации и клинической психологии</p><p>121099, Россия, Москва, ул. Новый Арбат, д. 32</p></bio><bio xml:lang="en"><p>Anna A. Kuzyukova, Cand. Sci. (Med.), Leading Researcher, Head of the Department of Neurorehabilitation and Clinical Psychology</p><p>32, Novyy Arbat St., Moscow, 121099, Russia </p></bio><email xlink:type="simple">kuzyukovaaa@nmicrk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4132-2853</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кияткин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiyatkin</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кияткин Владимир Александрович, к.м.н., доцент, ведущий научный сотрудник отдела соматической реабилитации, репродуктивного здоровья и активного долголетия</p><p>121099, Россия, Москва, ул. Новый Арбат, д. 32</p></bio><bio xml:lang="en"><p>Vladimir A. Kiyatkin, Cand. Sci. (Med.), Associate Professor, Leading Researcher of the Department of Somatic Rehabilitation, Reproductive Health and Active Longevity </p><p>32, Novyy Arbat St., Moscow, 121099, Russia </p></bio><email xlink:type="simple">va_k53@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр реабилитации и курортологии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center of Rehabilitation and Balneology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>16</issue><elocation-id>208–219</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Симонян М.А., Васильева В.А., Марченкова Л.А., Кузюкова А.А., Кияткин В.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Симонян М.А., Васильева В.А., Марченкова Л.А., Кузюкова А.А., Кияткин В.А.</copyright-holder><copyright-holder xml:lang="en">Simonyan M.A., Vasileva V.A., Marchenkova L.A., Kuzyukova A.A., Kiyatkin V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9565">https://www.med-sovet.pro/jour/article/view/9565</self-uri><abstract><p>В представленной статье проведен комплексный анализ современной эпидемиологии, патогенеза, диагностики и подходов к терапии макроангиопатий нижних конечностей у пациентов с сахарным диабетом (СД) 2-го типа. СД представляет собой серьезную медико-социальную проблему, что обусловлено его высокой распространенностью, сохраняющимися темпами роста числа больных, хроническим течением, определяющим кумулятивный характер заболевания, высокой инвалидизацией больных и необходимостью создания системы специализированной помощи. Отмечено, что распространенность СД2 и его макрососудистых осложнений, включая атеросклероз периферических артерий и ишемическую болезнь сердца, продолжает расти, что оказывает значительное влияние на смертность и качество жизни пациентов. Число взрослых пациентов с СД во всем мире превысило 800 млн, причем до 50% из них – лица трудоспособного возраста. Макроангиопатии существенно увеличивают риск сердечно-сосудистых событий и периферических нарушений кровотока. В патогенезе макроангиопатий ведущую роль играют инсулинорезистентность, хроническая гипергликемия и специфические формы диабетической дислипидемии. Клиническая диагностика макроангиопатий основана на комплексной оценке жалоб, физикальном обследовании и инструментальных методах. В лечении приоритет отдается коррекции факторов риска, медикаментозной терапии, а также немедикаментозным подходам, включая методы физической терапии. Перспективными направлениями названы методы (лазерная терапия, низкочастотная электростимуляция, вакуумная терапия), способствующие улучшению микроциркуляции. Авторы подчеркивают, что многофакторный подход, интеграция современных фармакологических и физических методов и регулярное клиническое наблюдение формируют фундамент эффективной реабилитации и профилактики тяжелых сосудистых осложнений у пациентов с СД.</p></abstract><trans-abstract xml:lang="en"><p>The present article provides a comprehensive analysis of the current epidemiology, pathogenesis, diagnostics, and therapeutic approaches for lower extremity macroangiopathies in patients with type 2 diabetes mellitus (DM). DM represents a significant medical and social challenge due to its high prevalence, continuing global growth, chronic progressive nature with cumulative complications, substantial rates of disability, and the associated demand for a specialized system of care. It is noted that the prevalence of DM type 2 and its macrovascular complications, including peripheral arterial atherosclerosis and ischemic heart disease, continues to rise, significantly impacting mortality and patients’ quality of life. The global number of adult patients with diabetes has exceeded 800 million, with up to 50% of them being of working age. Macroangiopathies markedly increase the risk of cardiovascular events and peripheral blood flow disorders. The pathogenesis of these microangiopathies is primarily driven by insulin resistance, chronic hyperglycemia, and specific forms of diabetic dyslipidemia. Clinical diagnosis of macroangiopathies is based on a comprehensive assessment of symptoms, physical examination, and instrumental methods. Treatment prioritizes risk factor modification, pharmacotherapy, as well as non-pharmacological approaches including physical therapy modalities. Promising techniques such as laser therapy, low-frequency electrical stimulation, and vacuum therapy are highlighted for their role in improving microcirculation. The authors emphasize that a multifactorial strategy, integrating modern pharmacological and physical methods alongside regular clinical monitoring, forms the foundation for effective rehabilitation and prevention of severe vascular complications in patients with DM.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>медицинская реабилитация</kwd><kwd>лодыжечно-плечевой индекс</kwd><kwd>ультразвуковое исследование</kwd><kwd>ангиографическое исследование</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>сердечно-лодыжечный сосудистый индекс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>medical rehabilitation</kwd><kwd>ankle-brachial index</kwd><kwd>ultrasonography</kwd><kwd>angiography</kwd><kwd>cardiovascular diseases</kwd><kwd>cardio-ankle vascular index</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов ИИ, Шестакова МВ, Викулова ОК, Железнякова АВ, Исаков МА, Сазонова ДВ, Мокрышева НГ. Сахарный диабет в Российской Федерации: динамика эпидемиологических показателей по данным Федерального регистра сахарного диабета за период 2010–2022 гг. Сахарный диабет. 2023;26(2):104–123. https://doi.org/10.14341/DM13035.</mixed-citation><mixed-citation xml:lang="en">Dedov II, Shestakova MV, Vikulova OK, Zheleznyakova AV, Isakov MA, Sazonova DV, Mokrysheva NG. Diabetes mellitus in the Russian Federation: dynamics of epidemiological indicators according to the Federal Register of Diabetes Mellitus for the period 2010–2022. Diabetes Mellitus. 2023;26(2):104–123. (In Russ.) https://doi.org/10.14341/DM13035.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bin Z, Archie WR, Edward WG, Kate ES, Rodrigo MC, James EB et al. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. ancet. 2024;404(10467):2077–2093. https://doi.org/10.1016/S0140-6736(24)02317-1.</mixed-citation><mixed-citation xml:lang="en">Bin Z, Archie WR, Edward WG, Kate ES, Rodrigo MC, James EB et al. Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants. ancet. 2024;404(10467):2077–2093. https://doi.org/10.1016/S0140-6736(24)02317-1.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Савельева ВА. Влияние длительности заболевания сахарным диабетом второго типа на развитие осложнений. В: Маскевич СА (ред.). Сахаровские чтения 2018 года: экологические проблемы XXI века: материалы конференции. Республика Беларусь, Минск, 17–18 мая 2018 г. Минск: ИВЦ Минфина; 2018. Ч. 2. C. 326–327. Режим доступа: http://aquacultura.org/upload/files/pdf/biblio/crustacea/Голубев_2018.pdf.</mixed-citation><mixed-citation xml:lang="en">Савельева ВА. Влияние длительности заболевания сахарным диабетом второго типа на развитие осложнений. В: Маскевич СА (ред.). Сахаровские чтения 2018 года: экологические проблемы XXI века: материалы конференции. Республика Беларусь, Минск, 17–18 мая 2018 г. Минск: ИВЦ Минфина; 2018. Ч. 2. C. 326–327. Режим доступа: http://aquacultura.org/upload/files/pdf/biblio/crustacea/Голубев_2018.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Демидова ТЮ, Зенина СГ. Молекулярно-генетические особенности развития сахарного диабета и возможности персонализации терапии. Сахарный диабет. 2020;23(5):467–474. https://doi.org/10.14341/DM12486.</mixed-citation><mixed-citation xml:lang="en">Demidova TY, Zenina SG. Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy. Diabetes Mellitus. 2020;23(5):467–474. (In Russ.) https://doi.org/10.14341/DM12486.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Barrera EFX, Szeto A, Mendez AJ, Garg R, Goldberg RB. The nature and characteristics of hypertriglyceridemia in a large cohort with type 2 diabetes. J Diabetes Complications. 2023;37(2):108387. https://doi.org/10.1016/j.jdiacomp.2022.108387.</mixed-citation><mixed-citation xml:lang="en">Barrera EFX, Szeto A, Mendez AJ, Garg R, Goldberg RB. The nature and characteristics of hypertriglyceridemia in a large cohort with type 2 diabetes. J Diabetes Complications. 2023;37(2):108387. https://doi.org/10.1016/j.jdiacomp.2022.108387.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Karakasis P, Theofilis P, Patoulias D, Vlachakis PK, Antoniadis AP, Fragakis N. Diabetes-Driven Atherosclerosis: Updated Mechanistic Insights and Novel Therapeutic Strategies. Int J Mol Sci. 2025;26(5):2196. https://doi.org/10.3390/ijms26052196.</mixed-citation><mixed-citation xml:lang="en">Karakasis P, Theofilis P, Patoulias D, Vlachakis PK, Antoniadis AP, Fragakis N. Diabetes-Driven Atherosclerosis: Updated Mechanistic Insights and Novel Therapeutic Strategies. Int J Mol Sci. 2025;26(5):2196. https://doi.org/10.3390/ijms26052196.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Haddad JA, Annabi FOA, Abbasi H, AlSamen MAA, Ammari FL, Haddad FH. The Prevalence of Atherosclerotic Cardiovascular Disease in Patients with Type 2 Diabetes in Jordan: The PACT-MEA Study. Diabetes Ther. 2025;16(5):899–913. https://doi.org/10.1007/s13300-025-01718-7.</mixed-citation><mixed-citation xml:lang="en">Haddad JA, Annabi FOA, Abbasi H, AlSamen MAA, Ammari FL, Haddad FH. The Prevalence of Atherosclerotic Cardiovascular Disease in Patients with Type 2 Diabetes in Jordan: The PACT-MEA Study. Diabetes Ther. 2025;16(5):899–913. https://doi.org/10.1007/s13300-025-01718-7.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17(1):83. https://doi.org/10.1186/s12933-018-0728-6.</mixed-citation><mixed-citation xml:lang="en">Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17(1):83. https://doi.org/10.1186/s12933-018-0728-6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gyldenkerne C, Olesen KKW, Thrane PG, Hansen MK, StødkildeJørgensen N, Sørensen HT et al. Trends in Peripheral Artery Disease, LowerExtremity Revascularization, and Lower-Extremity Amputation in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study. Diabetes Care. 2025;48(1):76–83.</mixed-citation><mixed-citation xml:lang="en">Gyldenkerne C, Olesen KKW, Thrane PG, Hansen MK, StødkildeJørgensen N, Sørensen HT et al. Trends in Peripheral Artery Disease, LowerExtremity Revascularization, and Lower-Extremity Amputation in Incident Type 2 Diabetes: A Danish Population-Based Cohort Study. Diabetes Care. 2025;48(1):76–83.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Boulton A, Connor H, Cavanagh P. The foot in diabetes 3rd ed. Wiley&amp;Sons; 2000. 372 p. https://doi.org/10.1002/dmrr.833.</mixed-citation><mixed-citation xml:lang="en">Boulton A, Connor H, Cavanagh P. The foot in diabetes 3rd ed. Wiley&amp;Sons; 2000. 372 p. https://doi.org/10.1002/dmrr.833.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Минаков ОЕ, Андреев АА, Остроушко АП. Синдром диабетической стопы. Вестник экспериментально и клинической хирургии. 2017;10(2):165–172. https://doi.org/10.18499/2070-478X-2017-10-2-165-172.</mixed-citation><mixed-citation xml:lang="en">Minakov OE, Andreev AA, Ostroushko AP. The Diabetic Foot Syndrome. Journal of Experimental and Clinical Surgery. 2017;10(2):165–172. (In Russ.) https://doi.org/10.18499/2070-478X-2017-10-2-165-172.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yotsu RR, Pham NM, Oe M, Nagase T, Sanada H, Hara H, et al. Comparison of characteristics and healing course of diabetic foot ulcers by etiological classification: neuropathic, ischemic, and neuro-ischemic type. J Diabetes Complications. 2014;28(4):528–535. https://doi.org/10.1016/j.jdiacomp.2014.03.013.</mixed-citation><mixed-citation xml:lang="en">Yotsu RR, Pham NM, Oe M, Nagase T, Sanada H, Hara H, et al. Comparison of characteristics and healing course of diabetic foot ulcers by etiological classification: neuropathic, ischemic, and neuro-ischemic type. J Diabetes Complications. 2014;28(4):528–535. https://doi.org/10.1016/j.jdiacomp.2014.03.013.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T et al. Borderline ankle-brachial index value of 0.91-0.99 is associated with endothelial dysfunction. Circ J. 2014;78(7):1740–1745. https://doi.org/10.1253/circj.cj-14-0165.</mixed-citation><mixed-citation xml:lang="en">Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T et al. Borderline ankle-brachial index value of 0.91-0.99 is associated with endothelial dysfunction. Circ J. 2014;78(7):1740–1745. https://doi.org/10.1253/circj.cj-14-0165.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressureindependent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13(2):101–107. https://doi.org/10.5551/jat.13.101.</mixed-citation><mixed-citation xml:lang="en">Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressureindependent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13(2):101–107. https://doi.org/10.5551/jat.13.101.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Namba T, Masaki N, Takase B, Adachi T. Arterial Stiffness Assessed by Cardio-Ankle Vascular Index. Int J Mol Sci. 2019;20(15):3664. https://doi.org/10.3390/ijms2015366.</mixed-citation><mixed-citation xml:lang="en">Namba T, Masaki N, Takase B, Adachi T. Arterial Stiffness Assessed by Cardio-Ankle Vascular Index. Int J Mol Sci. 2019;20(15):3664. https://doi.org/10.3390/ijms2015366.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Niwa H, Takahashi K, Dannoura M, Oomori K, Miyoshi A, Inada T et al. The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus. J Atheroscler Thromb. 2019;26(7):616–623. https://doi.org/10.5551/jat.45674.</mixed-citation><mixed-citation xml:lang="en">Niwa H, Takahashi K, Dannoura M, Oomori K, Miyoshi A, Inada T et al. The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index with Macroangiopathy in Patients with Type 2 Diabetes Mellitus. J Atheroscler Thromb. 2019;26(7):616–623. https://doi.org/10.5551/jat.45674.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T et al. Borderline ankle-brachial index value of 0.91-0.99 is associated with endothelial dysfunction. Circ J. 2014;78(7):1740–1745. https://doi.org/10.1253/circj.cj-14-0165.</mixed-citation><mixed-citation xml:lang="en">Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T et al. Borderline ankle-brachial index value of 0.91-0.99 is associated with endothelial dysfunction. Circ J. 2014;78(7):1740–1745. https://doi.org/10.1253/circj.cj-14-0165.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Носов АЕ, Горбушина ОЮ, Власова ЕМ, Алексеев ВБ. Прогностическая значимость параметров артериальной жесткости в выявлении пациентов очень высокого риска. Кардиология. 2020;60(10):27–32. https://doi.org/10.18087/cardio.2020.10.n.1239.</mixed-citation><mixed-citation xml:lang="en">Nosov AE, Gorbushina OY, Vlasova EM, Alekseev VB. Prognostic significance of arterial stiffness parameters in the identification of very high-risk patients. Kardiologiya. 2020;60(10):27–32. (In Russ.) https://doi.org/10.18087/cardio.2020.10.n.1239.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ghimire MR, Acharya S, Pandey S, Aryal D, Shah P, Soti B, et al. Screening of Peripheral Arterial Disease in Patients with Diabetes. J Nepal Health Res Counc. 2023;21(1):46–49. https://doi.org/10.33314/jnhrc.v21i1.4402.</mixed-citation><mixed-citation xml:lang="en">Ghimire MR, Acharya S, Pandey S, Aryal D, Shah P, Soti B, et al. Screening of Peripheral Arterial Disease in Patients with Diabetes. J Nepal Health Res Counc. 2023;21(1):46–49. https://doi.org/10.33314/jnhrc.v21i1.4402.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Akalu Y, Birhan A. Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia. J Diabetes Res. 2020;2020:9419413. https://doi.org/10.1155/2020/9419413.</mixed-citation><mixed-citation xml:lang="en">Akalu Y, Birhan A. Peripheral Arterial Disease and Its Associated Factors among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia. J Diabetes Res. 2020;2020:9419413. https://doi.org/10.1155/2020/9419413.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Song Y, Zhang Y, Zhang Y, Hu B. Two-dimensional ultrasound and twodimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus. Front Neurol. 2022;13:996199. https://doi.org/10.3389/fneur.2022.996199.</mixed-citation><mixed-citation xml:lang="en">Song Y, Zhang Y, Zhang Y, Hu B. Two-dimensional ultrasound and twodimensional shear wave elastography on femoral and saphenous neuropathy in patients with type 2 diabetes mellitus. Front Neurol. 2022;13:996199. https://doi.org/10.3389/fneur.2022.996199.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Tall S, Prahalad P, Adiels M, Rosengren A, Virtanen SM, Maahs DM, Knip M. Increased Risk of Type 1 Diabetes in Boys Under the Age of 5 Years During COVID-19 Lockdowns in Finland, Sweden and Stanford, CA, USA-An Observational Multicenter Study. Diabetes Metab Res Rev. 2025;41(6):e70084. https://doi.org/10.1002/dmrr.70084.</mixed-citation><mixed-citation xml:lang="en">Tall S, Prahalad P, Adiels M, Rosengren A, Virtanen SM, Maahs DM, Knip M. Increased Risk of Type 1 Diabetes in Boys Under the Age of 5 Years During COVID-19 Lockdowns in Finland, Sweden and Stanford, CA, USA-An Observational Multicenter Study. Diabetes Metab Res Rev. 2025;41(6):e70084. https://doi.org/10.1002/dmrr.70084.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1):41. https://doi.org/10.1038/s41572-019-0092-1.</mixed-citation><mixed-citation xml:lang="en">Feldman EL, Callaghan BC, Pop-Busui R, Zochodne DW, Wright DE, Bennett DL et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1):41. https://doi.org/10.1038/s41572-019-0092-1.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Шемякина НА. Новые возможности в диагностике и лечении макроангиопатий нижних конечностей у пациентов сахарным диабетом 2-го типа. Acta Biomedica Scientifica. 2023;26(2S):1–157. https://doi.org/10.12737/article_5a0a8ee3048e76.65175111.</mixed-citation><mixed-citation xml:lang="en">Shemyakina NA. To the question of diagnostics and ways of correction of the diabetic macrovascular disease of the lower extremities in patients with type 2 diabetes mellitus. Acta Biomedica Scientifica. 2023;26(2S):1–157. (In Russ.) https://doi.org/10.12737/article_5a0a8ee3048e76.65175111.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов ИИ, Шестакова МВ, Майоров АЮ, Мокрышева НГ, Андреева ЕН, Безлепкина ОБ и др. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Сахарный диабет. 2023;26(2 Suppl.):1–157. https://doi.org/10.14341/DM13042.</mixed-citation><mixed-citation xml:lang="en">Dedov I, Shestakova M, Mayorov A, Mokrysheva N, Andreeva E, Bezlepkina O et al. Standards of Specialized Diabetes Care. Diabetes Mellitus. 2023;26(2 Suppl.):1–157. (In Russ.) https://doi.org/10.14341/DM13042.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Демидова ТЮ. Сосудистые осложнения сахарного диабета 2 типа за гранью гликемического контроля. Сахарный диабет. 2010;13(3):111–116. https://doi.org/10.14341/2072-0351-5498.</mixed-citation><mixed-citation xml:lang="en">Demidova TY. Vascular complications of type 2 diabetes mellitus beyond the reach of glycemic control. Diabetes Mellitus. 2010;13(3):111–116. (In Russ.) https://doi.org/10.14341/2072-0351-5498.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Christian JB, Bourgeois N, Snipes R, Lowe KA. Prevalence of severe (500 to 2,000 mg/dl) hypertriglyceridemia in United States adults. Am J Cardiol. 2011;107(6):891–897. https://doi.org/10.1016/j.amjcard.2010.11.008.</mixed-citation><mixed-citation xml:lang="en">Christian JB, Bourgeois N, Snipes R, Lowe KA. Prevalence of severe (500 to 2,000 mg/dl) hypertriglyceridemia in United States adults. Am J Cardiol. 2011;107(6):891–897. https://doi.org/10.1016/j.amjcard.2010.11.008.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Temelkova-Kurktschiev T, Hanefeld M. The lipid triad in type 2 diabetes – prevalence and relevance of hypertriglyceridaemia/low high-density lipoprotein syndrome in type 2 diabetes. Exp Clin Endocrinol Diabetes. 2004;112(2):75–79. https://doi.org/10.1055/s-2004-815753.</mixed-citation><mixed-citation xml:lang="en">Temelkova-Kurktschiev T, Hanefeld M. The lipid triad in type 2 diabetes – prevalence and relevance of hypertriglyceridaemia/low high-density lipoprotein syndrome in type 2 diabetes. Exp Clin Endocrinol Diabetes. 2004;112(2):75–79. https://doi.org/10.1055/s-2004-815753.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Глебова АР, Батрак ГА. Особенности макроангиопатии нижних конечностей у пациентов сахарным диабетом 1-го и 2-го типа. В: Томилова ИК (ред.). Медико-биологические, клинические и социальные вопросы здоровья и патологии человека: сборник трудов конференции. Иваново, 7–8 апреля 2020 г. Иваново: Ивановская государственная медицинская академия; 2020. C. 319–321. Режим доступа: https://elibrary.ru/vbascd.</mixed-citation><mixed-citation xml:lang="en">Глебова АР, Батрак ГА. Особенности макроангиопатии нижних конечностей у пациентов сахарным диабетом 1-го и 2-го типа. В: Томилова ИК (ред.). Медико-биологические, клинические и социальные вопросы здоровья и патологии человека: сборник трудов конференции. Иваново, 7–8 апреля 2020 г. Иваново: Ивановская государственная медицинская академия; 2020. C. 319–321. Режим доступа: https://elibrary.ru/vbascd.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-Reactive protein in risk assessment. Am J Med. 2004;116:9–16. https://doi.org/10.1016/j.amjmed.2004.02.006.</mixed-citation><mixed-citation xml:lang="en">Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-Reactive protein in risk assessment. Am J Med. 2004;116:9–16. https://doi.org/10.1016/j.amjmed.2004.02.006.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Oliveira GH. Novel serologic markers of cardiovascular risk. Curr Atheroscler Rep. 2005;7(2):148–154. https://doi.org/10.1007/s11883-005-0038-9</mixed-citation><mixed-citation xml:lang="en">Oliveira GH. Novel serologic markers of cardiovascular risk. Curr Atheroscler Rep. 2005;7(2):148–154. https://doi.org/10.1007/s11883-005-0038-9</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Berg MJ, Graaf Y, Deckers JW, Kanter W, Algra A, Kappelle LJ et al. SMART study group. Smoking cessation and risk of recurrent cardiovascular events and mortality after a first manifestation of arterial disease. Am Heart J. 2019;213:112–122. https://doi.org/10.1016/j.ahj.2019.03.019.</mixed-citation><mixed-citation xml:lang="en">Berg MJ, Graaf Y, Deckers JW, Kanter W, Algra A, Kappelle LJ et al. SMART study group. Smoking cessation and risk of recurrent cardiovascular events and mortality after a first manifestation of arterial disease. Am Heart J. 2019;213:112–122. https://doi.org/10.1016/j.ahj.2019.03.019.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Selvarajah S, Black JH, Malas MB, Lum YW, Propper BW, Abularrage CJ. Preoperative smoking is associated with early graft failure after infrainguinal bypass surgery. J Vasc Surg. 2014;59(5):1308–1314. https://doi.org/10.1016/j.jvs.2013.12.011.</mixed-citation><mixed-citation xml:lang="en">Selvarajah S, Black JH, Malas MB, Lum YW, Propper BW, Abularrage CJ. Preoperative smoking is associated with early graft failure after infrainguinal bypass surgery. J Vasc Surg. 2014;59(5):1308–1314. https://doi.org/10.1016/j.jvs.2013.12.011.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Bohnert KL. Remote Research and Needs in People with Diabetes and Neuropathy. J Diabetes Sci Technol. 2023;(1):52–58. https://doi.org/10.1177/19322968221103610.</mixed-citation><mixed-citation xml:lang="en">Bohnert KL. Remote Research and Needs in People with Diabetes and Neuropathy. J Diabetes Sci Technol. 2023;(1):52–58. https://doi.org/10.1177/19322968221103610.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sorrentino S, Landmesser U. Nonlipid-lowering effects of statins. Curr Treat Options Cardiovasc Med. 2005;7(6):459–466. https://doi.org/10.1007/s11936-005-0031-1.</mixed-citation><mixed-citation xml:lang="en">Sorrentino S, Landmesser U. Nonlipid-lowering effects of statins. Curr Treat Options Cardiovasc Med. 2005;7(6):459–466. https://doi.org/10.1007/s11936-005-0031-1.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Naaman SC. Update on Pillars of Therapy in Diabetic Nephropathy. Diabetes Care. 2023;(9):1574–1586. https://doi.org/10.2337/dci23-0030.</mixed-citation><mixed-citation xml:lang="en">Naaman SC. Update on Pillars of Therapy in Diabetic Nephropathy. Diabetes Care. 2023;(9):1574–1586. https://doi.org/10.2337/dci23-0030.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимов СВ, Козлов А В. Современные подходы в лечении окклюзирующих рестенозов артерий нижних конечностей. Клинический случай. Кардиоваскулярная терапия и профилактика. 2023;22(7S):3635. https://doi.org/10.15829/1728-8800-2023-3635.</mixed-citation><mixed-citation xml:lang="en">Anisimov SV, Kozlov AV. Modern approaches in the treatment of occlusive restenosis of the arteries of the lower extremities. Case report. Cardiovascular Therapy and Prevention. 2023;22(7S):3635. (In Russ.) https://doi.org/10.15829/1728-8800-2023-3635.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Казанцев АВ, Корымасов ЕА. Выбор метода лечения облитерирующего атеросклероза артерий нижних конечностей на основе прогнозирования течения заболевания. Хирургическая практика. 2017;(1):33–37. Режим доступа: https://www.spractice.ru/jour/article/view/47/47.</mixed-citation><mixed-citation xml:lang="en">Kazantsev V, Korymasov EA. Choosing the method of treatment of oblitering atherosclerosis arteries of lower limbs based on prediction of the disease. Surgical Practice (Russia). 2017;(1):33–37. (In Russ.) Available at: https://www.spractice.ru/jour/article/view/47/47.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Сlinical Practice Guidelines. European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication. Eur J Vasc Endovasc Surg. 2024;67(1):9–96. https://doi.org/10.1016/j.ejvs.2023.08.067.</mixed-citation><mixed-citation xml:lang="en">Сlinical Practice Guidelines. European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication. Eur J Vasc Endovasc Surg. 2024;67(1):9–96. https://doi.org/10.1016/j.ejvs.2023.08.067.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Lackland DT, Weber MA. Global burden of cardiovascular disease and stroke: hypertension at the core. Can J Cardiol. 2015;31(5):569–571. https://doi.org/10.1016/j.cjca.2015.01.009.</mixed-citation><mixed-citation xml:lang="en">Lackland DT, Weber MA. Global burden of cardiovascular disease and stroke: hypertension at the core. Can J Cardiol. 2015;31(5):569–571. https://doi.org/10.1016/j.cjca.2015.01.009.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Pearce L, Ghosh J, Counsell A, Serracino-Inglott F. Cilostazol and peripheral arterial disease. Expert Opin Pharmacother. 2008;9(15):2683–2690. https://doi.org/10.1517/14656566.9.15.2683.</mixed-citation><mixed-citation xml:lang="en">Pearce L, Ghosh J, Counsell A, Serracino-Inglott F. Cilostazol and peripheral arterial disease. Expert Opin Pharmacother. 2008;9(15):2683–2690. https://doi.org/10.1517/14656566.9.15.2683.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Litchman ML. Using patient-generated health data from mobile technologies for diabetes self-management support. J Diabetes Sci Technol. 2021;15(2):415–420. https://doi.org/10.1177/1932296813511727.</mixed-citation><mixed-citation xml:lang="en">Litchman ML. Using patient-generated health data from mobile technologies for diabetes self-management support. J Diabetes Sci Technol. 2021;15(2):415–420. https://doi.org/10.1177/1932296813511727.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher EB. Peer support in diabetes self-management: evidence from clinical trials. Family Practice. 2017;34(3):284–290. https://doi.org/10.1377/hlthaff.2011.0914.</mixed-citation><mixed-citation xml:lang="en">Fisher EB. Peer support in diabetes self-management: evidence from clinical trials. Family Practice. 2017;34(3):284–290. https://doi.org/10.1377/hlthaff.2011.0914.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Coccheri S, Mannello F. Development and use of sulodexide in vascular diseases: implications for treatment. Drug Des Devel Ther. 2013;8:49–65. https://doi.org/10.2147/DDDT.S6762.</mixed-citation><mixed-citation xml:lang="en">Coccheri S, Mannello F. Development and use of sulodexide in vascular diseases: implications for treatment. Drug Des Devel Ther. 2013;8:49–65. https://doi.org/10.2147/DDDT.S6762.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kontopodis N, Tavlas E, Papadopoulos G, Pantidis D, Kafetzakis A, Chalkiadakis G, Ioannou C. Effectiveness of platelet-rich plasma to enhance healing of diabetic foot ulcers in patients with concomitant peripheral arterial disease and critical limb ischemia. Int J Low Extrem Wounds. 2016;15(1):45–51. https://doi.org/10.1177/1534734615575829.</mixed-citation><mixed-citation xml:lang="en">Kontopodis N, Tavlas E, Papadopoulos G, Pantidis D, Kafetzakis A, Chalkiadakis G, Ioannou C. Effectiveness of platelet-rich plasma to enhance healing of diabetic foot ulcers in patients with concomitant peripheral arterial disease and critical limb ischemia. Int J Low Extrem Wounds. 2016;15(1):45–51. https://doi.org/10.1177/1534734615575829.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Сучков ИА, Калинин РЕ, Мжаванадзе НД, Камаев АА, Буренин АГ, Ларьков РН. Эффективность и безопасность применения препарата на основе регуляторных полипептидов сосудов для лечения перемежающейся хромоты (результаты многоцентрового двойного слепого плацебо-контролируемого рандомизированного исследования). Ангиология и сосудистая хирургия. 2023;29(1):23–33. Режим доступа: https://www.angiolsurgery.org/magazine/2023/1.</mixed-citation><mixed-citation xml:lang="en">Suchkov IA, Kalinin RE, Mzhavanadze ND, Kamaev AA, Burenin AG, Larkov RN. Efficacy and safety of a vascular regulatory polypeptide-based drug for the treatment of intermittent claudication: results of a multicenter, double-blind, placebo-controlled randomized trial. Angiology and Vascular Surgery. 2023;29(1):23–33. (In Russ.) Available at: https://www.angiolsurgery.org/magazine/2023/1.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Bayliss EA. Multimorbidity and quality of life in adults with type 2 diabetes. Health Qual Life Outcomes. 2014;12:85. https://doi.org/10.4239/wjd.v8.i4.120.</mixed-citation><mixed-citation xml:lang="en">Bayliss EA. Multimorbidity and quality of life in adults with type 2 diabetes. Health Qual Life Outcomes. 2014;12:85. https://doi.org/10.4239/wjd.v8.i4.120.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Ivy JL. Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports Med. 1997;24(5):321–336. https://doi.org/10.2165/00007256-199724050-00004.</mixed-citation><mixed-citation xml:lang="en">Ivy JL. Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports Med. 1997;24(5):321–336. https://doi.org/10.2165/00007256-199724050-00004.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Garber AJ, Handelsman Y, Grunberger G, Einhorn D, Abrahamson MJ, Barzilay JI et al. Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehensive Type 2 Diabetes Management Algorithm – 2020 Executive Summary. Endocr Pract. 2020;26(1):107–139. https://doi.org/10.4158/cs-2019-0472.</mixed-citation><mixed-citation xml:lang="en">Garber AJ, Handelsman Y, Grunberger G, Einhorn D, Abrahamson MJ, Barzilay JI et al. Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehensive Type 2 Diabetes Management Algorithm – 2020 Executive Summary. Endocr Pract. 2020;26(1):107–139. https://doi.org/10.4158/cs-2019-0472.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Magkos F, Tsekouras Y, Kavouras S, Mittendorfer B, Sidossis LS. Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure. Clinical Science. 2008;114(1):59–64. https://doi.org/10.1042/CS20070134.</mixed-citation><mixed-citation xml:lang="en">Magkos F, Tsekouras Y, Kavouras S, Mittendorfer B, Sidossis LS. Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure. Clinical Science. 2008;114(1):59–64. https://doi.org/10.1042/CS20070134.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Signori LU, Rubin Neto LJ, Jaenisch RB, Puntel GO, Nunes GS, Paulitsch FS et al. Effects of therapeutic ultrasound on the endothelial function of patients with type 2 diabetes mellitus. Braz J Med Biol Res. 2023;56:e12576. https://doi.org/10.1590/1414-431X2023e12576.</mixed-citation><mixed-citation xml:lang="en">Signori LU, Rubin Neto LJ, Jaenisch RB, Puntel GO, Nunes GS, Paulitsch FS et al. Effects of therapeutic ultrasound on the endothelial function of patients with type 2 diabetes mellitus. Braz J Med Biol Res. 2023;56:e12576. https://doi.org/10.1590/1414-431X2023e12576.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Khalsa B, Archie M, Nazer B, Razavi MK. Noninvasive therapeutic ultrasound to increase perfusion in chronic limb-threatening ischemia: An early feasibility study. Vasc Med. 2025;30(1):20–26. https://doi.org/10.1177/1358863X241305093.</mixed-citation><mixed-citation xml:lang="en">Khalsa B, Archie M, Nazer B, Razavi MK. Noninvasive therapeutic ultrasound to increase perfusion in chronic limb-threatening ischemia: An early feasibility study. Vasc Med. 2025;30(1):20–26. https://doi.org/10.1177/1358863X241305093.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Ковалева ТВ. Опыт применения лазерной терапии у пациентов сахарным диабетом с дислипидемией. Проблемы эндокринологии. 2002;48(1):13–17. https://doi.org/10.14341/probl11426.</mixed-citation><mixed-citation xml:lang="en">Kovaleva TV. Laser therapy of diabetics with dyslipemia. Problemy Endokrinologii. 2002;48(1):13–17. (In Russ.) https://doi.org/10.14341/probl11426.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Deng YX, Wang XC, Xia ZY, Wan MY, Jiang DY. Efficacy and safety of negative pressure wound therapy for the treatment of diabetic foot ulcers: A metaanalysis. World J Diabetes. 2025;16(6):103520. https://doi.org/10.4239/wjd.v16.i6.103520.</mixed-citation><mixed-citation xml:lang="en">Deng YX, Wang XC, Xia ZY, Wan MY, Jiang DY. Efficacy and safety of negative pressure wound therapy for the treatment of diabetic foot ulcers: A metaanalysis. World J Diabetes. 2025;16(6):103520. https://doi.org/10.4239/wjd.v16.i6.103520.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Ren W, Duan Y, Jan YK, Li J, Liu W, Pu F, Fan Y. Effect of intermittent pneumatic compression with different inflation pressures on the distal microvascular responses of the foot in people with type 2 diabetes mellitus. Int Wound J. 2022;19(5):968–977. https://doi.org/10.1111/iwj.13693.</mixed-citation><mixed-citation xml:lang="en">Ren W, Duan Y, Jan YK, Li J, Liu W, Pu F, Fan Y. Effect of intermittent pneumatic compression with different inflation pressures on the distal microvascular responses of the foot in people with type 2 diabetes mellitus. Int Wound J. 2022;19(5):968–977. https://doi.org/10.1111/iwj.13693.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Delis KT, Labropoulos N, Nicolaides AN, Glenville B, Stansby G. Effect of intermittent pneumatic foot compression on popliteal artery haemodynamics. Eur J Vasc Endovasc Surg. 2000;19(3):270–277. https://doi.org/10.1053/ejvs.1999.1028.</mixed-citation><mixed-citation xml:lang="en">Delis KT, Labropoulos N, Nicolaides AN, Glenville B, Stansby G. Effect of intermittent pneumatic foot compression on popliteal artery haemodynamics. Eur J Vasc Endovasc Surg. 2000;19(3):270–277. https://doi.org/10.1053/ejvs.1999.1028.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Zuj KA, Prince CN, Hughson RL, Peterson SD. Enhanced muscle blood flow with intermittent pneumatic compression of the lower leg during plantar flexion exercise and recovery. J Appl Physiol. 2018;124(2):302–311. https://doi.org/10.1152/japplphysiol.00784.2017</mixed-citation><mixed-citation xml:lang="en">Zuj KA, Prince CN, Hughson RL, Peterson SD. Enhanced muscle blood flow with intermittent pneumatic compression of the lower leg during plantar flexion exercise and recovery. J Appl Physiol. 2018;124(2):302–311. https://doi.org/10.1152/japplphysiol.00784.2017</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Labropoulos N, Wierks C, Suffoletto B. Intermittent pneumatic compression for the treatment of lower extremity arterial disease: a systematic review. Vasc Med. 2002;7(2):141–148. https://doi.org/10.1191/1358863x02vm423oa.</mixed-citation><mixed-citation xml:lang="en">Labropoulos N, Wierks C, Suffoletto B. Intermittent pneumatic compression for the treatment of lower extremity arterial disease: a systematic review. Vasc Med. 2002;7(2):141–148. https://doi.org/10.1191/1358863x02vm423oa.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Баклушина ЕА, Ястребцева ИП. Электромиостимуляция в нейрореабилитации. Физиотерапия, бальнеология и реабилитация. 2016;(1):49–54. https://doi.org/10.18821/1681-3456-2016-15-1-49-54.</mixed-citation><mixed-citation xml:lang="en">Baklushina EA, Yastrebtsova IP. The application of electrical myostimulation for the purpose of neuro-rehabilitation. Russian Journal of Physiotherapy, Balneology and Rehabilitation. 2016;15(1):49–54. (In Russ.) https://doi.org/10.18821/1681-3456-2016-15-1-49-54.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Babber A, Ravikumar R, Onida L, Lane TRA, Davies AH. Effect of footplate neuromuscular electrical stimulation on functional and quality-of-life parameters in patients with peripheral artery disease: pilot, and subsequent randomized clinical trial. Br J Surg. 2020;107(4):355–363. https://doi.org/10.1002/bjs.11398.</mixed-citation><mixed-citation xml:lang="en">Babber A, Ravikumar R, Onida L, Lane TRA, Davies AH. Effect of footplate neuromuscular electrical stimulation on functional and quality-of-life parameters in patients with peripheral artery disease: pilot, and subsequent randomized clinical trial. Br J Surg. 2020;107(4):355–363. https://doi.org/10.1002/bjs.11398.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Burgess L, Smith S, Babber A, Shalhoub J, Fiorentino F, de la Rosa CN et al. Neuromuscular electrical stimulation as an adjunct to standard care in improving walking distances in intermittent claudication patients: the NESIC RCT. Southampton (UK): National Institute for Health and Care Research; 2023. https://doi.org/10.3310/WGRF4128.</mixed-citation><mixed-citation xml:lang="en">Burgess L, Smith S, Babber A, Shalhoub J, Fiorentino F, de la Rosa CN et al. Neuromuscular electrical stimulation as an adjunct to standard care in improving walking distances in intermittent claudication patients: the NESIC RCT. Southampton (UK): National Institute for Health and Care Research; 2023. https://doi.org/10.3310/WGRF4128.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Gomes Neto M, Oliveira FA, Reis HF, de Sousa Rodrigues- E Jr, Bittencourt HS, Oliveira Carvalho V. Effects of neuromuscular electrical stimulation on physiologic and functional measurements in patients with heart failure: A systematic review with meta-analysis. J Cardiopulm Rehabil Prev. 2016;36(3):157–166. https://doi.org/10.1097/hcr.0000000000000151.</mixed-citation><mixed-citation xml:lang="en">Gomes Neto M, Oliveira FA, Reis HF, de Sousa Rodrigues- E Jr, Bittencourt HS, Oliveira Carvalho V. Effects of neuromuscular electrical stimulation on physiologic and functional measurements in patients with heart failure: A systematic review with meta-analysis. J Cardiopulm Rehabil Prev. 2016;36(3):157–166. https://doi.org/10.1097/hcr.0000000000000151.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Smith A, Brown C, Jones D, Smith S, Rosa CN , Fiorentino F et al. Neuromuscular electrical stimulation in patients with intermittent claudication: a multicenter randomized controlled trial (NESIC). Eur J Vasc Endovasc Surg. 2023;65(1):88–96. https://doi.org/10.1016/j.ejvs.2022.08.012.</mixed-citation><mixed-citation xml:lang="en">Smith A, Brown C, Jones D, Smith S, Rosa CN , Fiorentino F et al. Neuromuscular electrical stimulation in patients with intermittent claudication: a multicenter randomized controlled trial (NESIC). Eur J Vasc Endovasc Surg. 2023;65(1):88–96. https://doi.org/10.1016/j.ejvs.2022.08.012.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Mahdi AA, Mahmoud RR. An eight-week pulsed electromagnetic field improves physical functional performance and ankle-brachial index in men with Fontaine stage II peripheral artery disease. Adv Rehabil. 2021;35(4):1–8. https://doi.org/10.5114/areh.2021.109710.</mixed-citation><mixed-citation xml:lang="en">Mahdi AA, Mahmoud RR. An eight-week pulsed electromagnetic field improves physical functional performance and ankle-brachial index in men with Fontaine stage II peripheral artery disease. Adv Rehabil. 2021;35(4):1–8. https://doi.org/10.5114/areh.2021.109710.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
