Афлиберцепт: в фокусе внимания побочные явления
Аннотация
В качестве второй линии терапии больных метастатическим раком толстой кишки зарегистрирован новый антиангиогенный препарат афлиберцепт, применение которого с режимом FOLFIRI значимо уменьшает риск прогрессирования болезни (ОР = 0,758, р = 0,00007). В то же время добавление афлиберцепта в исследовании VELOUR привело к развитию у 83,5% пациентов нежелательных явлений 3–4-й степени тяжести, включая не только осложнения, характерные для антиангиогенных препаратов, но и случаи диареи и нейтропении. В связи с этим онкологу необходимо разбираться в патогенезе, способах профилактики и лечения осложнений, связанных с применением афлиберцепта. Именно этим аспектам и посвящен данный обзор.
Об авторе
М. Ю. Федянин
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России
Россия
Россия
Доктор медицинских наук
Москва
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Рецензия
Для цитирования:
Федянин М.Ю. Афлиберцепт: в фокусе внимания побочные явления. Медицинский Совет. 2018;(10):18-26. https://doi.org/10.21518/2079-701X-2018-10-18-26
For citation:
Fedyanin M.Yu. Aflibercept: side effects in focus. Meditsinskiy sovet = Medical Council. 2018;(10):18-26. (In Russ.) https://doi.org/10.21518/2079-701X-2018-10-18-26
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