medsovetМедицинский СоветMeditsinskiy sovet = Medical Council2079-701X2658-5790REMEDIUM GROUP Ltd.10.21518/ms2026-057medsovet-9959Research ArticleКОСМЕТОЛОГИЯCOSMETOLOGYКлиническая эффективность комбинированного применения неодимового лазера и дермального геля на основе гиалуроновой кислоты с трегалозой у пациентов с эритематозно-телеангиэктатическим подтипом розацеаClinical efficacy of Nd:YAG-laser combined with hyaluronic acid and trehalose injections in patients with erythematotelangiectatic rosaceahttps://orcid.org/0000-0003-3010-0929НаумчикГ. А.NaumchikG. А.

Наумчик Галина Александровна, к.м.н., врач-дерматовенеролог, косметолог; руководитель проекта «Актуальная дерматология и косметология» 

119017, Москва, Погорельский пер., д. 5, стр. 2

Galina А. Naumchik, Cand. Sci. (Med.), Dermatologist/Venerologist, Cosmetologist; Supervisor, Modern Dermatology and Aesthetic Medicine Platform 

5, Bldg. 2, Pogorelsky Lane, Moscow, 119017

Spring27@mail.ruhttps://orcid.org/0009-0001-0788-0077ТрухачевМ. М.TrukhachevM. M.

Трухачев Михаил Михайлович, врач-дерматовенеролог, косметолог, пластический хирург, главный врач 

125466, Москва, ул. Родионовская, д. 12

Mikhail M. Trukhachev, Dermatologist/Venerologist, Cosmetologist, Plastic Surgeon Medical Director 

12, Rodionovskaya St., Moscow, 125466

m_truhachv@mail.ruhttps://orcid.org/0009-0005-1980-0184ЖукВ. П.ZhukV. P.

Жук Валентина Павловна, врач-дерматолог, косметолог, трихолог, главный врач 

119421, Москва, ул. Эльдара Рязанова, д. 4, пом. 244Н

Valentina P. Zhuk, Dermatologist, Cosmetologist, Trichologist, Medical Director 

4, Ste. 244Н, Eldar Ryazanov St., Moscow, 119421

i@vzhuk.ruhttps://orcid.org/0009-0000-4467-243XМураковаВ. С.MurakovaV. S.

Муракова Виктория Сергеевна, медицинский менеджер 

109544, Москва, Рогожский Вал ул., д. 4, оф. 1;

Viktoriya S. Murakova, Medical Representative 

4, Ste. 1, Rogozhsky Val St., Moscow, 109544

petrovavikt2505@yandex.ruЦентр косметологии и интегративной медицины «Nogerov International Clinic»РоссияNogerov International Clinic, Center for Aesthetic and Integrative MedicineRussian FederationЦентр эстетики PrimaeРоссияPrimae ClinicRussian FederationМикос клиникаРоссияMikos ClinicRussian FederationСИЭЛЭС ИНТЕРНЕШНЛРоссияCLS InternationalRussian Federation20261604202602147159Copyright © Наумчик Г.А., Трухачев М.М., Жук В.П., Муракова В.С., 20262026Наумчик Г.А., Трухачев М.М., Жук В.П., Муракова В.С.Naumchik G.А., Trukhachev M.M., Zhuk V.P., Murakova V.S.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-sovet.pro/jour/article/view/9959

Введение. Среди подтипов розацеа эритематозно-телеангиэктатическая форма встречается наиболее часто и характеризуется резистентностью к терапии ввиду комплексности ее патогенеза. Применение комбинированного подхода, сочетающего лазерное воздействие на сосудистый компонент и инъекционную биоревитализацию для нормализации функциональных свойств дермы, представляется патогенетически обоснованным. Однако эффективность и безопасность такого подхода требуют дополнительного изучения. Цель. Оценить клиническую эффективность и безопасность применения неодимового лазера и геля-биоревитализанта на основе гиалуроновой кислоты с трегалозой по отдельности и в комбинации у пациентов с эритематозно-телеангиэктатическим подтипом розацеа. Материалы и методы. В настоящем исследовании 20 пациентов с диагнозом розацеа эритематозно-телеангиэктатического подтипа были распределены в 4 группы: 1-я группа – комбинация лазерного воздействия и инъекционной биоревитализации в рамках одной процедуры; 2-я группа – чередование лазерного воздействия и инъекционной биоревитализации с интервалом 2 нед.; 3-я группа – лазерное воздействие; 4-я группа – инъекционная биоревитализация. Для изучения результатов лечения проводили объективную аппаратную диагностику и оценку с использованием валидированных шкал. Результаты. Комбинированная терапия обеспечила наиболее выраженное снижение эритемы, телеангиэктазий и плотности сосудистой сетки, а также высокие показатели улучшения качества кожи и удовлетворенности пациентов лечением. Существенной разницы между 1-й и 2-й группами выявлено не было. Монотерапия с применением неодимового лазера способствовала эффективной редукции сосудистых проявлений, но не влияла на качество кожи. Инъекционная монотерапия, напротив, улучшала гидратацию и текстуру кожи, однако, была недостаточно эффективной в отношении телеангиэктазий. Выводы. Высокая эффективность и безопасность комбинированного применения неодимового лазера и геля-биоревитализанта на основе гиалуроновой кислоты с трегалозой как в рамках одной процедуры, так и с разнесением процедур по времени позволяют рекомендовать использование данных протоколов в клинической практике для лечения пациентов с розацеа эритематозно-телеангиэктатического подтипа.

Introduction. Erythematotelangiectatic rosacea, the most prevalent subtype, is characterized by its resistance to standard therapeutic approaches. A combination of laser treatment for vascular lesions and injectable biorevitalization for the functional dermal remodeling appears pathogenetically justified. However, its clinical efficacy and safety require further investigation. Aim. To assess the clinical efficacy and safety of Nd:YAG-laser combined with hyaluronic acid/trehalose injections within a single procedure or with 2-week interval in patients with erythematotelangiectatic rosacea. Materials and methods. In this study, 20 patients diagnosed with erythematotelangiectatic rosacea were allocated to four groups: Group 1 (laser treatment combined with hyaluronic acid/trehalose injections within a single procedure); Group 2 (laser treatment combined with hyaluronic acid/trehalose injections with 2-week interval); Group 3 (laser treatment); Group 4 (hyaluronic acid/trehalose injections). Treatment outcomes were monitored using Antera 3D® three-dimensional skin analysis and validated clinical assessment and patient satisfaction scales. Results. Combination therapy (Groups 1 and 2) demonstrated the most significant reduction of erythema, telangiectasia and vascular lesions. These approaches were associated with the greatest improvements in overall skin condition and patient satisfaction. No significant difference between Groups 1 and 2 was found. Nd:YAG-laser monotherapy proved most effective for the reduction of vascular lesions, it had no significant impact on skin quality parameters. Hyaluronic acid/trehalose injections improved skin hydration and texture, however demonstrated limited efficacy against telangiectasias. Conclusion. The high efficacy and safety of Nd:YAG-laser combined with hyaluronic acid/trehalose injections both within a single procedure and with 2-week intervals support the inclusion of these treatment protocols in clinical algorithms for erythematotelangiectatic rosacea.

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The authors declare that there are no conflicts of interest present.