medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2026-081medsovet-9954Research ArticleЗАБОЛЕВАНИЯ КОЖИDERMAL DISEASESОценка клинической эффективности и безопасности применения топических средств на основе кальципотриола и дикалия глицирризината в терапии пациентов с ограниченными формами псориазаEvaluation of the clinical efficacy and safety of topical calcipotriol/dipotassium glycyrrhizinate agents in the treatment of patients with psoriasis and limited skin involvementhttps://orcid.org/0000-0001-8584-615XСмирноваИ. О.SmirnovaI. О.

Смирнова Ирина Олеговна, д.м.н., профессор, заведующая кафедрой дерматовенерологии и косметологии;  врач-дерматовенеролог 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а;192102, Санкт-Петербург, Набережная реки Волковки, д. 3

Irina О. Smirnova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenerology and Cosmetology; Dermatovenerologist

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106; 3, Volkovka River Emb., St Petersburg, 192102

driosmirnova@yandex.ruhttps://orcid.org/0000-0002-6489-4555ПетуноваЯ. Г.PetunovaYa. G.

Петунова Янина Георгиевна, к.м.н., доцент кафедры дерматовенерологии и косметологии; врач-дерматовенеролог 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а;192102, Санкт-Петербург, Набережная реки Волковки, д. 3

Yanina G. Petunova, Cand. Sci. (Med.), Associate Professor of the Department of Dermatovenerology and Cosmetology; Dermatovenerologist 

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106; 3, Volkovka River Emb., St Petersburg, 192102

yaninapetunova@yandex.ruhttps://orcid.org/0000-0002-8138-1639ШинН. В.ShinN. V.

Шин Наталья Валентиновна, к.м.н., доцент кафедры дерматовенерологии и косметологии 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а

Natalia V. Shin, Cand. Sci. (Med.), Associate Professor of the Department of Dermatovenerology and Cosmetology 

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106

shinataly2@gmail.comhttps://orcid.org/0000-0002-6592-1914КуликоваЕ. А.KulikovaЕ. А.

Куликова Евгения Александровна, к.м.н., доцент кафедры дерматовенерологии и косметологии 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а

Evgenia А. Kulikova, Cand. Sci. (Med.), Associate Professor of the Department of Dermatovenerology and Cosmetology 

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106

dr.e.kulikova@yandex.ruhttps://orcid.org/0000-0003-2848-1726ГусаровМ. В.GusarovМ. V.

Гусаров Михаил Вячеславович, ассистент кафедры дерматовенерологии и косметологии 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а

Mikhail V. Gusarov, Assistant of the Department of Dermatovenerology and Cosmetology 

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106

mvgusarov@gmail.comhttps://orcid.org/0009-0005-8404-7803ГоловченкоВ. В.GolovchenkoV. V.

Головченко Валерия Витальевна, старший лаборант кафедры дерматовенерологии и косметологии 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а

Valeriya V. Golovchenko, Senior Laboratory Assistant at the Department of Dermatovenerology and Cosmetology 

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106

valeriya.golovchenko@mail.ruhttps://orcid.org/0000-0002-1713-4123ПахалагеЧ. А.PahalageCh. A.

Пахалаге Чанилка Абегунавардана, аспирант кафедры дерматовенерологии и косметологии 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а

Chanilka А. Pahalage, Postgraduate Student of the Department of Dermatovenerology and Cosmetology 

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106

https://orcid.org/0000-0003-4699-1746ПташниковаП. Д.PtashnikovaP. D.

Пташникова Полина Дмитриевна, старший лаборант кафедры дерматовенерологии и косметологии 

199106, Санкт-Петербург, 21-я линия Васильевского острова, д. 8а

Polina D. Ptashnikova, Senior Laboratory Assistant at the Department of Dermatovenerology and Cosmetology 

8а, 21st Liniya Vasilevskogo Ostrova, St Petersburg, 199106

enternita7@yandex.ruСанкт-Петербургский государственный университет; Городской клинический специализированный центр дерматовенерологииРоссияSaint Petersburg State University; City Clinical Specialized Center of DermatovenereologyRussian FederationСанкт-Петербургский государственный университетРоссияSaint Petersburg State UniversityRussian Federation20261604202602103109Copyright © Смирнова И.О., Петунова Я.Г., Шин Н.В., Куликова Е.А., Гусаров М.В., Головченко В.В., Пахалаге Ч.А., Пташникова П.Д., 20262026Смирнова И.О., Петунова Я.Г., Шин Н.В., Куликова Е.А., Гусаров М.В., Головченко В.В., Пахалаге Ч.А., Пташникова П.Д.Smirnova I.О., Petunova Y.G., Shin N.V., Kulikova Е.А., Gusarov М.V., Golovchenko V.V., Pahalage C.A., Ptashnikova P.D.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9954

Введение. Псориаз остается одной из наиболее значимых проблем современной дерматологии ввиду высокой распространенности и хронического рецидивирующего течения. Важнейшим аспектом терапии является поиск эффективных и безопасных средств для наружного применения, способных не только купировать обострение, но и обеспечивать долгосрочный контроль заболевания. Цель. Оценить клиническую эффективность и безопасность применения средств Депсориол® (лосьон и крем), содержащих кальципотриол и дикалия глицирризинат, у пациентов с бляшечным псориазом. Материалы и методы. Проведено открытое многоцентровое наблюдательное исследование с участием 108 пациентов (61 мужчина, 47 женщин) в возрасте от 6 до 74 лет из 18 городов РФ. Эффективность оценивалась по динамике индекса PASI и субъективной удовлетворенности пациентов через 6–8 нед. терапии. Результаты. Установлено значимое снижение индекса PASI на 77,4% (с 10,6 ± 9,3 до 2,4 ± 2,6 балла; p < 0,001). Наиболее выраженный регресс отмечен в отношении инфильтрации (83,5%) и шелушения (85,3%), медиана которых к завершению наблюдения достигла 0 [0; 2]. Выраженность эритемы снизилась на 73,3% (с 2,66 до 0,71 балла). Терапевтический эффект обусловлен синергизмом кальципотриола, нормализующего дифференцировку кератиноцитов, и дикалия глицирризината, обладающего мощным противовоспалительным и антицитокиновым действием. Выводы. Сто шесть из 108 участников (98,1%) оценили результат терапии как положительный. Высокая приверженность лечению обусловлена быстрым купированием зуда и благоприятными органолептическими свойствами средств (быстрое впитывание, отсутствие липкости). Отсутствие стероидных побочных эффектов позволяет рекомендовать Депсориол® для длительного контроля заболевания, в т. ч. в режиме проактивной терапии.

Introduction. Psoriasis remains a major challenge in modern dermatology due to its high prevalence and chronic relapsing nature. A key therapeutic priority is the search for effective and safe topical agents capable of both managing flare-ups and providing long-term disease control. Aim. To evaluate the clinical efficacy and safety of Depsoriol® lotion and cream (containing calcipotriol and dipotassium glycyrrhizinate) in patients with plaque psoriasis. Materials and мethods. An open-label, multicenter observational study was conducted involving 108 patients (61 males, 47 females) aged 6 to 74 years across 18 Russian cities. Efficacy was assessed based on PASI score dynamics and patient satisfaction (5-point scale) over 6–8 weeks of therapy. Organoleptic properties and ease of use were also evaluated. Results. A statistically significant reduction in the PASI score by 77.4% was observed (from 10.6 ± 9.3 to 2.4 ± 2.6 points; p < 0.001). The most pronounced improvement occurred in infiltration (83.5% reduction) and scaling (85.3% reduction), with the median for these parameters reaching 0 [0; 2] by the final visit. Erythema regression reached 73.3% (from 2.66 to 0.71 points). The therapeutic effect is driven by the synergism of calcipotriol (regulation of keratinocyte differentiation) and dipotassium glycyrrhizinate (potent anti-inflammatory and anti-cytokine activity). Conclusion. Overall, 98.1% of participants rated the treatment results as positive. High treatment adherence was attributed to rapid itch relief and favorable organoleptic properties (fast absorption, non-greasy texture). The absence of steroid-related side effects and the positive safety profile support the use of Depsoriol® for long-term management, including proactive therapy for relapse prevention.

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The authors declare that there are no conflicts of interest present.