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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medsovet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский Совет</journal-title><trans-title-group xml:lang="en"><trans-title>Meditsinskiy sovet = Medical Council</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2079-701X</issn><issn pub-type="epub">2658-5790</issn><publisher><publisher-name>REMEDIUM GROUP Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21518/ms2026-109</article-id><article-id custom-type="elpub" pub-id-type="custom">medsovet-9973</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕРВНО-ПСИХИЧЕСКИЕ РАССТРОЙСТВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROPSYCHIATRIC DISORDERS</subject></subj-group></article-categories><title-group><article-title>Генерализованное тревожное расстройство в реальной клинической практике: перспективы диагностики и терапии</article-title><trans-title-group xml:lang="en"><trans-title>Generalized anxiety disorder in real-world clinical practice: Prospects for diagnosis and treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2228-6316</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петелин</surname><given-names>Д. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Petelin</surname><given-names>D. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петелин Дмитрий Сергеевич - к.м.н., доцент кафедры психиатрии и психосоматики Института клинической медицины имени Н.В. Склифосовского.</p><p>119048, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Dmitry S. Petelin - Cand. Sci. (Med.), Associate Professor of the Department of Psychiatry and Psychosomatics, Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">petelinhome1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-9983-6648</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Герасимов</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Gerasimov</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Герасимов Сергей Сергеевич – студент.</p><p>119048, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Sergey S. Gerasimov - Student, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">gerasimov.s3regey@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-8011-0307</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгополова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgopolova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Долгополова Юлия Валерьевна - врач-психиатр психотерапевтического отделения Клиники нервных болезней имени А.Я. Кожевникова.</p><p>119048, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Yulia V. Dolgopolova - Psychiatrist of the Psychotherapeutic Department, Kozhevnikov Clinic of Nervous Diseases, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">juliadolgopolova98@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0061-1798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Семин</surname><given-names>С. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Semin</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Семин Сергей Александрович - врач-психиатр психотерапевтического отделения Клиники нервных болезней имени А.Я. Кожевникова.</p><p>119048, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Sergey А. Semin - Psychiatrist of the Psychotherapeutic Department, Kozhevnikov Clinic of Nervous Diseases, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">semockin171@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6605-4851</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воронова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Voronova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воронова Евгения Ивановна - к.м.н., доцент кафедры психиатрии и психосоматики, заместитель директора Института клинической медицины имени Н.В. Склифосовского.</p><p>119048, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Evgeniya I. Voronova - Cand. Sci. (Med.), Associate Professor of the Department of Psychiatry and Psychosomatics, Deputy Director, Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University).</p><p>8, Bldg. 2, Trubetskaya St., Moscow, 119048</p></bio><email xlink:type="simple">voronova_e@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>19</day><month>04</month><year>2026</year></pub-date><volume>0</volume><issue>3</issue><fpage>92</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петелин Д.С., Герасимов С.С., Долгополова Ю.В., Семин С.A., Воронова Е.И., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Петелин Д.С., Герасимов С.С., Долгополова Ю.В., Семин С.A., Воронова Е.И.</copyright-holder><copyright-holder xml:lang="en">Petelin D.S., Gerasimov S.S., Dolgopolova Y.V., Semin S.A., Voronova E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-sovet.pro/jour/article/view/9973">https://www.med-sovet.pro/jour/article/view/9973</self-uri><abstract><p>Тревожные расстройства относятся к числу наиболее распространенных заболеваний психической сферы в современном мире, и одним из наиболее значимых среди них является генерализованное тревожное расстройство. Для этого расстройства характерны длительное существование стойкого и выраженного беспокойства по различным поводам, а также многочисленные тягостные телесные ощущения, утомляемость, нарушения сна и болевая симптоматика. В многочисленных исследованиях показано, что нелеченое генерализованное тревожное расстройство существенно снижает качество жизни пациентов, повышает риск инвалидизации, а также негативно влияет на течение ряда социально и клинически значимых соматических заболеваний. Несмотря на большое число разработанных методов диагностики и терапии, ведение пациентов с данным расстройством в реальной клинической практике остается непростой задачей, требующей от клинициста дифференцированного подбора терапевтических интервенций. Согласно современным данным, при генерализованном тревожном расстройстве могут быть эффективны рекомендации по коррекции образа жизни, психотерапевтические интервенции (в первую очередь когнитивно-поведенческая терапия), а также психофармакотерапия. Первой линией психофармакотерапии генерализованного тревожного расстройства являются ингибиторы обратного захвата моноаминов, а наиболее отчетливым быстрым противотревожным эффектом обладают транквилизаторы бензодиазепинового ряда. Тем не менее препараты обоих классов не лишены побочных эффектов и недостатков, что лимитирует их универсальное назначение всем пациентам с генерализованным тревожным расстройством. В статье на примере двух клинических наблюдений показано, как небензодиазепиновый анксиолитик – оригинальный препарат этифоксин – может оказаться полезной опцией в терапии генерализованного тревожного расстройства: в зависимости от клинической ситуации – как в монотерапии, так и в качестве дополнения к ингибитору обратного захвата серотонина и норадреналина.</p></abstract><trans-abstract xml:lang="en"><p>Anxiety disorders are among the most common forms of mental illness in the modern world, and one of the most significant is generalized anxiety disorder. This disorder is characterized by long-term, persistent, and severe anxiety about various issues, as well as numerous distressing sensations in the body, fatigue, sleep disturbances, and pain symptoms. Numerous studies have shown that untreated generalized anxiety disorder significantly reduces patients’ quality of life, increases the risk of disability, and negatively impacts the course of a number of socially and clinically significant somatic diseases. Despite the large number of developed diagnostic and therapeutic methods, managing patients with this disorder in real-world clinical practice remains a challenging task, requiring the clinician to select differentiated therapeutic interventions. According to current data, lifestyle modification recommendations, psychotherapeutic interventions (primarily cognitive behavioral therapy), and psychopharmacotherapy can be effective in treating generalized anxiety disorder. Monoamine reuptake inhibitors are the first-line psychopharmacotherapy for generalized anxiety disorder, and benzodiazepine tranquilizers have the most pronounced rapid anti-anxiety effect. However, both classes of medications are not without side effects and drawbacks, limiting their universal use in all patients with generalized anxiety disorder. This article concludes with two case reports demonstrating how the non-benzodiazepine anxiolytic original etifoxine may be a useful treatment option for generalized anxiety disorder, depending on the clinical situation, either as monotherapy or as an adjunct to a serotonin-norepinephrine reuptake inhibitor.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>генерализованное тревожное расстройство</kwd><kwd>психофармакотерапия</kwd><kwd>психотерапия</kwd><kwd>соматизированная тревога</kwd><kwd>оригинальный этифоксин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>generalized anxiety disorder</kwd><kwd>psychopharmacotherapy</kwd><kwd>psychotherapy</kwd><kwd>somatization anxiety</kwd><kwd>etifoxine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. 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