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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2026-055</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9902</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ALLERGOLOGY AND IMMUNOLOGY</subject></subj-group></article-categories><title-group><article-title>Эозинофильный эзофагит и рефрактерные к терапии эзофагиты у детей: осложненное течение с образованием стриктуры пищевода</article-title><trans-title-group xml:lang="en"><trans-title>Eosinophilic esophagitis and refractory esophagitis in children: Complicated course with esophageal stricture formation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2847-6268</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бережная</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Berezhnaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бережная Ирина Владимировна - к.м.н., доцент кафедры педиатрии имени академика Г.Н. Сперанского, РМАНПО; врач-педиатр, гастроэнтеролог, Детская ГКБ им. З.А. Башляевой.</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1; 125373, Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>Irina V. Berezhnaya - Cand. Sci. (Med.), Associate Professor of the Department of Pediatrics named after Academician G.N. Speransky, Russian Medical Academy of Continuous Professional Education; Pediatrician, Gastroenterologist, Bashlyaeva Children’s City Clinical Hospital.</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993; 28, Geroyev Panfilovtsev St., Moscow, 125373</p></bio><email xlink:type="simple">berezhnaya-irina26@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4200-4598</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Захарова Ирина Николаевна - д.м.н., профессор, заслуженный врач РФ, заведующая кафедрой педиатрии имени академика Г.Н. Сперанского.</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Irina N. Zakharova - Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Pediatrics named after Academician G.N. Speransky, Russian Medical Academy of Continuous Professional Education.</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993</p></bio><email xlink:type="simple">zakharova-rmapo@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3181-9601</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Османов</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Osmanov</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Османов Исмаил Магомедович - д.м.н., профессор, главный внештатный специалист-педиатр Департамента здравоохранения г. Москвы, главный врач, Детская ГКБ им. З.А. Башляевой.</p><p>125373, Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>Ismail M. Osmanov - Dr. Sci. (Med.), Professor, Chief Freelance Pediatric Specialist of the Moscow Department of Health, Chief Physician, Bashlyaeva Children’s City Clinical Hospital.</p><p>28, Geroyev Panfilovtsev St., Moscow, 125373</p></bio><email xlink:type="simple">OsmanovIM@zdrav.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3731-6263</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пыков</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pykov</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пыков Михаил Иванович - д.м.н., профессор, заведующий кафедрой лучевой диагностики, РМАНПО; врач ультразвуковой диагностики, Детская ГКБ им. З.А. Башляевой.</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1; 125373, Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>Mikhail I. Pykov - Dr. Sci. (Med.), Professor, Head of the Department of Radiology, Russian Medical Academy of Continuous Professional Education; Ultrasound Diagnostics Physician, Bashlyaeva Children’s City Clinical Hospital.</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993; 28, Geroyev Panfilovtsev St., Moscow, 125373</p></bio><email xlink:type="simple">pykov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-9227-9378</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скоробогатова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Skorobogatova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скоробогатова Екатерина Владимировна - к.м.н., ассистент кафедры педиатрии имени академика Г.Н. Сперанского, РМАНПО; заведующая отделением гастроэнтерологии, врач-гастроэнтеролог, Детская ГКБ им. З.А. Башляевой.</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1; 125373, Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>Ekaterina V. Skorobogatova - Cand. Sci. (Med.), Assistant Professor of the Department of Pediatrics named after Academician G.N. Speransky, Russian Medical Academy of Continuous Professional Education; Head of the Department of Gastroenterology, Gastroenterologist, Bashlyaeva Children’s City Clinical Hospital.</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow, 125993; 28, Geroyev Panfilovtsev St., Moscow, 125373</p></bio><email xlink:type="simple">katrinscor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-9745-9609</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусева</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Guseva</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гусева Дарья Владимировна - ординатор кафедры педиатрии имени академика Г.Н. Сперанского.</p><p>125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Daria V. Guseva - Resident of the Department of Pediatrics named after Academician G.N. Speransky, Russian Medical Academy of Continuous Professional Education.</p><p>2/1, Bldg. 1, Barrikadnaya St., Moscow</p></bio><email xlink:type="simple">dasha.sayapina99@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гончарова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Goncharova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гончарова Людмила Викторовна - врач-педиатр отделения педиатрии.</p><p>125373, Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>Lyudmila V. Goncharova - Pediatrician, Department of Pediatrics, Bashlyaeva Children’s City Clinical Hospital.</p><p>28, Geroyev Panfilovtsev St., Moscow, 125373</p></bio><email xlink:type="simple">GoncharovaLV4@zdrav.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2306-9743</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кошурникова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Koshurnikova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кошурникова Анастасия Сергеевна - к.м.н., заведующая эндоскопическим центром.</p><p>125373, Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>Anastasia S. Koshurnikova - Cand. Sci. (Med.), Head of the Endoscopy Center, Bashlyaeva Children’s City Clinical Hospital.</p><p>28, Geroyev Panfilovtsev St., Moscow, 125373</p></bio><email xlink:type="simple">saller03@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3795-3203</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Епифанова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Epifanova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Епифанова Елена Игоревна - врач-патологоанатом.</p><p>125373, Москва, ул. Героев Панфиловцев, д. 28</p></bio><bio xml:lang="en"><p>Elena I. Epifanova - Pathologist, Bashlyaeva Children’s City Clinical Hospital.</p><p>28, Geroyev Panfilovtsev St., Moscow, 125373</p></bio><email xlink:type="simple">elenz26.09.86@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российская медицинская академия непрерывного профессионального образования; Детская городская клиническая больница имени З.А. Башляевой<country>Россия</country></aff><aff xml:lang="en">Russian Medical Academy of Continuous Professional Education; Bashlyaeva Children’s City Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Российская медицинская академия непрерывного профессионального образования<country>Россия</country></aff><aff xml:lang="en">Russian Medical Academy of Continuous Professional Education<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Детская городская клиническая больница имени З.А. Башляевой<country>Россия</country></aff><aff xml:lang="en">Bashlyaeva Children’s City Clinical Hospital<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>24</day><month>03</month><year>2026</year></pub-date><volume>0</volume><issue>1</issue><fpage>177</fpage><lpage>188</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бережная И.В., Захарова И.Н., Османов И.М., Пыков М.И., Скоробогатова Е.В., Гусева Д.В., Гончарова Л.В., Кошурникова А.С., Епифанова Е.И., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Бережная И.В., Захарова И.Н., Османов И.М., Пыков М.И., Скоробогатова Е.В., Гусева Д.В., Гончарова Л.В., Кошурникова А.С., Епифанова Е.И.</copyright-holder><copyright-holder xml:lang="en">Berezhnaya I.V., Zakharova I.N., Osmanov I.M., Pykov M.I., Skorobogatova E.V., Guseva D.V., Goncharova L.V., Koshurnikova A.S., Epifanova E.I.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9902">https://www.med-sovet.pro/jour/article/view/9902</self-uri><abstract><p>Стеноз пищевода – редкое, но очень опасное состояние, приводящее не только к нарушению пассажа пищи, но и разрывам пищевода. Причины развития стеноза пищевода у детей различны, однако в основе заболевания всегда лежит длительный воспалительный процесс, сопровождающийся ремоделированием органа. Учитывая, что при эозинофильном эзофагите (ЭоЭ) стеноз пищевода чаще описывается у взрослых пациентов, что связывают с длительным течением заболевания, мы обратили внимание на данную проблему в педиатрической популяции. Терапия стеноза пищевода при ЭоЭ включает использование топического стероида на густом носителе для приема внутрь и, как дополнение, строгое соблюдение элиминационной диеты с исключением аллергенов 6 групп и использованием ингибиторов протонной помпы, а также биологической терапии. При стенозе неэозинофильного генеза достаточно назначения препаратов группы ингибиторов протонной помпы, антацидных препаратов и щадящей диеты на короткий промежуток времени. В некоторых случаях используются хирургические методы коррекции. Универсальным методом является использование комплексной терапии с включением эзофагопротектора, который содержит гиалуроновую кислоту и хондроитина сульфат на вязком носителе (полоксамер 407), что позволяет увеличить экспозицию препарата в пищеводе и быстро получить клинический и эндоскопический эффект восстановления слизистой без образования рубцовой ткани в местах эрозий и язв пищевода. В статье представлены два клинических наблюдения детей младшего возраста со стенозом пищевода различной этиологии. Первый случай – наблюдение и лечение мальчика 6,5 лет, у которого при эндоскопическом обследовании верхних отделов желудочно-кишечного тракта выявлены значительные изменения слизистой пищевода со стенозом и распространенными признаками ЭоЭ. Второй случай – девочка 5 лет со стенозом средней трети пищевода и язвенным эзофагитом. Продемонстрировано атипичное и тяжелое течение рефлюкс-эзофагита с формированием стеноза и развитием эрозивно-язвенного поражения слизистой оболочки на фоне скользящей грыжи пищеводного отверстия диафрагмы.</p></abstract><trans-abstract xml:lang="en"><p>Esophageal stenosis is a rare but very dangerous condition that can lead not only to obstruction of food passage, but also to esophageal ruptures. Many different disease processes can cause pediatric esophageal stenosis, but the underlying cause is always a long-term inflammatory process accompanied by organ remodeling. Considering that esophageal stenosis is more often described in adult patients with eosinophilic esophagitis (EoE), which is associated with a long-term course of the disease, we have addressed this issue in the pediatric population. Esophageal stenosis treatment includes topical steroid on a thick carrier for oral administration accompanied by strict compliance with six-food elimination diet (SFED), and the use of proton pump inhibitors (PPIs), as well as biological therapy. For non-eosinophilic stenosis, PPIs, antacids, and a gentle diet for a short period of time are sufficient for a short-term course treatment. In some cases, surgical correction techniques are applied. A universal method comprises the use of a combination therapy with an esophageal protector containing hyaluronic acid and chondroitin sulfate on a viscous carrier (poloxamer 407), which have been shown to increase drug exposure in the esophagus and rapidly achieve clinical and endoscopic restoration of the esophageal mucosa without scarring at the sites of esophageal erosions and ulcers. This article presents two clinical observation reports of young children with esophageal stenosis of various etiologies. The first case involved a 6.5-year-old boy, who was observed and treated due to significant changes in the esophageal mucosa with stenosis and widespread signs of eosinophilic esophagitis (EoE) found during upper gastrointestinal endoscopic examination. The second case involved a 5-year-old girl with stenosis of the middle third of the esophagus and ulcerative esophagitis. This article demonstrated an atypical and severe course of reflux esophagitis with stenosis formation and erosive and ulcerative lesions of the mucosa, secondary to a sliding hiatal hernia in a child.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>эозинофильный эзофагит</kwd><kwd>эзофагит</kwd><kwd>грыжа пищеводного отверстия диафрагмы</kwd><kwd>эзофагопротектор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>eosinophilic esophagitis</kwd><kwd>esophagitis</kwd><kwd>hiatal hernia</kwd><kwd>esophagoprotector</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chew KS, Em JM, Koay ZL, Jalaludin MY, Ng RT, Lum LCS, Lee WS. Low prevalence of infantile functional gastrointestinal disorders (FGIDs) in a multiethnic Asian population. 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