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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-512</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9633</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЦЕРЕБРОВАСКУЛЯРНЫЕ ЗАБОЛЕВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CEREBROVASCULAR DISEASES</subject></subj-group></article-categories><title-group><article-title>Уровень центральной сенситизации, тревоги и депрессии у пациентов в раннем восстановительном периоде ишемического инсульта</article-title><trans-title-group xml:lang="en"><trans-title>Levels of central sensitization, anxiety, and depression in patients after ischemic stroke in the early recovery period</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6762-8845</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Есин</surname><given-names>Р. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Esin</surname><given-names>R. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Есин Радий Германович, д.м.н., профессор, профессор кафедры неврологии с курсами психиатрии, клинической психологии и медицинской генетики, ведущий научный сотрудник научно­-исследовательской лаборатории «Нейрокогнитивные исследования»</p><p>420008, Казань, Республика Татарстан, ул. Кремлевская, д. 18</p></bio><bio xml:lang="en"><p>Radiy G. Esin, Dr. Sci. (Med.), Professor, Professor of the Department of Neurology with Courses In Psychiatry, Clinical Psychology and Medical Genetics, Leading Researcher at the Neurocognitive Research Laboratory</p><p>18, Kremlyovskaya St., Kazan, Republic of Tatarstan, 420008</p></bio><email xlink:type="simple">radyesin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2692-1698</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Замалетдинов</surname><given-names>Р. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Zamaletdinov</surname><given-names>R. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Замалетдинов Радиф Рифкатович, д.фил.н., профессор, директор Института филологии и межкультурной коммуникации, главный научный сотрудник научно-­исследовательской лаборатории «Нейрокогнитивные исследования»</p><p>420008, Казань, Республика Татарстан, ул. Кремлевская, д. 18</p></bio><bio xml:lang="en"><p>Radif R. Zamaletdinov, Dr. Sci. (Phil.), Professor, Director of the Institute of Philology and Intercultural Communication, Chief Researcher at the Neurocognitive Research Laboratory</p><p>18, Kremlyovskaya St., Kazan, Republic of Tatarstan, 420008</p></bio><email xlink:type="simple">sovet.rus16@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-7201-8465</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фатыхова</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Fatykhova</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фатыхова Алиса Фазыловна, инженер научно-­исследовательской лаборатории «Нейрокогнитивные исследования»</p><p>420008, Казань, Республика Татарстан, ул. Кремлевская, д. 18</p></bio><bio xml:lang="en"><p>Alisa A. Fatykhova, Engineer at the Neurocognitive Research Laboratory</p><p>18, Kremlyovskaya St., Kazan, Republic of Tatarstan, 420008</p></bio><email xlink:type="simple">alisafatyhova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8582-592X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гамирова</surname><given-names>Р. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gamirova</surname><given-names>R. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гамирова Римма Габдульбаровна, к.м.н., доцент, заведующая кафедрой неврологии с курсами психиатрии, клинической психологии и медицинской генетики, ведущий научный сотрудник  научно-исследовательской лаборатории «Нейрокогнитивные исследования»</p><p>420008, Казань, Республика Татарстан, ул. Кремлевская, д. 18</p></bio><bio xml:lang="en"><p>Rimma G. Gamirova, Cand. Sci. (Med.), Associate Professor, Head of the Department of Neurology with Courses in Psychiatry, Clinical Psychology and Medical Genetics, Leading Researcher at the Neurocognitive Research Laboratory</p><p>18, Kremlyovskaya St., Kazan, Republic of Tatarstan, 420008</p></bio><email xlink:type="simple">rgamirov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3859-5543</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горобец</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorobets</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горобец Елена Анатольевна, к.фил.н., доцент, ведущий научный сотрудник научно-исследовательской лаборатории «Нейрокогнитивные исследования», заведующая Центром патологии речи, заведующая кафедрой прикладной и экспериментальной лингвистики</p><p>420008, Казань, Республика Татарстан, ул. Кремлевская, д. 18</p></bio><bio xml:lang="en"><p>Elena A. Gorobets, Cand. Sci. (Phil.), Associate Professor, Leading Researcher at the Neurocognitive Research Laboratory, Head of the Center for Speech Pathology, Head of the Department of Applied and Experimental Linguistics</p><p>18, Kremlyovskaya St., Kazan, Republic of Tatarstan, 420008</p></bio><email xlink:type="simple">Elena.Gorobets@kpfu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-2387-278X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мардугалямова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mardugalyamova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мардугалямова Мария Викторовна, аспирант кафедры неврологии с курсами психиатрии, клинической психологии и медицинской генетики, младший научный сотрудник научно-исследовательской лаборатории «Нейрокогнитивные исследования»</p><p>420008, Казань, Республика Татарстан, ул. Кремлевская, д. 18</p></bio><bio xml:lang="en"><p>Mariya V. Mardugalyamova, Postgraduate Student of the Department of Neurology with Courses in Psychiatry, Clinical Psychology and Medical Genetics, Junior Researcher at the Neurocognitive Research Laboratory</p><p>18, Kremlyovskaya St., Kazan, Republic of Tatarstan, 420008</p></bio><email xlink:type="simple">marimarichen55@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Казанский (Приволжский) федеральный университет<country>Россия</country></aff><aff xml:lang="en">Kazan (Volga Region) Federal University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>04</day><month>12</month><year>2025</year></pub-date><volume>0</volume><issue>22</issue><fpage>20</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Есин Р.Г., Замалетдинов Р.Р., Фатыхова А.Ф., Гамирова Р.Г., Горобец Е.А., Мардугалямова М.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Есин Р.Г., Замалетдинов Р.Р., Фатыхова А.Ф., Гамирова Р.Г., Горобец Е.А., Мардугалямова М.В.</copyright-holder><copyright-holder xml:lang="en">Esin R.G., Zamaletdinov R.R., Fatykhova A.F., Gamirova R.G., Gorobets E.A., Mardugalyamova M.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9633">https://www.med-sovet.pro/jour/article/view/9633</self-uri><abstract><sec><title>Введение</title><p>Введение. Проблемы постинсультной тревоги, депрессии и боли актуальны для медицинской практики, поскольку представляют собой существенное препятствие для эффективной реабилитации пациентов. В литературе анализируется информация, связанная с постинсультной тревогой и депрессией, однако данных об уровне центральной сенситизации (ЦС), которая также указывает на наличие коморбидных расстройств, недостаточно. Кроме того, в выборках носителей различных языков народов Российской Федерации такие исследования до недавнего времени не проводились ввиду отсутствия диагностических инструментов на этих языках.</p></sec><sec><title>Цель</title><p>Цель. Сравнить показатели уровня ЦС, тревоги и депрессии у пациентов после ишемического инсульта в раннем восстановительном периоде, полученные посредством применения одного и того же инструментария на разных языках в сопоставимых выборках.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен анализ уровня ЦС, тревоги и депрессии в 4 группах. Группы исследования: 1) русскоязычные пациенты, перенесшие ишемический инсульт (30 пациентов, ранний восстановительный период); 2) татароязычные пациенты, перенесшие ишемический инсульт (30 пациентов, ранний восстановительный период). Группы сравнения: 1) русскоязычные информанты без неврологического дефицита (30 человек); 2) татароязычные информанты без неврологического дефицита (30 человек). Для оценки уровня ЦС, депрессии и тревоги использовались опросник ЦС (ОЦС, русскоязычный и татароязычный варианты) и госпитальная шкала тревоги и депрессии (ГШТД, русскоязычный и татароязычный варианты).</p></sec><sec><title>Результаты</title><p>Результаты. Показано наличие статистически значимых различий между группами пациентов и группами сравнения по параметру «субклиническая ЦС». Среди пациентов, перенесших инсульт, субклинический вариант ЦС встречается реже, чем у здоровых; у пациентов доминируют клинически выраженные варианты. Выявлено статистически значимое повышение тревожности по субшкале тревоги ГШТД, а также наличие депрессии по субшкале депрессии у русскоязычных и татароязычных пациентов в раннем восстановительном периоде ишемического инсульта.</p></sec><sec><title>Заключение</title><p>Заключение. Установлено повышение ЦС, тревожности и наличие депрессии у пациентов в раннем восстановительном периоде ишемического инсульта. Подтверждена универсальность диагностических шкал ОЦС и ГШТД для использования в диагностике тревоги, депрессии и ЦС как у русскоязычных, так и у татароязычных постинсультных пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Post-stroke anxiety, depression, and pain are relevant to medical practice, since they represent a significant obstacle to the effective rehabilitation of patients. Information related to post-stroke anxiety and depression is analyzed in the literature, data on the level of central sensitization (CS) which also indicates the presence of comorbid disorders are insufficient. Furthermore, such studies have not been conducted in samples of native speakers of various languages of the Russian Federation until recently due to the lack of diagnostic tools in these languages.</p></sec><sec><title>Aim</title><p>Aim. To compare the levels of СS, anxiety, and depression in patients after ischemic stroke in the early recovery period, using the same instrument in different languages in comparable samples.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The authors analyzed the level of CS, anxiety, and depression in 4 groups. Study groups: 1) Russian-speaking patients who had suffered ischemic stroke (30 people, early recovery period); 2) Tatar-speaking patients who had suffered ischemic stroke (30 people, early recovery period). Comparison groups: 1) Russian-speaking informants without neurological deficit (30 people); 2) Tatar-speaking informants without neurological deficit (30 people). The Central Sensitization Inventory (CSI, Russian and Tatar versions) and the Hospital Anxiety and Depression Scale (HADS, Russian and Tatar versions) were used to assess the level of CSI, depression, and anxiety.</p></sec><sec><title>Results</title><p>Results. Analysis of CSI data revealed statistically significant differences between the study and comparison groups in the subclinical CS parameter. Among stroke patients, the subclinical variant of CS is less common than in healthy controls; clinically significant variants predominate. Statistically significant differences were found in HADS anxiety subscale and HADS depression subscale for both the Russian-speaking and Tatar-speaking study and comparison groups.</p></sec><sec><title>Conclusion</title><p>Conclusion. The data were obtained in samples of native speakers of different languages; the results are comparable, which confirms the universality of the diagnostic scales CSI and HADS for use in the diagnosis of anxiety, depression and CS in post-stroke patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>центральная сенситизация</kwd><kwd>депрессия</kwd><kwd>тревога</kwd><kwd>ишемический инсульт</kwd><kwd>опросник центральной сенситизации</kwd><kwd>госпитальная шкала тревоги и депрессии</kwd><kwd>татароязычный опросник</kwd></kwd-group><kwd-group xml:lang="en"><kwd>central sensitization</kwd><kwd>depression</kwd><kwd>anxiety</kwd><kwd>ischemic stroke</kwd><kwd>Central Sensitization Inventory</kwd><kwd>Hospital Anxiety and Depression Scale</kwd><kwd>Tatar-language questionnaire</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование выполнено за счет гранта Российского научного фонда и Академии наук Республики Татарстан по проекту №25-­28-­20404, https://rscf.ru/project/25-­28­-20404/</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>The study was supported by a grant from the Russian Science Foundation and Tatarstan Аcademy of Sciences, project No. 25-28-20404, https://rscf.ru/project/25-28-20404/</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Tamasauskas A, Silva-Passadouro B, Fallon N, Frank B, Laurinaviciute S, Keller S, Marshall A. 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