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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2013-4-36-41</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-982</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕРВНО-ПСИХИЧЕСКИЕ РАССТРОЙСТВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROPSYCHIATRIC DISORDERS</subject></subj-group></article-categories><title-group><article-title>Депрессия при болезни Паркинсона как ведущий фактор ухудшения качества жизни пациентов: пато физиология, диагностика, терапия</article-title><trans-title-group xml:lang="en"><trans-title>Depression in Parkinson's disease as the key factor of deterioration in quality of life: pathophysiology, diagnostics and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нодель</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Nodel</surname><given-names>M. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Первый МГМУ им. И.М. Сеченова, Москва<country>Россия</country></aff><aff xml:lang="en">the First Moscow State Medical University named after I.M.Sechenov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2013</year></pub-date><volume>0</volume><issue>4</issue><fpage>36</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нодель М.Р., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Нодель М.Р.</copyright-holder><copyright-holder xml:lang="en">Nodel M.R.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/982">https://www.med-sovet.pro/jour/article/view/982</self-uri><abstract><p>Болезнь Паркинсона (БП) – мультисистемное нейродегенеративное заболевание с широким спектром не только двигательных, но и нервно-психических нарушений. Депрессия встречается в среднем у 40–50% пациентов с болезнью Паркинсона и является одним из ведущих факторов, снижающих качество жизни. В статье представлены современные представления о клинике, патофизиологии и подходах к терапии депрессии при болезни Паркинсона.</p></abstract><trans-abstract xml:lang="en"><p>Parkinson's disease (PD) is multisystem neurodegenerative disorder with a wide range of motor, nervous and mental disorders. On average, depression occurs in 40-50% of patients with Parkinson's disease and is a major factors of deterioration of life quality. The article tells about present-day knowledge about the disease pattern, pathophysiology and approaches to the treatment of depression in Parkinson's disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Паркинсона</kwd><kwd>депрессия</kwd><kwd>клиника</kwd><kwd>патофизиология</kwd><kwd>диагностика</kwd><kwd>терапия</kwd><kwd>Parkinson's disease</kwd><kwd>depression</kwd><kwd>disease pattern</kwd><kwd>pathophysiology</kwd><kwd>diagnostics</kwd><kwd>therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Яхно Н.Н. Невропсихиатрия. Место неврологов. X Всероссийский съезд неврологов с международным участием // Материалы съезда. Н. Новгород, 2012. С. 698.</mixed-citation><mixed-citation xml:lang="en">Яхно Н.Н. Невропсихиатрия. Место неврологов. X Всероссийский съезд неврологов с международным участием // Материалы съезда. Н. Новгород, 2012. С. 698.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Яхно Н.Н. Захаров В.В., Нодель М.Р. Когнитивные и другие нервно-психические нарушения болезни Паркинсона // Болезни движений: медицинские и социальные аспекты / под ред. Е.И. Гусева, А.Б. Гехт. М., 2010. С. 95–97.</mixed-citation><mixed-citation xml:lang="en">Яхно Н.Н. Захаров В.В., Нодель М.Р. Когнитивные и другие нервно-психические нарушения болезни Паркинсона // Болезни движений: медицинские и социальные аспекты / под ред. Е.И. Гусева, А.Б. Гехт. М., 2010. С. 95–97.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Нодель М.Р., Яхно Н.Н. Нервно-психические нарушения болезни Паркинсона // Неврология. Нейропсихиатрия. Психосоматика. 2009. №2. C. 3–8.</mixed-citation><mixed-citation xml:lang="en">Нодель М.Р., Яхно Н.Н. Нервно-психические нарушения болезни Паркинсона // Неврология. Нейропсихиатрия. Психосоматика. 2009. №2. C. 3–8.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Нодель М.Р. Недвигательные нарушения болезни Паркинсона // Доктор.Ру. Неврология. 2009. №4. C. 12–16.</mixed-citation><mixed-citation xml:lang="en">Нодель М.Р. Недвигательные нарушения болезни Паркинсона // Доктор.Ру. Неврология. 2009. №4. C. 12–16.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Левин О.С. Болезнь Паркинсона как нейропсихиатрическое заболевание: Руководство для врачей по материалам II Национального конгресса по болезни Паркинсона и расстройствам движений / под ред. С.Н. Иллариошкина, О.С. Левина. М., 2011. С. 99–104.</mixed-citation><mixed-citation xml:lang="en">Левин О.С. Болезнь Паркинсона как нейропсихиатрическое заболевание: Руководство для врачей по материалам II Национального конгресса по болезни Паркинсона и расстройствам движений / под ред. С.Н. Иллариошкина, О.С. Левина. М., 2011. С. 99–104.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Нодель М.Р. Клинические особенности и лечение недвигательных нарушений болезни Паркинсона // Медицинский совет. 2012. №4. С. 30–36.</mixed-citation><mixed-citation xml:lang="en">Нодель М.Р. Клинические особенности и лечение недвигательных нарушений болезни Паркинсона // Медицинский совет. 2012. №4. С. 30–36.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Aarsland D., Marsh L., Schrag А. Neuropsychiatric symptoms in Parkinsons Disease // Mov.Dis. 2009. Vol. 24(15). P. 2175–86.</mixed-citation><mixed-citation xml:lang="en">Aarsland D., Marsh L., Schrag А. Neuropsychiatric symptoms in Parkinsons Disease // Mov.Dis. 2009. Vol. 24(15). P. 2175–86.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">O’Sullivan S.S., Williams D.R., Gallarher D.A. et al. Non motor symptoms as presenting complaints in Parkinsons disease: a clinicopathological study // Mov. Dis. 2008. Vol. 23. P. 101–106.</mixed-citation><mixed-citation xml:lang="en">O’Sullivan S.S., Williams D.R., Gallarher D.A. et al. Non motor symptoms as presenting complaints in Parkinsons disease: a clinicopathological study // Mov. Dis. 2008. Vol. 23. P. 101–106.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Shrag A., Jahanshahi M., Quinn N.P. What contributes to quality life in patients with Parkinsons disease? // J. Neurol. Neurosurg. Neuropsych. 2000. Vol. 69. P. 308–312.</mixed-citation><mixed-citation xml:lang="en">Shrag A., Jahanshahi M., Quinn N.P. What contributes to quality life in patients with Parkinsons disease? // J. Neurol. Neurosurg. Neuropsych. 2000. Vol. 69. P. 308–312.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Scaravilli T., Gasparoli E., Rinaldi F. et al. Health related quality of life in Parkinsons disease // J. Nourol. Neurosurg. Psychiat. 2003. №74 (2). P. 163–169.</mixed-citation><mixed-citation xml:lang="en">Scaravilli T., Gasparoli E., Rinaldi F. et al. Health related quality of life in Parkinsons disease // J. Nourol. Neurosurg. Psychiat. 2003. №74 (2). P. 163–169.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">McKinlay A., Grace R.C., Dalrymple-Alford J.C. et al. A profile of neuropsychiatric problems and their relationship to quality of life for Parkinsons disease // Park. and Relat. disord. 2008. Vol. 14. P. 37–42</mixed-citation><mixed-citation xml:lang="en">McKinlay A., Grace R.C., Dalrymple-Alford J.C. et al. A profile of neuropsychiatric problems and their relationship to quality of life for Parkinsons disease // Park. and Relat. disord. 2008. Vol. 14. P. 37–42</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cole S.A., Woodard J.L., Juncos J.L. et al. Depression and disability in Parkinsons disease // J. Neuropsychiatry Clin. Neurosci. 1996. Vol. 8. P. 20–25.</mixed-citation><mixed-citation xml:lang="en">Cole S.A., Woodard J.L., Juncos J.L. et al. Depression and disability in Parkinsons disease // J. Neuropsychiatry Clin. Neurosci. 1996. Vol. 8. P. 20–25.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shrag A., Jahanshahi M., Quinn N.P. What contributes to depression in Parkinsons disease? // Psychol. Med. 2001. Vol. 31. P. 65–73.</mixed-citation><mixed-citation xml:lang="en">Shrag A., Jahanshahi M., Quinn N.P. What contributes to depression in Parkinsons disease? // Psychol. Med. 2001. Vol. 31. P. 65–73.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Starkstein S.E., Preziosi T.J., Robinson R.G. Sleep disorders, pain and Parkinsons disease depression in Parkinsons disease // Eur. Neurol. 1991. Vol. 31(6). P. 352–355.</mixed-citation><mixed-citation xml:lang="en">Starkstein S.E., Preziosi T.J., Robinson R.G. Sleep disorders, pain and Parkinsons disease depression in Parkinsons disease // Eur. Neurol. 1991. Vol. 31(6). P. 352–355.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Norman S., Troster A.I., Fields J.A. et al. Effects of depression and Parkinsons disease on cognitive functioning // J. Neuropsychiatr. Clin. Neurosci. 2002. Vol. 14(1). P. 31–36.</mixed-citation><mixed-citation xml:lang="en">Norman S., Troster A.I., Fields J.A. et al. Effects of depression and Parkinsons disease on cognitive functioning // J. Neuropsychiatr. Clin. Neurosci. 2002. Vol. 14(1). P. 31–36.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Нодель М.Р. Депрессия при болезни Паркинсона // Неврология. Нейропсихиатрия. Психосоматика. 2010. №4. C. 11–17. Полный список литературы вы можете запросить в редакции.</mixed-citation><mixed-citation xml:lang="en">Нодель М.Р. Депрессия при болезни Паркинсона // Неврология. Нейропсихиатрия. Психосоматика. 2010. №4. C. 11–17. Полный список литературы вы можете запросить в редакции.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Левин О.С. Болезнь Паркинсона как нейропсихиатрическое заболевание. //Руководство для врачей по материалам II Национального конгресса по болезни Паркинсона и расстройствам движений (под ред. С.Н. Иллариошкина, О.С. Левина). М. 2011. С.99–104.</mixed-citation><mixed-citation xml:lang="en">Левин О.С. Болезнь Паркинсона как нейропсихиатрическое заболевание. //Руководство для врачей по материалам II Национального конгресса по болезни Паркинсона и расстройствам движений (под ред. С.Н. Иллариошкина, О.С. Левина). М. 2011. С.99–104.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">М.Р. Нодель. Клинические особенности и лечение недвигательных нарушений болезни Паркинсона.// Медицинский совет. -2012.-N 4.-С.30-36.</mixed-citation><mixed-citation xml:lang="en">М.Р. Нодель. Клинические особенности и лечение недвигательных нарушений болезни Паркинсона.// Медицинский совет. -2012.-N 4.-С.30-36.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">D.Aarsland, Marsh L., A.Schrag . Neuropsychiatric symptoms in Parkinsons Disease. //Mov.Dis.-2009- Vol.24(15).-P.2175-86.</mixed-citation><mixed-citation xml:lang="en">D.Aarsland, Marsh L., A.Schrag . Neuropsychiatric symptoms in Parkinsons Disease. //Mov.Dis.-2009- Vol.24(15).-P.2175-86.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">OSullivan S.S., Williams D.R., Gallarher D.A., et,.al. Non motor symptoms as presenting complaints in Parkinsons disease: a clinicopathological study. //Mov.Dis.-2008-Vol.23-P.101-106.</mixed-citation><mixed-citation xml:lang="en">OSullivan S.S., Williams D.R., Gallarher D.A., et,.al. Non motor symptoms as presenting complaints in Parkinsons disease: a clinicopathological study. //Mov.Dis.-2008-Vol.23-P.101-106.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Shrag A., Jahanshahi M., Quinn N.P. What contributes to quality life in patients with Parkinsons disease?//J.Neurol.Neurosurg.Neuropsych.-2000.-Vol.69.-P.308-312.</mixed-citation><mixed-citation xml:lang="en">Shrag A., Jahanshahi M., Quinn N.P. What contributes to quality life in patients with Parkinsons disease?//J.Neurol.Neurosurg.Neuropsych.-2000.-Vol.69.-P.308-312.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Scaravilli T., Gasparoli E., Rinaldi F. et.al. Health related quality of life in Parkinsons disease. // J.Nourol.Neurosurg.Psychiat.-2003.-74 (2)-P.163-169.</mixed-citation><mixed-citation xml:lang="en">Scaravilli T., Gasparoli E., Rinaldi F. et.al. Health related quality of life in Parkinsons disease. // J.Nourol.Neurosurg.Psychiat.-2003.-74 (2)-P.163-169.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mc Kinlay A., Grace R.C., Dalrymple-Alford J.C., et.al. A profile of neuropsychiatric problems and their relationship to quality of life for Parkinsons disease. //Park. and Relat. disord.-2008.-Vol.14.-P.37-42</mixed-citation><mixed-citation xml:lang="en">Mc Kinlay A., Grace R.C., Dalrymple-Alford J.C., et.al. A profile of neuropsychiatric problems and their relationship to quality of life for Parkinsons disease. //Park. and Relat. disord.-2008.-Vol.14.-P.37-42</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Cole S. A., Woodard J. L. , Juncos J. L. , et. al. Depression and disability in Parkinsons disease. // J. Neuropsychiatry Clin. Neurosci. -1996. - Vol. 8. - P. 20-25.</mixed-citation><mixed-citation xml:lang="en">Cole S. A., Woodard J. L. , Juncos J. L. , et. al. Depression and disability in Parkinsons disease. // J. Neuropsychiatry Clin. Neurosci. -1996. - Vol. 8. - P. 20-25.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Shrag A., Jahanshahi M., Quinn N.P. What contributes to depression in Parkinsons disease?// Psychol.Med.-2001.-Vol.31.-P.65-73.</mixed-citation><mixed-citation xml:lang="en">Shrag A., Jahanshahi M., Quinn N.P. What contributes to depression in Parkinsons disease?// Psychol.Med.-2001.-Vol.31.-P.65-73.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">S.E.Starkstein, Preziosi T.J., Robinson R.G. Sleep disorders, pain and Parkinsons disease depression in Parkinsons disease. //Eur. Neurol.-1991.-Vol.31(6).-P.352-355.</mixed-citation><mixed-citation xml:lang="en">S.E.Starkstein, Preziosi T.J., Robinson R.G. Sleep disorders, pain and Parkinsons disease depression in Parkinsons disease. //Eur. Neurol.-1991.-Vol.31(6).-P.352-355.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Norman S., Troster A.I., Fields J.A., et.al. Effects of depression and Parkinsons disease on cognitive functioning. . // J.Neuropsychiatr.Clin. Neurosci.-2002.-Vol.14(1).-P.31-36.</mixed-citation><mixed-citation xml:lang="en">Norman S., Troster A.I., Fields J.A., et.al. Effects of depression and Parkinsons disease on cognitive functioning. . // J.Neuropsychiatr.Clin. Neurosci.-2002.-Vol.14(1).-P.31-36.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">М.Р. Нодель. Депрессия при болезни Паркинсона. //Неврология.</mixed-citation><mixed-citation xml:lang="en">М.Р. Нодель. Депрессия при болезни Паркинсона. //Неврология.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Нейропсихиатрия.Психосоматика.-2010.-N4.- C.11-17.</mixed-citation><mixed-citation xml:lang="en">Нейропсихиатрия.Психосоматика.-2010.-N4.- C.11-17.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Dooneief G., Mirabello E., Bell K., et.al. An estimate of the incidence of depression in idiopathic Parkinsons disease. //Arch.Neurol.-1992.-Vol.49(3).-P.305-307.</mixed-citation><mixed-citation xml:lang="en">Dooneief G., Mirabello E., Bell K., et.al. An estimate of the incidence of depression in idiopathic Parkinsons disease. //Arch.Neurol.-1992.-Vol.49(3).-P.305-307.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lemke M.R. Depressive symptoms in Parkinsons disease. //Eur. J.of Neurol.-2008.-Vol.15(Suppl.1).-P.21-25.</mixed-citation><mixed-citation xml:lang="en">Lemke M.R. Depressive symptoms in Parkinsons disease. //Eur. J.of Neurol.-2008.-Vol.15(Suppl.1).-P.21-25.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gotham A. M., Brown R. C. , Marsden C. D. Depression in Parkinsons disease: a quantitative and qualitative analysis in Parkinsons disease. // J. Neuropsychiatry Clin. Neurosci. -1996. - Vol. 8. - P. 20-25.</mixed-citation><mixed-citation xml:lang="en">Gotham A. M., Brown R. C. , Marsden C. D. Depression in Parkinsons disease: a quantitative and qualitative analysis in Parkinsons disease. // J. Neuropsychiatry Clin. Neurosci. -1996. - Vol. 8. - P. 20-25.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mayberg H.S., Starkstein S.E., Sadzot B., et.al. Selective hypometaboloism in the inferior frontal lobe in depressed patients with Parkinsons Disease. //Ann.Neurol.-1990.-Vol.28(1)-P.57-64.</mixed-citation><mixed-citation xml:lang="en">Mayberg H.S., Starkstein S.E., Sadzot B., et.al. Selective hypometaboloism in the inferior frontal lobe in depressed patients with Parkinsons Disease. //Ann.Neurol.-1990.-Vol.28(1)-P.57-64.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Matsiu H., Nishinaka K., Oda M., et.al. Depression in Parkinsons disease:diffusion tensor imaging study. //J.Neurol.-2007.-Vol.254.-P.1170-1173.</mixed-citation><mixed-citation xml:lang="en">Matsiu H., Nishinaka K., Oda M., et.al. Depression in Parkinsons disease:diffusion tensor imaging study. //J.Neurol.-2007.-Vol.254.-P.1170-1173.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Chaudhuri K.R., Schapira A. H.V. Non-motor symptoms of Parkinsons disease: dopaminergic pathophysiology 23. R.Mayeux, Y.Stern, I.Cote , J.B. Williams. Altered serotonin metabolism in depressed patients with Parkinsons Disease. //Neurol.-1984.-Vol.34(5).-P.642-646.</mixed-citation><mixed-citation xml:lang="en">Chaudhuri K.R., Schapira A. H.V. Non-motor symptoms of Parkinsons disease: dopaminergic pathophysiology 23. R.Mayeux, Y.Stern, I.Cote , J.B. Williams. Altered serotonin metabolism in depressed patients with Parkinsons Disease. //Neurol.-1984.-Vol.34(5).-P.642-646.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">M.Yamomoto. Depression in Parkinsons Disease : its prevalence, diagnosis, and neurochemical background. //J.Neurol.-2001.-Vol.248 (Suppl</mixed-citation><mixed-citation xml:lang="en">M.Yamomoto. Depression in Parkinsons Disease : its prevalence, diagnosis, and neurochemical background. //J.Neurol.-2001.-Vol.248 (Suppl</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">P.G.Frisina, V.Haroutunian, L.S.Libow. The neuropatological basis for depression in Parkinsons Disease. //Park. and Relat.Dis.-2009.-Vol.15.-P.144-148.</mixed-citation><mixed-citation xml:lang="en">P.G.Frisina, V.Haroutunian, L.S.Libow. The neuropatological basis for depression in Parkinsons Disease. //Park. and Relat.Dis.-2009.-Vol.15.-P.144-148.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Remy P., M.Doder, A.Lees, et.al. Depression in Parkinsons Disease: loss of dopamine and noradrenaline innervation in the limbic system. //Brain.-2005.-Vol.128.-P.1314-1322.</mixed-citation><mixed-citation xml:lang="en">Remy P., M.Doder, A.Lees, et.al. Depression in Parkinsons Disease: loss of dopamine and noradrenaline innervation in the limbic system. //Brain.-2005.-Vol.128.-P.1314-1322.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">M.Guttman, M.Torti, J.Warsh et.al. Are brain serotonin transporter levels decreased in depressed patients with Parkinsons Disease? //J.Neurol.Sci-2006.-Vol.248-P.299.</mixed-citation><mixed-citation xml:lang="en">M.Guttman, M.Torti, J.Warsh et.al. Are brain serotonin transporter levels decreased in depressed patients with Parkinsons Disease? //J.Neurol.Sci-2006.-Vol.248-P.299.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Alex K.D., Pehek E.A. Pharmacologic mechanisms of serotoninergic regulation of dopamine neurotransmission. // Pharmacol. Ther.-2007.-Vol.113-P.296-320.</mixed-citation><mixed-citation xml:lang="en">Alex K.D., Pehek E.A. Pharmacologic mechanisms of serotoninergic regulation of dopamine neurotransmission. // Pharmacol. Ther.-2007.-Vol.113-P.296-320.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">F.Fang, Q.Xu, Y.Park, X.Huang, et.al. Depression and the subsequent risk of Parkinsons disease in the NIN-AARP Diet and Health Study. //Mov.Dis.-2010-Vol.25.-N9.-P.1157-1162.</mixed-citation><mixed-citation xml:lang="en">F.Fang, Q.Xu, Y.Park, X.Huang, et.al. Depression and the subsequent risk of Parkinsons disease in the NIN-AARP Diet and Health Study. //Mov.Dis.-2010-Vol.25.-N9.-P.1157-1162.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Braak H., Del Tredici K., Rub U., et. al. Staging of brain pathology related to sporadic Parkinsons disease. //Neurology Aging - 2003.-Vol.24.-P.197-210.</mixed-citation><mixed-citation xml:lang="en">Braak H., Del Tredici K., Rub U., et. al. Staging of brain pathology related to sporadic Parkinsons disease. //Neurology Aging - 2003.-Vol.24.-P.197-210.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Santamaria J. , Tolosa E. , Valles A. Parkinsons disease with depression: a possible subgroup of idiopathic parkinsonism. //Neurology. -1986. - Vol. 36. - P. 1130-1133.</mixed-citation><mixed-citation xml:lang="en">Santamaria J. , Tolosa E. , Valles A. Parkinsons disease with depression: a possible subgroup of idiopathic parkinsonism. //Neurology. -1986. - Vol. 36. - P. 1130-1133.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">A.F.Leentjens, R.Lousberg, F.R.Verhey. Markers for depression in Parkinsons Disease. //Acta Psych.Scand.-2002.-Vol.106(3)-P.196-201.</mixed-citation><mixed-citation xml:lang="en">A.F.Leentjens, R.Lousberg, F.R.Verhey. Markers for depression in Parkinsons Disease. //Acta Psych.Scand.-2002.-Vol.106(3)-P.196-201.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Cummings J. L. Depression and Parkinsons disease: a review. // Am. J. Psychiatry-1992. - Vol. 149. - P. 443-454.</mixed-citation><mixed-citation xml:lang="en">Cummings J. L. Depression and Parkinsons disease: a review. // Am. J. Psychiatry-1992. - Vol. 149. - P. 443-454.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">E.Tanberg, J.P.Larsen, D.Aarsland et.al. Risk factors for depression in Parkinsons Disease. //Arch. Neurol.-1997.-Vol.54(5).-P.625-630.</mixed-citation><mixed-citation xml:lang="en">E.Tanberg, J.P.Larsen, D.Aarsland et.al. Risk factors for depression in Parkinsons Disease. //Arch. Neurol.-1997.-Vol.54(5).-P.625-630.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">A.Rojo , M.Agullar , M.T. Garolera , et.al. Depression and Parkinsons disease: clinical correlates and outcome. //Park. Relat Dis.- 2003.-Vol.10(1).-P.23-28.</mixed-citation><mixed-citation xml:lang="en">A.Rojo , M.Agullar , M.T. Garolera , et.al. Depression and Parkinsons disease: clinical correlates and outcome. //Park. Relat Dis.- 2003.-Vol.10(1).-P.23-28.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Cole S.A., Woodard J.L., Juncos J.L., et.al. Depression and disability in Parkinsons disease. //J.Neuropsychiatr.Clin. Neurosci-1996.-Vol.8(1).-P.20-25.</mixed-citation><mixed-citation xml:lang="en">Cole S.A., Woodard J.L., Juncos J.L., et.al. Depression and disability in Parkinsons disease. //J.Neuropsychiatr.Clin. Neurosci-1996.-Vol.8(1).-P.20-25.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">C.Becker, G.P.Brobert, S.Johansson et.al. Risk of incident depression in patients with Parkinsons disease in the UK. //Eur.J.of Neurol.-2011.-Vol.18.-P.448-453.</mixed-citation><mixed-citation xml:lang="en">C.Becker, G.P.Brobert, S.Johansson et.al. Risk of incident depression in patients with Parkinsons disease in the UK. //Eur.J.of Neurol.-2011.-Vol.18.-P.448-453.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">A.Althaus, O.A.Becker, A.Spottke, et.al. Frequency and treatment of depressive symptoms in a Parkinsons Disease registry. //Park. and Relat. disord.-2008.-Vol.14.-P.626-632</mixed-citation><mixed-citation xml:lang="en">A.Althaus, O.A.Becker, A.Spottke, et.al. Frequency and treatment of depressive symptoms in a Parkinsons Disease registry. //Park. and Relat. disord.-2008.-Vol.14.-P.626-632</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Y.Cheng, C.Liu, C.Mao et.al. Social support plays a role in depression in Parkinsons disease: a cross-section study in a Chinese cohort. //Park. аnd Related Dis.-2008.-Vol.14.-P.43-45.</mixed-citation><mixed-citation xml:lang="en">Y.Cheng, C.Liu, C.Mao et.al. Social support plays a role in depression in Parkinsons disease: a cross-section study in a Chinese cohort. //Park. аnd Related Dis.-2008.-Vol.14.-P.43-45.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Янакаева Т. А. Сравнительный анализ когнитивных и аффективных расстройств при дисциркуляторной энцефалопатии, болезни Паркинсона и болезни Альцгеймера. Диссертация …канд. мед. наук. – М., 1999.</mixed-citation><mixed-citation xml:lang="en">Янакаева Т. А. Сравнительный анализ когнитивных и аффективных расстройств при дисциркуляторной энцефалопатии, болезни Паркинсона и болезни Альцгеймера. Диссертация …канд. мед. наук. – М., 1999.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">E.Starkstein, Petracca G., Chemerinski E., et.al. Depression in classic versus akinetic-rigid Parkinsons disease. //J.Neur. Ment.Dis.-1998.-Vol.13(1).P.-29-33.</mixed-citation><mixed-citation xml:lang="en">E.Starkstein, Petracca G., Chemerinski E., et.al. Depression in classic versus akinetic-rigid Parkinsons disease. //J.Neur. Ment.Dis.-1998.-Vol.13(1).P.-29-33.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">F.Liebermann. Depression in Parkinsons Disease- a review. //Acta Neurol.Scand.-2006.-Vol.113-P.1-8.</mixed-citation><mixed-citation xml:lang="en">F.Liebermann. Depression in Parkinsons Disease- a review. //Acta Neurol.Scand.-2006.-Vol.113-P.1-8.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Lemke M.R. Depressive symptoms in Parkinsons disease. //Eur.J.of Neurol.-2008.-Vol.15(Suppl.1).-P.21-25.</mixed-citation><mixed-citation xml:lang="en">Lemke M.R. Depressive symptoms in Parkinsons disease. //Eur.J.of Neurol.-2008.-Vol.15(Suppl.1).-P.21-25.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">American Psychiatric Association. Diagnostic and Statistical Manual of mental Disorders, 4-th ed. Washington, ВС:APA Press 2000.</mixed-citation><mixed-citation xml:lang="en">American Psychiatric Association. Diagnostic and Statistical Manual of mental Disorders, 4-th ed. Washington, ВС:APA Press 2000.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">J.Reiff, N.Schmidt, B.Riebe, et.al. Subthreshold depression in Parkinsons disease. //Mov.Dis.-2011-Vol.26-N9.-P.1741-1744.</mixed-citation><mixed-citation xml:lang="en">J.Reiff, N.Schmidt, B.Riebe, et.al. Subthreshold depression in Parkinsons disease. //Mov.Dis.-2011-Vol.26-N9.-P.1741-1744.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">S.E.Starkstein , M.Merello, R.Jorge , et.al. A validity study of depressive syndromes in Parkinsons disease. // Mov.Dis.-2008-Vol.23-P.538-546.</mixed-citation><mixed-citation xml:lang="en">S.E.Starkstein , M.Merello, R.Jorge , et.al. A validity study of depressive syndromes in Parkinsons disease. // Mov.Dis.-2008-Vol.23-P.538-546.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">T.Inoue, M.Kitagawa, T.Tanaka, et.al. Depression and major depressive disorder in patients with Parkinsons disease. // Mov.Dis.-2010-Vol.25-N1-P.44-49.</mixed-citation><mixed-citation xml:lang="en">T.Inoue, M.Kitagawa, T.Tanaka, et.al. Depression and major depressive disorder in patients with Parkinsons disease. // Mov.Dis.-2010-Vol.25-N1-P.44-49.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Barone P., Antonini A., Colosimo C., et.al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson disease. //Mov.Dis.-2009.-Jun 9.-P.215-216.</mixed-citation><mixed-citation xml:lang="en">Barone P., Antonini A., Colosimo C., et.al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson disease. //Mov.Dis.-2009.-Jun 9.-P.215-216.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Shrag A., Barone P., Brown R.G. et.al. Depression rating scales in Parkinson disease: critique and recommendations. //Mov.Dis.-2007.-Vol.22.-P.1077-1192.</mixed-citation><mixed-citation xml:lang="en">Shrag A., Barone P., Brown R.G. et.al. Depression rating scales in Parkinson disease: critique and recommendations. //Mov.Dis.-2007.-Vol.22.-P.1077-1192.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Dujardin K., Sockeel P., Devos D., et.al. Characteristic of apathy in Parkinsons disease. // Mov.Dis.-2007.-Vol.22.-P.778-784.</mixed-citation><mixed-citation xml:lang="en">Dujardin K., Sockeel P., Devos D., et.al. Characteristic of apathy in Parkinsons disease. // Mov.Dis.-2007.-Vol.22.-P.778-784.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">М.Р. Нодель. Утомляемость при болезни Паркинсона и ее коррекция агонистом дофаминовых рецепторов прамипексолом //Неврология. Нейропсихиатрия.Психосоматика.-2011.-N 4.- C.22-26.</mixed-citation><mixed-citation xml:lang="en">М.Р. Нодель. Утомляемость при болезни Паркинсона и ее коррекция агонистом дофаминовых рецепторов прамипексолом //Неврология. Нейропсихиатрия.Психосоматика.-2011.-N 4.- C.22-26.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Barone P et al. Depression and antidepressant use in Parkinson’s disease: Results from the PRODEST-PD study. Abstract P1122 poster presented at 11th Congress of EFNS, Brussels, 26 Aug 2007.</mixed-citation><mixed-citation xml:lang="en">Barone P et al. Depression and antidepressant use in Parkinson’s disease: Results from the PRODEST-PD study. Abstract P1122 poster presented at 11th Congress of EFNS, Brussels, 26 Aug 2007.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Weintraub D., Morales K.H., Moberg P.J., et.al. Antidepressant studies in Parkinsons disease: a review and meta-analysis. // Mov.Dis.-2005.-Vol.20.-P.1161-1169.</mixed-citation><mixed-citation xml:lang="en">Weintraub D., Morales K.H., Moberg P.J., et.al. Antidepressant studies in Parkinsons disease: a review and meta-analysis. // Mov.Dis.-2005.-Vol.20.-P.1161-1169.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Miyasaki J.M., Shannon K., Voon V., et.al. Practice parameter: evaluation and treatment of depression, psychosis and dementia in Parkinsons disease (an evidence-based review):report of the Quality Standards Subcommittee of the American Academy of Neurology. //Neurol.-2006.-Vol.66.-P.996-1002.</mixed-citation><mixed-citation xml:lang="en">Miyasaki J.M., Shannon K., Voon V., et.al. Practice parameter: evaluation and treatment of depression, psychosis and dementia in Parkinsons disease (an evidence-based review):report of the Quality Standards Subcommittee of the American Academy of Neurology. //Neurol.-2006.-Vol.66.-P.996-1002.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Devos D., Dujardin K., Poirot I., et.al. Comparison of desipramine and citalopram treatments with depression in Parkinsons disease: a double-blind placebo-controlled study. //Mov.Dis.-2008.-Vol.23.-P.850-7.</mixed-citation><mixed-citation xml:lang="en">Devos D., Dujardin K., Poirot I., et.al. Comparison of desipramine and citalopram treatments with depression in Parkinsons disease: a double-blind placebo-controlled study. //Mov.Dis.-2008.-Vol.23.-P.850-7.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">I.H.Richard, M.P.McDermott, R.Kurlan et.al. A randomized, double –blind, placebo-controlled trial of antidepressants in Parkinsons disease. //Neurol.-2012-Vol.11-N9.-P.26-34.</mixed-citation><mixed-citation xml:lang="en">I.H.Richard, M.P.McDermott, R.Kurlan et.al. A randomized, double –blind, placebo-controlled trial of antidepressants in Parkinsons disease. //Neurol.-2012-Vol.11-N9.-P.26-34.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Menza M., Dobkin R.D., Marin H., et.al. A controlled trial of antidepressants in patients with Parkinsons disease and depression. //Neurol.-2009.-Vol.72.-P.886-92</mixed-citation><mixed-citation xml:lang="en">Menza M., Dobkin R.D., Marin H., et.al. A controlled trial of antidepressants in patients with Parkinsons disease and depression. //Neurol.-2009.-Vol.72.-P.886-92</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Mann J. J., Kapur S. A dopaminergic hypothesis of major depression. // Clin. Neuropharmacol. -1996. -Vol. 18(suppl. 1). -P. 57-65.</mixed-citation><mixed-citation xml:lang="en">Mann J. J., Kapur S. A dopaminergic hypothesis of major depression. // Clin. Neuropharmacol. -1996. -Vol. 18(suppl. 1). -P. 57-65.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Barbeu A. L. L-Dopa therapy in Parkinson disease: a critical review of nine years experience. // J. Can. Med. Assoc. -1969. -Vol. 101. -P. 791-800.</mixed-citation><mixed-citation xml:lang="en">Barbeu A. L. L-Dopa therapy in Parkinson disease: a critical review of nine years experience. // J. Can. Med. Assoc. -1969. -Vol. 101. -P. 791-800.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Нодель М.Р., Артемьев Д.В., Яхно Н.Н.. Эффективность дофаминового агониста Мирапекса при болезни Паркинсона. // Неврологический журнал. - 1999. – N6. - С. 45-49.</mixed-citation><mixed-citation xml:lang="en">Нодель М.Р., Артемьев Д.В., Яхно Н.Н.. Эффективность дофаминового агониста Мирапекса при болезни Паркинсона. // Неврологический журнал. - 1999. – N6. - С. 45-49.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Левин О.С., Федорова Н.В., Смоленцева И.Г. Применение агонистов дофаминовых рецепторов при болезни Паркинсона.//Неврологический журнал- 2002. -№1. С.41-45.</mixed-citation><mixed-citation xml:lang="en">Левин О.С., Федорова Н.В., Смоленцева И.Г. Применение агонистов дофаминовых рецепторов при болезни Паркинсона.//Неврологический журнал- 2002. -№1. С.41-45.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Lemke M.P., Brecht H.M., Koester J.K., et.al. Anhedonia, depression, and motor functioning in Parkinsons disease during treatment with Pramipexole. //J.Neuropsych.Clin.Neurosci-2005.-Vol.17.-P.2.-P.214-220.</mixed-citation><mixed-citation xml:lang="en">Lemke M.P., Brecht H.M., Koester J.K., et.al. Anhedonia, depression, and motor functioning in Parkinsons disease during treatment with Pramipexole. //J.Neuropsych.Clin.Neurosci-2005.-Vol.17.-P.2.-P.214-220.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Barone P., Poewe W., Tolosa E., et.al. Efficacy of double-blind, placebo-controlled pramipexole against depression in Parkinsons disease. Abstracts of the Movement Disorders Societys Thirteenth International Congress of Parkinson's disease and movement disorders. June 7-11-2009-Suppl.1 –P.291.</mixed-citation><mixed-citation xml:lang="en">Barone P., Poewe W., Tolosa E., et.al. Efficacy of double-blind, placebo-controlled pramipexole against depression in Parkinsons disease. Abstracts of the Movement Disorders Societys Thirteenth International Congress of Parkinson's disease and movement disorders. June 7-11-2009-Suppl.1 –P.291.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Schoenfeld M.A., Pantelie C.M., B. Schwartz . Clinical criteria for the switch of treatment strategies in Parkinson’s disease. //Clinical Neurol. and Neurosurg. -2003.-Vol. 105.-P.241-244.</mixed-citation><mixed-citation xml:lang="en">Schoenfeld M.A., Pantelie C.M., B. Schwartz . Clinical criteria for the switch of treatment strategies in Parkinson’s disease. //Clinical Neurol. and Neurosurg. -2003.-Vol. 105.-P.241-244.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
