FIVE REASONS TO PRESCRIBE A MACROLIDE FOR ENT DISEASE
https://doi.org/10.21518/2079-701X-2016-9-40-44
Abstract
Macrolides are antibiotics the chemical structure of which has a macrocyclic lactone ring. Macrolides have several advantages over other groups of antibiotics. They are characterized by high antibacterial activity against intracellular pathogens and have anti-inflammatory, immunomodulatory effects and regulate the mucus. The article names five reasons to prescribe macrolides for diseases of the upper respiratory tract: cross sensitivity to penicillin antibiotics; combination of inflammatory disease of the upper respiratory tract and ear with allergic disease; infections caused by atypical microorganisms (chlamydia, mycoplasma, etc.); upper respiratory tract infection characterized by biofilm formation; chronic rhinosinusitis with or without polyps, with
persistent course, frequent relapses and low efficiency of surgical treatment.
References
1. Практическое руководство по антиинфекционной химиотерапии. Под ред. Страчунского Л.С., Белоусова Ю.Б., Козлова С.Н. Смоленск: МАКМАХ, 2002. 350 с. / Practical guidance on anti-infective chemotherapy. Ed. by Strachunskiy L.S., Belousov Y.B., Kozlov S.N. Smolensk: IACMAC, 2002. 350 p.
2. Marriott HM, Mitchell TJ, Dockrell DH. Pneumolysin: A double-edged sword during the host-pathogen interaction. Current Molecular Medicine, 2008, 8: 497-509.
3. Torumkuney D, Gur D, Soyletir G, Gurler N, Aktas Z, Sener B, Tunger A, Bayramoglu G, Koksal I, Yalcin AN, Tanriver Y, Morrissey I, Barker K. Results from the Survey of Antibiotic Resistance (SOAR) 2002-09 in Turkey. J. Antimicrob. Chemother., 2016, 71(1): 185-191. doi: 10.1093/jac/dkw067.
4. Uncu H, Colakoğlu S, Turunç T, Demiroğlu YZ, Arslan H. In vitro resistance rates of Streptococcus pneumoniae and Haemophilus influenzae clinical isolates to the antibiotics used in therapy. Mikrobiyol Bul., 2007, 41(3): 441-446.
5. Zientara M, Rudy M, Nowakowska M, Martirosian G. Nosopharyngeal microflora in ambulatory treated children and adults with upper respiratory tract infections. Med. Dosw. Mikrobiol., 2006, 58(3): 239-245.
6. Kaneko Y, Yanagihara K, Seki M, Kuroki M, Miyazaki Y, Hirakata Y, Mukae H, Tomono K, Kadota J, Kohno S. Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis. Am. J. Physiol. Lung Cell Mol. Physiol., 2003, 285(4): 847-853.
7. Morikawa K, Zhang J, Nonaka M, Morikawa S. Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production. Int. J. of Antimicrobial Agents, 2002, 19(1): 53-59.
8. Morikawa K, Watabe H, Araaka A, Morikawa S. Modulatory effect of antibiotics on c cytokine production by human monocytes in vitro. Antimicrob. Agents and Chemother., 1996, 40(6): 1366-1370.
9. Страчунский Л.С., Козлов С.Н. Макролиды в современной клинической практике. Смоленск, «Русич». 1998: 304. / Strachunskiy L.S., Kozlov S.N. Macrolides in modern clinical practice. Smolensk, «Rusich». 1998: 304.
10. Gotfried MH. Clarithromycin (Biaxin) extendedrelease tablet: a therapeutic review. Expert Rev. Anti-Infect. Ther., 2003, 1(1): 9-20.
11. Гаращенко Т.И. Макролиды в терапии острого тонзиллита и его осложнений у детей. РМЖ, 2001, 19: 812-816. / Garaschenko T.I. Macrolides in the treatment of acute tonsillitis and its complications in children. RMZ, 2001, 19: 812-816.
12. Cillóniz C, Ardanuy C, Vila J, Torres A. What is the clinical relevance of drug-resistant pneumococcus? Curr. Opin. Pulm. Med., 2016, 22(3): 227-234. doi: 10.1097/MCP.0000000000000262.
13. Лопатин А.С., Свистушкин В.М. Острый риносинусит: этиология, патогенез, диагностика и принципы лечения. Клинические рекомендации. М., 2009: 25. / Lopatin A.S., Svistushkin A.M. Acute rhinosinusitis: etiology, pathogenesis, diagnosis and treatment approach. Clinical guidelines. M., 2009: 25.
14. Почуева Т.В., Ямпольская Е.Е. Особенности микробиологического статуса небных миндалин у детей с сопутствующим кариесом. Folia otorhinolaryngologiae et Pathologiae Respiratoriaea, 2014, 20(3): 104-110. / Pochueva T.V., Yampol’skaya E.E. The specific microbiological status of the tonsils in children with concomitant caries. Folia otorhinolaryngologiae et Pathologiae Respiratoriaea, 2014, 20 (3): 104-110.
15. Bennet JE, Dolin R, Blaser MJ. Principles and practice of infectious diseases. Book chapter Pharyngitis. 2014: 753-759.
16. Линьков В.И., Цурикова Г.П., Чурилина И.Е. и др. Значение хламидийной инфекции в развитии хронических воспалительных заболеваний глотки. Новости отоларингологии и логопатологии, 1995, 3(4): 146. / Lin’kov V.I., Tsurikova G.P., Churilina I.E. et al. The role of chlamydial infection in the development of chronic inflammatory diseases of the pharynx. Novosti Otolaringologii i Logopatologii, 1995, 3(4): 146.
17. Piacentini GL, Peroni DG, Blasi F, Pescollderungg L, Goller P, Gallmetzer L, Drago L, Bodini A, Boner AL. Atypical bacteria in adenoids and tonsils of children requiring adenotonsillectomy. Acta Otolaryngol, 2010, 130(5): 620-625.
18. Hoa M, Tomovic S, Nistico L, Hall-Stoodley L, Stoodley P, Sachdeva L, Berk R, Coticchia JM. Identification of adenoid biofilms with middle ear pathogens in otitis-prone children utilizing SEM and FIS. Int. J. of Pediatric Otorhinolaryngology, 2009, 73: 1242-1248. doi: 10.1016/j.ijporl.2009.05.016.
19. Calò L, Passàli GC, Galli J, Fadda G, Paludetti G. Role of biofilms in chronic inflammatory diseases of the upper airways. Adv. Otorhino laryngol., 2011, 72: 93-96. doi: 10.1159/000324622.
20. Винникова Н.В., Трофименко С.Л., Дударев И.В. К патогенезу хронического полипозного риносинусита. Российская оториноларинго логия. Приложение, 2016: 42- 44. / Vinnikova N.V., Trofimenko S.L., Dudarev I.V. The pathogenesis of chronic polypoid rhinosinusitis. Rossiyskaya Otorinolaringologiya. Supplement, 2016: 42-44.
21. Kaplan EL, Chhatwal GS, Rohde M. Reduced ability of penicillin to eradicate ingested group A streptococci from epithelial cells: clinical and pathogenetic implications. Clin. Infect. Dis., 2006, 43(11): 1398-1406.
22. Овчинников Ю.М. Отчет об эффективности и безопасности использования препарата Азитрал (Азитромицин) в лечении больных с острым и обострением хронического гнойного риносинусита и острого среднего отита. 2005:
23. / Ovchinnikov Y.M. Report on the effectiveness and safety of Azitral (Azithromycin) in the treatment of patients with acute and exacerbated chronic suppurative rhinosinusitis and acute otitis media. 2005: 23.
24. Морозова С.В., Мельник С.М. Применение препарата Азитрал для лечения хронического риносинусита в практике оториноларинголога. РМЖ, 2011, 31: 1976- 979. / Morozova S.V., Mel’nik S.M. Use of Azitral for the treatment of chronic rhinosinusitis in ENT practice. RMZ, 2011, 31: 1976-1979.
25. Miyamoto D, Hasegawa S, Sriwilaijaroen N, Yingsakmongkon S, Hiramatsu H, Takahashi T, Hidari K, Guo CT, Sakano Y, Suzuki T, Suzuki Y. Clarithromycin inhibits progeny virus production from human influenza virus-infected host cells. Biol. Pharm. Bull., 2008, 31(2): 217-222.
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For citations:
SHILENKOVA VV. FIVE REASONS TO PRESCRIBE A MACROLIDE FOR ENT DISEASE. Meditsinskiy sovet = Medical Council. 2016;(9):40-44. (In Russ.) https://doi.org/10.21518/2079-701X-2016-9-40-44
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