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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2025-510</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9650</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>COVID-19</subject></subj-group></article-categories><title-group><article-title>Некоторые параллели между синдромом хронической усталости и постковидным синдромом: роль иммунной дисрегуляции</article-title><trans-title-group xml:lang="en"><trans-title>Some parallels between chronic fatigue syndrome and post-COVID syndrome: The role of immune dysregulation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9663-3766</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Василькова</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilkova</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Василькова Диния Сиябековна, к.м.н., доцент, доцент кафедры педиатрии Института дополнительного профессионального образования </p><p>454092, Челябинск, ул. Воровского, д. 64</p></bio><bio xml:lang="en"><p>Diniya S. Vasilkova, Cand. Sci. (Med.), Associate Professor, Associate Professor of the Department of Pediatrics at the Institute of Continuing Professional Education </p><p>64 Vorovskiy St., Chelyabinsk, 454092</p></bio><email xlink:type="simple">diva2905@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3289-9052</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пищальников</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pishchalnikov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пищальников Александр Юрьевич, д.м.н., профессор, заведующий кафедрой педиатрии Института дополнительного профессионального образования </p><p>454092, Челябинск, ул. Воровского, д. 64</p></bio><bio xml:lang="en"><p>Alexander Yu. Pishchalnikov, Dr. Sci. (Med.), Professor, Head of the Department of Pediatrics at the Institute of Continuing Professional Education </p><p>64 Vorovskiy St., Chelyabinsk, 454092</p></bio><email xlink:type="simple">pau6277@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7086-5657</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамовских</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramovskikh</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абрамовских Ольга Сергеевна, д.м.н., доцент, заведующий кафедрой клинической лабораторной диагностики</p><p>454092, Челябинск, ул. Воровского, д. 64</p></bio><bio xml:lang="en"><p>Olga S. Abramovskikh, Dr. Sci. (Med.), Associate Professor, Head of the Department of the Department of Clinical Laboratory Diagnostics </p><p>64 Vorovskiy St., Chelyabinsk, 454092</p></bio><email xlink:type="simple">abramoschel@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Южно-Уральский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South Ural State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>12</day><month>12</month><year>2025</year></pub-date><volume>0</volume><issue>20</issue><fpage>71</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Василькова Д.С., Пищальников А.Ю., Абрамовских О.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Василькова Д.С., Пищальников А.Ю., Абрамовских О.С.</copyright-holder><copyright-holder xml:lang="en">Vasilkova D.S., Pishchalnikov A.Y., Abramovskikh O.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9650">https://www.med-sovet.pro/jour/article/view/9650</self-uri><abstract><sec><title>Введение</title><p>Введение. Многофакторность формирования синдрома хронической усталости после перенесенной пациентами коронавирусной инфекции COVID-19 или так называемого постковидного синдрома актуализирует необходимость дальнейшего изучения этиопатогенетических механизмов развития заболевания и совершенствования методов реабилитации.</p></sec><sec><title>Цель</title><p>Цель. Провести прескриптивную аналитику для повышения методов реабилитации пациентов на основе дескриптивного анализа литературных источников по формированию синдрома хронической усталости у лиц, перенесших коронавирусную инфекцию.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Источниками дескриптивного анализа явились литературные данные научных баз: Web of Science, eLIBRARY, MEDLINE, PubMed Central, Scopus. По результатам хронологического обзора литературы проведено сравнение клинических проявлений и патогенетических гипотез развития постковидного синдрома и постинфекционных феноменов с прескриптивной аналитикой.</p></sec><sec><title>Результаты и обсуждение</title><p>Результаты и обсуждение. При сравнении клинической картины пациентов выявлены более разнообразные симптомы постковидного состояния по сравнению с синдромом хронической усталости. Современные исследования патогенеза обнаружили схожие иммунные механизмы, характерные как для синдрома хронической усталости, так и для постковидного состояния, а именно разнонаправленную дисфункцию иммунитета в виде пролонгированной стимуляции с развитием неадекватного ответа и аутоиммунного воспаления, которая со временем трансформируется в «синдром иммунного истощения». Схожесть клиники постковидного синдрома и синдрома хронической усталости с начальными проявлениями аутоиммунных болезней, широкое распространение этих постинфекционных состояний в популяции вызывают озабоченность ученых и врачей и диктуют необходимость дальнейшего изучения данной проблемы. Кроме того, чрезвычайно важным с точки зрения оценки долгосрочного влияния COVID-19 на здоровье человека является возможный запуск аутоиммунного процесса с формированием аутоиммунных заболеваний.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные результаты дескриптивного анализа литературных источников подтверждают актуальность дальнейшего исследования проблем постковидного синдрома и необходимость проведения прескриптивной аналитики для уменьшения долгосрочного воздействия на здоровье человека и предупреждения развития хронических заболеваний.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. The multifactorial nature of the formation of chronic fatigue syndrome after patients have suffered coronavirus infection COVID-19 or the so-called covid syndrome actualizes the need for further study of the etiopathogenetic mechanisms of the disease and improvement of rehabilitation methods.</p></sec><sec><title>Aim</title><p>Aim. Based on a descriptive analysis of literature sources on the formation of chronic fatigue syndrome in people who have suffered from coronavirus infection, prescriptive analytics should be performed to improve patient rehabilitation methods.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The sources of descriptive analysis were the literary data of scientific databases.: Web of Science, eLIBRARY, MEDLINE, PubMed Central, Scopus. Based on the results of a chronological review of the literature, a comparison of clinical manifestations and pathogenetic hypotheses of the development of postcovoid syndrome and postinfectious phenomena with prescriptive analytics was carried out.</p></sec><sec><title>Results and discussion</title><p>Results and discussion. When comparing the clinical picture of patients, more diverse symptoms of post-ovoid condition were revealed compared with chronic fatigue syndrome. Modern studies of pathogenesis have revealed similar immune mechanisms characteristic of both chronic fatigue syndrome and post-ovarian syndrome, namely, multidirectional immune dysfunction in the form of prolonged stimulation with the development of an inadequate response and autoimmune inflammation, which eventually transforms into an “immune depletion syndrome”. The similarity of the clinic of post-cystic syndrome and chronic fatigue syndrome with the initial manifestations of autoimmune diseases, the widespread occurrence of these post-infectious conditions in the population are of concern to scientists and doctors and dictate the need for further study of this problem. In addition, the possible launch of an autoimmune process with the formation of autoimmune diseases is extremely important from the point of view of assessing the long-term impact of COVID-19 on human health.</p></sec><sec><title>Conclusion</title><p>Conclusion. The obtained results of a descriptive analysis of literary sources confirm the relevance of further research into the problems of postcovoid syndrome and the need for prescriptive analytics to reduce the long-term impact of the disease on human health and prevent the development of chronic diseases.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>здоровье человека</kwd><kwd>коронавирусная инфекция</kwd><kwd>постковидный синдром</kwd><kwd>синдром хронической усталости</kwd><kwd>long COVID</kwd><kwd>иммунная дисрегуляция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>human health</kwd><kwd>coronavirus infection</kwd><kwd>covid syndrome</kwd><kwd>chronic fatigue syndrome</kwd><kwd>long COVID</kwd><kwd>immune dysregulation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Komaroff AL, Lipkin WI. 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