Clinico-anamnestic and immunological characteristics of premature infants with respiratory distress syndrome
https://doi.org/10.21518/2079-701X-2017-1-29-33
Abstract
Purpose of the study: compare perinatal factors, clinical-anamnestic data and the levels of anti-inflammatory IL-10 and indirect marker of fibrosis - metalloproteinase 3 (MMP3) in preterm infants with and without respiratory distress syndrome (RDS) to clarify their role in the pathogenesis of lung injury during the period from 3 to 6 weeks of life.
Patients and methods: 15 premature infants with RDS (group 1) and 10 premature infants without RDS (group 2) were examined in the same period of life.
Results: The proportion of children with reduced IL-10 was 60% in group 1 compared to 20% in group 2 (p = 0.048). The proportions of children with reduced MMP3 were 47 and 27%, respectively (p = 0.17). The proportions of elevated IL-10 and MMP3 values were comparable in the two groups (27 and 20% for IL-10 and 13 and 10% for MMP3), the data was unreliable. Children with elevated IL-10 in combination with decreased MMP3 had a history of frequent ARVI complicated by obstructive bronchitis and pneumonia in the first year of life.
Conclusion: Premature infants with RDS are characterized by reduced levels of IL-10 and MMP3 compared with the same biomarkers for premature infants without RDS.
About the Authors
E. A. Zhdanovich
Perm State Medical University named after acad. E.A. Vagner, Russia’s Ministry of Health
Russian Federation
Russian Federation
E. G. Furman
Perm State Medical University named after acad. E.A. Vagner, Russia’s Ministry of Health
Russian Federation
MD, Prof.
Russian Federation
MD, Prof.
M. E. Bronnikova
Children’s Clinical Hospital No. 13, Perm
Russian Federation
Russian Federation
S. A. Kalenova
Children’s Clinical Hospital No. 13, Perm
Russian Federation
Russian Federation
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Review
For citations:
Zhdanovich EA, Furman EG, Bronnikova ME, Kalenova SA. Clinico-anamnestic and immunological characteristics of premature infants with respiratory distress syndrome. Meditsinskiy sovet = Medical Council. 2017;(1):29-33. (In Russ.) https://doi.org/10.21518/2079-701X-2017-1-29-33
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