<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/2079-701X-2013-4-82-91</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-990</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Практика</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Practice</subject></subj-group></article-categories><title-group><article-title>Лечение ушибов головного мозга</article-title><trans-title-group xml:lang="en"><trans-title>Treatment of brain injury</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Талыпов</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Talypov</surname><given-names>A. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петриков</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrikov</surname><given-names>S. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пурас</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Puras</surname><given-names>Yu. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Солодов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solodov</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Titova</surname><given-names>Yu. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИСП им. Н.В. Склифосовского, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosofskiy Research Institute of Emergency Medical Aid, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2013</year></pub-date><volume>0</volume><issue>4</issue><fpage>82</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Талыпов А.Э., Петриков С.С., Пурас Ю.В., Солодов А.А., Титова Ю.В., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Талыпов А.Э., Петриков С.С., Пурас Ю.В., Солодов А.А., Титова Ю.В.</copyright-holder><copyright-holder xml:lang="en">Talypov A.E., Petrikov S.S., Puras Y.V., Solodov A.A., Titova Y.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/990">https://www.med-sovet.pro/jour/article/view/990</self-uri><abstract><p>В статье представлен анализ современных методов хирургического и консервативного лечения ушибов головного мозга с учетом концепции первичных и вторичных повреждений головного мозга.</p></abstract><trans-abstract xml:lang="en"><p>Modern methods of surgical and conservative treatment of  primary and secondary brain injury are analyzed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ушиб головного мозга</kwd><kwd>вторичные повреждения</kwd><kwd>лечение</kwd><kwd>цитиколин</kwd><kwd>brain injury</kwd><kwd>secondary injury</kwd><kwd>treatment</kwd><kwd>citicoline</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лекции по нейрохирургии под редакцией В.В. Крылова. М., Медицина, 2010; 318 с.</mixed-citation><mixed-citation xml:lang="en">Лекции по нейрохирургии под редакцией В.В. Крылова. М., Медицина, 2010; 318 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Langlois J.A., Rutland-Brown W., Wald M.M. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006; 21:375–8.</mixed-citation><mixed-citation xml:lang="en">Langlois J.A., Rutland-Brown W., Wald M.M. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006; 21:375–8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tagliaferri F., Compagnone C., Korsic M., Servadei F., Kraus J. A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien) 2006; 148:255–68.</mixed-citation><mixed-citation xml:lang="en">Tagliaferri F., Compagnone C., Korsic M., Servadei F., Kraus J. A systematic review of brain injury epidemiology in Europe. Acta Neurochir (Wien) 2006; 148:255–68.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kraus M.F., Susmaras T., Caughlin P., Walker C.J., Sweeney J.A., Little D.M. White mater integrity and cognition in chronic traumaticbrain injury: a diffusion tensor imaging study. Brain. 2007; 130:2508–2519.</mixed-citation><mixed-citation xml:lang="en">Kraus M.F., Susmaras T., Caughlin P., Walker C.J., Sweeney J.A., Little D.M. White mater integrity and cognition in chronic traumaticbrain injury: a diffusion tensor imaging study. Brain. 2007; 130:2508–2519.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kontos H.A., Povlishock J.T. Oxygen radicals in brain injury. Cent Nerv Syst Trauma. 1986; 3:257–63.</mixed-citation><mixed-citation xml:lang="en">Kontos H.A., Povlishock J.T. Oxygen radicals in brain injury. Cent Nerv Syst Trauma. 1986; 3:257–63.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Smith S.L., Andrus P.K., Zhang J.R., Hall E.D. Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J Neurotrauma. 1994; 11:393–404.</mixed-citation><mixed-citation xml:lang="en">Smith S.L., Andrus P.K., Zhang J.R., Hall E.D. Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J Neurotrauma. 1994; 11:393–404.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Xiong Y., Gu Q., Peterson P.L., Muizelaar J.P., Lee C.P. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. J Neurotrauma. 1997;14:23–34.</mixed-citation><mixed-citation xml:lang="en">Xiong Y., Gu Q., Peterson P.L., Muizelaar J.P., Lee C.P. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. J Neurotrauma. 1997;14:23–34.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Singh I.N., Sullivan P.G., Deng Y., Mbye L.H., Hall E.D. Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy. J Cereb Blood Flow Metab. 2006; 26: 1407–18.</mixed-citation><mixed-citation xml:lang="en">Singh I.N., Sullivan P.G., Deng Y., Mbye L.H., Hall E.D. Time course of post-traumatic mitochondrial oxidative damage and dysfunction in a mouse model of focal traumatic brain injury: implications for neuroprotective therapy. J Cereb Blood Flow Metab. 2006; 26: 1407–18.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Черепно-мозговая травма. Клиническое руководство под редакцией А.Н. Коновалова// М. Антидор., часть 2. 675 с.</mixed-citation><mixed-citation xml:lang="en">Черепно-мозговая травма. Клиническое руководство под редакцией А.Н. Коновалова// М. Антидор., часть 2. 675 с.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Temple M., O’Leary D., Faden A. The role of glutamate receptors in the pathophysiology of traumatic brain injury. In: L Miller, R Hayes, JNewcomb, eds. HeadTrauma. New York, NY: John Wiley &amp; Sons; 2001: 87-113.</mixed-citation><mixed-citation xml:lang="en">Temple M., O’Leary D., Faden A. The role of glutamate receptors in the pathophysiology of traumatic brain injury. In: L Miller, R Hayes, JNewcomb, eds. HeadTrauma. New York, NY: John Wiley &amp; Sons; 2001: 87-113.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Marklund N. Bakshi A. Castelbuono D.J. Conte V. McIntosh T.K. Evaluation of pharmacological treatment strategies in traumatic brain injury. Curr. Pharm. Des. 2006; 12: 1645–1680.</mixed-citation><mixed-citation xml:lang="en">Marklund N. Bakshi A. Castelbuono D.J. Conte V. McIntosh T.K. Evaluation of pharmacological treatment strategies in traumatic brain injury. Curr. Pharm. Des. 2006; 12: 1645–1680.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Faden A.I. Pharmacologic treatment of acute traumatic brain injury. JAMA. 1996; 276: 569-570.</mixed-citation><mixed-citation xml:lang="en">Faden A.I. Pharmacologic treatment of acute traumatic brain injury. JAMA. 1996; 276: 569-570.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bullock M., Lyeth B., Muizelaar J. Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies. Neurosurgery. 1999; 45: 207-217.</mixed-citation><mixed-citation xml:lang="en">Bullock M., Lyeth B., Muizelaar J. Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies. Neurosurgery. 1999; 45: 207-217.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Faden A.I. Neuroprotection and traumatic brain injury: theoretical option or realistic proposition. Curr. Opin. Neurol. 2002; 15: 707–712.</mixed-citation><mixed-citation xml:lang="en">Faden A.I. Neuroprotection and traumatic brain injury: theoretical option or realistic proposition. Curr. Opin. Neurol. 2002; 15: 707–712.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Narayan R.K. Michel M.E. Ansell B. et.al. Clinical trials in head injury. J. Neurotrauma. 2002; 19: 503–557.</mixed-citation><mixed-citation xml:lang="en">Narayan R.K. Michel M.E. Ansell B. et.al. Clinical trials in head injury. J. Neurotrauma. 2002; 19: 503–557.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Maas A.I. Marmarou A. Murray G.D. Teasdale S.G. Steyerberg E.W. Prognosis and clinical trial design in traumatic brain injury: the Impact study. J. Neurotrauma. 2007; 24: 232–238.</mixed-citation><mixed-citation xml:lang="en">Maas A.I. Marmarou A. Murray G.D. Teasdale S.G. Steyerberg E.W. Prognosis and clinical trial design in traumatic brain injury: the Impact study. J. Neurotrauma. 2007; 24: 232–238.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Corwin H.L. Gettinger A. Rodriguez R.M. Pearl R.G. Gubler K.D. Enny C. Colton T. Corwin M.J. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Crit. Care Med. 1999;27:2346–2350.</mixed-citation><mixed-citation xml:lang="en">Corwin H.L. Gettinger A. Rodriguez R.M. Pearl R.G. Gubler K.D. Enny C. Colton T. Corwin M.J. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Crit. Care Med. 1999;27:2346–2350.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Camacho-Arroyo I. Pasapera A.M. Cerbon M.A. Regulation of progesterone receptor gene expression by sex steroid hormones in the hypothalamus and the cerebral cortex of the rabbit. Neurosci. Lett. 1996; 214:25–28.</mixed-citation><mixed-citation xml:lang="en">Camacho-Arroyo I. Pasapera A.M. Cerbon M.A. Regulation of progesterone receptor gene expression by sex steroid hormones in the hypothalamus and the cerebral cortex of the rabbit. Neurosci. Lett. 1996; 214:25–28.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H. Lynch J.R. Song P. Yang H.J. Yates R.B. Mace B. Warner D.S. Guyton J.R. Laskowitz D.T. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp. Neurol. 2007; 206:59–69.</mixed-citation><mixed-citation xml:lang="en">Wang H. Lynch J.R. Song P. Yang H.J. Yates R.B. Mace B. Warner D.S. Guyton J.R. Laskowitz D.T. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp. Neurol. 2007; 206:59–69.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Tanovic A., Alfaro V., Secades J. Citicoline in the treatment of traumatic brain injury Drugs on today, 2004 (Suppl. B): 1-18.</mixed-citation><mixed-citation xml:lang="en">Tanovic A., Alfaro V., Secades J. Citicoline in the treatment of traumatic brain injury Drugs on today, 2004 (Suppl. B): 1-18.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Maas A.I. Neuroprotective agents in traumatic brain injury Drugs 2001; 10: 753-767.</mixed-citation><mixed-citation xml:lang="en">Maas A.I. Neuroprotective agents in traumatic brain injury Drugs 2001; 10: 753-767.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Corwin H.L. Gettinger A. Rodriguez R.M. Pearl R.G. Gubler K.D. Enny C. Colton T. Corwin M.J. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Crit. Care Med. 1999;27:2346–2350.</mixed-citation><mixed-citation xml:lang="en">Corwin H.L. Gettinger A. Rodriguez R.M. Pearl R.G. Gubler K.D. Enny C. Colton T. Corwin M.J. Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Crit. Care Med. 1999;27:2346–2350.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Camacho-Arroyo I. Pasapera A.M. Cerbon M.A. Regulation of progesterone receptor gene expression by sex steroid hormones in the hypothalamus and the cerebral cortex of the rabbit. Neurosci. Lett. 1996; 214:25–28.</mixed-citation><mixed-citation xml:lang="en">Camacho-Arroyo I. Pasapera A.M. Cerbon M.A. Regulation of progesterone receptor gene expression by sex steroid hormones in the hypothalamus and the cerebral cortex of the rabbit. Neurosci. Lett. 1996; 214:25–28.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H. Lynch J.R. Song P. Yang H.J. Yates R.B. Mace B. Warner D.S. Guyton J.R. Laskowitz D.T. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp. Neurol. 2007; 206:59–69.</mixed-citation><mixed-citation xml:lang="en">Wang H. Lynch J.R. Song P. Yang H.J. Yates R.B. Mace B. Warner D.S. Guyton J.R. Laskowitz D.T. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp. Neurol. 2007; 206:59–69.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Tanovic A., Alfaro V., Secades J. Citicoline in the treatment of traumatic brain injury Drugs on today, 2004 (Suppl. B): 1-18.</mixed-citation><mixed-citation xml:lang="en">Tanovic A., Alfaro V., Secades J. Citicoline in the treatment of traumatic brain injury Drugs on today, 2004 (Suppl. B): 1-18.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Maas A.I. Neuroprotective agents in traumatic brain injury Drugs 2001; 10: 753-767.</mixed-citation><mixed-citation xml:lang="en">Maas A.I. Neuroprotective agents in traumatic brain injury Drugs 2001; 10: 753-767.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
