Генетические и молекулярные основы бессимптомной бактериурии у детей: что нового?

В последние годы в связи с совершенствованием генетических и молекулярных методов исследования как микроорганизмов, так и отдельных структур клеток человека возрос интерес ученых к тончайшим механизмам взаимодействия макро- и микроорганизма. Изучение микробиома и разнообразия микроорганизмов на всех участках организма человека дало толчок к новому пониманию развития многих заболеваний и, соответственно, к возможности создания новых терапевтических подходов. Не является исключением и микробиота мочевого пузыря, которая вызывает интерес многих ученых в отношении механизмов формирования бессимптомной бактериурии (ББ) и инфекции мочевых путей (ИМП). Представленная статья посвящена обзору исследований последних лет, сконцентрированных на изучении генетических, иммунных и молекулярных механизмов взаимодействия макро- и микроорганизма при развитии ИМП.

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