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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-375</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9572</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРИКЛАДНЫЕ АСПЕКТЫ ЭНДОКРИНОЛОГИИ И КАРДИОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>APPLIED ASPECTS OF ENDOCRINOLOGY AND CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Значимость некоторых лейкоцитарных индексов у пациентов с сахарным диабетом 2-го типа, перенесших новую коронавирусную инфекцию</article-title><trans-title-group xml:lang="en"><trans-title>Significance of certain leukocyte indices in patients with type 2 diabetes who have had novel coronavirus infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7080-8713</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суханов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukhanov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суханов Сергей Александрович, ассистент кафедры терапии и общей врачебной практики</p><p>603005, Россия, Нижний Новгород, площадь Мининаи Пожарского, д. 10/1</p></bio><bio xml:lang="en"><p>Sergey A. Sukhanov, Assistent of the Department of Therapy and General Medical Practice</p><p>10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603950, Russia</p></bio><email xlink:type="simple">sukhanov.aleck@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8430-237X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сорокина</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokina</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сорокина Юлия Андреевна, к.б.н., доцент кафедры общей и клинической фармакологии</p><p>603005, Россия, Нижний Новгород, площадь Мининаи Пожарского, д. 10/1</p></bio><bio xml:lang="en"><p>Yulia A. Sorokina, Cand. Sci. (Biol.), Associate Professor of the Department of General and Clinical Pharmacology</p><p>10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603950, Russia</p></bio><email xlink:type="simple">zwx@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1830-3600</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Занозина</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zanozina</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Занозина Ольга Владимировна, д.м.н., доцент, профессор кафедры терапии и общей врачебной практики; заведующая эндокринологическим отделением</p><p>603005, Россия, Нижний Новгород, площадь Мининаи Пожарского, д. 10/1</p><p>603126, Россия, Нижний Новгород, ул. Родионова, д. 190</p></bio><bio xml:lang="en"><p>Olga V. Zanozina, Dr. Sci. (Med.), Associate Professor, Professor of the Department of Therapy and General Medical Practice; Head of the Endocrinology Department </p><p>10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603950, Russia</p><p>190, Rodionov St., Nizhny Novgorod, 603126, Russia</p></bio><email xlink:type="simple">zwx2@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3659-3576</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мосина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mosinа</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мосина Анна Алексеевна, ассистент кафедры общей и клинической фармакологии</p><p>603005, Россия, Нижний Новгород, площадь Мининаи Пожарского, д. 10/1</p></bio><bio xml:lang="en"><p>Anna A. Mosinа, Assistent of the Department of General and Clinical Pharmacology </p><p>10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603950, Russia</p></bio><email xlink:type="simple">anna.mosina.99@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-3372-5437</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капранова</surname><given-names>И. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kapranova</surname><given-names>I. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Капранова Ирина Дмитриевна, студент лечебного факультета</p><p>603005, Россия, Нижний Новгород, площадь Мининаи Пожарского, д. 10/1</p></bio><bio xml:lang="en"><p>Irina D. Kapranova, Student of the Faculty of Medicine</p><p>10/1, Minin and Pozharsky Square, Nizhny Novgorod, 603950, Russia</p></bio><email xlink:type="simple">ikapranova5@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Приволжский исследовательский медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Privolzhsky Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Приволжский исследовательский медицинский университет;&#13;
Нижегородская областная клиническая больница имени Н.А. Семашко</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Privolzhsky Research Medical University;&#13;
Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>20</day><month>11</month><year>2025</year></pub-date><volume>0</volume><issue>16</issue><elocation-id>283–290</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Суханов С.А., Сорокина Ю.А., Занозина О.В., Мосина А.А., Капранова И.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Суханов С.А., Сорокина Ю.А., Занозина О.В., Мосина А.А., Капранова И.Д.</copyright-holder><copyright-holder xml:lang="en">Sukhanov S.A., Sorokina Y.A., Zanozina O.V., Mosinа A.A., Kapranova I.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9572">https://www.med-sovet.pro/jour/article/view/9572</self-uri><abstract><p>Одним из механизмов развития сахарного диабета 2-го типа является хроническое низкоинтенсивное воспаление. С целью объективизации данного процесса используются некоторые лейкоцитарные индексы (отношение нейтрофилов к лимфоцитам – NLR, отношение тромбоцитов к лимфоцитам – PLR, отношение лимфоцитов к моноцитам – LMR, отношение моноцитов к лимфоцитам – MLR, а также индекс системного иммунного воспаления SII (рассчитывается с учетом нейтрофилов, лимфоцитов, тромбоцитов) с учетом наличия у больных с сахарным диабетом как микрососудистых, так и макрососудистых поздних оосложнений. Новая коронавирусная инфекция значимо увеличивает процесс воспаления, при этом многие лейкоцитарные индексы являются прогностическими маркерами исхода заболевания. В статье приведены последние данные о значимости маркеров воспаления у мультиморбидных пациентов при наличии новой коронавирусной инфекции. Сделан акцент на то, что данные об изучении лейкоцитарных индексов у больных с сахарным диабетом, перенесших новую коронавирусную инфекцию, единичны, а информация о применении такого простого инструмента изучения воспаления, как лейкоцитарные индексы в оценке постковидных нарушений у больных с сахарным диабетом, отсутствует. Приведены собственные данные. Сделан вывод о том, что изучение воспаления у больных с СД 2-го типа и постковидным синдромом с использованием лейкоцитарных индексов представляет большой интерес.</p></abstract><trans-abstract xml:lang="en"><p>Сhronic low-intensity inflammation is the one of the mechanisms of development of diabetes mellitus type 2. In order to objectify this process, some leukocyte indices are used (the ratio of neutrophils to lymphocytes – NLR, the ratio of platelets to lymphocytes – PLR, the ratio of lymphocytes to monocytes – LMR, the ratio of monocytes to lymphocytes – MLR, as well as the index of systemic immune inflammation SII (calculated taking into account neutrophils, lymphocytes, platelets), taking into account the presence of both microvascular and macrovascular late complications in patients with diabetes mellitus. The new coronavirus infection significantly increases the inflammation process that’s why some leukocyte indices are to be prognostic markers of the disease outcomes. The article presents the latest data on the significance of inflammation markers in multimorbid patients with a new coronavirus infection. It is emphasized that data on the study of leukocyte indices in patients with diabetes mellitus who have had a new coronavirus infection are scarce, and information on the use of such a simple tool for studying inflammation as leukocyte indices in assessing post-COVID disorders in patients with diabetes mellitus is absent. Our data concluded that the learning information about inflammation in patients with type 2 diabetes and post-COVID syndrome using leukocyte indices is really promising.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лейкоцитарные индексы</kwd><kwd>воспаление</kwd><kwd>сахарный диабет 2-го типа</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>постковидный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>leukocyte indices</kwd><kwd>inflammation</kwd><kwd>type 2 diabetes mellitus</kwd><kwd>new coronavirus infection</kwd><kwd>post-COVID syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Климонтов ВВ, Тян НВ, Фазуллина ОН, Мякина НЕ, Лыков АП, Коненков ВИ. Клинические и метаболические факторы, ассоциированные с хроническим воспалением низкой интенсивности, у больных сахарным диабетом 2-го типа. 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