Стратегия выбора ингибитора протонной помпы нового поколения декслансопразола в терапии гастроэзофагеальной рефлюксной болезни
https://doi.org/10.21518/2079-701X-2018-3-32-41
Аннотация
Гибкость дозирования в сочетании с увеличением продолжительности поддержания терапевтической концентрации в плазме декслансопразола с модифицированным высвобождением и длительным подавлением секреции кислоты после приема препарата позволяет предположить, что декслансопразол обладает рядом преимуществ для пациентов с кислотозависимыми заболеваниями. Фармакокинетический профиль декслансопразола характеризуется наличием двух пиков Тmax через 1–2 и 4–5 ч после приема препарата и обеспечивает устойчивую концентрацию его в крови. Эффективность декслансопразола в рамках терапии различных форм гастроэзофагеальной рефлюксной болезни была подтверждена несколькими рандомизированными контролируемыми клиническими исследованиями.
Об авторах
Н. В. Топчий
Российская медицинская академия непрерывного профессионального образования; Ассоциация врачей общей практики (семейных врачей) РФ; Российская гастроэнтерологическая ассоциация, Москва
Россия
к.м.н.
Россия
к.м.н.
А. С. Топорков
Российская медицинская академия непрерывного профессионального образования; Ассоциация врачей общей практики (семейных врачей) РФ; Российская гастроэнтерологическая ассоциация, Москва
Россия
к.м.н.
Россия
к.м.н.
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Рецензия
Для цитирования:
Топчий НВ, Топорков АС. Стратегия выбора ингибитора протонной помпы нового поколения декслансопразола в терапии гастроэзофагеальной рефлюксной болезни. Медицинский Совет. 2018;(3):32-41. https://doi.org/10.21518/2079-701X-2018-3-32-41
For citation:
Topchiy NV, Toporkov AS. The strategy for choosing a new-generation proton pump inhibitor dexlansoprazole in the treatment of gastroesophageal reflux disease. Meditsinskiy sovet = Medical Council. 2018;(3):32-41. (In Russ.) https://doi.org/10.21518/2079-701X-2018-3-32-41
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