АНТИБИОТИК-АССОЦИИРОВАННЫЕ ДИАРЕИ У ДЕТЕЙ: ЧТО НОВОГО?
Аннотация
В статье представлены данные по распространенности инфекционных заболеваний у детей в России и частоте применения антибактериальной терапии. Уделено особое внимание бесконтрольному применению антибиотиков, что приводит к антибиотикорезистентности, нарушению равновесия симбиотной микробиоты, развитию острых аллергических реакций и других заболеваний. Приведена современная тактика лечения детей с антибиотик-ассоциированной диареей согласно международным рекомендациям ESPGHAN и ESPID.
Ключевые слова
Об авторах
И. Н. Захарова
Российская медицинская академия непрерывного профессионального образования Минздрава России
Россия
Россия
д.м.н., профессор,
Москва
И. В. Бережная
Российская медицинская академия непрерывного профессионального образования Минздрава России
Россия
Россия
к.м.н.,
Москва
Н. Г. Сугян
Российская медицинская академия непрерывного профессионального образования Минздрава России
Россия
Москва
Россия
Москва
Список литературы
1. Gill SR, et al. Metagenomic analysis of the human distal gut microbiome. Science, 2006, 312: 1355–1359.
2. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature, 2011, 474: 327–336.
3. Инфекционная заболеваемость в Российской Федерации за январь 2016 г. (по данным формы №1 «Сведения об инфекционных и паразитарных заболеваниях»).
4. Van Boeckel TP, Gandra S, Ashok A, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis, 2014, 14: 742-50.
5. Turnbaugh PJ, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 2006, 444: 1027–1031.
6. McArdle MA, Finucane OM, Connaughton RM, et al. Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritionalstrategies. Frontiersin Endocrinology, 2013, 4(52).
7. Lee J. Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes. Archives of Pharmacal Research, 2013, 36: 208–222.
8. Marrs T, Flohr C. How do Microbiota Influence the Development and Natural History of Eczema and Food Allergy? The Pediatric Infectious Disease Journal, 2016 November, 35(11): 1258-1261.
9. ВОЗ: Лечение диареи, 2006.
10. Bartlett JG. Antibiotic-associated diarrhea. N Engl J Med, 2002, 346: 334–339.
11. Barakat Maha, El-Kady Zeinab, Mostafa Mohamed, Naglaa Ibrahim and Hamdy Ghazaly. Antibiotic-associated Bloody Diarrhea in Infants: Clinical, Endoscopic and Histopathologic Profiles. JPGN, Jan 2011, 52(1).
12. LaRosa M, Bottaro G, Gulino N, et al. Prevention of antibiotic–associated diarrhea with Lactobacillus sporogens and fructo–oligosaccharides in children: a multi-centric doubleblind vs. placebo study. Minerva Pediatr, 2003, 55: 447–52.
13. Turck D, Bernet JP, Marx J, et al. Incidence and risk factors for of oral antibiotic–associated diarrhea in an outpatient pediatric population. J Pediatr Gastroenterol Nutr, 2003, 37: 22–6.
14. McFarland LV. Diarrhea acquired in the hospital. Gastroenterol Clin North Am, 1993, 22: 563–577.
15. Hogenauer C, Hammer HF, Krejs GJ, Reisinger EC. Mechanisms and management of antibiotic-associated diarrhea. Clin Infect Dis, 1998, 27: 702-710.
16. Захарова И.Н., Дмитриева Ю.А. Антибиотико-ассоциированные диареи: лечение и профилактика. Consilium medicum. Педиатрия, 2009, 2: 7-10.
17. Hempel S, Newberry SJ, Maher AR et al. Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea. A Systematic Review and Meta-analysis. JAMA, 2012 May 9, 307(18).
18. Boyce JM, Havill NL. Nosocomial antibioticassociated diarrhea associated with enterotoxin-producing strains of methicillin–resistant Staphylococcus aureus. Am J Gastroenterol, 2005 Aug, 100(8): 1828–34.
19. Шевяков М.А. Антибиотик-ассоциированная диарея и кандидоз кишечника: возможности лечения и профилактики. Антибиотики и химиотерапия, 2004, 49(10): 26-29.
20. Krause R, Reisinger EC. Candida and antibiotic– associated diarrhea. Clin Microbiol Infect, 2005, 11: 1–2.
21. Hogenauer C, Langner C, Beubler E et al. Klebsiella oxytoca as a causative organism of antibiotic-associated hemorrhagic colitis. N Engl J Med, 2006, 355: 2418–26.
22. Zollner-Scwetz I et al. Role of Klebsiella oxytoca in Antibiotic-Associated Diarrhea. Clinical Infectious Diseases Journal, 2008, 47: e74-8.
23. Малов В.А. Инфекция Clostridium Difficile: современное состояние проблемы. Фарматека, 2010, 4.
24. Hickson M, D’Souza A, Muthu N et al. Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ, 2007, 335: 80.
25. Ayyagari A, Agarwal J, Garg A. Antibiotic associated diarrhoea: Infectious causes. Indian Journal of Medical Microbiology, 2003, 21(1): 6–11.
26. Hedge DD, Strain JD, Heins JR, Farver DK. New advances in the treatment of Clostridium difficile infection (CDI). Therapeutics and Clinical Risk Management, 2008, 4(5).
27. Ивашкин В.Т., Ющук Н.Д., Маев И.В., Лапина Т.Л., Полуэктова Е.А., Шифрин О.С., Тертычный А.С., Трухманов А.С., Шептулин А.А., Баранская Е.К., Ляшенко О.С., Ивашкин К.В. Рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению Clostridium difficile-ассоциированной болезни. Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2016, 26(5): 56-65.
28. Marra AR, Edmond MB, Wenzel RP, Bearman GM. Hospitalacquired Clostridium difficileassociated disease in the intensive care unit setting: epidemiology, clinical course and outcome. BMC Infect Dis, 2007, 7(42).
29. Lupse M, Flonta M, Cioara A, Filipescu I, Todor N. Predictors of First Recurrence in Clostridium di¬cile-Associated Disease. A Study of 306 Patients Hospitalized in a Romanian Tertiary Referral Center. J Gastrointestin Liver Dis, 2013 Dec, 22(4): 397–403.
30. Harris AD, Pineles L, Belton B, et al. Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU: A Randomized Trial. JAMA, 2013, 310(15): 1571-1580.
31. Захарова И.Н., Мазанкова Л.Н. и соавт. Антибиотик-ассоциированные диареи у детей: проблема и решение. М., 2011. 48 с.
32. Curtin BF, Zarbalian Y, Flasar MH, von Rosenvinge E. Clostridium difficile -associated disease: Adherence with current guidelines at a tertiary medical center. World J Gastroentero, 2013 Dec 14, 19(46): 8647–8651.
33. Nyc O, Pituch H, Matejkova J, ObuchWoszczatynski P, Kuijper EJ. Clostridium difficile PCR ribotype 176 in the Czech Republic and Poland. Lancet,. 2011 Apr 23, 377(9775): 1407.
34. Nylund CM, Goudie A, Garza JM, Fairbrother G, Cohen M.B. Clostridium difficile infection in hospitalized children in the United States. Arch Pediatr Adolesc Med, 2011, 165: 451–457. PMID: 21199971 DOI: 10.1001/archpediatrics.2010.282.
35. Lupse M, Flonta M, Cioara A, Filipescu I, Todor N. Predictors of First Recurrence in Clostridium difficile-Associated Disease. A Study of 306 Patients Hospitalized in a Romanian Tertiary Referral Center. J Gastrointestin Liver Dis, 2013 December, 22(4): 397-403.
36. Minino A, Xu J and Kochanek K. Deaths: preliminary data for 2008. National Vital Statistics Report 59. Hyattsville, MD: National Center for Health Statistics. 2010. Available at: http: // www.cdc.gov/ nchs/data/nvsr/nvsr59/ nvsr59_02.pdf/
37. Bauer MP, Notermans DW, van Benthem BH, Brazier JS, Wilcox MH, Rupnik M, Monnet DL, van Dissel JT, Kuijper EJ, ECDIS Study Group. Clostridium difficile infection in Europe: a hospital-based survey. Lancet, 2011, 377: 63-73.
38. Curtin BF, Zarbalian Y, Flasar MH, von Rosenvinge E. Clostridium difficile -associated disease: Adherence with current guidelines at a tertiary medical center. World J Gastroenterol, 2013 December 14, 19(46): 8647-8651.
39. Zilberberg MD, Tillotso GS, McDonald LC. Clostridium difficile Infections among Hospitalized Children, United States , 1997– 2006. Emer g. Infect. Dis., 2010 April, 16(4): 604–609.
40. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, Pepin J, Wilcox MH, Society for Healthcare Epidemiology of America, Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Disases Society of America (IDSA). Infect Contr Hosp Epidem, 2010, 5: 431-455.
41. Elliott B, Reed R, Chang BJ, Riley TV. Bacteremia with a large clostridial toxin-negative, binary toxin-positive strain of Clostridium difficile. J. Anaerobe, 2009, 15: 249–251.
42. Kociolek LK, Gerding DN. Clinical utility of laboratory detection of Clostridium difficile strain BI/ NAP1/027. J Clin Microbiol, 2016, 54(1): 19-24.
43. Vardakas KZ, Konstantelias AA, Loizidis G, Rafailidis PI, Falagas ME. Risk factors for development of Clostridium difficile infection due to BI/NAP1/027 strain: a meta-analysis. Int J Infect Dis, 2012, 16(11): 768-73.
44. Sartelli M, Malangoni MA, Abu-Zidan FM, Griffiths EA, di Bella S, et al. WSES guidelines for management of Clostridium difficile infection in surgical patients. World J Emerg Surg, 2015, 10: 38.
45. Surawicz СM, Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, McFarland LV, Mellow M, Zuckerbraun BS. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol, 2013, 108(4): 478-98.
46. Crobach MJT, Planche T, Eckert C, Barbut F, et al. European society of clinical microbiology and infectious diseases: Update of the diagnostic guidance document for Clostridium difficile infection. Clin Microbiol Infect, 2016, 22: 63-81.
47. Peterson LR, Kelly JP, Nordbrock HA. Role of culture and toxin detection in laboratory testing for diagnosis of Clostridium difficile – associated diarrhea. Eur. J. Clin. Microbiol. Infect. Dis., 1996, 15: 330-6.
48. Kachrimanidou M, Malisiovas N. Clostridium difficile Infection: A comprehensive review. Crit. Rev. Microbiol., 2011, 37(3): 178-187.
49. Qin J et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. Nature Publishing Group, 2012, 490(7418): 55-60.
50. Алешкин В.А., Селькова Е.П., Миронов А.Ю., Гренкова Т.А., Шелыгин Ю.А. Лабораторная диагностика Clostridium difficileассоциированных диарей. Федеральные клинические рекомендации. 2017, c. 24.
51. Guarino А, Albano F, Ashkenazi S et al. European society for paediatric gastroenterology, hepatology, and nutrition/european society for paediatric infectious diseases evidencebased guidelines for the management of acute gastroenteritis in children in europe: executive summary. Journal of Pediatric Gastroenterology and Nutrition, 2008, 46(5): 619–621.
Для цитирования:
Захарова И.Н., Бережная И.В., Сугян Н.Г. АНТИБИОТИК-АССОЦИИРОВАННЫЕ ДИАРЕИ У ДЕТЕЙ: ЧТО НОВОГО? Медицинский Совет. 2017;(19):126-133. https://doi.org/10.21518/2079-701X-2017-19-126-133
For citation:
Zakharova I.N., Berezhnaya I.V., Sugyan N.G. ANTIBIOTIC ASSOCIATED DIARHEAS IN CHILDREN: WHAT’S NEW? Meditsinskiy sovet = Medical Council. 2017;(19):126-133. (In Russ.) https://doi.org/10.21518/2079-701X-2017-19-126-133
Просмотров: 423
Послать статью по эл. почте 
