Modern ideas about the use of probiotics in pediatric practice
https://doi.org/10.21518/2079-701X-2017-1-144-148
Abstract
Probiotics are widely used drugs with the proven effect that improve the health of the host organism. They differ in composition, therefore their choice should be based on the results of past clinical trials. Mechanisms of action of probiotics are not limited to simple colonization of the intestine, they exert antagonistic action against pathogens, strengthen the barrier function of the intestine, stimulate the immune defense and form immunological tolerance. Indications for their purpose is very broad: it is an acute intestinal infection, antibiotic-associated diarrhea, functional gastrointestinal disorders, treatment of chronic infections and inflammatory bowel diseases, prevention of allergic diseases and infections in frequently ill children. A rational choice of a probiotic depends on the age, as the disease structure and the purpose of the probiotics in different age groups may vary. The probiotic Primadophilus for infants and older children provides these features.
About the Author
E. A. Kornienko
Saint-Petersburg State Pediatric Medical University
Russian Federation
MD, Prof.
Russian Federation
MD, Prof.
References
1. Lilly DM, Stillwell RH. Probiotics: growth-promoting factors produced by microorganisms. Science, 1965, 147: 747–8.
2. Parker RB. Probiotics, the other half of the antibiotic story. Animal Nutr Health, 1974, 29: 4–8.
3. FAO/WHO. Working group on drafting guidelines for the evaluation of probiotics in food. Guidelines for the evaluation of probiotics in food. 2002. ftp://ftp.fao.org/es/esn/food/wgreport2.pdf.
4. Madsen K, Jijon H, Jeung H et al., DNA from probiotic bacteria exerts anti-inflammatory action on epithelial cells by inhibition of NF-kB. Gastroenterology, 2002, 122: A-64.
5. Probiotic bacteria in dietetic products for infants: a commentary by the ESPGHAN Committee on Nutrition. J. Pediatr. Gastroenterol. Nutr., 2004, 38: 365-374.
6. Cruchet S, Furoes R, Maruy A et al. The use of probiotics in pediatric gastroenterology: A review of literature and recommendations by Latin-American experts. Pediatr. Drugs, 2015 Jun, 17(3): 199-216. DOI 10.1007/s40272-015-0124-6.
7. Borchers AT et al. Probiotics and immunity. J Gastroenterol, 2009, 4: 26-46.
8. Supplementation of infant formula with probiotics and/or prebiotics: a systemic rewiew and comment by the ESPGHAN Commitee on Nutrition. J. Pediatr. Gastroenterol., 2011, 52(2): 238-250.
9. Bezkorovainy A. Probiotics: determinants of survival and growth in the gut. Am. J. Clin. Nutr., 2001, 73(2): 399s-405s.
10. General report of the Scientific Committee on Food of European Commission on the revision of essential requirements of infant formulas and follow-up formulas, 2003. http://europa. en.int/comm/food/fs/sc/scf/index.en.html.
11. Mercenier A, Pavan S, Pot B. Probiotics as biotherapeutic agents: present knowledge and future prospects. Curr. Pharm. Des., 2003, 9(2): 175-191.
12. Borriello SP et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis, 2003, 36: 775-780.
13. Karpa KD. Probiotics for Clostridium difficile diarrhea: putting it into perspective. Ann Pharmacother., 2007, 41: 1284–1287.
14. Ng SC, Hart AL, Kamm MA et al. Mechanisms of action of probiotics: recent advances. Inflamm. Bowel Dis., 2009, 15(2): 301-312.
15. Resta-Lenert S, Barrett KE. Live probiotics protect intestinal epithelial cells from the effects of infection. Gut, 2003, 52(7): 988-997.
16. Spinler JK, Tawelchotipatr M, Rognerud CL et al. Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens. Anaerobe, 2008, 14: 166-171.
17. Juntunen M, Kirjavainen PV. Ouwehand AC. Salminen SJ. Isolauri E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin Diagn Lab Immunol, 2001, 8(2): 293-6.
18. Rakoff-Naboum S, Paglimo J, Eslami-Varzanch F et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell, 2004, 118: 229-241.
19. Yan F, Polk DB. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J. Biol. Chem., 2002, 277: 50959-50965.
20. Ouwehand A, Isolauri E, Salminen S. The role of intestinal microflora for development of the immune system in early childhood. Eur. J. Nutr., 2002, 41(1): 132-137.
21. Righy R, Kamm MA, Knight SC et al. Pathogenic bacteria stimulate colonic dendritic cells to produce pro-inflammatory IL-12 while the response to probiotic bacteria is to produce anti-inflammatory IL-10. Gut, 2002, 50: A70.
22. Smits HH, Engering A, van Der KD et al. Selective probiotic bacteria induce IL-10- producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J. Allergy Clin. Immunol., 2005, 115: 1260-1267.
23. Houghteling PD,Walker WA. Why is initial bsterial colonization of the intestine important to infants’ and children’s health. J. Pediatr. Gasteroenterol. Nutr., 2015, 60(3): 294-307.
24. Braat H, van Den BJ, van Tol E et al. Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. Am. J. Clin. Nutr., 2004, 80: 1618-1625.
25. Dalmasso G, Cotrez F, Imbert V et al. Saccharomyces boulardii inhibits inflammatory bowel disease by trapping T cells in mesenteric lymph nodes. Gastroenterology, 2006, 131: 1812-1825.
26. Fang H, Elina T, Heikki A et al. Modulation of humoral immune response through probiotic intake. Immunol. Med. Microbiol., 2000, 29: 47-52.
27. Ouwehand A, Isolauri E, Salminen S. The role of the intestinal microflora for the development of the immune system in early childhood. Eur. J. Nutr., 2002, 41(1): I32-137.
28. Savino F, Cordisco L, Tarasco V et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized double-blind, placebo controlled trial. Pediatrics, 2010, 126: 526-533.
29. Topping DL, Clifton PM. Short-chain fatty acids and human colonic function. Phisiol. Rev., 2001, 81: 1031-1064.
Review
For citations:
Kornienko EA. Modern ideas about the use of probiotics in pediatric practice. Meditsinskiy sovet = Medical Council. 2017;(1):144-148. (In Russ.) https://doi.org/10.21518/2079-701X-2017-1-144-148
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