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ПРУКАЛОПРИД В ЛЕЧЕНИИ ХРОНИЧЕСКИХ ЗАПОРОВ

https://doi.org/10.21518/2079-701X-2017-15-51-55

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Аннотация

В статье представлены факторы, которые участвуют в развитии запора. Основное значение имеет нарушение моторной функции кишечника, характеризующееся неэффективным продвижением содержимого по толстой кишке. Фармакологическое воздействие на 5НТ4-серотониновые рецепторы пациентов с запорами является наиболее физиологическим путем восстановления моторики толстой кишки, сохраняющим суточные ритмы дефекации, инициирующим ее высокоамплитудные пропульсивные сокращения без существенных побочных эффектов, свойственных некоторым энтерокинетикам и слабительным препаратам. Методом такого воздействия является применение прукалоприда. Он эффективен при хроническом запоре и обеспечивает новые терапевтические альтернативы пациентам, у которых симптомы запора не были полностью устранены слабительными средствами. Представлен отечественный прукалоприд Вегапрат.

 

Об авторах

Е. Ю. Плотникова
Кемеровский государственный медицинский университет Минздрава России
Россия

д.м.н., профессор



Т. Ю. Грачева
Кемеровский государственный медицинский университет Минздрава России
Россия

д.м.н., профессор



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ISSN 2079-701X (Print)
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