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Безопасность и переносимость НПВС: фокус на ацеклофенак

https://doi.org/10.21518/2079-701X-2019-9-110-120

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Аннотация

В статье обсуждаются основные проблемы безопасности нестероидных противовоспалительных средств (НПВС). Приводятся результаты рандомизированных клинических исследований, фармакоэпидемиологических исследований и метаанализов, предполагающие более высокую безопасность ацеклофенака по сравнению с диклофенаком и другими широко применяемыми НПВС. Особое внимание уделяется новой лекарственной форме ацеклофенака – таблеткам с модифицированным высвобождением, изготовленным по технологии Clanza, зарегистрированной под торговым наименованием Ацеклагин. Он предназначен для однократного введения в сутки, что позволяет повысить приверженность терапии.

Об авторах

Е. А. Ушкалова
Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов».
Россия

д.м.н., профессор кафедры общей и клинической фармакологии Федерального государственного автономного образовательного учреждения высшего образования «Российский университет дружбы народов».



С. К. Зырянов
Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов».
Россия

д.м.н., профессор, заведующий кафедрой общей и клинической фармакологией Федерального государственного автономного образовательного учреждения высшего образования «Российский университет дружбы народов».



К. Э. Затолочина
Федеральное государственное автономное образовательное учреждение высшего образования «Российский университет дружбы народов».
Россия

к.м.н., ассистент кафедры общей и клинической фармакологии Федерального государственного автономного образовательного учреждения высшего образования «Российский университет дружбы народов».



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