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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-432</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9571</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРИКЛАДНЫЕ АСПЕКТЫ ЭНДОКРИНОЛОГИИ И КАРДИОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>APPLIED ASPECTS OF ENDOCRINOLOGY AND CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Рабдомиолиз как грозное осложнение первичного гиперальдостеронизма</article-title><trans-title-group xml:lang="en"><trans-title>Rhabdomyolysis as a dangerous complication of primary hyperaldosteronism</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7840-4174</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Реброва</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebrova</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Реброва Дина Владимировна, к.м.н., доцент кафедры эндокринной хирургии, врач-эндокринолог</p><p>Scopus Author ID:57195152806; Researcher ID: AHD-5099-2022</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154</p></bio><bio xml:lang="en"><p>Dina V. Rebrova, Cand. Sci. (Med.), Associate Professor of Endocrine Surgery Department, Endocrinologist</p><p>Scopus Author ID: 57195152806; Researcher ID: AHD-5099-2022</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">endocrinology@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4897-6144</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Непомнящая</surname><given-names>С. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nepomnyashchaya</surname><given-names>S. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Непомнящая Светлана Леонидовна, к.м.н., доцент кафедры хирургии, врач-хирург</p><p>Researcher ID: Е-5875-2017</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154</p></bio><bio xml:lang="en"><p>Svetlana L. Nepomnyashchaya, Cand. Sci. (Med.), Associate Professor of Surgery Department, Surgeon</p><p>Researcher ID: Е-5875-2017</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">nsmapo@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6807-778X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Русаков</surname><given-names>В. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Rusakov</surname><given-names>V. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Русаков Владимир Федорович, к.м.н., врач-эндокринолог</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154 </p></bio><bio xml:lang="en"><p>Vladimir F. Rusakov, Cand. Sci. (Med.), Associate Professor, Endocrinologist</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">rusvf@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1294-811X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федоров</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorov</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Федоров Елисей Александрович, к.м.н., врач-хирург</p><p>Scopus Author ID: 57190018578</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154</p></bio><bio xml:lang="en"><p>Elisey A. Fedorov, Cand. Sci. (Med.), Associate Professor, Surgeon</p><p>Scopus Author ID: 57190018578</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">elick@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4449-0251</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Краснов</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnov</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Краснов Леонид Михайлович, д.м.н., начальник учебно-образовательного отдела</p><p>Scopus Author ID: 7003572477 </p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154 </p></bio><bio xml:lang="en"><p>Leonid M. Krasnov, Dr. Sci. (Med.), Head of Educational Department</p><p>Scopus Author ID: 7003572477</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">krasnov.surg@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5531-423X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бахтиярова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakhtiyarova</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бахтиярова Алюза Рамильевна, сотрудник учебно-образовательного отдела</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154 </p></bio><bio xml:lang="en"><p>Alyuza R. Bakhtiyarova, Researcher of Educational Department</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">alyuza_endo@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2484-4895</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинова</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginova</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Логинова Ольга Ивановна, врач-рентгенолог</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154 </p></bio><bio xml:lang="en"><p>Olga I. Loginova, Radiologist</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">olga7.smirnova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3001-664X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черников</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernikov</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черников Роман Анатольевич, д.м.н., профессор кафедры эндокринной хирургии, заведующий отделением эндокринной хирургии</p><p>Scopus Author ID: 57190294900; Researcher ID: AAZ-1549-2021</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154 </p></bio><bio xml:lang="en"><p>Roman A. Chernikov, Dr. Sci. (Med.), Professor of Endocrine Surgery Department, Head of Endocrine Surgery Department</p><p>Scopus Author ID: 57190294900; Researcher ID: AAZ-1549-2021</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">yaddd@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1903-5081</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слепцов</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sleptsov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Слепцов Илья Валерьевич, д.м.н., заведующий кафедрой эндокринной хирургии, врач-хирург</p><p>Scopus Author ID: 57216017997; Researcher ID: F-1670-2019</p><p>190103, Россия, Санкт-Петербург, наб. р. Фонтанки, д. 154 </p></bio><bio xml:lang="en"><p>Ilya V. Sleptsov, Dr. Sci. (Med.), Head of Endocrine Surgery Department</p><p>Scopus Author ID: 57216017997; Researcher ID: F-1670-2019</p><p>154, Fontanka River Emb., St Petersburg, 190103, Russia </p></bio><email xlink:type="simple">newsurgery@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Клиника высоких медицинских технологий имени Н.И. Пирогова Санкт-Петербургского государственного университета</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg State University Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>16</issue><elocation-id>273–282</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Реброва Д.В., Непомнящая С.Л., Русаков В.Ф., Федоров Е.А., Краснов Л.М., Бахтиярова А.Р., Логинова О.И., Черников Р.А., Слепцов И.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Реброва Д.В., Непомнящая С.Л., Русаков В.Ф., Федоров Е.А., Краснов Л.М., Бахтиярова А.Р., Логинова О.И., Черников Р.А., Слепцов И.В.</copyright-holder><copyright-holder xml:lang="en">Rebrova D.V., Nepomnyashchaya S.L., Rusakov V.F., Fedorov E.A., Krasnov L.M., Bakhtiyarova A.R., Loginova O.I., Chernikov R.A., Sleptsov I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9571">https://www.med-sovet.pro/jour/article/view/9571</self-uri><abstract><p>Рабдомиолиз является редким грозным осложнением первичного гиперальдостеронизма (ПГА), возникающим на фоне гипокалиемии. Своевременная диагностика ПГА как причины развития гипокалиемии является актуальной задачей для врачей различных специальностей. Прогрессирующая мышечная слабость как основной симптом развития поражения мышц является обязательным поводом для контроля электролитного баланса, а при выявлении гипокалиемии – дальнейшего обследования с целью выявления ее причин, а не только назначения симптоматической терапии. Представляем подробное описание двух случаев развития рабдомиолиза на фоне гипокалиемии. Пациентка 1, 45 лет, с повышением артериального давления (АД) до 220/120 мм рт. ст., не поддающимся коррекции на фоне трехкомпонентной гипотензивной терапии, с жалобами на головные боли, головокружения, потливость, выраженную мышечную слабость конечностей, боли в мышцах, поступила остро в стационар, где выявлены креатинфосфокиназа (КФК) 17204 МЕ/л (до 145), КФК-МВ 205 МЕ/л (до 24), аспартатаминотрасфераза (АСТ) 889 Е/л (до 35), аланинаминотрансфераза (АЛТ) 232 Е/л (до 40), калий крови 2,0 ммоль/л (3,3–5,5). Неврологом, ревматологом исключена патология. Выявлена альдостерома правого надпочечника с нормализацией АД и уровня калия после адреналэктомии. Пациентка 2, 55 лет, с повышением АД 200/110 мм рт. ст., общей и мышечной слабостью, выраженными болями в мышцах и суставах конечностей, одышкой при физической нагрузке, ощущением перебоев в работе сердца, в течение 6 лет наблюдалась кардиологом, неврологом, ревматологом, с неоднократными госпитализациями, в т. ч. по поводу рабдомиолиза. Несмотря на повторяющуюся гипокалиемию, обследование надпочечников выполнено только после консультации эндокринолога в связи с потерей сознания на фоне гипогликемии. При обследовании выявлен первичный гиперпаратиреоз, двусторонний ПГА, узловой нетоксический зоб, микроаденома гипофиза. На пробе с 72-часовым голоданием гипогликемия не достигнута. Клинически установлен синдром множественной эндокринной неоплазии 1-го типа. В доступной литературе на русском и английском языке нами найдено описание менее 40 подобных случаев, описание которых также представлено в обсуждении.</p></abstract><trans-abstract xml:lang="en"><p>Rhabdomyolysis is a rare, dangerous complication of primary hyperaldosteronism (PHA) induced by hypokalemia. PHA is underdiagnosed because it does not have a specific, easily identifiable feature and clinicians can be poorly aware of the disease. Prompt diagnosis of PHA and the use of targeted treatment strategies mitigate aldosterone-specific target organ damage, such as rhabdomyolysis. Progressive muscle weakness, as the main symptom of the development of muscle damage, is a reason to monitor electrolyte balance. We present a detailed description of two cases of rhabdomyolysis with hypokalemia. Patient 1, 45 y.o., with an increase in blood pressure (BP) to 220/120 mmHg, which could not be corrected against the background of 3-component antihypertensive therapy, with complaints of headaches, dizziness, sweating, severe muscle weakness of the extremities, muscle pain, was acutely admitted to the hospital, where creatine phosphokinase (CPK) 17204 IU/l (up to 145), CPKMB 205 IU/L (up to 24), AST 889 U/L (up to 35), ALT 232 U/L (up to 40), blood potassium 2.0 mmol/L (3.3–5.5). Neurologist, rheumatologist excluded pathology. Aldosteroma of the right adrenal gland was detected with normalization of BP and potassium levels after adrenalectomy. Patient 2, 55 y.o., with an increased BP of 200/110 mmHg, general and muscular weakness, severe pain in the muscles and joints of the extremities, shortness of breath during physical exertion, heart arrhythmia, was observed for 6 years by a cardiologist, neurologist, rheumatologist, with repeated hospitalizations, including for about rhabdomyolysis. Despite recurrent hypokalemia, the adrenal gland examination was performed only after consultation with an endocrinologist due to loss of consciousness in case of hypoglycemia. The examination revealed primary hyperparathyroidism, bilateral PHA, non-toxic nodular goiter, pituitary microadenoma. Hypoglycemia was not achieved in the 72-hour fasting trial. Multiple endocrine neoplasia type 1 syndrome has been established clinically. In the available literature in Russian and in English, we have found the description of less than 40 similar case reports. A detailed description of those cases is also provided.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мышечная слабость</kwd><kwd>тетрапарез</kwd><kwd>гипокалиемия</kwd><kwd>идиопатический гиперальдостеронизм</kwd><kwd>альдостерома</kwd><kwd>синдром МЭН1</kwd></kwd-group><kwd-group xml:lang="en"><kwd>muscle weakness</kwd><kwd>hypokalemia</kwd><kwd>primary aldosteronism</kwd><kwd>bilateral hyperaldoateronism</kwd><kwd>aldosteroma</kwd><kwd>MEN1 syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Реброва ДВ, Ворохобина НВ, Баранов ВЛ, Великанова ЛИ. Способ дифференциальной диагностики основных форм первичного гиперальдостеронизма с применением высокоэффективной жидкостной хроматографии. 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