The value of vitamin D for the health of perimenopausal women

In recent years, there have been reports of the effect of vitamin D on the intensity of early manifestations of menopausal syndrome (hot flushes, mood instability and symptoms of depression, sleep disorders) in perimenopausal women. This review of Russian and foreign literature presents the latest data on the role of vitamin D in maintaining the physical and emotional health of women during this period of life. According to the results of the study, it was found that vitamin D significantly reduces the intensity of early manifestations of climacteric syndrome in perimenopausal women. Prevention of vitamin D deficiency has a positive effect on the health of women in perimenopause, reducing the severity of manifestations of menopausal syndrome.

On the basis of the studied literature data it is shown that the effect of calciferol on serotonin metabolism is similar to the effect of serotonin reuptake inhibitors, which are used in therapy of fever episodes.

Inclusion of vitamin D (if there is a deficiency of it) in the complex therapy helps to cope with depression and insomnia. A normal supply of vitamin D provides maintenance of an optimal concentration of intracellular calcium in nerve cells, which reduces the likelihood of depression. During the perimenopause, in addition to the normalization of physical health, it is necessary to maintain its mental component. It has been proven that taking vitamin D in addition to menopausal hormonal therapy can quickly improve the emotional background, sexual function and quality of life. But still, there are cases when taking vitamin D does not cause positive changes. Most often, this is due to polymorphism of vitamin D receptors. The problem needs further study, as there is no clearly formulated treatment tactics in such situations.

1. Dedov I.I., MeLnichenko G.A., Pigarova E.A., Rozhinskaya L.YA., BeLaya ZH.E., Dzeranova L.K. et aL. Vitamin D deficiency in adults: diagnosis, treatment and prevention: clinical recommendations. Moscow; 2015. (In Russ.) AvaiLabLe at: https://minzdrav.gov-murman.ru/documents/poryadki-okazaniya-meditsin-skoy-pomoshchi/D%2019042014.pdf.

2. Savchenko T.N., Dergacheva I.A., OzoLinya LA. ActuaL view on the vitamin D effect on women's heaLth. Arkhiv akusherstva i ginekologii im. V.F. Snegireva = V.F. Snegirev Archives of Obstetrics and Gynecology. 2019;6(2):73-79. (In Russ.) AvaiLabLe at: https://eLibrary.ru/item.asp?id=38246482.

3. BakLeicheva M.O., KovaLeva I.V., BespaLova O.N., Kogan I .Yu. The effect of vitamin d on women's reproductive heaLth. Zhurnal akusherstva izhenskikh boleznei = Journal of Obstetrics and Women’s Diseases. 2018;67(3):4-19. (In Russ.) doi: 10.17816/JOWD6734-19.

4. ApoLikhina I.A., KuLikov I.A. InfLuence of Hormone D on Women's HeaLth. Effektivnaya farmakoterapiya. Endokrinologiya = Effective Pharmacotherapy. Endocrinology. 2018;(4):44-46. (In Russ.) AvaiLabLe at: https://umedp.ru/articLes/vLiyanie_gormona_d_na_zdorove_zhenshchin.htmL.

5. SaveL'eva G.M., Sukhikh G.T., Serov V.N., Radzinskiy V.E, Manukhin I.B. (eds.) Gynecology: National Guidelines. 2nd ed. Мoscow: GEOTAR-Media; 2017. 1008 p. (In Russ.) AvaiLabLe at: https://www.rosmedLib.ru/book/ISBN9785970441527.htmL.

6. Dikke G.B. MenopausaL syndrome: associated symptoms and their mechanisms are the keys to comprehend aLternative pathogenic treatment. RMZh. Mat i ditya = Russian Journal of Woman and Child Health. 2019;(1):57-64. (In Russ.) doi: 10.32364/2618-8430-2019-2-1-57-64.

7. Lapochkina N.P., Matasheva A.V., Krupenina E.A. SeLective inhibitors of serotonin reverse capture in the correction of psycho-vegetative disorders in women with cLimacteric syndrome. Vestnik Ivanovskoy meditsinskoy aka-demii = Bulletin of the Ivanovo Medical Academy. 2015;20(4):34-38. (In Russ.) AvaiLabLe at: https://vestnik-ivgma.ru/issues/45/pubLications/997?LocaLe=ru.

8. Sabir M.S., HaussLer M.R., MaLLick S., Kaneko I., Lucas D.A., HaussLer C.A. et aL. OptimaL vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cuLtured rat serotonergic neuronaL ceLL Lines. Genes Nutr. 2018(13):19. doi: 10.1186/s12263-018-0605-7.

9. Patrick R.P, Ames B.N. Vitamin D hormone reguLates serotonin synthesis. Part 1: reLevance for autism. Faseb J. 2014;28(6):2398-2413. doi: 10.1096/fj.13-246546.

10. Askin M., Koc E.M., Soyoz M., Aksun S., Aydogmus S., Sozmen K. ReLationship between PostmenopausaL Vitamin D LeveL, MenopausaL Symptoms and SexuaL Functions. J Coll Physicians Surg Pak. 2019;29(9):823-827. doi: 10.29271/jcpsp.2019.09.823.

11. Bromberger J.T., Epperson C.N. Depression During and after the Perimenopause: Impact of Hormones, Genetics, and EnvironmentaL Determinants of Disease. Obstet Gynecol Clin North Am. 2018;45(4):663-678. doi: 10.1016/j.ogc.2018.07.007.

12. Okereke O.I., Singh A. The roLe of vitamin D in the prevention of Late-Life depression. J Affect Disord. 2016;198:1-14. doi: 10.1016/j.jad.2016.03.022.

13. Berridge MJ. Vitamin D and Depression: CeLLuLar and ReguLatory Mechanisms. Pharmacol Rev. 2017;69(2):80-92. doi: 10.1124/pr.116.013227.

14. Morozova Yu.E., Tarasova M.A. The physioLogicaL roLe of vitamin d and the significance of its deficiency in the pathogenesis of cLimacteric syndrome. Zhurnal akusherstva i zhenskikh boleznei = Journal of Obstetrics and Women's Diseases. (In Russ.) 2018;67(3):74-82. doi: 10.17816/JOWD67374-82.

15. Yachinskaya T.V. MenopausaL hormone therapy and vitamin d in postmenopausaL women: the quaLity of Life today and in future. Dalnevostochnyy meditsinskiy zhurnal = Far East Medical Journal. 2017;(3):28-31. (In Russ.) AvaiLabLe at: https://eLibrary.ru/item.asp?id=30079661.

16. Gao Q., Kou T., Zhuang B., Ren Y., Dong X., Wang Q. The Association between Vitamin D Deficiency and SLeep Disorders: A Systematic Review and Meta-AnaLysis. Nutrients. 2018;10(10):1395. doi: 10.3390/nu10101395.

17. Madayeva I.M., Semenova N.V., Danusevich I.N., KoLesnikova L.I. CLimacteric Syndrome, SLeep Disorders and MeLatonin. Effektivnaya farmakoterapiya. = Effective Pharmacotherapy. 2016;(19):86-93. (In Russ.) AvaiLabLe at: https://www.eLibrary.ru/item.asp?id=26512650.

18. Santoro N. Perimenopause: From Research to Practice. J Womens Health. 2016;25(4):332-339. doi: 10.1089/jwh.2015.5556.

19. Filchenko I.A., Korostovtseva L.S., Sviryaev Yu.V. Opportunities of pharmacological therapy with vitamin d for management of sleep disorders. Effektivnaya farmakoterapiya = Effective Pharmacotherapy. 2018;(35):24-33. (In Russ.) Available at: https://www.elibrary.ru/item.asp?id=36415172&.

20. Samoylova A.V., Vasilyeva E.N., Maltseva L.I., Gunin A.G., Denisova T.G., Gerasimova L.I. Vitamin D receptors expression in endometrial cells in patients with preeclampsia. Problemy reproduktsii = Russian Journal of Human Reproduction. 2018;24(4):108-111. (In Russ.) doi: 10.17116/repro201824041108.

21. Boron D., Kaminski A., Kotrych D., Bogacz A., Uzar I., Mrozikiewicz P.M., Czerny B. Polymorphism of vitamin D3 receptor and its relation to mineral bone density in perimenopausal women. Osteoporos Int. 2015;26(3):1045-1052. doi: 10.1007/s00198-014-2947-3.

22. Bizzaro G., Antico A., Fortunato A., Bizzaro N. Vitamin D and Autoimmune Diseases: Is Vitamin D Receptor (VDR) Polymorphism the Culprit? Isr Med Assoc J. 2017;19(7):438-443. Available at: https://pubmed.ncbi.nlm.nih. gov/28786260.

23. Gromova O.A., Torshin I .Yu., Pronin A.V. Features of pharmacology of the micelle-based water-soluble form of vitamin D. Farmateka. 2015;(1):28-35. (In Russ.) Available at: https://elibrary.ru/item.asp?id=2291170.