Эффективность безглютеновой диеты при неврологических заболеваниях и психиатри ческих расстройствах: миф или реальность?
Аннотация
Вопрос о том, каким образом употребление глютена может быть связано с различными нарушениями здоровья человека, включая неврологические заболевания, продолжает активно обсуждаться в научных и общественных кругах. Особый интерес представляет перспектива использования безглютеновой диеты в комплексной терапии таких заболеваний, как аутизм, шизофрения, а также пограничных неврологических расстройств, включая синдром хронической усталости, различные когнитивные нарушения, депрессию и т.д. В статье представлен обзор результатов исследований в отношении эффективности безглютеновой диеты при различных неврологических заболеваниях и психиатрических расстройствах, а также рассмотрены потенциальные механизмы нейротропного действия глютена.
Ключевые слова
Об авторах
Ю. А. Дмитриева
Российская медицинская академия непрерывного профессионального образования Минздрава России
Россия
Россия
Кандидат медицинских наук.
Москва
И. Н. Захарова
Российская медицинская академия непрерывного профессионального образования Минздрава России
Россия
Россия
Доктор медицинских наук, профессор.
МоскваСписок литературы
1. Brown CW. Sprue and Its Treatment. London: J Bale, Sons, and Danielson, 1908.
2. Elders C. Tropical sprue and pernicious anaemia, aetiology and treatment. Lancet, 1925, i: 75–77.
3. Cooke WT, Thomas-Smith W. Neurological disorders associated with adult coeliac disease. Brain, 1966, 89: 683–722.
4. Hadjivassiliou M, Gibson A, Davies-Jones GAB, Lobo A, Stephenson TJ, Milford-Ward A. Is cryptic gluten sensitivity an important cause of neurological illness? Lancet, 1996, 347: 369–71.
5. Luostarinen L, Pirttilä T, Collin P. Coeliac disease presenting with neurological disorders. Eur Neurol, 1999, 42: 132–135.
6. Holmes GKT. Neurological and psychiatric complications in coeliac disease. In: Gobbi G, Anderman F, Naccarato S, et al, eds. Epilepsy and Other Neurological Disorders in Celiac Disease. London: John Libbey, 1997: 251–264.
7. Briani C, Zara G, Alaedini A, et al. Neurological complications of coeliac disease and autoimmune mechanisms: a prospective study. J Neuroimmunol, 2008, 195: 171–75.
8. Chin RL, Latov N, Green P et al. Neurologic Complica tions of Celiac Disease. J Clin Neuromusc Dis, 2004, 5: 129–137.
9. Hu WT, Murray JA, Greenaway MC, Parisi JE, Josephs KA. Cognitive impairment and celiac disease. Arch Neurol, 2006, 63: 1440–6.
10. Currie S, Hadjivassiliou M, Clark M, et al. Should we be ‘nervous’ about coeliac disease? Brain abnormalities in patients with coeliac disease referred for neurological opinion. J Neurol Neurosurg Psychiatry, 2012, 83: 1216–21.
11. Zelnik N, Pacht A, Obeid R, Lerner A. Range of neurological disorders in patients with celiac disease. Pediatrics, 2004, 113: 1672–6.
12. Всероссийский консенсус по диагностике и лечению целиакии у детей и взрослых. Принят на 42-й Научной сессии ЦНИИГ (2–3 марта 2016 г.). Consilium Medicum. Педиатрия. (Прил.), 2016, 01: 6-19.
13. Abele M, Bu¨rk K, Schöls L, et al. The aetiology of sporadic adult-onset ataxia. Brain, 2002, 125: 961–968.
14. Kaplan JG, Pack D, Horoupian D, et al. Distal axonopathy associated with chronic gluten enteropathy: a treatable disorder. Neurology, 1988, 38: 642–645.
15. Muller AF, Donnelly MT, Smith CM, et al. Neurological complications of celiac disease: a rare but continuing problem. Am J Gastroenterol, 1996, 91: 1430–1435.
16. Lionetti E, Francavilla R, Pavone P et al. The neurology of coeliac disease in childhood: what is the evidence? A systematic review and metaanalysis. Dev Med Child Neurol, 2010, 52(8): 700-7.
17. Luostarinen L, Himanen SL, Luostarinen M, et al. Neuromuscular and sensory disturbances in patients with well-treated celiac disease. J Neurol Neurosurg Psychiatry, 2003, 74: 490–494.
18. Chin RL, Sander HW, Brannagan TH, et al. Celiac neuropathy. Neurology, 2003, 60: 1581–1585.
19. Parisi P, Pietropaoli N, Ferretti A et al. Role of the gluten-free diet on neurological-EEG findings and sleep disordered breathing in children with celiac disease. Seizure, 2015 Feb, 25: 181-3.
20. Işikay S, Hizli Ş, Çoşkun S, Yilmaz K Increased tissue transglutaminase levels are associated with increased epileptiform activity in electroencephalography among patients with celiac disease. Arq Gastroenterol, 2015 Dec, 52(4): 272-7.
21. Lichtwark IT, Newnham ED, Robinson SR, et al. Cognitive impairment in coeliac disease improves on a gluten-free diet and correlates with histological and serological indices of disease severity. Aliment Pharmacol Ther, 2014, 40: 160–70.
22. Volta U, Caio G, De Giorgio R et al. Non-celiac gluten sensitivity: a work-in-progress entity in the spectrum of wheat-related disorders. Best Pract Res Clin Gastroenterol, 2015 Jun, 29(3): 477-91.
23. Volta U, Bardella MT, Calabr A et al. Study Group for Non-Celiac Gluten Sensitivity. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med, 2014, 12: 85.
24. Francavilla R, Cristofori F, Castellaneta S et al. Clinical, serologic, and histologic features of gluten sensitivity in children. J Pediatr, 2014, 164: 463e7.
25. McElhanon BO, McCracken C, Karpen S, Sharp WG (2014) Gastrointestinal symptoms in autism spectrum disorder: a metaanalysis. Pediatrics, 133: 872–883.
26. Piwowarczyk A, Horvath A, Łukasik J et al. Glutenand casein-free diet and autism spectrum disorders in children: a systematic review. Eur J Nutr, 2017 Jun 13. doi: 10.1007/s00394-017-1483-2.
27. Lyra L, Rizzo LE, Sunahara CS et al. What do Cochrane systematic reviews say about interventions for autism spectrum disorders? Sao Paulo Med J, 2017 Mar-Apr, 135(2): 192-201.
28. Sathe N, Andrews JC, McPheeters ML et al. Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic Review. Pediatrics, 2017 Jun, 139(6). pii: e20170346.
29. Bender L. Childhood schizophrenia. Psychiatr. Q, 1953, 27: 663–681.
30. Dohan FC. Cereals and schizophrenia. Data and hypothesis. Acta Psychiatr. Scand., 1966, 42: 125–152.
31. Dohan FC, Grasberger J, Lowell F, Johnston H, Arbegast AW: Relapsed schizophrenics: more rapid improvement on a milk-and cereal-free diet. Br J Psychiatry, 1969, 115(522): 595–596.
32. Singh MM, Kay SR. Wheat gluten asa pathogenic factor in schizophrenia. Science, 1976: 191(4225): 401–402.
33. Dohan FC, Harper EH, Clark MH et al. Is schizophrenia rare if grain is rare? Biol. Psychiatry, 1984, 19: 385–399.
34. Vlissides DN, Venulet A, Jenner F. A double-blind gluten-free/gluten-load controlled trial in a secure ward population. Br J Psychiatry, 1986,148(4): 447–452.
35. Potkin SG, Weinberger D, Kleinman J et al. Wheat gluten challenge in schizophrenic patients. Am J Psychiatry, 1981, 138(1208): 11.
36. Osborne M, Crayton JW, Javaid J, Davis JM Lack of effect of a gluten-free diet on neuroleptic blood levels in schizophrenic patients. Biol Psychiatry, 1982, 17(5): 627–629.
37. Arroll MA, Wilder L, Neil J. Nutritional interventions for the adjunctive treatment of schizophrenia: a brief review. Nutrition Journal, 2014, 13: 91.
38. Murray-Kolb LE, Beard JL. Iron treatment normalizes cognitive functioning in young women. Am J Clin Nutr, 2007, 85: 778–87.
39. Balion C, Griffith L, Strifler L, et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology, 2012, 79: 1397–405.
40. Ramos M, Allen L, Mungas D, et al. Lowfolate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging. Am J Clin Nutr, 2005, 82: 1346–52.
41. Kieslich M, Errázuriz G, Posselt HG, Moeller-Hartmann W, Zanella F, Boehles H. Brain white-matter lesions in celiac disease: a prospective study of 75 diet-treated patients. Pediatrics, 2001, 108(2): E21.
42. Husby S, Koletzko S, Korponay-Szabó IR et al. European Society for Pediatric Gastroente rology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr, 2012 Jan, 54(1): 136-60.
43. Udit S, Gautron L. Molecular anatomy of the gutbrain axis revealed with transgenic technologies: implications in metabolic research. Front. Neurosci., 2013, 7: 134.
44. Karakuła-Juchnowicz H, Dzikowski M, Pelczar ska A et al. The brain-gut axis dysfunctions and hypersensitivity to food antigens in the etiopathogenesis of schizophrenia. Psychiatr Pol, 2016, 50(4): 747-760.
45. de Magistris L, Familiari V, Pascotto A et al (2010) Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr, 51: 418–424.
46. D’Eufemia P, Celli M, Finocchiaro R et al. Abnormal intestinal permeability in children with autism. Acta Paediatr, 1996, 85: 1076–1079.
47. Lu R, Wang W, Uzzau S et al. Affinity purification and partial characterization of the zonulin/zonula occludens toxin (zot) receptor from human brain. J. Neurochem., 2000, 74: 320–326.
48. Shattock P, Kennedy A, Rowell F, Berney T. Role of neuropeptides in autism and their relationships with classical neurotransmitters. Brain Dysfunct, 1990, 3: 328–345.
49. Ly V, Bottelier M, Hoekstra PJ et al. Elimination diets’ efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry, 2017 Feb 11. doi: 10.1007/s00787-017-0959-1.
50. Choi S, DiSilvio B, Fernstrom MH, Fernstrom JD. Meal ingestion, aminoacids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rats. Physiol Behav, 2009, 98: 156–62.
51. Schuppan D, Pickert G, Ashfaq-Khan M et al. Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. Best Pract Res Clin Gastroenterol, 2015 Jun, 29(3): 469-76.
52. Turrin NP, Plata-Salam_an CR. Cytokine-cytokine interactions and the brain. Brain Res Bull, 2000, 51: 3–9.
53. Banks WA, Farr SA, Morley JE. Entry of bloodborne cytokines into the central nervous system: effects on cognitive processes. Neuroimmunomodulation, 2002, 10: 319.
54. Karakuła-Juchnowicz H, Dzikowski M, Pelczarska A et al. The brain-gut axis dysfunctions and hypersensitivity to food antigens in the etiopathogenesis of schizophrenia. Psychiatr Pol, 2016, 50(4): 747-760.
55. Wang L, Christophersen CT, Sorich MJ et al. Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder. Dig. Dis. Sci., 2012, 57: 2096–2102.
56. Thomas RH, Meeking MM, Mepham JR et al. The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development ofa rodent model of autism spectrum disorders. J. Neuroinflammation, 2012, 9: 153.
57. Sandler RH, Finegold SM, Bolte ER, Buchanan CP, Maxwell AP, Vaisanen ML. et al. Shortterm benefit from oral vancomycin treatment of regressiveonset autism. J. Child Neurol, 2000, 15(7): 429–435.
58. Iyer LM, Aravind L, Coon SL, Klein DC, Koonin EV. Evolution of cell-cell signaling in animals: Did late horizontal gene transfer from bacteria havea role? Trends Genet, 2004, 20(7): 292–299.
59. Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG. The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. J. Psychiatr. Res., 2008, 43: 164–174.
60. Irwin MR, Miller AH. Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav. Immun., 2007, 21: 374–383.
61. Bercik P, Denou E, Collins J. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology, 2011, 141: 599–609.
62. Heijtz RD, Wang S, Anuar F. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci, 2011, 108: 3047–52.
63. Tillisch K, Labus J, Kilpatrick L. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology, 2013, 144: 1394–401.
Для цитирования:
Дмитриева Ю.А., Захарова И.Н. Эффективность безглютеновой диеты при неврологических заболеваниях и психиатри ческих расстройствах: миф или реальность? Медицинский Совет. 2018;(2):156-161. https://doi.org/10.21518/2079-701X-2018-2-156-161
For citation:
Dmitrieva Yu.A., Zakharova I.N. EFFICACY OF GLUTEN-FREE DIET IN PATIENTS WITH NEUROLOGICAL DISEASES AND PSYCHIATRIC DISORDERS: MYTH OR REALITY? Meditsinskiy sovet = Medical Council. 2018;(2):156-161. (In Russ.) https://doi.org/10.21518/2079-701X-2018-2-156-161
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